@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARL2_HUMAN: (2020-01-31 )
MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFTAD
Atome Classification :
(31 SA)
.........10........20........30........40-.........50........60........70........80........90........100.......110..--.....120.......130.......140...------------....150.......160..------.....170.......180..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
G
L
L
T
I
L
K
K
M
K
Q
K
E
R
E
L
R
L
L
M
L
GLDNAGK
T
T
I
L
K
KFNGED--IDTISPTL
G
F
N
I
K
T
L
EHR
G
F
K
L
N
I
W
DVG
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
ESTD
G
L
I
W
V
VDS
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R--LAG
A
T
L
L
I
F
ANKQDLPGA
L
S
S
N
A
I
R
E
V
L
E
L
D
------------
S
IRS
H
H
W
C
I
QGCSAVTGEN------LL
P
G
I
D
W
L
L
D
D
I
S
S
RIFTAD
21
HHSearch
93.90
100%
-116
- C2 -
-
3DOE
1
ARL2_HUMAN
A:
[2-184]
-
G
L
L
T
I
L
K
K
M
K
Q
K
E
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
I
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
S
N
A
I
R
E
V
L
E
L
D
------------
S
I
R
S
H
H
W
C
I
Q
G
C
S
A
V
T
G
E
N
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
I
F
T
A
D
1
PsiBlast_PDB
93.90
100%
-116
- C2 -
-
3DOE
1
ARL2_HUMAN
A:
[2-184]
-
G
L
L
T
I
L
K
K
M
K
Q
K
E
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
I
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
S
N
A
I
R
E
V
L
E
L
D
------------
S
I
R
S
H
H
W
C
I
Q
G
C
S
A
V
T
G
E
N
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
I
F
T
A
D
2
PsiBlast_PDB
92.80
100%
-114
- C2 -
-
3DOF
1
ARL2_HUMAN
A:
[2-184]
-
G
L
L
T
I
L
K
K
M
K
Q
K
E
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
I
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
S
N
A
I
R
E
V
L
E
L
D
------------
S
I
R
S
H
H
W
C
I
Q
G
C
S
A
V
T
G
E
N
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
I
F
T
A
D
4
PsiBlast_PDB
91.03
96%
-128
- C2 -
-
1KSG
1
ARL2_MOUSE
A:
[3-181]
M
G
L
L
T
I
L
K
K
M
K
Q
K
E
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
V
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
C
N
A
I
Q
E
A
L
E
L
D
------------
S
I
R
S
H
H
W
R
I
Q
G
C
S
A
V
T
G
E
D
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
