@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DHX36_HUMAN: (2020-01-31 )
MSYDYHQNWGRDGGPRSSGGGYGGGPAGGHGGNRGSGGGGGGGGGGRGGRGRHPGHLKGREIGMWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKNDKESEAQISWFAPEDHGYGTEVSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGTLDQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQEKATPRNFPPRFQDGYYS
Atome Classification :
(26 SA)
-------------------------------------.........10........20........30........40........50........60......-----..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180---......-.190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300......-.310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460...-....470........480.......490.......500.......510..-----.----.----...520.......530.......----540---.---.---.------.....550.......560.......570.......580.........590.......600.......610.......620.-.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.-....-..730.......740.......750.......760.......770.......780.......790.......800.......810..-.....820.......830.........840.......850---.......860.--..-....870.....--..880.......890.......900.......910....-...920.......930.......940.......950.......960.......970.......980.......990.......1000.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------MSYDYHQNWGRDGGPRSSGGGYGGGPAGGHGGNRGSGGGGGGGGGGRGGRGRHPGHLKGRE
I
G
M
W
Y
A
-----
K
KQGQKN
K
E
A
E
R
Q
E
R
A
V
V
H
M
D
E
R
R
E
E
Q
I
V
Q
L
L
N
S
V
QAKNDKESEA
Q
I
S
W
FAPEDHGYGTEVSTKNTPCSENKL
D
I
Q
E
K
K
L
I
N
Q
E
K
K
M
F
R
IRNRSYIDRD
S
E
Y
L
LQENEPDG
T
L
D
Q
---
K
L
L
E
D
L
-
Q
K
KKNDL
R
Y
I
E
M
Q
H
F
R
E
KLPSYG
M
Q
K
E
L
V
N
L
IDNH
Q
V
T
V
I
SGETGCGK
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
E
RGKG
S
A
C
R
I
V
CTQPR
R
I
S
A
I
S
V
A
E
R
V
A
A
E
R
A
E
SCGSGNST
G
Y
Q
I
R
L
Q
SRLPRKQG
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
QSDP
Y
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
NL
Q
S
D
V
L
M
T
V
V
K
D
L
L
N
F
R
S
D
L
K
V
I
L
M
SATL
N
A
E
K
F
S
E
Y
FGNC
P
M
I
H
IPG
F
T
F
P
V
V
E
Y
L
L
E
D
V
I
E
K
I
RYVPE
Q
K
E
H
R
S
Q
F
K
R
G
F
M
Q
GHV
N
R
Q
E
K
E
E
K
E
A
I
Y
K
E
R
W
P
D
Y
V
R
E
L
R
R
RYSAS
T
V
D
V
I
E
M
M-EDDKV-
D
L
N
L
I
V
A
L
I
R
Y
I
VLEEED
G
A
I
L
V
F
LPGWD
N
I
S
T
L
H
D
L
L
M
S
Q
V
M
F-----K----S----D
K
F
L
I
I
P
L
H
S
LMPTVNQT
Q
V
FKR----TP----P---G---
V
------
R
K
I
V
I
A
TNIA
E
T
S
I
T
I
D
D
V
V
Y
V
IDG
G
K
I
K
E
T
HFDTQ--NNI
S
T
M
S
A
E
W
V
S
KAN
A
K
Q
RKGRAGRVQPG
H
C
Y
H
L
Y
N
G
L
R
A
S
-
L
-LDDYQ
L
P
E
I
L
R
T
P
L
E
E
L
C
L
Q
I
K
I
L
RLG
G
I
A
Y
F
L
S
R
LMDPPSN
E
A
V
L
L
S
I
R
H
L
M
E
L
NALDKQEELT
P
L
G
V
H
L
A
RLPVEPHI
G
K
M
I
L
F
G
A
L
F
C
C
L
D
P
V
L
T
I
A
A
-SLSF-KD
P
F
V
I
PL
G
K
E
K
I
A
D
A
R
R
K
E
L
A
K
D
TRSD
H
L
T
V
V
N
A
F
E
G
W
E
E
A
R
R
RGFRY
E
K
D
Y
C
W
E
Y
FLSS
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
E
H
L
L
G
AGFVSSR-NPKDPESNINS
D
N
E
K
I
--
I
K
A
V
I
C
AGLY
P
K
V
A
K
I
R
LNLGK---K
R
K
M
V
K
V
Y
TKT--D
G
-
L
V
A
VHPKSVNVE--QT
D
F
H
Y
N
W
L
I
Y
H
L
K
M
RT
S
S
I
Y
L
Y
DCTEVS
P
Y
C
L
L
F
FG
G
D
-
I
S
I
QKDNDQ
E
T
I
A
V
D
E
W
I
V
FQS
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
KIESPHPVDWNDTKS
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
Q
EKATPRNFPPRFQDGYYS
1
PsiBlast_PDB
99.03
91%
-105
- C3 -
-
5VHE
-
DHX36_BOVIN
A:
[3-905]
------------------------------------------------------------------------------------------
P
G
H
L
K
G
R
E
I
G
L
W
Y
A
-----
K
K
Q
G
Q
K
N
K
E
A
E
R
Q
E
R
A
V
V
H
M
D
E
R
R
E
E
Q
I
V
Q
L
L
H
S
V
Q
T
K
--------------------
T
E
---------------------------------
A
Y
I
D
R
D
S
E
Y
L
L
Q
E
N
E
P
D
A
T
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
E
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
I
S
G
E
T
G
C
G
K
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
E
R
G
K
G
S
A
C
R
I
V
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
A
E
R
A
E
S
C
G
N
G
N
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
Q
S
D
P
H
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
N
L
Q
S
D
V
L
M
T
V
V
K
D
L
L
S
Y
R
P
D
L
K
V
V
L
M
S
A
T
L
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
K
I
R
Y
V
P
E
Q
K
------------
G
H
V
N
R
Q
E
K
Y
Y
Y
E
A
I
Y
K
E
R
W
P
G
Y
L
R
E
L
R
Q
R
Y
S
A
S
T
V
D
V
V
E
M
M
-
D
D
E
K
V
-
D
L
N
L
I
A
A
L
I
R
Y
I
V
L
E
E
E
D
G
A
I
L
V
F
L
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
Q
V
M
F
-----
K
----
S
----
D
K
F
I
I
I
P
L
H
S
L
M
P
T
V
N
Q
T
Q
V
F
K
R
----
T
P
----
P
---
G
---
V
------
R
K
I
V
I
A
T
N
I
A
E
T
S
I
T
I
D
D
V
V
Y
V
I
D
G
G
K
I
K
E
T
H
F
D
T
Q
--
N
N
I
S
T
M
S
A
E
W
V
S
K
A
N
A
K
Q
R
K
G
R
A
G
R
V
Q
P
G
H
C
Y
H
L
Y
N
S
L
R
A
S
-
L
-
L
D
D
Y
Q
L
P
E
I
L
R
T
P
L
E
E
L
C
L
Q
I
K
I
L
R
L
G
G
I
A
H
F
L
S
R
L
M
D
P
P
S
N
E
A
V
L
L
S
I
K
H
L
M
E
L
N
A
L
D
K
Q
E
E
L
T
P
L
G
V
H
L
A
R
L
P
V
E
P
H
I
G
K
M
I
L
F
G
A
L
F
C
C
L
D
P
V
L
T
I
A
A
-
S
L
S
F
-
K
D
P
F
V
I
P
L
G
K
E
K
V
A
D
A
R
R
K
E
L
A
A
A
T
A
S
D
H
L
T
V
V
N
A
F
K
G
W
E
K
A
K
Q
R
G
F
R
Y
E
K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
E
H
L
L
G
A
G
F
V
S
S
R
-
N
P
Q
D
P
E
S
N
I
N
S
D
N
E
K
I
--
I
K
A
V
I
C
A
G
L
Y
P
K
V
A
K
I
R
L
N
L
G
K
---
K
R
K
M
V
K
V
Y
T
K
T
--
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
--
Q
T
E
F
N
Y
N
W
L
I
Y
H
L
K
M
R
T
S
S
I
Y
L
Y
D
C
T
E
V
S
P
Y
C
L
L
F
F
G
G
D
-
I
S
I
Q
K
D
N
D
Q
E
T
I
A
V
D
E
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
-------------------
3
PsiBlast_PDB
95.80
94%
-113
- C3 -
-
5VHC
1
DHX36_BOVIN
D:
[18-842]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
S
E
Y
L
L
Q
E
N
E
P
D
A
T
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
E
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
I
S
G
E
T
G
C
G
K
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
E
R
G
K
G
S
A
C
R
I
V
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
A
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R
A
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S
C
G
N
G
N
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
Q
S
D
P
H
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
N
L
Q
S
D
V
L
M
T
V
V
K
D
L
L
S
Y
R
P
D
L
K
V
V
L
M
S
A
T
L
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
K
I
R
Y
V
P
E
----------------------
Y
Y
Y
E
A
I
Y
K
E
R
W
P
G
Y
L
R
E
L
R
Q
R
Y
S
A
S
T
V
D
V
V
E
M
M
-
D
D
E
K
V
-
D
L
N
L
I
A
A
L
I
R
Y
I
V
L
E
E
E
D
G
A
I
L
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F
L
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
Q
V
M
F
-----
K
----
S
----
D
K
F
I
I
I
P
L
H
S
L
M
P
T
V
N
Q
T
Q
V
F
K
R
----
T
P
----
P
---
G
---
V
------
R
K
I
V
I
A
T
N
I
A
E
T
S
I
T
I
D
D
V
V
Y
V
I
D
G
G
K
I
K
E
T
H
F
D
T
Q
--
N
N
I
S
T
M
S
A
E
W
V
S
K
A
N
A
K
Q
R
K
G
R
A
G
R
V
Q
P
G
H
C
Y
H
L
Y
N
S
L
R
A
S
-
L
-
L
D
D
Y
Q
L
P
E
I
L
R
T
P
L
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L
C
L
Q
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I
L
R
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G
G
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H
F
L
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A
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L
L
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K
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L
M
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N
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L
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Q
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L
T
P
L
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V
