@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ITAM_HUMAN: (2020-02-01 )
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
Atome Classification :
(20 SA)
.........10........20.......--.30.-.......40...-----.....50.---.......60.......-.70........80.......---------.90........100.......110.....--..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360..-.....370.......-380...-------------....390.......400.......410.-........420......-.430....--...440.......450.......460.......470.......480.......490----.......500.......510.......520.......530.......540.-......550.......560.......570.......580........590.......600.....--..610.......620.......630.......640......-.650.......660.......670.......680.......690.......700.....--..710.......720.--......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.....-..910..-.....920.......930......--------.940.-.-...-..950.......960...-....970.......980.......990.......1000......1010......1020......1030......1040......1050......-1060........1070......1080......1090......1100......1110......1120......1130......1140......1150
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
L
R
V
L
L
L
T
A
L
T
L
C
HGFNLDTENA
M
T
F
Q
--
E
N
A
R
-
G
F
G
Q
S
V
V
QLQG
S
-----
R
V
V
VGA
P
Q
---
E
I
V
AANQRG
S
L
Y
Q
C
DY-STGSC
E
P
I
R
L
QV
P
V
E
A
V
N
M
S---------LG
L
S
L
AATTSPP
Q
L
L
ACGP
T
V
H
QTCSENT--
Y
V
K
G
L
C
F
L
FG
S
N
L
R
Q
Q
P
Q
K
F
P
E
A
L
RGCPQEDS
D
I
A
F
L
IDGSGSII
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
YSE
E
F
R
I
H
F
T
F
K
E
FQNNP
N
P
R
S
L
V
K
P
I
T
Q
L
LGRTH
T
A
T
G
I
R
K
V
V
R
E
L
F
N
ITNGARK
N
A
F
K
I
L
V
V
I
TDGEKFGDPLGYEDVIPEADRE
G
V
I
R
Y
V
IGV
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
ASKPPRD
H
V
F
QVN
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
I
F
A
I
EGTQTGSSS
S
F
E
H
E
M
S
QEGF
S
A
AITSNGP-
L
L
S
TVGSYDWA
G
G
V
F
-
L
Y
TSKE-------------K
S
T
F
I
N
M
T
RVDSDM
N
D
A
Y
L
G
Y
A
A
A
I
--
I
-
L
R
N
R
V
Q
S
L
VLGAPRYQ
H
-
I
G
L
V
A
M
F
R--QNTGMWESNANVKG
T
Q
I
G
A
Y
FG
A
S
L
C
S
V
D
VDSNGST
D
L
V
L
IGAP
H
Y
Y
E
QTRGG
Q
V
S
----
V
CPLPRGRA
R
W
Q
C
D
A
V
L
YGEQGQPWGRF
G
A
A
L
T
V
L
GDVNGD
K
L
T
D
V
A
IGAP-GEEDN
R
G
A
V
Y
L
F
HGTSGSGISP
S
H
S
QRIAGSKL
S
P
R
L
Q
-
Y
F
G
Q
SLSGGQDLTMDG
L
V
D
L
T
VGAQG--
H
V
L
L
L
RSQ
P
V
L
R
V
K
A
I
MEF
N
P
R
E
V
A
R
N
V
F
ECND
Q
V
VKGKEA-G
E
V
R
V
C
L
H
V
Q
K
S
T
R
D
R
L
REGQ
I
Q
S
V
V
T
Y
D
L
ALDSGRPH
S
R
A
V
F
N
ETKNSTR
R
Q
T
Q
V
L
G
L--TQ
T
C
E
T
L
K
LQL
P
N
C
IE--DPVS
P
I
V
L
R
L
N
F
S
L
VG
T
P
L
S
A
FGNLR
P
V
L
A
E
D
A
Q
R
L
F
T
A
L
FPFEKNCGNDNICQDD
L
S
I
T
F
S
F
M
S
L
D
C
L
V
VGGP
R
E
F
N
V
T
V
T
V
RNDGED
S
Y
R
T
Q
V
T
F
F
F
PLDL
S
Y
R
K
V
S
T
L
Q
N
Q
R
SQR
S
W
R
L
A
CESASSTEVSGALKSTSCSINHPIFPEN
S
E
V
T
F
N
I
T
F
DVDSKASLG
N
K
L
L
L
K
A
NVTSENNM-PRTNK
T
E
-
F
Q
L
ELP
V
K
Y
A
V
Y
M
V
V
TSHGV
S
T
K
Y
--------
L
N
F
TA-S-E
N
T
-
S
R
V
M
Q
H
Q
Y
Q
V
S
NLGQRSL-
P
I
S
L
V
F
L
V
P
V
RLN
Q
T
V
I
WDRPQ
V
T
F
S
EN
L
S
S
TC
H
T
K
ERLP
S
H
S
D
F
L
A
E
L
R
KAPVVN
C
S
I
A
V
C
Q
R
IQCDIPFFG
I
Q
E
EFN
A
T
L
KGN
L
S
F
D
W
Y
I
KT-SH--N
H
L
L
I
V
S
T
A
E
I
L
FND
S
V
F
T
LLPGQ
G
A
F
V
RSQTETKVEPFEVPNPL
P
L
I
VGSS
V
G
G
L
L
L
L
A
L
I
T
A
A
L
Y
K
L
G
F
F
K
R
Q
Y
K
D
M
M
SEGGPPGAEPQ
4
PsiBlast_PDB
84.90
60%
-83
- C2 -
-
5ES4
8
ITAX_HUMAN (first)
A:
[1-1080]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
N
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
T
--
Q
L
T
Q
R
L
P
V
S
R
Q
E
C
P
R
Q
E
Q
D
I
V
F
L
I
D
G
S
G
S
I
S
S
R
N
F
A
T
M
M
N
F
V
R
A
V
I
S
Q
F
Q
R
P
S
T
Q
F
S
L
M
Q
F
S
N
K
F
Q
T
H
F
T
F
E
E
F
R
R
S
S
N
P
L
S
L
L
A
S
V
H
Q
L
Q
G
F
T
Y
T
A
T
A
I
Q
N
V
V
H
R
L
F
H
A
S
Y
G
A
R
R
D
A
A
K
I
L
I
V
I
T
D
G
K
K
E
G
D
S
L
D
Y
K
D
V
I
P
M
A
D
A
A
G
I
I
R
Y
A
I
G
V
G
L
A
F
Q
N
R
N
S
W
K
E
L
N
D
I
A
S
K
P
S
Q
E
H
I
F
K
V
E
D
F
D
A
L
K
D
I
Q
N
Q
L
K
E
K
I
F
A
I
E
G
T
E
T
T
S
S
S
S
F
E
L
E
M
A
Q
E
G
F
S
A
V
F
T
P
D
G
P
-
V
L
G
A
V
G
S
F
T
W
S
G
G
A
F
-
L
Y
P
P
N
M
-------------
S
P
T
F
I
N
M
S
Q
E
N
V
D
M
R
D
S
Y
L
G
Y
S
T
E
L
--
A
-
L
W
K
G
V
Q
S
L
V
L
G
A
P
R
Y
Q
H
-
T
G
K
A
V
I
F
T
--
Q
V
S
R
Q
W
R
M
K
A
E
V
T
G
T
Q
I
G
S
Y
F
G
A
S
L
C
S
V
D
V
D
S
D
G
S
T
D
L
V
L
I
G
A
P
H
Y
Y
E
Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
E
Q
G
H
P
W
G
R
F
G
A
A
L
T
V
L
G
D
V
N
G
D
K
L
T
D
V
V
I
G
A
P
-
G
E
E
E
N
R
G
A
V
Y
L
F
H
G
V
L
G
P
S
I
S
P
S
H
S
Q
R
I
A
G
S
Q
L
S
S
R
L
Q
-
Y
F
G
Q
A
L
S
G
G
Q
D
L
T
Q