-----
22
HHSearch
89.19
96%
-132
- C2 -
-
1KSH
1
ARL2_MOUSE
A:
[17-181]
--------------
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
V
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
C
N
A
I
Q
E
A
L
E
L
D
------------
S
I
R
S
H
H
W
R
I
Q
G
C
S
A
V
T
G
E
D
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
-----
3
PsiBlast_PDB
89.19
96%
-132
- C2 -
-
1KSH
1
ARL2_MOUSE
A:
[17-181]
--------------
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
V
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
C
N
A
I
Q
E
A
L
E
L
D
------------
S
I
R
S
H
H
W
R
I
Q
G
C
S
A
V
T
G
E
D
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
-----
5
PsiBlast_PDB
87.08
94%
-129
- C2 -
-
1KSJ
2
ARL2_MOUSE
A:
[17-181]
--------------
R
E
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
N
G
E
D
--
V
D
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
Q
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
C
N
A
I
Q
E
A
L
E
L
D
------------
S
I
R
S
H
H
W
R
I
Q
G
C
S
A
V
T
G
E
D
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
-----
6
PsiBlast_PDB
84.78
95%
-140
- C2 -
-
4GOK
1
ARL2_MOUSE
B:
[2-164]
----------------
L
R
L
L
M
L
G
L
D
N
A
G
K
T
T
I
L
K
K
F
--------
T
I
S
P
T
L
G
F
N
I
K
T
L
E
H
R
G
F
K
L
N
I
W
D
V
G
G
L
K
S
L
R
S
Y
W
R
N
Y
F
E
S
T
D
G
L
I
W
V
V
D
S
A
D
R
Q
R
M
Q
D
C
Q
R
E
L
Q
S
L
L
V
E
E
R
--
L
A
G
A
T
L
L
I
F
A
N
K
Q
D
L
P
G
A
L
S
C
N
A
I
Q
E
A
L
E
L
D
------------
S
I
R
S
H
H
W
R
I
Q
G
C
S
A
V
T
G
E
D
------
L
L
P
G
I
D
W
L
L
D
D
I
S
S
R
-----
7
PsiBlast_PDB
76.66
56%
-131
- C2 -
-
5DI3
1
ARL3_CHLRE
A:
[16-176]
---------------
E
A
R
I
L
V
L
G
L
D
N
A
G
K
T
T
I
L
K
A
L
S
E
E
D
--
I
T
T
I
T
P
T
Q
G
F
N
I
K
S
L
S
R
D
G
F
N
L
K
I
W
D
I
G
G
Q
K
S
I
R
P
Y
W
R
N
Y
F
D
Q
T
D
A
L
I
Y
V
I
D
S
A
D
S
K
R
L
S
E
S
E
F
E
L
T
E
L
L
Q
E
E
K
--
M
T
G
V
P
L
L
V
F
A
N
K
Q
D
L
V
G
A
L
A
A
D
E
I
A
S
T
L
D
L
T
------------
S
I
R
D
R
P
W
Q
I
Q
A
C
S
A
K
Q
G
T
G
------
L
K
E
G
M
E
W
M
M
K
Q
V
--------
28
HHSearch
75.61
46%
-143
- C2 -
-
1MOZ
1
ARL1_YEAST
B:
[6-180]
---
S
S
M
F
D
K
L
W
G
S
N
K
E
L
R
I
L
I
L
G
L
D
G
A
G
K
T
T
I
L
Y
R
L
Q
I
G
E
--
V
V
T
T
K
P
T
I
G
F
N
V
E
T
L
S
Y
K
N
L
K
L
N
V
