@TOME V3
(Feb 2022)

Ref. - - Doc.
Global output mode :
Sort entries by :
Sequence Color type :

Show alignment :
Column output:
Score:

Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ECM29_HUMAN: (2020-02-01 )
MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNELKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERNADTLPDQEELIQSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLPIPSEGSGFTKLHLVESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVEAKQIELQFTIGEAITSAAIGTSSVAARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKHIISPNPHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQDQQELVSTLVETLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPDLVYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTDKSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPCLLDKGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLLQKLNGWYMEKEEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEKEECNLWTEVWQENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASIAKQTSSLVPPYLGMILTALLQGLAGRTWAGKEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSLESSGVRTTKNEEENEKEKELQLEYLLGAFESLGKAWPRNAETQRCYRQELCKLMCERLKLSTWKVQLGVLQSMNAFFQGLMLLEEEHADPEALAEILLETCKSITYSLENKTYSSVRTEALSVIELLLKKLEESKQWECLTSECRVLLIESLATMEPDSRPELQEKAALLKKTLENLE

Atome Classification :

(20 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720......---.730.......740.......750.......760.......770.--......780...-.....790.......800-..-.....810.......820....------------.-..830.......840.......850.......860.....-..870.---------------..-----....880.......890-----------.-------------------..-------------------.-.....-900.......910...-....920......-.-930.......------------940......-..950-........----960.......970..-----.--..--..980........990.-...--.--..1000......1010.....-----.------1020.----........1030.--.-....---1040.........1050......--1060.......1070.....----.----1080......1090.---.--------------....1100....-------...1110.-------.--.-.-------------------..-...1120......1130.-----------.--.-------.....1140......1150.--.-.-..----...1160.-.....1170-------..--..-....1180......1190..-...-.1200.......1210-------.-------------------------------------------------------.---.-.----------...1220....-------..1230......1240......1250.-.-....---------1260---------..-------..-----------------------------------.-----------------------------------.1270---.........1280....-------------------.-------.1290......1300..--.-....1310..----....--..1320---.-.-..---------..-..1330-----......-..1340--------.........----1350---------------------.-----.-----.--...-...1360....-...-1370-----------.----------------------------------.--------------....--...1380......1390.------.-.....1400....-...-1410--------------.-----------------..-.------------.....1420......1430.-.-----.--------------------.----.--.-.1440......1450.....-----------..1460......---------1470--------.-------.-----..-.---.-..1480-------------------------------........-.--1490.-----------.--.---------.-------....1500......-1510......1520...--...1530-.....----------------.-.------------1540--------.---------------........1550......---1560--.........1570....-.-.----1580-........1590......1600......1610-......1620----------------....----------------.-.--.-------------------------.1630......1640......1650......1660....-..1670......1680......1690......1700......1710........1720.....------------.-------------------------1730....----..1740......1750....--..1760......------1770------.......-.1780......1790......1800......1810......1820.---.....1830......1840..
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNE---LKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSE--QQDLERN-ADTL-PDQEELIQSATETIGSFL-DS-TSPLLAIAACTALGEIGRNGPL------------P-IPSEGSGFTKLHLVESLLSRIPSSKETNKMKERAIQTLGY-FPVGDG---------------DF-----PHQKLLLQGLMDSVE-------------A-------------------KQ-------------------I-ELQFT-IGEAITSAAIGTSSVA-ARDAWQMTEEEYT-P-PAGAKVNDVV------------PW-VLDVIL-NKHI--ISPNPHVR----QAACIWLLSLVRKLS-----T--HK--EVKS-HLKEIQSAFVSV-LSE--N--DELSQDVASKGLGLVYELGNE-----Q------D---Q----QELVSTLVETLMT--G-KRVK---H---EVSGETVVFQGGALGKTPD--GQG-LSTYKELCSLASDLSQ----P----DLVYKFMNLANHHAM---W--------------NSRKGAA-FGFN-------VIAT---R-------A--G-E-------------------QL-APFLPQLVPRLYRY--QF-----------D--P-------NLGIRQAMTSIWNALVT--D--K-S-MV----DKYLKEIL-QDLVKNL---------TS--NM-WRVRESSCLALNDLLRGRPL-DDI-ID-KLPEIWETLFRV--------Q-------------------------------------------------------D---D-I----------KESVRKAAELA-------LKTLSKVCVKMCDPAKGAAGQRTIAAL-L-PCLL---------DKGM---------MS-------TV-----------------------------------T-----------------------------------EV------RALSINTLVKISKSAGA-------------------M-------LKPHAPKLIPALL-ESL--S-VLEPQ--VLN----YLSL--RAT-E----Q-E-KA---------AM-DSAR-------LSAAKS-SPM-----------METINMCLQ----Y------------------------L-----D-----V--SVL-GELVP-RLCEL-IRS-G--------------V----------------------------------G--------------LGTK--GGCASVIVSLTTQCP-QD------L-TPYSGKLM-SALL-SGL-T-----------------D-----------------RN-S------------VIQKSCAFAMGHLVRT-SRD-S-----S--------------------T----E--K-LLQKLNGWYMEKE-EPIYKT-----------SCALTIHAIGRY---------SP----------D-------V-----LK-N---H-AKE----------------------------------VLPLAFLG-M--HE--I-----------A--D---------E-------EKSEKEECNLWTEV-WQENVPGSFGGIRLYLQ--ELITIT--QKALQ----------------S-Q------------S-----------W---------------KMKAQGAIAMASIAKQTS---S-----LVPPYLGMILTALLQGL-A-G----R-T--WAGKEELLKAIACVVTACSAELEKSVPNQPST-NEILQAVL------------------KECS----------------K-E--N-------------------------VKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSL-ESSGVRTTKNEEENEKEKELQLEYLLGAFESLGKAWPRNAETQ--RCYRQELCKLMCERLKLS------------T-------------------------WKVQLGVL----QSMNAFFQGLMLLEEEHADP--EALAEILLETCK------SI--------TYSLENK-TYSSVRTEALSVIELLLKKLEESKQWECLTSECRVLLIESLATMEP---DSRPELQEKAALLKKTLENLE
