@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ENOB_HUMAN: (2020-02-01 )
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKGVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK
Atome Classification :
(30 SA)
.........10........20........30.........40........50-----------........60........70........80..--......90........100.......110.......120.......130.......140.-.-.......150.......160.......170.......180.......190.......200.......210.......220.......230....--.--..240.......250.--......260.---.-.....270.......280.......290.......300.......310-.--.....---..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....-...430..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
M
Q
K
I
F
A
R
E
I
L
DSRGN
P
T
V
E
V
D
L
HTAKG
R
-
F
R
AAVPSGAS
T
G
I
Y
E
A
L
ELRD-----------GDKG
R
Y
L
G
K
G
V
L
K
A
V
E
N
I
NNTL
G
P
A
L
L
Q
K
K
L
S
--VV
D
Q
E
K
V
D
K
F
M
I
E
LDGTENKSKFGA
N
A
I
L
G
V
S
L
A
V
CKAGAAEKG
V
P
L
Y
R
H
I
A
D
LAGN--P-
D
-
L
I
L
PVP
A
F
N
V
INGGSHAG
N
K
L
A
M
Q
E
F
M
I
L
PV
G
A
S
S
F
K
E
A
M
R
I
G
A
E
V
Y
H
H
L
K
G
V
I
K
A
KYGKDATNVGDEGGFAPNILE
N
N
E
A
L
E
L
L
K
T
A
I
Q
AAGY--P--
D
K
V
V
I
GMD
V
A
A
S
E
F
Y
R--NGKYDLDFKS---P-DD
P
A
RH
I
T
G
E
K
L
G
E
L
Y
K
S
F
I
KNYP
V
V
SIEDPFDQ
D
D
W
A
T
W
T
S
F
LSG
V
--
N
--
I
Q
I
V
G---DDLTVT
N
P
K
R
I
A
Q
A
V
E
K
KAC
N
C
L
L
L
K
VNQI
G
S
V
T
E
S
I
Q
A
C
KLAQSNG
W
G
V
M
V
SHRSGET
E
D
T
F
I
A
D
L
V
V
G
L
CTGQIKTGAP
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
A
LGDKAIFAGR-KFRNPKAK
1
PsiBlast_PDB
98.47
99%
-77
- C4 -
-
2XSX
13
ENOB_HUMAN
A:
[2-435]
M
A
M
Q
K
I
F
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
H
T
A
K
G
R
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
G
R
Y
L
G
K
G
V
L
K
A
V
E
N
I
N
S
T
L
G
P
A
L
L
Q
K
K
L
S
--
V
A
D
Q
E
K
V
D
K
F
M
I
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
K
G
V
P
L
Y
R
H
I
A
D
L
A
G
N
--
P
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
S
S
F
K
E
A
M
R
I
G
A
E
V
Y
H
H
L
K
G
V
I
K
A
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
N
E
A
L
E
L
L
K
T
A
I
Q
A
A
G
Y
--
P
--
D
K
V
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
N
G
K
Y
D
L
D
F
K
S
---
P
-
D
D
P
A
R
H
I
T
G
E
K
L
G
E
L
Y
K
S
F
I
K
N
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
T
W
T
S
F
L
S
G
V
--
N
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
A
Q
A
V
E
K
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
Q
A
C
K
L
A
Q
S
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
D
K
A
I
F
A
G
R
-
K
F
R
N
P
K
A
K
2
PsiBlast_PDB
93.66
83%
-81
- C4 -
-
4ZA0
1
ENOG_HUMAN
A:
[1-431]
M
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
6
PsiBlast_PDB
93.54
83%
-77
- C4 -
-
5TD9
-
ENOG_HUMAN
A:
[1-431]
M
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
5
PsiBlast_PDB
93.20
83%
-84
- C4 -
-
5IDZ
2
ENOG_HUMAN
A:
[1-431]
M
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
7
PsiBlast_PDB
93.14
83%
-86
- C4 -
-
5TIJ
1
ENOG_HUMAN
A:
[2-431]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
3
PsiBlast_PDB
93.10
83%
-83
- C4 -
-
4ZCW
1
ENOG_HUMAN
A:
[2-431]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
4
PsiBlast_PDB
93.04
83%
-79
- C4 -
-
5EU9
1
ENOG_HUMAN
A:
[2-431]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
13
PsiBlast_PDB
92.97
83%
-79
- C4 -
-
3UJE
2
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
22
HHSearch
92.95
84%
-80
- C4 -
-
2AKZ
1
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
14
PsiBlast_PDB
92.73
83%
-78
- C4 -
-
3UJF
1
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
12
PsiBlast_PDB
92.73
83%
-80
- C4 -
-
2AKZ
1
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
10
PsiBlast_PDB
92.66
83%
-81
- C4 -
-
1TE6
1
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
16
PsiBlast_PDB