W
D
L
G
----
I
R
P
Y
W
R
C
Y
Y
A
D
T
A
A
V
I
F
V
V
D
S
T
D
K
D
R
M
S
T
A
S
K
E
L
H
L
M
L
Q
E
E
E
--
L
Q
D
A
A
L
L
V
F
A
N
K
Q
D
Q
P
G
A
L
S
A
S
E
V
S
K
E
L
N
L
V
------------
E
L
K
D
R
S
W
S
I
V
A
S
S
A
I
K
G
E
G
------
I
T
E
G
L
D
W
L
I
D
V
I
K
E
------
8
PsiBlast_PDB
75.31
57%
-125
- C2 -
-
5DE3
1
ARL3_CHLRE
A:
[2-160]
-----------------
R
I
L
V
L
G
L
D
N
A
G
K
T
T
I
L
K
A
L
S
E
E
D
--
I
T
T
I
T
P
T
Q
G
F
N
I
K
S
L
S
R
D
G
F
N
L
K
I
W
D
I
G
G
Q
K
S
I
R
P
Y
W
R
N
Y
F
D
Q
T
D
A
L
I
Y
V
I
D
S
A
D
S
K
R
L
S
E
S
E
F
E
L
T
E
L
L
Q
E
E
K
--
M
T
G
V
P
L
L
V
F
A
N
K
Q
D
L
V
G
A
L
A
A
D
E
I
A
S
T
L
D
L
T
------------
S
I
R
D
R
P
W
Q
I
Q
A
C
S
A
K
Q
G
T
G
------
L
K
E
G
M
E
W
M
M
K
Q
V
--------
17
PsiBlast_PDB
74.76
54%
-135
- C2 -
-
3BH6
1
ARL3_MOUSE
A:
[4-164]
---------------
E
V
R
I
L
L
L
G
L
D
N
A
G
K
T
T
L
L
K
Q
L
A
S
E
D
--
I
S
H
I
T
P
T
Q
G
F
N
I
K
S
V
Q
S
Q
G
F
K
L
N
V
W
D
I
G
G
L
R
K
I
R
P
Y
W
R
S
Y
F
E
N
T
D
I
L
I
Y
V
I
D
S
A
D
R
K
R
F
E
E
T
G
Q
E
L
T
E
L
L
E
E
E
K
--
L
S
C
V
P
V
L
I
F
A
N
K
Q
D
L
L
T
A
A
P
A
S
E
I
A
E
G
L
N
L
H
------------
T
I
R
D
R
V
W
Q
I
Q
S
C
S
A
L
T
G
E
G
------
V
Q
D
G
M
N
W
V
C
K
N
V
--------
14
PsiBlast_PDB
74.68
47%
-150
- C2 -
-
1MOZ
1
ARL1_YEAST
A:
[7-178]
----
S
M
F
D
K
L
W
G
S
N
K
E
L
R
I
L
I
L
G
L
D
G
A
G
K
T
T
I
L
Y
R
L
Q
I
G
E
--
V
V
T
T
K
P
T
I
G
F
N
V
E
T
L
S
Y
K
N
L
K
L
N
V
W
D
L
G
----
I
R
P
Y
W
R
C
Y
Y
A
D
T
A
A
V
I
F
V
V
D
S
T
D
K
D
R
M
S
T
A
S
K
E
L
H
L
M
L
Q
E
E
E
--
L
Q
D
A
A
L
L
V
F
A
N
K
Q
D
Q
P
G
A
L
S
A
S
E
V
S
K
E
L
N
L
V
------------
E
L
K
D
R
S
W
S
I
V
A
S
S
A
I
K
G
E
G
------
I
T
E
G
L
D
W
L
I
D
V
I
--------
26
HHSearch
74.19
46%
-128
- C2 -
-
3LRP
1
ARF1_PLAF7
A:
[10-179]
--------
N
R
L
F
Q
K
K
D
V
R
I
L
M
V
G
L
D
A
A
G
K
T
T
I
L
Y
K
V
K
L
G
E
--
V
V
T
T
I
P
T
I
G
F
N
V
E
T
V
E
F
R
N
I
S
F
T
V
W
D
V
G
G
Q
D
K
I
R
P
L
W
R
H
Y
Y
S
N
T
D
G
L
I
F
V
V
D
S
N
D
R
E
R
I
D
D
A
R
E
E
L
H
R
M
I
N
E
E
E
--
L
K
D
A
I
I
L
V
F
A
N
K
Q
D
L
P
N
A
M
S
A
A
E
V
T
E
K
L
H
L
N
------------
T
I
R
E
R
N
W
F
I
Q
S
T
C
A
T
R
G
D
G
------
L
Y
E
G
F
D
W
L
T
T
H
L
N
N
------
36
HHSearch
73.95
48%
-148
- C2 -
-
1R8S
4
ARF1_BOVIN
A:
[1-160]
----------------
M
R
I
L
M
V
G
L
D
A
A
G
K
T
T
I