21 HHSearch 73.4013% -20 - C1 - - 3W3W - IMB3_YEAST A:[19-1055] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FAS-DNQIRSVAEKALSEEWITENN-----IEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIR----------------------KEVLAQIRSSLLKGF-LSERADSIRHKLSDAIAECVQDDLP------------------A----WPELLQALIESLKS--GNPNFRESSFRILTT-VPYLIT---------------A------VDINSILPIFQSGFT-------------D-------------------AS-------------------D-NVKIA-AVTAFVGYFKQLPKSE-W-SK-----------------LGILL------------PS-LLNSL--PRFL--DDGKDDAL----ASVFESLIELVELAP-----K------LFKD-MFDQIIQFTDMV-IKNKDL--EPPARTTALELLTVFSENAPQ-----MCKSNQNY---G----QTLVMVTLIMMTE--V-SID----------DDDAAEWIESDDTDDEE--EVTYDHARQALDRVALKLGG----EYLAAPLFQYLQQMIT-STE---W--------------RERFAAM-MALS-------SAAE---G-------C--A-D-------------------VL-IGEIPKILDMVIPL--IN-----------D--P-------HPRVQYGCCNVLGQIST--D--F-SPFIQ---RTAHDRIL-PALISKL---------TSE-CT-SRVQTHAAAALVNFSEFASK-DIL-EP-YLDSLLTNLLVL--------L-------------------------------------------------------Q---S-N----------KLYVQEQALTT-------IAFIAEAAKNKF--------IKYYDTL-M-PLLL----------NVL---------KV--------N-----------------------------------S-----------------------------------VL------KGKCMECATLIGFAVGKE------------------K-------FHEHSQELISILV-ALQ--N-S----------------------------------------------DALR-------SYLEQ------------------SWSRICR----ILGD---------------------D-----F-----V--PLL-PIVIP-PLLIT-AKA-T--------------QDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSV--------------LDDK--VSAMELLQSYATLLR-GQ------F-AVYVKEVM-EEIALPSL-DF----------------Y-----------------LH-D------------GVRAAGATLIPILLSC-LLA-AEELVLL--------------------W----H--K-ASSKLIGGLMSEP-MPEITQ-----------VYHNSLVNGIKV---------MG----------DN------C-----LSED---Q-LAA----------------------------------FTKGVSAN-L--TD--T-----------Y--ERMQDRDEYNE-------DFTDEDLLDEINKS-IAAVLKTTNGHYLKNLE--NIWPMI--NTFLL-------------------------------E-----------P---------------ILVIFALVVIGDLIQY-----E-----QTASMKNAFIPKVTECL-I-S----P-D--ARIRQAASYIIGVCAQYAPSTYA------DVC-IPTLDTLV------------------QIVDGSKL------------E-E--N-------------------------RSSTENASAAIAKILYAYNSNIP---DTYTANWFKTLPT-I-------T-----------DKEAASFNYQFLSQ--------VCAQSNISAVVDSVIQALNER------------SL-----------------------------TVI----SSVKKLLGFLPS--------------------------------------------------------------------------------------------------------------------
51 Fugue 68.7515% -7 - C1 - - 3W3W - IMB3_YEAST A:[3-1077] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALPEEVNRTLLQIVQAFASDNQIRSVA--EKALSEE-WITE-NNIEYLLTFLAEQAAF----S-QDTTVAALSAVLFRKLALKAPI------------THIRKEVLAQIRSSLLKGFLS-----ERADSIRHKLSDAIA---ECVQD---------------DL-----PAWPELLQALIESLK-------------S-------------------GN-------------------P-NFRES-SFRILTTVPYLITAVD-INSILPIFQSGFTDA-SDNVKIAAVTAFVGYFKQLPKSEW-SKLGIL-LPSL--LNSLPRFLDDGKDDALASVFESLIELV-----ELAPK--LFKD-MFDQII-QFTDM-VIK--N--KDLEPPARTTALELLTVFSENAPQMCK------S---N----QNYGQTLVMVTLI--MMTEVS---I---DDDDAAEWIESDDTDDEEE--VTY-DHARQALDRVALKLGG----E----YLAAPLFQYLQQMITSTEW--------------RERFAAM-MALS-------SAAE---G-------C--A-D-------------------VL-IGEIPKILDMVIPL--IN-----------D--P-------HPRVQYGCCNVLGQIST--DFSP-F-IQ----RTAHDRIL-PALISKL---------TS--ECTSRVQTHAAAALVNFSEFASK-DIL-EP-YLDSLLTNLLVLLQSNKLYVQ-------------------------------------------------------E---Q-A----------LTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMECAT-L-IGFAVGKEKFHEHSQEL---------IS-------IL-----------------------------------V-----------------------------------ALQNSDALRSYLEQSWSRICRILGD-------------------D-------FVPLLPIVIPPLL-ITA--K-ATQDV--GLI----EEEE--AAN-F----Q-Q-YP---------DW-DVVQVQGKHIAIHTSVL-DDK-----------VSAMELLQS----Y------------------------A-----T-----LLRGQF-AVYVK-EVMEE-IAL-P--------------SLDFYLHD---------------------------G--------------VRAA--GATLIPILLSCLLAA-EE------L-VLLWHKAS-SKLI-GGLMS-----------------E-----------------PM-P------------EITQVYHNSLVNGIKV-MGD-N-----CL-------------------S----E--D-QLAAFTKGVSANL-TDTYERMQDRDEYNEDFTDEDLLDEINKS---------IA----------A-------V-----LK-TTNGH-YLK----------------------------------NLENIWPM-I--NT--F-----------L--L---------E-------PILVIFALVVIGDL-IQ------YEQTASMKN--AFIPKV--TECLI----------------S-P------------D-----------A---------------RIRQAASYIIGVCAQYAP---S-----TYADVCIPTLDTLVQIV-D-G----S-K--LEENRSSTENASAAIAKILYAYNSNIPDTYTA-NWF-KTLP------------------TITD----------------K-E--A-------------------------ASFNYQFLS------QVCAQSNISAVVDSVIQALNERSLTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 HHSearch 67.3113% -9 - C1 - - 5VCH - ? A:[97-1103] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-GKDAVRHANARVIASIGSE--------------------------WPELIPNLLQAACD--SNPKIRETAIFIILS-LLESFN---------------ANLA---LHIDDFLNLFAQTIN-------------DS------------------AS-------------------L-ETRSL-SAQALSYVSSLIEEEGEINPQYAA-------------KFASLI------------PS-VVQVL--DATI--REGDTTNT----KLIFNCLNDFLLLDS-----Q------LTGN-TIADLVKLALQI-AVNSDV--DEDIRVFAVQFVTSALVYRKS-----KINQAK-L---G----PEITLAALKVASE--E-IDVEDELTNED-----ENTPALTALR---------------LISNASGELSPSQVGV----PIIEHLPTML-SSSN---P--------------FERRSIL-LAIS-------VLVT---G-------S--P-D-------------------YT-LSQFDKIIPATVTG--LK-----------D--S-------EAVVQLAALKCIVQLST--N--L-QDEV----ARYHEQYL-PLVIDII---------DSA-KH-VVIYKYATLALDGLLEFIAH-NDI-IK-YLDPLMNKLFQM--------L-------------------------------------------------------E---TQQ----------SPKLRAAIVSA-------IGSCAFAAGSGF--------VPYFKTS-V-QYLQ----------QFIQNVSQIEGLSE-------DD-----------------------------------I-----------------------------------EL------KALTFENISTMGRAVKSA------------------A-------FAEYAEPLVNAAY-EAI--K-TDSA--------------------------------------------RLR-------ESGYA------------------FIANMAK----VYGK---------------------D-----F-----A--PFL-QTIIP-EIFKT-LEQ-EEYTVNT--------G----------------------------------I--------------AYEK--EVAAAALSELAIASK-EH------F-LEYVEPSL-KVLA-EQV-N-----------------------------------ES-Y------------GLKETALHSMWAIVKA-VLL-T-----ANLKEGEYPKGVPSGSYVDASALAVIQ--T-VREVSLNNVIEEVETSMVIS-----------VFQDLSEMLRLF---------GP----------I-------IIMDNGDS-T---H-LDQ----------------------------------LCREALSV-L--KG--E-----------H--A---------CQTILDA-SETEATLLDVALDI-YVALSTNLVGGFAQVFT--TAKPVI--LQLCQ----------------S-K------------S-----------K---------------NKRSFAVGALSEIALGMR---D-----E-NPFIQELLEALIISLTN-D----K-S--LEVRCNASYGVGLLIEYSSFDVS------AIY-SPVLKSLY------------------EILSVADEKNLATEDDEATKE-I--V-------------------------DRTFSNVCGCVARMILKHQNLV--PLEHTIPALLSHLPF-N----T--A------------FEEYDPIFKLFLKLFQEQNSTI--INEAPKVIAIFATVFEKE------------SERIELETNSTLGREENLEKRKQFQSEEIKQQVI----ELLKHLNQQFNG--------------------------------------------------------------------------------------------------------------------