D
G
L
V
D
L
A
V
G
A
R
G
--
Q
V
L
L
L
R
T
R
P
V
L
W
V
G
V
S
M
Q
F
I
P
A
E
I
P
R
S
A
F
E
C
R
E
Q
V
V
S
E
Q
T
L
-
V
Q
S
N
I
C
L
Y
I
D
K
R
S
K
N
L
L
G
S
R
D
L
Q
S
S
V
T
L
D
L
A
L
D
P
G
R
L
S
P
R
A
T
F
Q
E
T
K
N
R
S
L
S
R
V
R
V
L
G
L
--
K
A
H
C
E
N
F
N
L
L
L
P
S
C
V
E
--
D
S
V
T
P
I
T
L
R
L
N
F
T
L
V
G
K
P
L
L
A
F
R
N
L
R
P
M
L
A
A
D
A
Q
R
Y
F
T
A
S
L
P
F
E
K
N
C
G
A
D
H
I
C
Q
D
N
L
G
I
S
F
S
F
P
G
L
K
S
L
L
V
G
S
N
L
E
L
N
A
E
V
M
V
W
N
D
G
E
D
S
Y
G
T
T
I
T
F
S
H
P
A
G
L
S
Y
R
Y
V
A
E
G
Q
K
Q
G
Q
L
R
S
L
H
L
T
C
D
S
A
P
V
G
--
S
Q
G
T
W
S
T
S
C
R
I
N
H
L
I
F
R
G
G
A
Q
I
T
F
L
A
T
F
D
V
S
P
K
A
V
L
G
D
R
L
L
L
T
A
N
V
S
S
E
N
N
T
-
P
R
T
S
K
T
T
-
F
Q
L
E
L
P
V
K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
N
F
S
E
-
S
-
E
E
K
E
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
R
D
L
-
P
V
S
I
N
F
W
V
P
V
E
L
N
Q
E
A
V
W
M
D
V
E
V
S
H
P
Q
N
P
S
L
R
C
S
S
E
K
I
A
P
P
A
S
D
F
L
A
H
I
Q
K
N
P
V
L
D
C
S
I
A
G
C
L
R
F
R
C
D
V
P
S
F
S
V
Q
E
E
L
D
F
T
L
K
G
N
L
S
F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
T
F
D
T
S
V
Y
S
Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
-----------------------------------------------------
5
PsiBlast_PDB
84.88
60%
-85
- C2 -
-
4NEH
1
ITAX_HUMAN
A:
[1-1084]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
D
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
T
--
Q
L
T
Q
R
L
P
V
S
R
Q
E
C
P
R
Q
E
Q
D
I
V
F
L
I
D
G
S
G
S
I
S
S
R
N
F
A
T
M
M
N
F
V
R
A
V
I
S
Q
F
Q
R
P
S
T
Q
F
S
L
M
Q
F
S
N
K
F
Q
T
H
F
T
F
E
E
F
R
R
S
S
N
P
L
S
L
L
A
S
V
H
Q
L
Q
G
F
T
Y
T
A
T
A
I
Q
N
V
V
H
R
L
F
H
A
S
Y
G
A
R
R
D
A
A
K
I
L
I
V
I
T
D
G
K
K
E
G
D
S
L
D
Y
K
D
V
I
P
M
A
D
A
A
G
I
I
R
Y
A
I
G
V
G
L
A
F
Q
N
R
N
S
W
K
E
L
N
D
I
A
S
K
P
S
Q
E
H
I
F
K
V
E
D
F
D
A
L
K
D
I
Q
N
Q
L
K
E
K
I
F
A
I
E
G
T
E
T
T
S
S
S
S
F
E
L
E
M
A
Q
E
G
F
S
A
V
F
T
P
D
G
P
-
V
L
G
A
V
G
S
F
T
W
S
G
G
A
F
-
L
Y
P
P
N
M
-------------
D
P
T
F
I
N
M
S
Q
E
N
V
D
M
R
D
S
Y
L
G
Y
S
T
E
L
--
A
-
L
W
K
G
V
Q
S
L
V
L
G
A
P
R
Y
Q
H
-
T
G
K
A
V
I
F
T
--
Q
V
S
R
Q
W
R
M
K
A
E
V
T
G
T
Q
I
G
S
Y
F
G
A
S
L
C
S
V
D
V
D
S
D
G
S
T
D
L
V
L
I
G
A
P
H
Y
Y
E
Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
E
Q
G
H
P
W
G
R
F
G
A
A
L
T
V
L
G
D
V
N
G
D
K
L
T
D
V
V
I
G
A
P
-
G
E
E
E
N
R
G
A
V
Y
L
F
H
G
V
L
G
P
S
I
S
P
S
H
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Q
R
I
A
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Q
L
S
S
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L
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-
Y
F
G
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A
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G
G
Q
D
L
T
Q
D
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L
V
D
L
A
V
G
A
R
G
--
Q
V
L
L
L
R
T
R
P
V
L
W
V
G
V
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M
Q
F
I
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A
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I
P
R
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A
F
E
C
R
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Q
V
V
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Q
T
L
-
V
Q
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N
I
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L
Y
I
D
K
R
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K
N
L
L
G
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D
L
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V
T
L
D
L
A
L
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L
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L
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R
V
L
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L
--
K
A
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C
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N
F
N
L
L
L
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--
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L
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L
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L
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M
L
A
A
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A
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F
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A
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L
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F