92.62
83%
-79
- C4 -
-
3UJS
2
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
8
PsiBlast_PDB
92.57
84%
-80
- C4 -
-
3UCC
2
ENOG_HUMAN
A:
[1-430]
-
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
9
PsiBlast_PDB
92.50
84%
-79
- C4 -
-
3UCD
1
ENOG_HUMAN
A:
[1-430]
-
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
11
PsiBlast_PDB
92.45
83%
-80
- C4 -
-
2AKM
1
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
15
PsiBlast_PDB
92.19
83%
-83
- C4 -
-
3UJR
2
ENOG_HUMAN
A:
[1-430]
-
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
--
S
-
D
-
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
--
D
G
K
Y
D
L
D
F
K
S
---
P
-
T
D
P
S
R
Y
I
T
G
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
--
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
-
N
F
R
N
P
---
18
PsiBlast_PDB
91.76
83%
-73
- C4 -
-
3B97
-
ENOA_HUMAN
A:
[1-432]
-
S
I
L
K
I
H
A
R
E
I
F
D
S
R
G
N
P
T
V
E
V
D
L
F
T
S
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
N
D
K
T
R
Y
M
G
K
G
V
S
K
A
V
E
H
I
N
K
T
I
A
P
A
L
V
S
K
K
L
N
--
V
T
E
Q
E
K
I
D
K
L
M
I
E
M
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
V
E
K
G
V
P
L
Y
R
H
I
A
D
L
A
G
N
--
S
-
E
-
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
A
N
F
R
E
A
M
R
I
G
A
E
V
Y
H
N
L
K
N
V
I
K
E
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
K
E
G
L
E
L
L
K
T
A
I
G
K
A
G
Y
--
T
--
D
K
V
V
I
G
M
D
V
A
A
S
E
F
F
R
--
S
G
K
Y
D
L
D
F
K
S
---
P
-
D
D
P
S
R
Y
I
S
P
D
Q
L
A
D
L
Y
K
S
F
I
K
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
G
A
W
Q
K
F
T
A
S
A
--
G
--
I
Q
V
V
G
---
D
D
L
T
V
T
N
P
K
R
I
A
K
A
V
N
E
K
S
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
L
Q
A
C
K
L
A
Q
A
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
K
A
K
F
A
G
R
-
N
F
R
N
P
L
A
-
17
PsiBlast_PDB
91.71
83%
-73
- C4 -
-
2PSN
-
ENOA_HUMAN
A:
[2-433]
-
S
I
L
K
I
H
A
R
E
I
F
D
S
R
G
N
P
T
V
E
V
D
L
F
T
S
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
-----------
N
D
K
T
R
Y
M
G
K
G
V
S
K
A
V
E
H
I
N
K
T
I
A
P
A
L
V
S
K
K
L
N
--
V
T
E
Q
E
K
I
D
K
L
M
I
E
M
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
V
E
K
G
V
P
L
Y
R
H
I
A
D
L
A
G
N
--
S
-
E
-
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
A
N
F
R
E
A
M
R
I
G
A
E
V
Y
H
N
L
K
N
V
I
K
E
K
Y
G
K
D
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
K
E
G
L
E
L
L
K
T
A
I
G
K
A
G
Y
--
T
--
D
K
V
V
I
G
M
D
V
A
A
S
E
F
F
R
--
S
G
K
Y
D
L
D
F
K
S
---
P
-
D
D
P
S
R
Y
I
S
P
D
Q
L
A
D
L
Y
K
S
F
I
K
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
G
A
W
Q
K
F
T
A
S
A
--
G
--
I
Q
V
V
G
---
D
D
L
T
V
T
N
P
K
R
I
A
K
A
V
N
E
K
S
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
L
Q
A
C
K
L
A
Q
A
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
K
A
K
F
A
G
R
-
N
F
R
N
P
L
A
-
20
PsiBlast_PDB
80.42
71%
-28
- C4 -
-
1PDY
1
ENO_HOMGA
A:
[1-432]
-
S
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
-----------
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
L
K
--
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
N
Y
--
D
-
E
-
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
L
K
A
V
I
K
A
R
F
G
L
D
A
T
A
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
--
T
--
G
K
I
E
I
G
M
D
V
A
A
S
E
F
Y
K
Q-
N
N
I
Y
D
L
D
F
K
T
---
A
N
N
D
G
S
Q
K
I
S
G
D
Q
L
R
D
M
Y
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
G
T
--
T
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
K
-
N
F
R
A
P
---
19
PsiBlast_PDB
80.35
71%
-26
- C4 -
-
1PDZ
1
ENO_HOMGA
A:
[2-433]
-
S
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
-
F
R
A
A
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
-----------
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
L
K
--
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
N
Y
--