32 HHSearch 66.2113% -68 - C1 - - 4FDD - TNPO1_HUMAN A:[59-831] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-EDEPTRSLSGLILKNNVKAHFQ------------N-FPNG----VTDFIKSECLNNIGD--SSPLIRATVGILITT-IASKGE---------------L------QNWPDLLPKLCSLLD-------------S-------------------ED-------------------Y-NTCEG-AFGALQKICEDSAEIL-DSDV-----------------LDRPL------------NI-MIPKF--LQFF--KHSSPKIR----SHAVACVNQFIISRT-----Q------ALML-HIDSFIENLFAL-AGD--E--EPEVRKNVCRALVMLLEVRMD-----R------LLPHM----HNIVEYMLQRTQD--Q----------------------------------------------------------------------------D---E--------------NVALEAC-EFWL-------TLAE---Q-------PICK-D-------------------VL-VRHLPKLIPVLVNG--MKYSDIDIILLKG---S-------DWNLRKCSAAALDVLAN--V--Y-R-------DELLPHIL-PLLKELL---------FH--HE-WVVKESGILVLGAIAEGCMQ--GM-IP-YLPELIPHLIQC--------L-------------------------------------------------------S---D-K----------KALVRSITCWT-------LSRYAHWVVSQP-------PDTYLKPL-M-TELL----------KRI---------LD-------SN-----------------------------------K-----------------------------------RV------QEAACSAFATLEEEACT-------------------E-------LVPYLAYILDTLV-FAF--S-KYQH--------------------------------------------KNL-------LILY------------------DAIGTLAD----S------------------------V-----GHHLNKP--EYI-QMLMP-PLIQK-WNM-LK-------------D----------------------------------E--------------DKDL--FPLLECLSSVATALQ-SG------F-LPYCEPVY-QRCV-NLV-Q-----------------KTLAQAMLNNAQPDQYEAPD-K------------DFMIVALDLLSGLAEG-LGG-N-----IEQL-----------------V----ARSN-ILTLMYQCMQDKM--PEVRQ-----------SSFALLGDLTKA---------CF----------Q-------H-----VK-P---C-IAD----------------------------------FMPILGTN-L--NP--E-----------F--I----------------------SVCNNATWA-IGEISIQMGIEMQPYIP--MVLHQL--VEIIN----------------R-PNT----------P-----------K---------------TLLENTAITIGRLGYVCP---Q-----EVAPMLQQFIRPWCTSL-R-N----IRD--NEEKDSAFRGICTMISVNPSGVI------QDF-IFFCDAVA------------------SWIN----------------P-K----------------------------DDLRDMFCKILHGFKNQVGDENW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37 HHSearch 64.4714% -6 - C1 - - 4XRI ? A:[21-873] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-PDATLRHAAEQQLTHAAETN-------------------------FSQYLLTLVQALANESSEGHIRAAAGIALKN-AFSAREFARQAALQAKWLNQTDQ-----ETRTRVKQLALETLA-------------S-------------------PN-------------------S-KAGQA-AAQVIAAIAAIELPR-------------------------NQW------------PE-LMHAL--VRNA--SEGGQHQK----QASLTAIGFICETQD-----T--DLRNSLVG-HSNAILTAVVQG-ARKEEP--NNEVRFAAITALGDSLEFVGN-----NFKHEG-E---R----NYIMQVVCEATQA--Q-D-------------SRIQQGAFGCLNRIMALYYEH-MRYY---------M------E----KALFGLTILGMKSDD---E--------------DVAKLAV-EFWS-------TVCE---E-------E--I-AIEDDNAQVESSEQMRPFYNFA-RVATNEVVPVLLQL--LT-----------K--QDEDASDDEYNISRAAYQCLQLYAQ--A--V-G-------STIIPPVI-QFVEHNL---------RH--AD-WHFRDAAVSAFGAIMDGPEE-KVL-EP-IVKTGMQPLIAM--------M-------------------------------------------------------E---D-E----------SIQVRDSTAYA-------LGRITEACSEAIDP------NTHLEPL-I-RSLF----------NGL---------MN--------S-----------------------------------P-----------------------------------KM------AASCCWALMNIAERFAG-------------------EPGAAQNPLTPHFNQSVTNLL-TVT--A-PMN-----------------------------------------GD-STVR-------TAAYE------------------VLSVFVQ----N------------------------AAND--S-----L--SAV-ASLST-VILQR-LEE-T--------------L----------------------------------PLQQQVVSVEDKLILEDMQ--TSLCTVLQATVQRLD-KE------I-APQGDRIM-QVLL-QIL-S-----------------TCG---------------GK-S------------SVPEGVFAAISALANA-MEE-EFAK--Y--------------------M----E--A-FAPFLYNALGNQE-EPSLCS-----------MAIGLVSDVTRS---------LG----------E-------R-----SQ-P---Y-CDN----------------------------------FMNYLLGN-L--RSTTL-----------A--N----------------------QFKPAILQC-FGDIASAIGGHFETYLT--IVAQVL--QQAAT----------------I-TAGPDGSYEMIDYV-----------I---------------SLREGIMDAWGGIIGAMK---TSNKTNVLQPYVESIFALLNSIA-N-D----P-NRSEALMRASMGVIGDLADAYPNGQL----ADAFR-QDWITAMI------------------RETRSNR-------------E-F--G-------------------------ARTIETARWAREQVKRQIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 HHSearch 63.8815% -28 - C1 - - 1U6G - CAND1_HUMAN C:[46-1130] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQ---VETIVDTLCTNMLSD-KEQLRDISSIGLKTVIGELP----------------------S-ALAANVCKKITGRLTSAIAKQ-EDVSVQLEALDIMADMLSRQGG--------------LLVN----FHPSILTCLLPQLTS--PRLAVRKRTIIALGH-LVMSC-------------------------FVDLIEHLLSELSK------------N-------------------DS-------------------M-STTRT-YIQCIAAISRQAGHR--I---------------------GEYL------------EK-IIPLV--VKFC--NVDDDELR----EYCIQAFESFVRRCP-----K------EVYP-HVSTIINICLKY-LTY---DMSWKVRRAAAKCLDAVVSTRHE------------M---L----PEFYKTVSPA-------------------------------------------------------------------------LISRF-KERE---E--------------NVKADVF-HAYL-------SLLK---QTRPVGETP--L-T-------------------ML-QSQVPNIVKALHKQ--MK-----------E--K-------SVKTRQCCFNMLTELVN--V--L-PGAL----TQHIPVLV-PGIIFSL---------NDKSSS-SNLKIDALSCLYVILCNHSP-QVF-HP-HVQALVPPVVAC--------V-------------------------------------------------------G---D-P----------FYKITSEALLV-------TQQLVKVIRPLDQPS-SFDATPYIKDL-F-TCTI----------KRL---------KAAD-----ID-----------------------------------Q-----------------------------------EV------KERAISCMGQIICNLGD-------------------N-------LGSDLPNTLQIFL-ERL--K-NE----------------------------------------------ITR-------LTTVK------------------ALTLIAGSPLKI------------------------D-----L-----R--PVL-GEGVP-ILASF-LRK----------------N----------------------------------Q--------------RALK--LGTLSALDILIKNYS-DSL-----T-AAMIDAVL-DELP-PLI-S-----------------E-----------------SD-M------------HVSQMAISFLTTLAKV-YPS-SLSK--I--------------------S----G--S-ILNELIGLVRSPLLQGGALS-----------AMLDFFQALVVT---------GTNN--------L-------G-----YM-D---L-LRMLTGPVYSQTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQD-V--KNSRS-----------T--D----------------------SIRLLALLS-LGEVGHHID---LSGQL--ELKSVI--LEAFS----------------S-P------------S-----------E---------------EVKSAASYALGSISVGNL---------------PEYLPFVLQEI-T-S------Q--PKRQYLLLHSLKEIISSASVVGL-----KPYV-ENIWALLL------------------KHCE----------------C-A--E-------------------------EGTRNVVAECLGKLTLIDPETLLPR----LKGYLI---S-G-------------------SSYARSSVVTAVKFTISDHPQPI--DPLLKNCIGDFLKTLEDP------------D-------------------------LNVRRVAL----VTFNSAAHNKPSLIR-------DLLDTVLPHLYNETKVRKELIREVEMGPFKHTV-D-DGLDIRKAAFECMYTLLDSCLDRLD--------IFEFLNHVEDGLK---D-HYDIKMLTFLMLVRL----