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K
N
C
G
A
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H
I
C
Q
D
N
L
G
I
S
F
S
F
P
G
L
K
S
L
L
V
G
S
N
L
E
L
N
A
E
V
M
V
W
N
D
G
E
D
S
Y
G
T
T
I
T
F
S
H
P
A
G
L
S
Y
R
Y
V
A
E
G
Q
K
Q
G
Q
L
R
S
L
H
L
T
C
D
S
A
P
V
G
--
S
Q
G
T
W
S
T
S
C
R
I
N
H
L
I
F
R
G
G
A
Q
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F
L
A
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P
K
A
V
L
G
D
R
L
L
L
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A
N
V
S
S
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N
T
-
P
R
T
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K
T
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-
F
Q
L
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L
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K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
C
F
S
E
-
S
-
E
E
K
E
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
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D
L
-
P
V
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I
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W
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L
N
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A
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W
M
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V
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P
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L
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C
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K
I
A
P
P
A
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D
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L
A
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Q
K
N
P
V
L
D
C
S
I
A
G
C
L
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F
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C
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V
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S
F
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V
Q
E
E
L
D
F
T
L
K
G
N
L
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F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
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V
V
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A
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F
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Y
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L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
K
-
P
G
------------------------------------------------
37
HHSearch
84.50
60%
-83
* C2 *
-
4NEH
1
ITAX_HUMAN
A:
[1-1081]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
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V
V
Q
Y
A
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S
-----
W
V
V
V
G
A
P
Q
---
K
I
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A
A
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Q
T
G
G
L
Y
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C
G
Y
-
S
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G
A
C
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P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
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V
H
H
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--
Y
L
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L
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F
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-
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L
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-
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M
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-
L
Y
P
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M
-------------
D
P
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F
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Q
E
N
V
D
M
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D
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Y
L
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Y
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--
A
-
L
W
K
G
V
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L
V
L
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A
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-