H
L
A
R
L
P
V
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P
H
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G
K
M
I
L
F
G
A
L
F
C
C
L
D
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V
L
T
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A
A
-
S
L
S
F
-
K
D
P
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P
L
G
K
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A
R
R
K
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L
A
K
D
T
K
S
D
H
L
T
V
V
N
A
F
K
G
W
E
K
A
K
Q
R
G
F
R
Y
E
K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
E
H
L
L
G
A
G
F
V
S
S
R
-
N
P
Q
D
P
E
S
N
I
N
S
D
N
E
K
I
--
I
K
A
V
I
C
A
G
L
Y
P
K
V
A
K
I
R
L
N
L
-------
K
M
V
K
V
Y
T
K
T
--
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
--
Q
T
E
F
N
Y
N
W
L
I
Y
H
L
K
M
R
T
S
S
I
Y
L
Y
D
C
T
E
V
S
P
Y
C
L
L
F
F
G
G
D
-
I
S
I
Q
K
D
N
D
Q
E
T
I
A
V
D
E
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
-------------------
4
PsiBlast_PDB
95.09
94%
-114
- C3 -
-
5VHD
1
DHX36_BOVIN
D:
[18-843]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
S
E
Y
L
L
Q
E
N
E
P
D
A
T
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
E
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
I
S
G
E
T
G
C
G
K
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
E
R
G
K
G
S
A
C
R
I
V
C
T
Q
P
R
R
I
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A
I
S
V
A
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R
V
A
A
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R
A
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S
C
G
N
G
N
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
Q
S
D
P
H
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
N
L
Q
S
D
V
L
M
T
V
V
K
D
L
L
S
Y
R
P
D
L
K
V
V
L
M
S
A
T
L
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
K
I
R
Y
V
P
E
----------------------
Y
Y
Y
E
A
I
Y
K
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R
W
P
G
Y
L
R
E
L
R
Q
R
Y
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A
S
T
V
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V
V
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M
M
-
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D
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K
V
-
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L
N
L
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A
L
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Y
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L
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L
V
F
L
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
Q
V
M
F
-----
K
----
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----
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K
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P
L
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L
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----
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----
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---
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---
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------
R
K
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V
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--
N
N
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A
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K
G
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Q
P
G
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C
Y
H
L
Y
N
S
L
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A
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-
L
-
L
D
D
Y
Q
L
P
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L
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P
L
E
E
L
C
L
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K
I
L
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L
G
G
I
A
H
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L
S
R
L
M
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P
P
S
N
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A
V
L
L
S
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K
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L
M
E
L
N
A
L
D
K
Q
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L
T
P
L
G
V
H
L
A
R
L
P
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P
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G
K
M
I
L
F
G
A
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C
L
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V
L
T
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A
A
-
S
L
S
F
-
K
D
P
F
V
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P
L
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K
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K
V
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A
R
R
K
E
L
A
K
D
T
K
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D
H
L
T
V
V
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A
F
K
G
W
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A
K
Q
R
G
F
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Y
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K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
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H
L
L
G
A
G
F
V
S
S
R
-
N
P
Q
D
P
E
S
N
I
N
S
D
N
E
K
I
--
I
K
A
V
I
C
A
G
L
Y
P
K
V
A
K
I
R
L
N
---------
M
V
K
V
Y
T
K
T
--
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
--
Q
T
E
F
N
Y
N
W
L
I
Y
H
L
K
M
R
T
S
S
I
Y
L
Y
D
C
T
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V
S
P
Y
C
L
L
F
F
G
G
D
-
I
S
I
Q
K
---
Q
E
T
I
A
V
D
E
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
Q
------------------
2
PsiBlast_PDB
94.84
94%
-108
- C3 -
-
5VHA
-
DHX36_BOVIN
A:
[18-845]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
S
E
Y
L
L
Q
E
N
E
P
D
A
T
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
E
M
Q
R
F
R
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K
L
P
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Y
G
M
Q
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L
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M
I
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N
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Q
V
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G
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T
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C
G
K
T
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F
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L
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I
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R
G
K
G
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A
C
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C
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P
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A
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A
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V
A
A
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A
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G
N
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R
L
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R
L
P
R
K
Q
G
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-
Y
C
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G
I
I
L
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L