25 HHSearch 63.2712% -36 - C1 - - 3W3U - IMB3_YEAST A:[136-1067] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVD---INSILPIFQSGFTD-ASDNVKIAAVTAFVGYFKQLPKSEW--------------------SKLGILLPSLLNSLPRFL-DD-GKDDALASVFESLIELVELAP-------------K-LFKD----MFDQIIQFTDMVIKNKDLEPPARTTALELLTV-FSENAP---------------QMCKSNQNYGQTLVMVTLIMMT-------------EVSIDDDDAAEWIESDDTDDEE-------------------E-VTYDH-AAAALARVALKLGG-------------------------EYLA------------AP-LFQYL--QQMI--TSTEWRER----FAAMMALSSAAAGCA-----D------VLIG-EIPKILDMVIPL-IND--P--HPRVQYGCCKVLGQISTAFSP-----F------I---Q----RTAHDR-------------------------------------------------------------------------ILPALISKLTSECT---S--------------RVQTHAA-AALV-------AFSE---F-------A--S-KD------------------IL-EPYLDSLLTNLLVL--LQ-----------S--N-------KLYVQEQALTTIAFIAE--A--A-KNKF----IKYYDTLM-PLLLNVL---------KV---N-SVLKGKCMECATLIGFAVGK-EKF-HE-HSQELISILVAL--------Q-------------------------------------------------------NSDID-E----------DDALRSYLEQS-------WSRICRILGDDF--------VPLLPIV-I-PPLL----------ITA---------KA-------TQ-----------------------------------DVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDD------KVSAMELLQSYATLLRG-------------------Q-------FAVYVKEVMEEIALPSL--D-FY------------------------------------------LH-DGVR-------AAGAT------------------LIPILLS----C------------------------LLAAEEL-----V--LLW-HKASS-KLIGG-LMS-E--------------P----------------------------------M--------------PEIT--QVYHNSLVNGIKVMG-DNC-----LSEDQLAAFT-KGVS-ANL-TDTYERMQDRDEYNE---F-----------------TD-E------------DLLDEINKSIAAVLKT-TNG-HYLK--N--------------------L----E--N-IWPMINTFLLDNE-P-ILVI-----------FALVVIGDLIQY---------GG----------E-------Q-----TA-S---M-KNA----------------------------------FIPKVTEC-L--IS--P-----------D--A----------------------RIRQAASYI-IGVCAQYAPSTYADVCI--PTLDTL--VQIVDPGSKL-----------E-E------------N-----------R---------------SSTENASAAIAKILYAY---------------VDTYTANWFKTL-PTI----T-D--KEAASFNYQFLSQLIENNS---------QSNI-SAVVDSVI------------------QALN----------------E-R--SL-----------------------------TVISSVKKLLGFLPSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 HHSearch 59.0213% -20 - C1 - - 5VE8 - ? B:[97-1103] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-GKDAVRHANARVIASIGSEELD----------------EK----KWPELIPNLLQAACD--SNPKIRETAIFIILS-LLESFN---------------ANLA---LHIDDFLNLFAQTIN-------------DS------------------AS-------------------L-ETRSL-SAQALSYVSSLIEEEGEINPQYAA-------------KFASLI------------PS-VVQVL--DATI--REGDTTNT----KLIFNCLNDFLLLDS-----Q------LTGN-TIADLVKLALQI-AVNSDV--DEDIRVFAVQFVTSALVYRKS-----KINQAK-L---G----PEITLAALKVASE--E-IDVEDELTNED----EENTPALTALR---------------LISNASGELSPSQVGV----PIIEHLPT-L-SSSN---P--------------FERRSIL-LAIS-------VLVT---G-------S--P-D-------------------YT-LSQFDKIIPATVTG--LK-----------D--S-------EAVVQLAALKCIVQLST--N--L-QDEV----ARYHEQYL-PLVIDII---------DSA-KH-VVIYKYATLALDGLLEFIAH-NDI-IK-YLDPL-NKLFQ---------L-------------------------------------------------------E---TQQ----------SPKLRAAIVSA-------IGSCAFAAGSGF--------VPYFKTS-V-QYLQ----------QFIQNVSQIEGLSE-------DD-----------------------------------I-----------------------------------EL------KALTFENIST-GRAVKSA------------------A-------FAEYAEPLVNAAY-EAI--K-TDSA--------------------------------------------RLR-------ESGYA------------------FIAN-AK----VYGK---------------------D-----F-----A--PFL-QTIIP-EIFKT-LEQ-EEYQFTVNT------G----------------------------------I--------------AYEK--EVAAAALSELAIASK-EH------F-LEYVEPSL-KVLA-EQV-N-----------------------------------ES-Y------------GLKETALHS-WAIVKA-VLL-T-----ANLKEGEYPKGVPSGSYVDASALAVIQ--T-VREVSLNNVIEEVETS-VIS-----------VFQDLSE-LRLF---------GP----------I-------IIDNG-DS-T---H-LDQ----------------------------------LCREALSV-L--KG--E-----------H--A---------CQTIDLDASETEATLLDVALDI-YVALSTNLVGGFAQVFT--TAKPVI--LQLCQ----------------S-K------------S-----------K---------------NKRSFAVGALSEIALG-R---D-----E-NPFIQELLEALIISLTN-D----K-S--LEVRCNASYGVGLLIEYSSFDVS------AIY-SPVLKSLY------------------EILSVADEKNDEATK-----E-I--V-------------------------DRTFSNVCGCVAR-ILKHQNLV--PLEHTIPALLSHLPF-N----T--A------------FEEYDPIFKLFLKLFQEQNSTI--INEAPKVIAIFATVFEKE------------SERIELETNSTLGREENLEKRKQFQSEEIKQQVI----ELLKHLNQQFNG--------------------------------------------------------------------------------------------------------------------