T
G
K
A
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Q
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Q
W
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M
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A
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V
T
G
T
Q
I
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Y
F
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A
S
L
C
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V
D
V
D
S
D
G
S
T
D
L
V
L
I
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A
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H
Y
Y
E
Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
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G
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A
A
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V
L
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D
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N
G
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K
L
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V
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-
G
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A
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-
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F
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G
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L
L
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V
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L
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F
P
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L
L
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N
L
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L
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A
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V
M
V
W
N
D
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G
T
T
I
T
F
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A
G
L
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Y
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A
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K
Q
G
Q
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L
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L
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A
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L
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L
L
L
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A
N
V
S
S
E
S
N
T
-
P
R
-
T
S
K
T
T
F
Q
L
E
L
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V
K
Y
A
V
Y
T
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--
V
S
S
H
-
E
Q
F
TKY-----
L
C
F
S
E
S
E
-
E
K
E
-
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
R
D
L
-
P
V
S
I
N
F
W
V
P
V
E
L
N
Q
E
A
V
W
M
D
V
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V
S
H
P
Q
N
P
S
L
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C
S
S
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K
I
A
P
P
A
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F
L
A
H
I
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K
N
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V
L
D
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A
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C
L
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F
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L
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L
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N
L
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F
G
W
V
-
R
Q
I
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
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F
D
T
S
V
Y
S
Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
----------------------------------------------------
6
PsiBlast_PDB
83.43
60%
-86
- C2 -
-
4NEN
-
ITAX_HUMAN
A:
[1-1083]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
D
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
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--
Q
L
T
Q
R
L
P
V
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P
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Q
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Q
D
I
V
F
L
I
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G