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V
L
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N
L
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L
M
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V
K
D
L
L
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Y
R
P
D
L
K
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V
L
M
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A
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L
N
A
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K
F
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Y
F
G
N
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P
M
I
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F
P
V
V
E
Y
L
L
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D
I
I
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K
I
R
Y
V
P
E
Q
------------------
Q
E
K
Y
Y
Y
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A
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Y
K
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W
P
G
Y
L
R
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L
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------
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P
L
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D
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L
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M
L
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--
I
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A
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I
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A
K
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R
L
N
L
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---
K
R
K
M
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V
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--
D
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-
V
V
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P
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--
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T
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Y
N
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C
L
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L
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K
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K
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R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
Q
E
K
----------------
21
HHSearch
94.48
95%
-113
- C3 -
-
5VHE
-
DHX36_BOVIN
A:
[96-905]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
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M
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Q
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T
I
A
V
D
E
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
-------------------
22
HHSearch
93.83
95%
-113
- C3 -
-
5VHA
-
DHX36_BOVIN
A:
[33-845]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
---
Q
L
L
E
D
L
-
Q
K
K
K
T
D
L
R
Y
I
E
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
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S
G
E
T
G
C
G
K
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
E
R
G
K
G
S
A
C
R
I
V
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
A
E
R
A
E
S
C
G
N
G
N
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
Q
S
D
P
H
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
N
L
Q
S
D
V
L
M
T
V
V
K
D
L
L
S
Y
R
P
D
L
K
V
V
L
M
S
A
T
L
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
K
I
R
Y
V
P
E
Q
------------------
Q
E
K
Y
Y
Y
E
A
I
Y
K
E
R
W
P
G
Y
L
R
E
L
R
Q
R
Y
S
A
S
T
V
D
V
V
E
M
M
-
D
D
E
K
V
-
D
L
N
L
I
A
A
L
I
R
Y
I
V
L
E
E
E
D
G
A
I
L
V
F
L
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
Q
V
M
F
-----
K
----
S
----
D
K
F
I
I
I
P
L
H
S
L
M
P
T
V
N
Q
T
Q
V
F
K
R
----
T
P
----
P
---
G
---
V
------
R
K
I
V
I
A
T
N
I
A
E
T
S
I
T
I
D
D
V
V
Y
V
I
D
G
G
K
I
K
E
T
H
F
D
T
Q
--
N
N
I
S
T
M
S
A
E
W
V
S
K
A
N
A
K
Q
R
K
G
R
A
G
R
V
Q
P
G
H
C
Y
H
L
Y
N
S
L
R
A
S
-
L
-
L
D
D
Y
Q
L
P
E
I
L
R
T
P
L
E
E
L
C
L
Q
I
K
I
L
R
L
G
G
I
A
H
F
L
S
R
L
M
D
P
P
S
N
E
A
V
L
L
S
I
K
H
L
M
E
L
N
A
L
D
K
Q
E
E
L
T
P
L
G
V
H
L
A
R
L
P
V
E
P
H
I
G
K
M
I
L
F
G
A
L
F
C
C
L
D
P
V
L
T
I
A
A
-
S
L
S
F
-
K
D
P
F
V
I
P
L
G
K
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K
V
A
D
A
R
R
K
E
L
A
K
D
T
K
S
D
H
L
T
V
V
N
A
F
K
G
W
E
K
A
K
Q
R
G
F
R
Y
E
K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
E
H
L
L
G
A
G
F
V
S
S
R
-
N
P
Q
D
P
E
S
N
I
N
S
D
N
E
K
I
--
I
K
A
V
I
C
A
G
L
Y
P
K
V
A
K
I
R
L
N
L
G
K
---
K
R
K
M
V
K
V
Y
T
K
T
--
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
--
Q
T
E
F
N
Y
N
W
L
I
Y
H
L
K
M
R
T
S
S
I
Y
L
Y
D
C
T
E
V
S
P
Y
C
L
L
F
F
G
G
D
-
I
S
I
Q
K
D
N
D
Q
E
T
I
A
V
D
E
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
Q
E
K
----------------
14
PsiBlast_PDB
78.33
38%
-42
- C3 -
-
5N9D
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
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I
H
E
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S
V
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T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
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D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
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K
L
R
L
P
-
E
S
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C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
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Q
Q
A
V
F
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R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
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D
V
V
Y
V
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R
T
K
A
T
N
Y
D
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--
T
N
I
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L
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V
W
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A
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Q
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R
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R
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L
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A
R
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-
R
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M
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I
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P
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L
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L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
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A
P
N
P
E
A
I
K
M
G
V
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L
L
K
R
I
E
A
L
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Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
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Q
M
G
K
M
I
L
M
S
A
L
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C
C
L
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P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
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I
K
R
R
M
A
R
N
M
R
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H
L
M
V
H
N
T
I
I
A
Y
R
D
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R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