28 HHSearch 57.0311% -39 - C1 - - 3W3W - IMB3_YEAST A:[125-1060] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVD---INSILPIFQSGFTD-ASDNVKIAAVTAFVGYFKQLPKSEW--------------------SKLGILLPSLLNSLPRFL-DD-GKDDALASVFESLIELVELAP-------------K-LFKD----MFDQIIQFTDMVIKNKDLEPPARTTALELLTV-FSENAP---------------QMCKSNQNYGQTLVMVTLIMMT-------------E-------------------VSIDDDDAAEWIESDDTDDEEE-VTYDH-ARQALDRVALKLGG-------------------------EYLA------------AP-LFQYL--QQMI--TSTEWRER----FAAMMALSSAAEGCA-----D------VLIG-EIPKILDMVIPL-IND--P--HPRVQYGCCNVLGQISTDFSP-----F------I---Q----RTAHDR-------------------------------------------------------------------------ILPALISKLTSECT---S--------------RVQTHAA-AALV-------NFSE---F-------A--S-KD------------------IL-EPYLDSLLTNLLVL--LQ-----------S--N-------KLYVQEQALTTIAFIAE--A--A-KNKF----IKYYDTLM-PLLLNVL---------KV---N-SVLKGKCMECATLIGFAVGK-EKF-HE-HSQELISILVAL--------Q-------------------------------------------------------NS----------------DALRSYLEQS-------WSRICRILGDDF--------VPLLPIV-I-PPLL----------ITA---------KA-------TQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVL-----------------------------------DD------KVSAMELLQSYATLLRG-------------------Q-------FAVYVKEVMEEIALPSL--DFYL-------------------------------------------H-DGVR-------AAGAT------------------LIPILLS----C------------------------LLAAEEL-----V--LLW-HKASS-KLIGG-LMS-E--------------P----------------------------------M--------------PEIT--QVYHNSLVNGIKVMG-DNC-----LSEDQLAAFT-KGVS-ANL-TDTYERMQDRDEYNED--F-----------------TD-E------------DLLDEINKSIAAVLKT-TNG-HYLK--N--------------------L----E--N-IWPMINTFLL--E-P-ILVI-----------FALVVIGDLIQY---------------------E-------Q-----TA-S---M-KNA----------------------------------FIPKVTEC-L--IS--P-----------D--A----------------------RIRQAASYI-IGVCAQYAPSTYADVCI--PTLDTL--VQIVDGSKL------------E-E------------N-----------R---------------SSTENASAAIAKILYAYN---S-----NIP---DTYTANWFKTL-PTI----T-D--KEAASFNYQFLSQ--------VC----AQSNI-SAVVDSVI------------------QALN----------------E-R--SL-----------------------------TVISSVKKLLGFLPSSDAMA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 HHSearch 55.5214% -52 - C1 - - 4FDD - TNPO1_HUMAN A:[25-827] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDTTIQRTVQQKLEQ-LNQ-YP---------------D--------FNNYLIFVLTKLK-------------S-------------------ED-------------------E-PTRSL-SGLILKNNVKAHFQNF----------------------PNGVT------------DF-IKSEC--LNNI--GDSSPLIR----ATVGILITTIASKGE-----L---------Q-NWPDLLPKLCSL-LDS--E--DYNTCEGAFGALQKICEDSAE-----I------L---D----SDVLDRPLN---------------------------------------------------------------------IMIPKFLQFFKH-SS---P--------------KIRSHAV-ACVN-------QFII---S-------R--T-Q-------------------AL-MLHIDSFIENLFAL--AG-----------D--E-------EPEVRKNVCRALVMLLE--V--R-MDRL----LPHMHNIV-EYMLQRT---------QD--QD-ENVALEACEFWLTLAEQPICKDVL-VR-HLPKLIPVLVNG--------M-------------------------------------------------------K---Y-SDIDIILLKGSDWNLRKCSAAA-------LDVLANVYR-----------DELLPHI-L-PLLK----------ELL---------FH-------HE-----------------------------------W-----------------------------------VV------KESGILVLGAIAEGCMQ-------------------G-------MIPYLPELIPHLI-QCL--S-DKK--------------------------------------------ALVR-------SITCW------------------TLSRYAH----W------------------------VVSQP-P-----D--TYL-KPLMT-ELLKR-ILD----------------S----------------------------------N--------------KRVQ--EAACSAFATLEEEAC-TE------L-VPYLAYIL-DTLV-FAF-S-----------------K-----------------YQ-H------------KNLLILYDAIGTLADS-VGH-HLNKPEY--------------------I----Q--M-LMPPLIQKWNMLKDEDKDLF-----------PLLECLSSVATA---------LQ----------S-------G-----FL-P---Y-CEP----------------------------------VYQRCVNL-V--QK--TLAQAMLNNAQPD--Q---------Y-------EAPDKDFMIVALDL-LSGLAEGLGGNIEQLVARSNILTLM--YQCMQ----------------D-K------------M-----------P---------------EVRQSSFALLGDLTKACF---Q-----HVKPCIADFMPILGTNL-N-P----E-F--ISVCNNATWAIGEISIQMGIEMQ------PYI-PMVLHQLV------------------EIIN----------------R-PNTP-------------------------KTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRN-I---------------R---DNEEKDSAFRGICTMISVNPSGV--IQDFIFFCDAVASWINPK--------------------------------------DDLRDMFC----KILHGFKNQVG---------------------------------------------------------------------------------------------------------------------
29 HHSearch 54.8413% -21 - C1 - - 1QBK - TNPO1_HUMAN B:[23-872] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSPDTTIQRTVQQKLEQLNQYPDF-----N-NYLIFVLTKLK-SEDEPTRSLSGLILKNNVKAHFQNFPN-----------------------GVTDFIKSECLNNI-GD-SSPLIRATVGILITTIASKGEL-----------------Q----NWPDLLPKLCSLLDS--EDYNTCEGAFGALQK-ICEDSA---------------EILDSD-RPLNIMIPKFLQFFK-------------H-------------------SS-------------------P-KIRSH-AVACVNQFIISRTQAL-----------------------MLHI------------DS-FTENL--FALA--GDEEPEVR----KNVCRALVMLLEVRM-----D------RLLP-HMHNIVEYMLQR-TQD--Q--DENVALEACEFWLTLAEQPICK----D------V---LVRHLPKLIPVLVNGMKY--S-DI------------------------------D---I------------------------ILLKGDV---EEDET---I--------------PDSEQDIRPRFH-------RSRTVAQQ-------H--D-E-------------------D------DDDDDEIDDD--DT-----------I--S-------DWNLRKCSAAALDVLAN--V--Y-R-------DELLPHIL-PLLKELL---------FH--HE-WVVKESGILVLGAIAEGCMQ--GM-IP-YLPELIPHLIQC--------L-------------------------------------------------------S---D-K----------KALVRSITCWT-------LSRYAHWVVSQP-------PDTYLKPL-M-TELL----------KRI---------LD-------SN-----------------------------------K-----------------------------------RV------QEAACSAFATLEEEACT-------------------E-------LVPYLAYILDTLV-FAF--S-KYQH--------------------------------------------KNL-------LILYD------------------AIGTLAD----S------------------------V-----GHHL--NKPEYI-QMLMP-PLIQK-WNM-LK-------------D----------------------------------E--------------DKDL--FPLLECLSSVATALQ-SG------F-LPYCEPVY-QRCV-NLV-QKTLAQAMLNNAQPDQYEA-----------------PD-K------------DFMIVALDLLSGLAEG-LGG-N-----I--------------------EQLV-ARSN-ILTLMYQCMQDKM--PEVRQ-----------SSFALLGDLTKA---------CF----------Q-------H-----VK-P---C-IAD----------------------------------FMPILGTN-L--NP--E-----------F--I----------------------SVCNNATWA-IGEISIQMGIEMQPYIP--MVLHQL--VEIIN----------------R-PNT----------P-----------K---------------TLLENTAITIGRLGYVCP---Q-----EVAPMLQQFIRPWCTSL-R-N----IRD--NEEKDSAFRGICTMISVNPSGVI------QDF-IFFCDAVA------------------SWIN----------------P-K----------------------------DDLRDMFCKILHGFKNQVGDENWRRF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43 Fugue 54.0310% 10 - C1 - - 1U6G - CAND1_HUMAN