S
G
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S
R
N
F
A
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M
M
N
F
V
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A
V
I
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Q
F
Q
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P
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T
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L
M
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K
F
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F
E
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R
R
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S
N
P
L
S
L
L
A
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H
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L
Q
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T
A
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A
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V
V
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A
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R
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A
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K
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L
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A
F
-
L
Y
P
P
N
M
-------------
D
P
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F
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Q
E
N
V
D
M
R
D
S
Y
L
G
Y
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--
A
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L
W
K
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L
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A
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F
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----
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--
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--
K
A
H
C
E
N
F
N
L
L
L
P
S
C
V
E
--
D
S
V
T
P
I
T
L
R
L
N
F
T
L
V
G
K
P
L
L
A
F
R
N
L
R
P
M
L
A
A
D
A
Q
R
Y
F
T
A
S
L
P
F
E
----------
D
N
L
G
I
S
F
S
F
P
G
L
K
S
L
L
V
G
S
N
L
E
L
N
A
E
V
M
V
W
N
D
G
E
D
S
Y
G
T
T
I
T
F
S
H
P
A
G
L
S
Y
R
Y
V
A
----------
L
H
L
T
C
D
S
A
P
V
G
--
S
Q
G
T
W
S
T
S
C
R
I
N
H
L
I
F
R
G
G
A
Q
I
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F
L
A
T
F
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P
K
A
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L
G
D
R
L
L
L
T
A
N
V
S
S
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S
N
T
-
P
R
T
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K
T
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-
F
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L
E
L
P
V
K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
C
F
S
E
-
S
-
E
E
K
E
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
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D
L
-
P
V
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I
N
F
W
V
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L
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Q
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A
V
W
M
D
V
E
V
S
H
P
Q
N
P
S
L
R
C
S
S
E
K
I
A
P
P
A
S
D
F
L
A
H
I
Q
K
N
P
V
L
D
C
S
I
A
G
C
L
R
F
R
C
D
V
P
S
F
S
V
Q
E
E
L
D
F
T
L
K
G
N
L
S
F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
T
F
D
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V
Y
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Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
K
-
P
-------------------------------------------------
1
PsiBlast_PDB
83.43
60%
-83
- C2 -
-
3K6S
3
ITAX_HUMAN
A:
[1-1082]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
N
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
T
--
Q
L
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Q
R
L
P
V
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C
P
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D
I
V
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L
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R
N
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A
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M
M
N
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L
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L
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V
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R