Q
I
---
K
N
R
V
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
15
PsiBlast_PDB
77.99
38%
-45
- C3 -
-
5N9E
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
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N
Q
V
I
L
I
V
G
S
T
G
C
G
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L
L
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G
C
A
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C
R
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T
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R
R
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A
I
A
I
A
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W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
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D
P
L
M
H
N
L
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V
L
I
L
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I
H
E
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V
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T
D
L
L
M
G
L
L
K
V
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L
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L
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I
L
M
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A
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C
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Y
F
N
N
C
P
M
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E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
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L
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L
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E
S
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C
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D
F
I
A
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Y
Y
I
C
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P
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A
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L
V
F
L
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Y
D
K
I
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L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
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F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
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------
R
K
V
I
I
S
T
I
I
A
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S
V
T
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V
V
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--
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L
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G
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R
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T
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P
L
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M
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K
L
P
I
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Q
M
G
K
M
I
L
M
S
A
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C
L
D
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A
A
A
-
A
L
S
F
-
K
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F
Y
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R
N
M
R
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D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
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R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
7
PsiBlast_PDB
77.95
38%
-44
- C3 -
-
5N8U
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
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V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
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V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
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N
S
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R
T
K
A
T
N
Y
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--
T
N
I
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L
D
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V
W
V
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A
N
T
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Q
R
R
G
R
A
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R
V
R
P
G
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C
Y
N
L
F
S
R
A
R
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D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
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A
I
K
M
G
V
E
L
L
K
R
I
E
A
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Q
T
G
T
L
T
P
L
G
M
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A
K
L
P
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Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
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S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
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K
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
10
PsiBlast_PDB
77.38
38%
-45
- C3 -
-
5N94
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
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Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
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K
L
R
L
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-
E
S
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C
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F
I
A
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L
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Y
Y
I
C
E
N
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P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
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N
Y
D
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--
T
N
I
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L
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V
W
V
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A
N
T
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Q
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A
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-
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I
L
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L
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S
I
I
L
S
L
K
L
L
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I
D
D
P
Y
R
F
L
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T
L
I
N
A
P
N
P
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A
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K
M
G
V
E
L
L
K
R
I
E
A
L
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Q
T
G
T
L
T
P
L
G
M
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L
A
K
L
P
I
D
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Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
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S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
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K
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S
R
V
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E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
13
PsiBlast_PDB
77.37
38%
-44
- C3 -
-
5N9A
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
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R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