C:[4-1210] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPSAL---AANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL-LPQLTSPRLAVRKRTIIALGHLV-MS-CFVDLIEHLLSELSK----NDS------------M-STTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDD-DELREY---------------CI-----QAFESFVRRCPKEVY-------------P-------------------HV-------------------S-TIINI-CLKYLTYDMSWKVRRA-AAKCLDAVVSTRH-E-MLPEFYKTVS------------PA-LI------SRF--KEREENVK----ADVFHAYLSLLKQTRPVGETP--LT--MLQS-QVPNIVKALHKQ-MKE--K--SVKTRQCCFNMLTELVNVLPGAL---T------Q---H----IPVLVPGIIFSLN--D-KSSS---S---NLKIDALSCLYVILCNHSP--QVF-HPHVQALVPPVVACVG----D----P------FYKITSEA---L--------------LVTQQLV-KVIR-------PLDQ---P-------S--S-F-------------------DA-TPYIKDLFTCTIKRLKAA-----------D--I-------DQEVKERAISCMGQIIC--NL-G-D-NL----GSDLPNTL-QIFLERL---------KN--E---ITRLTTVKALTLIAGSPLK-IDL-RP-VLGEGVPILASF--------L-------------------------------------------------------R---K-N----------QRALKLGTLSA-------LDILIKN-------YSDSLTAAMIDAV-L-D-EL---------PPLI---------SE-------SD-----------------------------------M-----------------------------------HV------SQMAISFLTTLAKVYPS-------------------S-------LSKISGSILNELI-GLV--R-----------------SP--LLQ-G----G-A-LS---------AM-LDFF-------QALVVT-GT--------------------------------------------------------N-----N--LGY-MDLLR-MLTGP-VYS-Q--------------T----------------------------------H--------------KQSY--YSIAKCVAALTRACP-KE------G-PAVVGQFI-QDVK-N---S-----------------R-----------------ST-D------------SIRLLALLSLGEVGHH-IDL-S-----G--------------------Q----L--E-LKSVILEAFSSPS-EEVKSA-----------ASYALGSISVGN---------LP----------E-------Y-----LP-F---V-LQE----------------------------------ITS--------------------------------------Q-------PKRQYLLLHSLKEI-ISSASVVG---LKPYVE--NIWALL--LKHCE----------------C-A------------E-----------E---------------GTRNVVAECLGKLTLIDP---E-----T-------LLPRLKGYL-I-S----G-S--SYARSSVVTAVKFTISDHPQPI------DPLL-KNCIGDFL------------------KTLE----------------D-P--D-------------------------LNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKV-RKELIREVEMGPFKHTVDD-GLDIRKAAFECMYTLLDSC--LD--RLDIFEFLNHVEDGLK-D------------H-------------------------YDIKMLTF----LMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVK------AN--------SVKQEFE-KQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAA---------------------------
42 HHSearch 54.0113% - - C1 - - 3ND2 - IMB1_YEAST A:[52-859] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-TKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQ-VSPE----AKNQIKTNALTALVS--IEPRIANAAAQLIAA-IADIEL---------------PH-----GAWPELMKIMVDNTG-------------A-------------------EQ-------------------PENVKRA-SLLALGYMCESADPQS---QAL-----------------VSSS------------NN-ILIAIV--QGAQSTETSKAVR----LAALNALADSLIFIK-----N--NM--EREG-ERNYLMQVVCEA-TQA--E--DIEVQAAAFGCLCKIMSLYYT-----F------M---KPYM-EQALYALTIATMK-----------------------------------------------------------------------------SPN---D--------------KVASMTV-EFWS-------TICE---E-------E--I-DIAYELAQFPQSPLQSYN--FA-LSSIKDVVPNLLNL--LTRQNEDPE----D--D-------DWNVSMSAGACLQLFAQ--N--C-G-------NHILEPVL-EFVEQNI---------TA--DN-WRNREAAVMAFGSIMDGPDK--VQ-RTYYVHQALPSILNL--------M-------------------------------------------------------N---D-Q----------SLQVKETTAWC-------IGRIADSVAESID------PQQHLPGV-V-QACL----------IGL---------QD--------H-----------------------------------P-----------------------------------KV------ATNCSWTIINLVEQLAEATPS---------------P-------IYNFYPALVDGLI-GAA--N-RID-----------------------------------------NE-FNAR-------ASAFS------------------ALTTMVE----Y------------------------ATDT--V-----A--ETS-ASIST-FVMDK-LGQ-TMSVDENQLTLEDAQS----------------------------------L--------------QELQ--SNILTVLAAVIRKSP-SS------V-EPVADMLM-GLFF-RLL-E-----------------K-----------------KDSA------------FIEDDVFYAISALAAS-LGK-GFEK--Y--------------------L----E--T-FSPYLLKALNQVD-S-PVSI-----------TAVGFIADISNS---------LE----------E-------D-----FR-R---Y-SDA----------------------------------MMNVLAQM-I--SN--PNA---------R--R----------------------ELKPAVLSV-FGDIASNIGADFIPYLN--DIMALC--VAAQN----------------T-K------------PENGTLEALDYQI---------------KVLEAVLDAYVGIVAGLHDKPE-----ALFPYVGTIFQFIAQVA-E-DPQLYS-E--DATSRAAVGLIGDIAAMFPDGSI-----KQFYGQDWVIDYI------------------KRTRSGQ-------------L-F--S-------------------------QATKDTARWAREQQKRQL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 HHSearch 53.8212% -7 - C1 - - 5VCH - ? A:[116-1103] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWPELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSAQALSYVSSLIEEEGEINP----Q---------YA-AKFASLIPSVVQVLDATI-RE-GDTTNTKLIFNCLNDFLLLDSQ--------------LTGN----TIADLVKLALQIAVNSDVDEDIRVFAVQFVTS-ALVYRK---------------SKINQA-KLGPEITLAALKVASEEIDVEDELTNED--------------------------------------------ENTP-ALTALRLISNASGEL----------------------SPSQVG------------VP-IIEHL--PTML--SSSNPFER----RSILLAISVLVTGSP-----D------YTLS-QFDKIIPATVTG-LKD--S--EAVVQLAALKCIVQLSTNLQD-----E------VARYH----EQYLPLVID-----------------------------------------------------------------------------IIDSAKH---V--------------VIYKYAT-LALD-------GLLE---F-------I--A-HN------------------DI-IKYLDPLMNKLFQM--LE-----------TQ-Q-------SPKLRAAIVSAIGSCAF--A--A-GSGF----VPYFKTSV-QYLQQFIQNVSQIEGLSE--DD-IELKALTFENISTMGRAVKS-AAF-AE-YAEPLVNAAYEA--------I-------------------------------------------------------K---T-D----------SARLRESGYAF-------IANMAKVYGKDF--------APFLQTI-I-PEIF----------KTL---------EQEEYTVNTGI-----------------------------------A-----------------------------------YE------KEVAAAALSELAIASKE-------------------H-------FLEYVEPSLKVLA-EQV--N-E-SY--------------------------------------------GLK-------ETALH------------------SMWAIVK----AVLLTANLKEGEYPKGVPSGSYVDAS-----A-----L--AVI-QTVRE-VSLNN-VIE-E--------------V----------------------------------E--------------TSMV--ISVFQDLSEMLRLFG-PIIIMDNGD-STHLDQLC-REAL-SVL-K-----------------G-----------------EH-ACQTILDASETEATLLDVALDIYVALSTN-LVG-GFAQ--V--------------------F----T--T-AKPVILQLCQSKS--KNKRS-----------FAVGALSEIALG---------MR----------D-------E------N-P---F-IQE----------------------------------LLEALIISLT--ND--K-----------S--L----------------------EVRCNASYG-VGLLIEYSSFDVSAIYS--PVLKSL--YEILSVADEKNLATEDDEATKE-I------------V-----------D---------------RTFSNVCGCVARMILKHQ---N-----LV--PLEHTIPALLSHL-P-FN---T-A--FEEYDPIFKLFLKLFQEQNSTII------NEA-PKVIAIFA------------------TVFE----------------K-E--SERIELETNSTLGREENLEKRKQFQSEEIKQQVIELLKHLNQQFNG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55 