R
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K
K
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L
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L
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P
P
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M
-------------
S
P
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F
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M
R
D
S
Y
L
G
Y
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--
A
-
L
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K
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L
V
L
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A
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-
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A
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--
Q
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K
A
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T
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T
Q
I
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Y
F
G
A
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L
C
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V
D
V
D
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T
D
L
V
L
I
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A
P
H
Y
Y
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Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
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Q
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W
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A
L
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L
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L
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V
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-
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-
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A
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S
H
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F
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Y
--------
L
N
F
S
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-
S
-
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K
E
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H
V
A
M
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-
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L
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-
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G
Q
E
A
F
M
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A
Q
T
T
T
V
L
E
K
Y
K
---------------------------------------------------
21
Fugue
83.12
60%
-83
- C2 -
-
3K6S
3
ITAX_HUMAN
A:
[1-1082]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
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V
V
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-----
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V
V
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---
K
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A
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V
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P
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A
V
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M
S
---------
L
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L
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L
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-------------
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----
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A
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A
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E
N
N
T
-
P
R
T
S
K
T
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-
F
Q
L
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L
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V
K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
N
F
S
E
-
S
E
E
K
E
-
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
R
D
L
-
P
V
S
I
N
F
W
V
P
V
E
L
N
Q
E
A
V
W
M
D
V
E
V
S
H
P
Q
N
P
S
L
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C
S
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E
K
I
A
P
P
A
S
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F
L
A
H
I
Q
K
N
P
V
L
D
C
S