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W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
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D
E
I
H
E
R
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V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
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D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
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-
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S
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C
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Y
Y
I
C
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E
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A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
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------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
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N
Y
D
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--
T
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I
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L
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W
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A
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L
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R
A
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-
R
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L
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L
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L
L
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D
D
P
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T
L
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A
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N
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A
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M
G
V
E
L
L
K
R
I
E
A
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G
T
L
T
P
L
G
M
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L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
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C
C
L
D
P
I
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A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
5
PsiBlast_PDB
77.31
38%
-44
- C3 -
-
5N8R
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
12
PsiBlast_PDB
77.22
38%
-43
- C3 -
-
5N98
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
9
PsiBlast_PDB
77.18
38%
-45
- C3 -
-
5N90
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
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--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
16
PsiBlast_PDB
77.05
38%
-42
- C3 -
-
5N9F
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
-----------
P
P
E
R
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
Q
I
---
K
N
R
V
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
11
PsiBlast_PDB
77.02
38%
-45
- C3 -
-
5N96
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
---------------
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
R
L
P
-
E
S
E
G
C
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
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D
-
R
-
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
6
PsiBlast_PDB
77.01
38%
-43
- C3 -
-
5N8S
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
S
V
N
F
E
E
F
V
A
E
T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
R
Q
L
E
E
N
A
K
K
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
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P
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I
L
L
D
D
A
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R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
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S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
---------
E
F
Q
K
--------------
R
R
M
K
H
E
A
M
I
E
P
Y
L
R
R
I
R
N
S
Y
D
S
R
V
L
D
K
L
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L
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-
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S
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C
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I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
S
-----
K
----
G
QRWR
D
H
M
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
----
P
P
----
A
---
G
---
Q
------
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
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G
I
C
Y
N
L
F
S
R
A
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-
R
-
M
D
D
I
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T
P
E
I
L
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K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
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E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
F
-
K
S
P
F
Y
S
P
L
G
K
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
-
N
C
K
D
A
A
S
N
K
N
S
E
K
I
P
L
--
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
K
S
R
---------
R
A
I
H
T
M
A
TD
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
--
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
-
V
E
A
G
V
T
Q
N
T
P
Y
L
C
V
A
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
43
Fugue
76.98
33%
21
- C3 -
-
5AOR
2
MLE_DROME
A:
[119-1158]
LGEAYRPLEQRDMNEAEAFDVNAAIHGNWTIENAKER
L
N
I
Y
K
Q
T
N
N
I
R
D
D
Y
K
Y
T
P
V
G
P
E
H
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
L
N
R
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
HLNVI
E
P
F
S
G
T
L
K
K
D
E
Q
L
K
P
Y
P
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
P
V
V
N
P
R
N
I
K
I
------------
E
L
D
G
P
P
I
P
L
I
V
N
L
S
R
I
-
E
S
S
V
I
P
W
A
P
P
Q
A
N
W
N
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W
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A
C
N
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G
E
L
A
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I
D
D
L
S
M
D
Y
---
E
R
-
S
L
R
-
D
R
R
Q
N
D
N
E
Y
R
Q
F
L
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F
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K
L
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I
A
A
M
R
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L
T
A
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D
N
P
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V
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G
N
T
G
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A
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A
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A
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C
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--
L
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G
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F
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R
P
Y
G
A
I
L
-
F
C
T
V
G
V
L
L
R
K
L
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A
G
--
L
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G
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H
I
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D
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N
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D
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L
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Y