Fugue 52.1615% -33 - C1 - - 5IFE - SF3B1_HUMAN C:[463-1304] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPFLK------------PD-DIQYFD-KLLV--DVDESEEQ----KERKIMKLLLKIKNG-----T--PP--MRKA-ALRQITDKAREF-G----------AGPLFNQILPLLMSPTLE-----D------Q---E----RHLLVKVIDRILYKLD-DLVR---P---YVHKILVVIEPLLID--ED--YYA-RVEGREIISNLAKAAG----L----ATMISTMRPDIDNMD---E--------------YVRNTTA-RAFA-------VVAS---A-------L--GIP-------------------SL-LPFLKAVCKS-------------------K--K-------SWQARHTGIKIVQQIAI--L--MGC-AI----LPHLRSLV-EIIEHGL---------VD--EQ-QKVRTISALAIAALAEAATP-YGI----------ESFDSV--------L-------------------------------------------------------K---P-L----------WKGIRQHRGKG-------LAAFLKAIGYLI-PLMDAEYANYYTRE-V-MLIL---------IREF---------QS-------PD-----------------------------------E-----------------------------------EM------KKIVLKVVKQCCGTDGV-------------------E-------ANYIKTEILPPFF-KHFWQH-RMALD--RRN----YRQL--VDT-T----V-E-LA---------NKVGAAE-------IISRIV-DDLKDEAEQYRKMVMETIEKIMG----N------------------------L-----G-----A--ADIDHKLEE-QLIDG-ILY-A--------------F----------------------------------Q--------------EQTTEDSVMLNGFGTVVNALG-KR------V-KPYLPQIC-GTVL-WRL-N-----------------N-----------------KS-A------------KVRQQAADLISRTAVV-MKT-C-----Q--------------------E----E--K-LMGHLGVVLYEYL-GEEYPE-----------VLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTP-------I-----LK-N---R-HEK----------------------------------VQENCIDL-V--GR--I-----------A--DRG-------A-------EYVSAREWMRICFE-LLELLKAHKKAIRRATV--NTFGYI--AKAIG----------------P-H------------D-----------V---------------LATLQNRVCTTVAIAIVA---E-----TCSPF--TVLPALMNEY-R-V----P-E--LNVQNGVLKSLSFLFEYIG---EMGKDYIYAV-TPLLEDAL------------------MD--------------------R--D-------------------------LVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVF-ETS---------------PHVIQAVMGALEGLRVAIGPCRMLQ--YCLQGLFHPA--RKVRDV------------Y-------------------------WKIYNSIYIGSQDALIAHYPRIYNDDKNTYIR--YELDYIL---------------------------------------------------------------------------------------------------
45 Fugue 50.7412% 15 - C1 - - 1QBK - TNPO1_HUMAN B:[3-889] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEWKPDEQGLQQILQLLKESQSPDTTIQR---TVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNV--KAHFQNFPNGVT-DFIKSECLNNIGDSSPLI-RA-TVGILITTIASKGELQNWPDLL------------P-KLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDRPLNIMIPKFLQ---------------FFKH---SSPKIRSHAVACVNQ-------------F-------------------II-------------------S-RTQALMLHIDSFTENLFALAGD-EEPEVRKNVCRAL-VMLLEVRMDRLL------------PHMHNIVEYMLQRT--QDQDENVA----LEACEFWLTLAEQPI-----C--KD--VLVR-HLPKLIPVLVNGMKYS--D--IDIILLKGDVEEDETIPDSEQ-----D------I---R----PRFHRSRTVAQQH--D-EDDD---D---DDEIDD---DDTISDWNLR--KCS-AAALDVLANVYRDELL----P----HILPLLKELLFHHE----W--------------VVKESGI-LVLG-------AIAE--------------G-CM------------------QGMIPYLPELIPHLIQC--LS-----------D--K-------KALVRSITCWTLSRYAH--WV-V-S-QP----PDTYLKPLMTELLKRI---------LD--SN-KRVQEAACSAFATLEEEAC--TEL-VP-YLAYILDTLVFA--------F-------------------------------------------------------S---K-Y----------QHKNLLILYDA-------IGTLADSV--------GHHLNKPEYIQMLMPPLI---------QKWNM--------LK-------DE-----------------------------------D-----------------------------------KD------LFPLLECLSSVATALQS-------------------G-------FLPYCEPVYQRCV-NLV--Q-KTLAQ-------------------AM---L-N-NA---------QP-DQYE-------APDKDFMIVA-----------LDLLSGLAE----G------------------------L-----G-----G--NIE-QLVARSNILTLMYQCMQ--------------D----------------------------------KM-------------PEVR--QSSFALLGDLTKACF-QH------V-KPCIAD-FMPILG-TNL-N-----------------P-----------------EF-I------------SVCNNATWAIGEISIQMGIEMQ-----P--------------------Y----I--PMVLHQLVEIINRPNTPKTLLE-----------NTAITIGRLGYV---------CP----------Q-------E-----V--A---PMLQQ----------------------------------FIRPWCTS-L--RN--I-----------R--D------------------NEEKDSAFRGICTMISVNPSGVIQDFIFFCD--AVASWINPKDDLR----------------DMF------------C-----------K---------------ILHGFKNQVGDENWRRFS---D-----QFPLPLKERLAAFYG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 HHSearch 50.2013% -15 - C1 - - 1U6G - CAND1_HUMAN C:[172-1097] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSC-------FVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRI------------------------GEYLEKIIPLVVKFC-NV-DDDELREYCIQAFESFVRRCPK------------E--VYP----HVSTIINICLKYLTY-DMSWKVRRAAAKCLDA-VVSTRH---------------EMLP---EFYKTVSPALISRFK-------------E-------------------RE-------------------E-NVKAD-VFHAYLSLLKQTRPV---------------GE-TPLTMLQSQV------------PN-IVKAL--HKQM--KEKSVKTR----QCCFNMLTELVNVLP-----G------ALTQ-HIPVLVPGIIFS-LNDKSS--SSNLKIDALSCLYVILCNHSP-----Q------V---FHPHVQALVPPVVACVGD--P----------------------------------------------------------------------------F---Y--------------KITSEAL-LVTQQLVKVIRPLDQ---P-------S--S-F-------------------DA-TPYIKDLFTCTIKR--LK-----------AADI-------DQEVKERAISCMGQIIC--N--L-GDNL----GSDLPNTL-QIFLERL---------KN--E---ITRLTTVKALTLIAGSPLK-IDL-RP-VLGEGVPILASF--------L-------------------------------------------------------R---K-N----------QRALKLGTLSA-------LDILIKNYSDS-------LTAAMIDAV-L-DELP----------PLI---------SE-------SD-----------------------------------M-----------------------------------HV------SQMAISFLTTLAKVYPS-------------------S-------LSKISGSILNELI-GLV--R-SPLLQGGALSAMLDFFQALVVTG-TNNLGYMDLLRMLTGPVYSQTH-KQSY-------YSIA------------------KCVAALTR----A------------------------C-----P-----K--E-G-PAVVG-QFIQD-VKNSR--------------S----------------------------------T--------------DSIR--LLALLSLGEVGHHID-LS------G----QLELK-SVIL-EAF-S-----------------S-----------------PS-E------------EVKSAASYALGSISVG-NLP-E------------------------------------YLPFVLQEITS-Q-P-KRQY-----------LLLHSLKEIISS---------ASV---------V-------G-----LK-P---Y-VEN----------------------------------IWALLLKH-C--EC--A-----------E--E----------------------GTRNVVAEC-LGKLTLID-------PE--TLLPRL--KGYLI----------------S-G------------S-----------S---------------YARSSVVTAVKFTISDHP---Q-----PIDPLLKNCIGDFLKTL-E-D----P-D--LNVRRVALVTFNSAAHNKPSLIR------DLL-DTVLPHLYNETKVRKELIREVEMGPFKHTV----------------D-D--G-------------------------LDIRKAAFECMYTLLDSCL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40 