L
Y
K
L
K
L
G
E
--
I
V
T
T
I
P
T
I
G
F
N
V
E
T
V
E
Y
K
N
I
S
F
T
V
W
D
V
G
G
Q
D
K
I
R
P
L
W
R
H
Y
F
Q
N
T
Q
G
L
I
F
V
V
D
S
N
D
R
E
R
V
N
E
A
R
E
E
L
M
R
M
L
A
E
D
E
--
L
R
D
A
V
L
L
V
F
A
N
K
Q
D
L
P
N
A
M
N
A
A
E
I
T
D
K
L
G
L
H
------------
S
L
R
H
R
N
W
Y
I
Q
A
T
C
A
T
S
G
D
G
------
L
Y
E
G
L
D
W
L
S
N
Q
L
--------
20
PsiBlast_PDB
73.43
46%
-145
- C2 -
-
1R8Q
2
ARF1_BOVIN
A:
[15-180]
-------------
K
K
E
M
R
I
L
M
V
G
L
D
A
A
G
K
T
T
I
L
Y
K
L
K
L
G
E
--
I
V
T
T
I
P
T
I
G
F
N
V
E
T
V
E
Y
K
N
I
S
F
T
V
W
D
V
G
G
Q
D
K
I
R
P
L
W
R
H
Y
F
Q
N
T
Q
G
L
I
F
V
V
D
S
N
D
R
E
R
V
N
E
A
R
E
E
L
M
R
M
L
A
E
D
E
--
L
R
D
A
V
L
L
V
F
A
N
K
Q
D
L
P
N
A
M
N
A
A
E
I
T
D
K
L
G
L
H
------------
S
L
R
H
R
N
W
Y
I
Q
A
T
C
A
T
S
G
D
G
------
L
Y
E
G
L
D
W
L
S
N
Q
L
R
N
Q
-----
15
PsiBlast_PDB
73.33
54%
-132
- C2 -
-
3BH7
1
ARL3_MOUSE
A:
[4-164]
---------------
E
V
R
I
L
L
L
G
L
D
N
A
G
K
T
T
L
L
K
Q
L
A
S
E
D
--
I
S
H
I
T
P
T
Q
G
F
N
I
K
S
V
Q
S
Q
G
F
K
L
N
V
W
D
I
G
G
Q
R
K
I
R
P
Y
W
R
S
Y
F
E
N
T
D
I
L
I
Y
V
I
D
S
A
D
R
K
R
F
E
E
T
G
Q
E
L
T
E
L
L
E
E
E
K
--
L
S
C
V
P
V
L
I
F
A
N
K
Q
D
L
L
T
A
A
P
A
S
E
I
A
E
G
L
N
L
H
------------
T
I
R
D
R
V
W
Q
I
Q
S
C
S
A
L
T
G
E
G
------
V
Q
D
G
M
N
W
V
C
K
N
V
--------
23
HHSearch
72.66
41%
-139
- C2 -
-
1ZJ6
1
ARL5A_HUMAN
A:
[4-178]
--
L
F
T
R
I
W
R
L
-
F
N
H
Q
E
H
K
V
I
I
V
G
L
D
N
A
G
K
T
T
I
L
Y
Q
F
S
M
N
E
--
V
V
H
T
S
P
T
I
G
S
N
V
E
E
I
V
I
N
N
T
R
F
L
M
W
D
I
G
G
----
R
S
S
W
N
T
Y
Y
T
N
T
E
F
V
I
V
V
V
D
S
T
D
R
E
R
I
S
V
T
R
E
E
L
Y
K
M
L
A
H
E
D
--
L
R
K
A
G
L
L
I
F
A
N
K
Q
D
V
K
E
C
M
T
V
A
E
I
S
Q
F
L
K
L
T
------------
S
I
K
D
H
Q
W
H
I
Q
A
C
C
A
L
T
G
E
G
------
L
C
Q
G
L
E
W
M
M
S
R
L
K
I
------
29
HHSearch
72.23
43%
-140
- C2 -
-
2H17
1
ARL5A_HUMAN
A:
[21-180]
---------------
E
H
K
V
I
I
V
G
L
D
N
A
G
K
T
T
I
L
Y
Q
F
S
M
N
E
--
V
V
H
T
S
P
T
I
G
S
N
V
E
E
I
V
I
N
N
T
R
F
L
M
W
D
I
G
G
Q
E
S
L
R
S
S
W
N
T
Y
Y
T
N
T
E
F
V
I
V
V
V
D
S
T
D
R
E
R
I
S
V
T
R
E
E
L
Y
K
M
L
A
H
E
D
--
L
R
K
A
G
L
L
I
F
A
N
K
Q
D
V
K
E
C
M
T
V
A
E
I
S
Q
F
L
K
L
T
------------
S
I
K
D
H
Q
W
H
I
Q
A
C
C
A
L
T
G
E
G
------
L
C
Q
G
L
E
W
M
M
S
R
---------
30
HHSearch
71.94
46%
-115
- C2 -
-
2X77
1
?