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A
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F
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-
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R
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V
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D
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L
L
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D
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D
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-------
I
N
Y
N
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N
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----
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----
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----
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---
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---
V
------
T
K
I
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T
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D
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F
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A
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M
K
L
F
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--
N
N
L
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M
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L
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D
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L
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L
C
L
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L
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P
-------
N
I
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---
H
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R
K
V
L
T
T
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--
S
K
-
A
A
L
L
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K
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A
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L
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R
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L
A
A
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N
---
I
V
R
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W
L
N
F
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N
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V
V
K
D
L
C
V
K
S
A
G
D
F
G
L
Q
R
------
24
HHSearch
76.56
43%
-40
- C3 -
-
5N9D
-
?
B:
[143-928]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
R
L
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A
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K
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Y
A
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--
N
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-
Y
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N
N
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L
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L
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F
R
D
R
R
P
K
-----------
R
D
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R
R
M
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A
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L
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D
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P
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-----
K
GQRW
R
----
D
H
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A
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L
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A
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Y
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N
C
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N
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--
L
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A
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I
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A
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V
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R
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--
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---
Y
E
K
Q
L
I
K
A
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L
L
L
S
L
D
E
R
----------------
8
PsiBlast_PDB
76.15
38%
-44
- C3 -
-
5N8Z
-
?
A:
[52-909]
----------------------------------------------------------------------------------------------------------------------------------------
I
R
L
G
C
N
V
S
A
P
S
G
V
L
E
R
V
K
E
L
M
----
E
D
Y
S
--------
R
A
P
---------
D
A
K
F
Q
Q
Q
F
R
H
L
L
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N
F
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F
V
A
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T
K
E
R
N
A
D
L
D
W
V
N
P
K
L
D
E
---
R
L
Q
L
E
L
-
G
Q
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Q
L
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E
N
A
K
K
R
L
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R
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K
L
P
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Y
A
D
D
I
I
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A
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N
Q
V
I
L
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R
R
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A
I
A
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A
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Y
E
R
C
E
S
L
G
--
N
S
V
G
Y
Q
I
R
L
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S
R
K
A
R
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R
A
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I
T
-
Y
C
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L
L
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L
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L
L
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L
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N
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G
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V
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M
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L
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V
L
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K
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Y
---------
E
F
Q
K
---------------
R
M
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-----
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----
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D
H
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A
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L
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----
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P
----
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---
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------
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-
A
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Y
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A
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A
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L
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L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------------------------
41
HHSearch
62.25
34%
-55
- C3 -
-
6FAC
1
?