D
-
E
-
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
L
K
A
V
I
K
A
R
F
G
L
D
A
T
A
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
--
T
--
G
K
I
E
I
G
M
D
V
A
A
S
E
F
Y
K
Q-
N
N
I
Y
D
L
D
F
K
T
---
A
N
N
D
G
S
Q
K
I
S
G
D
Q
L
R
D
M
Y
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
G
T
--
T
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
K
-
N
F
R
A
P
---
25
HHSearch
78.64
63%
-24
- C4 -
-
3QTP
1
ENO1_ENTHI
A:
[6-440]
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
-
F
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
-----------
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
K
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
--
K
-
E
-
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y
G
Q
D
A
T
N
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
EE
T
K
K
Y
D
L
G
K
K
I
PAD
K
-
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G-
N
--
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
-
P
Y
A
G
K
-
N
W
R
N
S
T
--
35
HHSearch
78.22
63%
-22
- C4 -
-
2PTY
2
?
A:
[4-427]
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
-
F
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
L
A
S
L
A
G
T
--
K
-
E
-
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
D
A
V
N
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
--
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
EK
K
Q
Q
Y
N
L
T
F
K
S
------
P
E
P
T
W
V
T
A
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
KG
K
--
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
-----------
34
HHSearch
78.09
63%
-22
- C4 -
-
2PTZ
2
?
A:
[4-427]
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
-
F
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
L
A
S
L
A
G
T
--
K
-
E
-
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
D
A
V
N
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
--
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
EK
K
Q
Q
Y
N
L
T
F
K
S
------
P
E
P
T
W
V
T
A
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
KG
K
--
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
-----------
26
HHSearch
77.04
63%
-22
- C4 -
-
3QTP
1
ENO1_ENTHI
B:
[6-440]
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
-
F
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
-----------
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
K
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
--
K
-
E
-
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y
G
Q
D
A
T
N
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
EE
T
K
K
Y
D
L
G
K
K
I
PAD
K
-
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G-
N
--
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
-
P
Y
A
G
K
-
N
W
R
N
S
T
--
23
HHSearch
76.06
64%
12
- C4 -
-
2AL1
1
ENO1_YEAST
A:
[1-434]
-
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
-----------
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
I
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
KT
S
-
P
-
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
Y
G
A
S
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
--
D
G
K
Y
D
L
D
F
K
N
P--
N
-
S
D
K
S
K
W
L
T
G
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
-
N
F
H
H
G
D
--
24
HHSearch
75.56
64%
13
- C4 -
-
1EBG
1
ENO1_YEAST
A:
[1-434]
-
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
-----------
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
I
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
L
A
D
L
S
K
S
KT
S
-
P
-
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
Y
G
A
S
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
--
D
G
K
Y
D
L
D
F
K
N
P--
N
-
S
D
K
S
K
W
L
T
G
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
-
N
F
H
H
G
D
--
36
HHSearch
66.49
52%
25
- C4 -
-
6NB2
5
?