A:
[17-186]
----------
L
P
A
D
R
K
I
R
V
L
M
L
G
L
D
N
A
G
K
T
S
I
L
Y
R
L
H
L
G
D
--
V
V
T
T
V
P
T
V
G
V
N
L
E
T
L
Q
Y
K
N
I
S
F
E
V
W
D
L
G
G
Q
T
G
V
R
P
Y
W
R
C
Y
F
S
D
T
D
A
V
I
Y
V
V
D
S
T
D
R
D
R
M
G
V
A
K
H
E
L
Y
A
L
L
D
E
D
E
--
L
R
K
S
L
L
L
I
F
A
N
K
Q
D
L
P
D
A
A
S
E
A
E
I
A
E
Q
L
G
V
S
------------
S
I
M
N
R
T
W
T
I
V
K
S
S
S
K
T
G
D
G
------
L
V
E
G
M
D
W
L
V
E
R
L
R
E
Q
G
----
24
HHSearch
71.02
43%
-124
- C2 -
-
1MR3
19
ARF2_YEAST
F:
[5-180]
---
A
S
K
L
F
S
N
L
F
G
N
K
E
M
R
I
L
M
V
G
L
D
G
A
G
K
T
T
V
L
Y
K
L
K
L
G
E
--
V
I
T
T
I
P
T
I
G
F
N
V
E
T
V
Q
Y
K
N
I
S
F
T
V
W
D
V
G
G
Q
D
R
I
R
S
L
W
R
H
Y
Y
R
N
T
E
G
V
I
F
V
I
D
S
N
D
R
S
R
I
G
E
A
R
E
V
M
Q
R
M
L
N
E
D
E
--
L
R
N
A
V
W
L
V
F
A
N
K
Q
D
L
P
E
A
M
S
A
A
E
I
T
E
K
L
G
L
H
------------
S
I
R
N
R
P
W
F
I
Q
S
T
C
A
T
S
G
E
G
------
L
Y
E
G
L
E
W
L
S
N
N
L
K
N
Q
-----
27
HHSearch
70.87
45%
-140
- C2 -
-
3VHX
1
ARF6_MOUSE
A:
[2-162]
---------------
E
M
R
I
L
M
L
G
L
D
A
A
G
K
T
T
I
L
Y
K
L
K
L
G
Q
--
S
V
T
T
I
P
T
V
G
F
N
V
E
T
V
T
Y
K
N
V
K
F
N
V
W
D
V
G
G
L
D
K
I
R
P
L
W
R
H
Y
Y
T
G
T
Q
G
L
I
F
V
V
D
C
A
D
R
D
R
I
D
E
A
R
Q
E
L
H
R
I
I
N
D
R
E
--
M
R
D
A
I
I
L
I
F
A
N
K
Q
D
L
P
D
A
M
K
P
H
E
I
Q
E
K
L
G
L
T
------------
R
I
R
D
R
N
W
Y
V
Q
P
S
C
A
T
S
G
D
G
------
L
Y
E
G
L
T
W
L
T
S
N
Y
--------
40
HHSearch
69.76
46%
-138
- C2 -
-
3TJZ
1
ARF1_YEAST
A:
[1-159]
----------------
M
R
I
L
M
V
G
L
D
G
A
G
K
T
T
V
L
Y
K
L
K
L
G
E
--
V
I
T
T
I
P
T
I
G
F
N
V
E
T
V
Q
Y
K
N
I
S
F
T
V
W
D
V
G
G
Q
D
R
I
R
S
L
W
R
H
Y
Y
R
N
T
E
G
V
I
F
V
V
D
S
N
D
R
S
R
I
G
E
A
R
E
V
M
Q
R
M
L
N
E
D
E
--
L
R
N
A
A
W
L
V
F
A
N
K
Q
D
L
P
E
A
M
S
A
A
E
I
T
E
K
L
G
L
H
------------
S
I
R
N
R
P
W
F
I
Q
A
T
C
A
T
S
G
E
G
------
L
Y
E
G
L
E
W
L
S
N
S
---------
25
HHSearch
69.27
41%