A:
[9-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Q
K
I
-
E
E
A
E
R
A
Q
R
--
T
I
Q
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---
G
N
R
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A
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Y
Y
T
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A
P
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N
-----------------------------------------
Y
---------------------------
L
E
A
A
L
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-----
L
GKR-
V
----
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----
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----
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---
G
---
A
------
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A
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C
S
R
A
A
A
N
Q
R
M
G
R
A
G
R
V
K
P
G
K
C
F
R
L
Y
T
K
Y
A
Y
L
S
E
-
M
D
E
S
P
T
P
E
I
Q
R
T
S
L
S
S
V
V
L
Q
L
K
A
L
G
I
D
D
L
L
G
F
--
D
F
L
D
P
P
P
T
E
L
L
I
K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
E
F
P
T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
V
S
E
V
L
T
I
V
S
-
M
L
G
E
V
G
T
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
V
E
A
E
Y
-----
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
E
A
-
S
-----
C
G
-
G
V
N
N
P
T
P
--
I
L
R
A
L
T
A
A
F
F
L
N
A
A
R
L
N
R
A
G
D
--------
G
Y
R
T
L
K
N
--
N
I
-
T
V
Y
V
H
P
S
S
V
V
R
G
--
M
D
-
P
P
P
K
V
I
I
Y
H
E
L
V
V
T
S
K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
-----------------------------------------------------------------------------------------------
40
HHSearch
61.10
34%
-55
- C3 -
-
6FAA
6
?
A:
[17-655]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
A
Q
R
--
T
I
Q
E
V
R
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
---
G
N
R
K
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
V
A
D
E
M
G
V
R
L
G
--
H
E
V
G
Y
S
I
R
F
E
D
C
T
S
-
E
K
T
I
L
K
-
Y
M
T
D
G
M
L
L
R
E
M
V
T
S
P
D
L
A
D
Y
S
C
I
M
I
D
E
A
H
E
R
T
V
H
T
D
I
L
L
A
L
I
K
D
L
T
R
A
R
P
E
L
R
L
I
I
S
S
A
T
L
N
A
E
K
F
S
A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
S
A
P
E
S
N
-----------------------------------------
Y
---------------------------
L
E
A
A
L
V
T
V
F
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
T
G
Q
E
E
I
E
R
A
C
E
R
V
E
E
I
R
R
K
-----
L
GKR-
V
----
P
E
I
I
A
L
P
I
Y
S
N
M
P
S
E
M
Q
A
K
I
F
E
P
----
T
P
----
P
---
G
---
A
------
R
K
V
V
F
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
I
D
S
G
Y
V
K
E
N
T
F
S
P
V
--
T
G
Q
S
T
L
A
V
V
P
C
S
R
A
A
A
N
Q
R
M
G
R
A
G
R
V
K
P
G
K
C
F
R
L
Y
T
K
Y
A
Y
L
S
E
-
M
D
E
S
P
T
P
E
I
Q
R
T
S
L
S
S
V
V
L
Q
L
K
A
L
G
I
D
D
L
L
G
F
--
D
F
L
D
P
P
P
T
E
L
L
I
K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
E
F
P
T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
V
S
E
V
L
T
I
V
S
-
M
L
G
E
V
G
T
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
V
E
A
E
Y
-----
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
E
A
-
S
-----
C
G
-
G
V
N
N
P
T
P
--
I
L
R
A
L
T
A
A
F
F
L
N
A
A
R
L
N
R
A
G
D
--------
G
Y
R
T
L
K
N
--
N
I
-
T
V
Y
V
H
P
S
S
V
V
R
G
--
M
D
-
P
P
P
K
V
I
I
Y
H
E
L
V
V
T
S
K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
A
----------------------------------------------------------------------------------------------
39
HHSearch
60.60
33%
-66
* C3 *
-
5XDR
1
DHX15_HUMAN
A:
[12-661]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
N
L
-
P
H
T
P
R
Y
Y
D
---
I
L
K
K
R
L
Q
L
P
V
W
E
Y
K
D
R
F
T
D
I
L
V
R
H
Q
S
F
V
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
W
C
V
E
Y
M
R
S
L
-
P
G
P
K
R
G
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
M
D
V
M
L
G
--
Q
E
V
G
Y
S
I
R
F
E
D
C
S
S
-
A
K
T
I
L
K
-
Y
M
T
D
G
M
L
L
R
E
A
M
N
D
P
L
L
E
R
Y
G
V
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
V
L
K
E
V
V
R
Q
R
S
D
L
K
V
I
V
M
S
A
T
L
D
A
G
K
F
Q
I
Y
F
D
N
C
P
L
L
T
I
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
P
E
R
D
Y
-----------------------------------------
L
--------
E
------------------
A
A
I
R
T
V
I
Q
I
H
M
C
E
E
E
E
G
D
L
L
L
F
L
T
G
Q
E
E
I
D
E
A
C
K
R
I
K
R
E
V
D
D
LGP--
E
----
V
----
G
D
I
K
I
I
P
L
Y
S
T
L
P
P
Q
Q
Q
Q
R
I
F
E
P
----
P
P
----
P
---
K
---
K
QNGAIG
R
K
V
V
V
S
T
N
I
A
E
T
S
L
T
I
D
G
V
V
F
V
I
D
P
G
F
A
K
Q
K
V
Y
N
P
R
--
I
R
V
E
S
L
L
V
T
A
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
K
A
Y
K
-
T
E
M
Q
D
N
T
Y
P
E
I
L
R
S
N
L
G
S
V
V
L
Q
L
K
K
L
G
I
D
D
L
V
H
F
--
D
F
M
D
P
P
A
P
E
T
L
M
R
A
L
E
L
L
N
Y
L
A
A
L
N
D
D
G
D
L
T
E
L
G
S
M
M
A
E
F
P
L
D
P
Q
L
A
K
M
V
I
A
S
C
D
Y
N
C
S
N
E
V
L
S
I
T
A
-
M
L
S
V
-
P
Q
C
F
V
R
P
T
E
A
K
K
A
A
D
E
A
K
M
R
F
A
-
H
I
D
G
D
H
L
T
L
L
N
V
Y
H
A
F
K
Q
N
H
E
-----
S
V
Q
W
C
Y
D
N
F
I
N
Y
R
S
L
M
S
A
D
N
V
R
Q
Q
L
S
R
I
M
D
R
F
N
L
P
R
R
S
-
S
D
-----
F
T
S
R
D
Y
Y
I
N
--
I
R
K
A
L
V
T
G
Y
F
M
Q
V
A
H
L
E
R
T
G
---------
H
Y
L
T
V
K
D
--
N
Q
-
V
V
Q
L
H
P
S
T
V
L
D
H
------
K
P
E
W
V
L
Y
N
E
F
V
L
T
T
K
N
Y
I
R
T
C
T
D
I
K
P
E
W
L
V
K
I
A
P
Q
-
Y
Y
------------------------------------------------------------------------------------------
37
HHSearch
59.71
34%
-49
- C3 -
-
5LTJ