B:
[9-425]
M
H
I
H
K
I
Q
A
R
E
I
L
D
S
R
G
N
P
T
I
E
A
D
V
T
L
T
T
G
I
I
G
R
A
S
V
P
S
G
A
S
T
G
S
R
E
A
C
E
L
R
D
-----------
N
D
P
K
R
Y
A
G
K
G
V
Q
K
A
V
K
H
V
N
N
E
I
N
Q
A
L
Q
--
G
L
S
--
V
E
D
Q
E
N
L
D
R
I
L
C
Q
L
D
N
T
E
N
K
S
H
L
G
A
N
A
I
L
A
T
S
L
A
C
A
R
A
R
A
L
S
L
N
Q
P
L
Y
M
T
L
N
----
Q
--
G
D
M
-
M
T
M
P
V
P
M
M
N
I
L
N
G
G
A
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
I
G
A
P
D
F
P
V
A
L
Q
M
G
T
E
I
F
H
V
L
K
S
V
L
K
K
Q
-
G
L
-
N
T
A
V
G
D
E
G
G
F
A
P
N
I
Q
S
N
R
Q
A
L
D
L
L
S
E
A
I
E
K
A
G
F
--
R
LG
E
D
I
V
F
A
L
D
V
A
A
S
E
L
F
N
--
E
G
F
Y
H
M
Y
S
E
---------
N
Q
K
F
D
S
H
Q
L
I
E
Y
Y
A
N
L
I
S
S
Y
P
I
V
S
I
E
D
G
L
D
E
K
D
W
S
G
W
K
Q
L
T
T
H
L
--
G
NK
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
K
I
L
R
E
G
I
A
Q
G
I
A
N
A
I
L
I
K
V
N
Q
I
G
T
L
S
E
T
R
Q
A
I
K
L
A
Y
D
N
G
Y
R
C
V
M
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
A
V
A
S
G
C
G
Q
I
K
T
G
S
L
C
R
T
D
R
T
A
K
Y
N
Q
L
L
R
I
N
E
L
A
S
-
L
-
P
Y
A
G
K
---------
33
HHSearch
66.05
49%
18
- C4 -
-
5BOE
3
ENO_STAAU
A:
[2-433]
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
-----------
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
G
E
FS
V
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
L
G
G
F
-----
N
-
G
-
K
Q
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
-
G
-
L
E
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
KP
G
--
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
E
--
N
G
V
Y
D
Y
S
K
F
E
---
G
--
E
H
G
A
K
R
T
A
A
E
Q
V
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
--
G
--
D
R
V
Q
L
VGD
D
L
-
F
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
39
HHSearch
64.53
52%
27
- C4 -
-
5J04
1
ENO_SYNP6
B:
[3-421]
T
Q
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
-----------
S
V
G
L
A
Q
V
P
S
G
A
S
TGTFEAHELRD
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
A
-
I
E
D
A
L
I
--
G
L
S
--
A
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
L
----
G
G
--
P
-
L
A
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
G
L
--
A
T
G
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
KP
G
--
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
--
N
G
L
Y
T
C
D
-----------
G
V
S
H
E
P
A
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
--
G
--
S
T
V
Q
L
VGD
D
L
-
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
A
-
I
G
L
-----