HHSearch 49.1814% -10 * C1 * - 4XRI ? A:[113-869] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N---S--------------KAGQAAA-QVIA-------AIAA---I-------E--L-P-------------------R---NQWPELMHALVRN--AS-----------E--G-------GQHQKQASLTAIGFICE--T--Q-DTDLRNSLVGHSNAIL-TAVVQGA---------RKEEPN-NEVRFAAITALGDSLEFVGN-NFKHEG-ERNYIMQVVCEA--------T-------------------------------------------------------Q---A-Q----------DSRIQQGAFGC-------LNRIMALYYEHM--------RYYMEKA-L-FGLT---------ILGM---------KS-------DD-----------------------------------E-----------------------------------DV------AKLAVEFWSTVCEEEIAIEDDNAQVESSEQMRPFYNF-------ARVATNEVVPVLL-QLL--T-KQDED--A-------------------------SD---------DE-YNIS-------RAAY------------------QCLQLYAQ----A------------------------V-----G-----S--TII-PPVIQ-FVEHN-LRH----------------A----------------------------------D--------------WHFR--DAAVSAFGAIMDGPEEKV------L-EPIVKTGM-QPLI-AMM-E-----------------D-----------------ES-I------------QVRDSTAYALGRITEA-CSE-AIDPNTH--------------------L----E--P-LIRSLFNGLMN-S-P-KMAA-----------SCCWALMNIAER---------FA----------GEPGAAQNP-----LT-P---H-FNQ----------------------------------SVTNLLTV-TAPMN--G-----------D--S----------------------TVRTAAYEV-LSVFVQNAANDSLSAVA--SLSTVI--LQRLE----------------E-T------------L-----------PLQQQVVSVEDKLILEDMQTSLCTVLQATVQRLD---K-----EIAPQGDRIMQVLLQIL-S-TCG--G-K--SSVPEGVFAAISALANAMEEEFA------KYM-EAFAPFLY------------------NALG----------------NQE--E-------------------------PSLCSMAIGLVSDVTRSLGERSQPYCDNFMNYLLGNLRS-T-------T----------LANQFKPAILQCFGDIASAIGGHF--ETYLTIVAQVLQQAATITAGPDGSYEMIDYV-------------------------ISLREGIM----DAWGGIIGAMKTSNKT------NVLQPYVESIFA------LL--------NSIANDPNRSEALMRASMGVIGDLADAYPNGQLADA----FRQDWITAMIRETRSNREFGARTIETARWAREQVK---
44 Fugue 47.3810% -27 - C1 - - 1QGR - IMB1_HUMAN A:[1-876] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELITILEKTVSPDRLELEAAQKFLE--RAAVENL-PTFL-VELSRVLANPGNS--QVA-RV-AAGLQIKNSLTSKDPDIKAQYQ------------Q-RWLAIDANARREVKNYVLHTLGTETYRPSSASQCVAGIAC-AEIPVN---------------QW-----PE---LIPQLVANVT-------------N-------------------P----------------------------------NSTEHMKEST-LEAIGYICQDIDP-E-QLQDKSNEIL------------TA-IIQGMR-KE-----EPSNNVK----LAATNALLNSLEFTK-----A--NF--DKES-ERHFIMQVVCEA-TQC--P--DTRVRVAALQNLVKIMSLYYQ-----Y------M---E----TYMGPALFAITIE--AMKSDI---D---EVALQGIEFWSNVCDEEMD--LAI-EASEAAEQGRPPEHTS----K----FYAKGALQYLVPILT---QTLTKQDENDDDDDWNPCKAAG-VCLM-------LLAT---C-------C--E-D-------------------DI-VPHVLPFIKEHIK----------------N--P-------DWRYRDAAVMAFGCILEGPE--P-S-QL----KPLVIQAM-PTLIELM---------KD--PS-VVVRDTAAWTVGRICEL--L-PEA-AI-NDVYLAPLLQCL--------I-------------------------------------------------------E---G-L----------SAE-PRVASNV-------CWAFSSLAEAAYEAADVADDQEEPATY-C-LSSS---------FELI---------VQ-------KL-----------------------------------L-----------------------------------ET------TDRPDGHQNNLRSSAYE-------------------S-------LMEIVKNSAKDCY-PAV--Q-KTTLV--IME----RLQQ--VLQME----S-H-IQ---------ST-SDRI-------QFNDLQ-SLL-----------CATLQNVLR----K------------------------V-----Q-----H--QDA-LQISD-VVMAS-LLR-M--------------F----------------------------------S--------------GGVQ--EDALMAVSTLVEVLG-GE------F-LKYMEAFK-PFLG-IGL-K-----------------NY----------------AE-Y------------QVCLAAVGLVGDLCRA-LQS-N-----I--------------------I----P--F-CDEVMQLLLENLG-NENVHR-----------SVKPQILSVFGD---------IA----------L-------A-----IG-G---E-FKK----------------------------------YLEVVLNT-L--QQ--A-----------S--Q---------A-------QVDKSD------------------YDMVDYLN--ELRESC--LEAYT----------------G-I------------V-----------Q---------------GLKGDQENVHPDVML-------------VQPRVEFILSFIDHIA-G-D----E-D----HTDGVVACAAGLIGDLCTAFGKDVLKLVEA-RPMIHELL------------------TEGR----------------R-S--K-------------------------TNKAKTLARWATKELRKLKNQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 HHSearch 44.9214% -1 - C1 - - 1QBK - TNPO1_HUMAN B:[59-865] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEDEPTR----SLSGLILKNNVKAHF-----Q------NFPNGVTDFIKSECLNN-IGD--S--SPLIRATVGILITTIASKGEL-----Q------N---W----PDLLPKLCSLLDS--E-DY-------------NTCEGAFGALQKICE--DSA---EILDS---DRP--L----N----IMIPKFLQFFKH-SS---P--------------KIRSHAV-ACVN-------QFII---S-------R--T-Q-------------------AL-MLHIDSFTENLFAL--AG-----------D--E-------EPEVRKNVCRALVMLLE--V--R-MDRL----LPHMHNIV-EYMLQRT---------QD--QD-ENVALEACEFWLTLAEQPICKDVL-VR-HLPKLIPVLVNG--------MKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDDDDDDEIDDDDT---I-S----------DWNLRKCSAAA-------LDVLANVYR-----------DELLPHI-L-PLLK----------ELL---------FH-------HE-----------------------------------W-----------------------------------VV------KESGILVLGAIAEGCMQ-------------------G-------MIPYLPELIPHLI-QCL--S-DK-------------------------------------------K-ALVR-------SITCW------------------TLSRYAH----W------------------------V-----VSQPP-D--TYL-KPLMT-ELLKR-ILD----------------S----------------------------------N--------------KRVQ--EAACSAFATLEEEAC-TE------L-VPYLAYIL-DTLV-FAF-S-----------------K-----------------YQ-H------------KNLLILYDAIGTLADS-VGH-HLNKPEY--------------------I----Q--M-LMPPLIQKWNMLKDEDKDLF-----------PLLECLSSVATA---------LQ----------S-------G-----FL-P---Y-CEP----------------------------------VYQRCVNL-V--QK--TLAQAMLNNA--QPDQ---------Y-------EAPDKDFMIVALDL-LSGLAEGLGGNIEQLVARSNILTLM--YQCMQ----------------D-K------------M-----------P---------------EVRQSSFALLGDLTKACF---Q-----HVKPCIADFMPILGTNL-N-P----E-F--ISVCNNATWAIGEISIQMGIEMQ------PYI-PMVLHQLV------------------EIIN----------------R-PNTP-------------------------KTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRN-I---------------R---DNEEKDSAFRGICTMISVNPSGV--IQDFIFFCDAVASWI-NP------------K-------------------------DDLRDMFC----KILHGFKNQVG---------------------------------------------------------------------------------------------------------------------