9
?
A:
[29-673]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
L
K
A
R
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
Y
D
E
L
P
H
Q
--
T
G
K
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
--
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
-
S
K
T
L
L
K
-
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
A
E
R
D
--------------------------------------------------------------------
Y
V
E
A
A
I
R
T
V
L
Q
I
H
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
E
MIRES
D
----
A
----
G
P
M
S
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
K
APQP
F
R
----
P
---
G
GRP
G
------
R
K
C
I
V
A
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
I
Y
N
P
R
--
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
K
E
-
L
I
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
--
D
L
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
D
G
E
L
T
P
L
G
N
L
A
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F
P
L
D
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A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
-
L
L
S
V
-
P
Q
I
W
V
R
P
A
N
A
R
K
R
A
D
E
M
K
A
Q
F
A
-
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
K
G
A
E
A
R
-
G
E
D
M
K
K
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
E
L
V
S
-
T
P
F
-----
H
D
K
N
Y
Y
T
N
--
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
S
S
N
S
K
-------
V
Y
K
T
V
K
D
--
E
Q
-
L
V
L
I
H
P
S
T
T
V
T
T
------
P
Y
E
W
V
V
Y
N
E
F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
-
Y
-------------------------------------------------------------------------------------------
38
HHSearch
59.12
34%
-52
- C3 -
-
6QIE
9
?
A:
[28-672]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
L
K
A
R
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
Y
D
E
L
P
H
Q
--
T
G
K
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
--
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
-
S
K
T
L
L
K
-
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
A
E
R
D
-----------------------------------------
Y
---------------------------
V
E
A
A
I
R
T
V
L
Q
I
H
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
E
MIRES
D
----
A
----
G
P
M
S
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
K
----
A
P
QPFR
P
GGR
P
---
G
------
R
K
C
I
V
A
T
N
I
A
E
T
G
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
I
Y
N
P
R
--
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
K
E
-
L
I
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
--
D
L
M
D
P
P
A
P
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M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
D
G
E
L
T
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L
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N
L
A
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E
F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
-
L
L
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V
-
P
Q
I
W
V
R
P
A
N
A
R
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R
A
D
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D
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L
L
N
A
Y
H
A
Y
K
G
A
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-
G
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L
S
S
A
D
N
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A
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K
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L
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S
-
T
P
F
-----
H
D
K
N
Y
Y
T
N
--
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
S
S
N
S
K
-------
V
Y
K
T
V
K
D
--
E
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-
L
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T
T
V
T
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------
P
Y
E
W
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E
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L
T
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W
L
L
E
I
A
P
V
-
Y
-------------------------------------------------------------------------------------------
45
Fugue
29.73
39%
8
- C3 -
-
3LLM
1
DHX9_HUMAN
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
W
S
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P
Q
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D
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R
I
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P
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I
L
P
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H
A
-
S
I
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L
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--
I
R
G
I
S
H
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I
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D
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L
L
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D
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P
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F
F
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C
P
I
I
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------