-139
- C2 -
-
1Z6Y
1
ARL5A_HUMAN
B:
[6-175]
----
T
R
I
W
R
L
-
F
N
H
Q
E
H
K
V
I
I
V
G
L
D
N
A
G
K
T
T
I
L
Y
Q
F
S
M
N
E
--
V
V
H
T
S
P
T
I
G
S
N
V
E
E
I
V
I
N
N
T
R
F
L
M
W
D
I
G
G
Q
E
S
L
R
S
----
Y
Y
T
N
T
E
F
V
I
V
V
V
D
S
T
D
R
E
R
I
S
V
T
R
E
E
L
Y
K
M
L
A
H
E
D
--
L
R
K
A
G
L
L
I
F
A
N
K
Q
D
V
K
E
C
M
T
V
A
E
I
S
Q
F
L
K
L
T
------------
S
I
K
D
H
Q
W
H
I
Q
A
C
C
A
L
T
G
E
G
------
L
C
Q
G
L
E
W
M
M
S
R
---------
35
HHSearch
67.84
46%
-143
- C2 -
-
3N5C
1
ARF6_HUMAN
B:
[1-160]
----------------
M
R
I
L
M
L
G
L
D
A
A
G
K
T
T
I
L
Y
K
L
K
L
G
Q
--
S
V
T
T
I
P
T
V
G
F
N
V
E
T
V
T
Y
K
N
V
K
F
N
V
W
D
V
G
G
Q
D
K
I
R
P
L
W
R
H
Y
Y
T
G
T
Q
G
L
I
F
V
V
D
C
A
D
R
D
R
I
D
E
A
R
Q
E
L
H
R
I
I
N
D
R
E
--
M
R
D
A
I
I
L
I
F
A
N
K
Q
D
L
P
D
A
M
K
P
H
E
I
Q
E
K
L
G
L
T
------------
R
I
R
D
R
N
W
Y
V
Q
P
S
C
A
T
S
G
D
G
------
L
Y
E
G
L
T
W
L
T
S
N
Y
--------
31
HHSearch
67.21
46%
-131
- C2 -
-
2X77
1
?
B:
[17-185]
----------
L
P
A
D
R
K
I
R
V
L
M
L
G
L
D
N
A
G
K
T
S
I
L
Y
R
L
H
L
G
D
--
V
V
T
T
------
N
L
E
T
L
Q
Y
K
N
I
S
F
E
V
W
D
L
G
G
---------
C
Y
F
S
D
T
D
A
V
I
Y
V
V
D
S
T
D
R
D
R
M
G
V
A
K
H
E
L
Y
A
L
L
D
E
D
E
--
L
R
K
S
L
L
L
I
F
A
N
K
Q
D
L
P
D
A
A
S
E
A
E
I
A
E
Q
L
G
V
S
------------
S
I
M
N
R
T
W
T
I
V
K
S
S
S
K
T
G
D
G
------
L
V
E
G
M
D
W
L
V
E
R
L
R
E
Q
-----
32
HHSearch
66.61
31%
-121
- C2 -
-
2FA9
1
SAR1B_CRIGR
B:
[4-188]
---
S
S
V
L
Q
F
L
G
L
Y
K
K
T
G
K
L
V
F
L
G
L
D
N
A
G
K
T
T
L
L
H
M
L
K
----------
P
T
L
H
P
T
S
E
E
L
T
I
A
G
M
T
F
T
T
F
D
L
G
G
G
I
Q
A
R
R
V
W
K
N
Y
L
P
A
I
N
G
I
V
F
L
V
D
C
A
D
H
E
R
L
L
E
S
K
E
E
L
D
S
L
M
T
D
E
T
--
I
A
N
V
P
I
L
I
L
G
N
K
I
D
R
P
E
A
I
S
E
E
R
L
R
E
M
F
G
L
Y
GQTTGKGSVSLK
E
L
N
A
R
P
L
E
V
F
M
C
S
V
L
K
R
Q
G
------
Y
G
E
G
F
R
W
M
A
Q
Y
I
--------
34
HHSearch
65.83
31%
-116
- C2 -
-
1F6B
1
SAR1B_CRIGR
A:
[14-197]
----
S
V
L
Q
F
L
G
L
Y
K
K
T
G
K
L
V
F
L
G
L
D
N
A
G
K
T
T
L
L
H
M
L
K
D
D
--------
P
T
L
H
P
T
S
E
E
L
T
I
A
G
M
T
F
T
T
F
D
L
G
G
----
R
R
V
W
K
N
Y
L
P
A
I
N
G
I
V
F
L
V
D
C
A
D
H
E
R
L
L
E
S
K
E
E
L
D
S
L
M
T
D
E
T
--
I
A
N
V
P
I
L
I
L
G
N
K
I
D
R
P
E
A
I
S
E
E
R
L
R
E
M
F
G
L
Y
GQTTGKGSVSLK
E
L
N
A
R
P
L
E
V
F
M
C
S
V
L
K
R
Q
G
------
Y
G
E
G
F
R
W
M
A
Q
Y
I
--------
37
HHSearch
63.93
33%
-95
- C2 -
-
4M9Q
1
ARL13_CHLRE
B:
[3-172]
--------------
R
K
I
T
I
A
L
L
G
L
D
N
A
G
K
T
T
L
L
N
S
I
Q
G
E
V
--
D
R
D
T
T
P
T
F
G
F
N
S
T
T
L
N
E
G
K
Y
K
I
E
V
F
D
L
G
G
G
K
N
I
R
G
V
W
K
K
Y
L
A
E
V
H
A
I
V
Y
V
V
D
A
A
D
P
G
R
F
E
E
S
K
M
T
M
A
E
V
L
E
N
Q
F
--
M
R
D
K
P
I
C
I
F
A
N
K
Q
D
L
P
T
A
A
P
A
A
E
V
V
K
G
L
G
L
A
------------
T
C
-
R
N
S
H
N
V
F
P
C
T
A
K
M
P
A
G
QDVDHR
L
R
D
G
L
K
W
L
V
G
T
V
D
R
E
-----
38
HHSearch
53.94
36%
13
- C2 -
-
2H57
2
ARL6_HUMAN
C:
[21-186]
---------------
E
V
H
V
L
C
L
G
L
D
N
S
G
K
T
T
I
I
N
K
L
K
P
S
N
AQ
S
Q
N
I
L
P
T
I
G
F
S
I
E
K
F
K
S
S
S
L
S
F
T
V
F
D
M
S
G
Q
G
R
Y
R
N
L
W
E
H
Y
Y
K
E
G
Q
A
I
I
F
V
I
D
S
S
D
R
L
R
M
V
V
A
K
E
E
L
D
T
L
L
N
H
P
D
IK
H
R
R
I
P
I
L
F
F
A
N
K
M
D
L
R
D
A
V
T
S
V
K
V
S
Q
L
L
C
L
E
------------
N
I
K
D
K
P
W
H
I
C
A
S
D
A
I
K
G
E
G
------
L
Q
E
G
V
D
W
L
Q
D
Q
I
Q
-------
39
HHSearch
53.28
36%
16
- C2 -
-
2H57
1
ARL6_HUMAN
B:
[20-186]
--------------
K
E
V
H
V
L
C
L
G
L
D
N
S
G
K
T
T
I
I
N
K
L
K
P
S
N
AQ
S
Q
N
I
L
P
T
I
G
F
S
I
E
K
F
K
S
S
S
L
S
F
T
V
F
D
M
S
G
Q
G
R
Y
R
N
L
W
E
H
Y
Y
K
E
G
Q
A
I
I
F
V
I
D
S
S
D
R
L
R
M
V
V
A
K
E
E
L
D
T
L
L
N
H
P
D
IK
H
R
R
I
P
I
L
F
F
A
N
K
M
D
L
R
D
A
V
T
S
V
K
V
S
Q
L
L
C
L
E
------------
N
I
K
D
K
P
W
H
I
C
A
S
D
A
I
K
G
E
G
------
L
Q
E
G
V
D
W
L
Q
D
Q
I
Q
-------