I
A
G
C
L
R
F
R
C
D
V
P
S
F
S
V
Q
E
E
L
D
F
T
L
K
G
N
L
S
F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
T
F
D
T
S
V
Y
S
Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
K
---------------------------------------------------
3
PsiBlast_PDB
78.95
60%
-75
- C2 -
-
3K72
1
ITAX_HUMAN
A:
[1-1082]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
N
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
T
--
Q
L
T
Q
R
L
P
V
S
R
Q
E
C
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
F
E
L
E
M
A
Q
E
G
F
S
A
V
F
T
P
D
G
P
-
V
L
G
A
V
G
S
F
T
W
S
G
G
A
F
-
L
Y
P
P
N
M
-------------
S
P
T
F
I
N
M
S
Q
E
N
V
D
M
R
D
S
Y
L
G
Y
S
T
E
L
--
A
-
L
W
K
G
V
Q
S
L
V
L
G
A
P
R
Y
Q
H
-
T
G
K
A
V
I
F
T
--
Q
V
S
R
Q
W
R
M
K
A
E
V
T
G
T
Q
I
G
S
Y
F
G
A
S
L
C
S
V
D
V
D
S
D
G
S
T
D
L
V
L
I
G
A
P
H
Y
Y
E
Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
E
Q
G
H
P
W
G
R
F
G
A
A
L
T
V
L
G
D
V
N
G
D
K
L
T
D
V
V
I
G
A
P
-
G
E
E
E
N
R
G
A
V
Y
L
F
H
G
V
L
G
P
S
I
S
P
S
H
S
Q
R
I
A
G
S
Q
L
S
S
R
L
Q
-
Y
F
G
Q
A
L
S
G
G
Q
D
L
T
Q
D
G
L
V
D
L
A
V
G
A
R
G
--
Q
V
L
L
L
R
T
R
P
V
L
W
V
G
V
S
M
Q
F
I
P
A
E
I
P
R
S
A
F
E
C
R
E
Q
V
V
S
E
Q
T
L
-
V
Q
S
N
I
C
L
Y
I
D
K
R
S
K
N
L
L
G
S
R
D
L
Q
S
S
V
T
L
D
L
A
L
D
P
G
R
L
S
P
R
A
T
F
Q
E
T
K
N
R
S
L
S
R
V
R
V
L
G
L
--
K
A
H
C
E
N
F
N
L
L
L
P
S
C
V
E
--
D
S
V
T
P
I
T
L
R
L
N
F
T
L
V
G
K
P
L
L
A
F
R
N
L
R
P
M
L
A
A
D
A
Q
R
Y
F
T
A
S
L
P
F
E
K
N
C
G
A
D
H
I
C
Q
D
N
L
G
I
S
F
S
F
P
G
L
K
S
L
L
V
G
S
N
L
E
L
N
A
E
V
M
V
W
N
D
G
E
D
S
Y
G
T
T
I
T
F
S
H
P
A
G
L
S
Y
R
Y
V
A
E
G
Q
K
Q
G
Q
L
R
S
L
H
L
T
C
D
S
A
P
V
G
--
S
Q
G
T
W
S
T
S
C
R
I
N
H
L
I
F
R
G
G
A
Q
I
T
F
L
A
T
F
D
V
S
P
K
A
V
L
G
D
R
L
L
L
T
A
N
V
S
S
E
N
N
T
-
P
R
T
S
K
T
T
-
F
Q
L
E
L
P
V
K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
N
F
S
E
-
S
-
E
E
K
E
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
R
D
L
-
P
V
S
I
N
F
W
V
P
V
E
L
N
Q
E
A
V
W
M
D
V
E
V
S
H
P
Q
N
P
S
L
R
C
S
S
E
K
I
A
P
P
A
S
D
F
L
A
H
I
Q
K
N
P
V
L
D
C
S
I
A
G
C
L
R
F
R
C
D
V
P
S
F
S
V
Q
E
E
L
D
F
T
L
K
G
N
L
S
F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
T
F
D
T
S
V
Y
S
Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
K
---------------------------------------------------
2
PsiBlast_PDB
78.84
60%
-73
- C2 -
-
3K71
1
ITAX_HUMAN
A:
[1-1081]
----------------
F
N
L
D
T
E
E
L
T
A
F
R
--
V
D
S
A
-
G
F
G
D
S
V
V
Q
Y
A
N
S
-----
W
V
V
V
G
A
P
Q
---
K
I
T
A
A
N
Q
T
G
G
L
Y
Q
C
G
Y
-
S
T
G
A
C
E
P
I
G
L
Q
V
P
P
E
A
V
N
M
S
---------
L
G
L
S
L
A
S
T
T
S
P
S
Q
L
L
A
C
G
P
T
V
H
H
E
C
G
R
N
M
--
Y
L
T
G
L
C
F
L
L
G
P
T
--
Q
L
T
Q
R
L
P
V
S
R
Q
E
C
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
M
A
Q
E
G
F
S
A
V
F
T
P
D
G
P
-
V
L
G
A
V
G
S
F
T
W
S
G
G
A
F
-
L
Y
P
P
N
M
-------------
S
P
T
F
I
N
M
S
Q
E
N
V
D
M
R
D
S
Y
L
G
Y
S
T
E
L
--
A
-
L
W
K
G
V
Q
S
L
V
L
G
A
P
R
Y
Q
H
-
T
G
K
A
V
I
F
T
--
Q
V
S
R
Q
W
R
M
K
A
E
V
T
G
T
Q
I
G
S
Y
F
G
A
S
L
C
S
V
D
V
D
S
D
G
S
T
D
L
V
L
I
G
A
P
H
Y
Y
E
Q
T
R
G
G
Q
V
S
----
V
C
P
L
P
R
G
W
R
R
W
W
C
D
A
V
L
Y
G
E
Q
G
H
P
W
G
R
F
G
A
A
L
T
V
L
G
D
V
N
G
D
K
L
T
D
V
V
I
G
A
P
-
G
E
E
E
N
R
G
A
V
Y
L
F
H
G
V
L
G
P
S
I
S
P
S
H
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Q
R
I
A
G
S
Q
L
S
S
R
L
Q
-
Y
F
G
Q
A
L
S
G
G
Q
D
L
T
Q
D
G
L
V
D
L
A
V
G
A
R
G
--
Q
V
L
L
L
R
T
R
P
V
L
W
V
G
V
S
M
Q
F
I
P
A
E
I
P
R
S
A
F
E
C
R
E
Q
V
V
S
E
Q
T
L
-
V
Q
S
N
I
C
L
Y
I
D
K
R
S
K
N
L
L
G
S
R
D
L
Q
S
S
V
T
L
D
L
A
L
D
P
G
R
L
S
P
R
A
T
F
Q
E
T
K
N
R
S
L
S
R
V
R
V
L
G
L
--
K
A
H
C
E
N
F
N
L
L
L
P
S
C
V
E
--
D
S
V
T
P
I
T
L
R
L
N
F
T
L
V
G
K
P
L
L
A
F
R
N
L
R
P
M
L
A
A
D
A
Q
R
Y
F
T
A
S
L
P
F
E
K
N
C
G
A
D
H
I
C
Q
D
N
L
G
I
S
F
S
F
P
G
L
K
S
L
L
V
G
S
N
L
E
L
N
A
E
V
M
V
W
N
D
G
E
D
S
Y
G
T
T
I
T
F
S
H
P
A
G
L
S
Y
R
Y
V
A
E
G
Q
K
Q
G
Q
L
R
S
L
H
L
T
C
D
S
A
P
V
G
--
S
Q
G
T
W
S
T
S
C
R
I
N
H
L
I
F
R
G
G
A
Q
I
T
F
L
A
T
F
D
V
S
P
K
A
V
L
G
D
R
L
L
L
T
A
N
V
S
S
E
N
N
T
-
P
R
T
S
K
T
T
-
F
Q
L
E
L
P
V
K
Y
A
V
Y
T
V
V
S
S
H
E
Q
F
T
K
Y
--------
L
N
F
S
E
-
S
-
E
E
K
E
S
H
V
A
M
H
R
Y
Q
V
N
N
L
G
Q
R
D
L
-
P
V
S
I
N
F
W
V
P
V
E
L
N
Q
E
A
V
W
M
D
V
E
V
S
H
P
Q
N
P
S
L
R
C
S
S
E
K
I
A
P
P
A
S
D
F
L
A
H
I
Q
K
N
P
V
L
D
C
S
I
A
G
C
L
R
F
R
C
D
V
P
S
F
S
V
Q
E
E
L
D
F
T
L
K
G
N
L
S
F
G
W
V
R
Q
I
-
L
Q
--
K
K
V
S
V
V
S
V
A
E
I
T
F
D
T
S
V
Y
S
Q
L
P
G
Q
E
A
F
M
R
A
Q
T
T
T
V
L
E
K
Y
----------------------------------------------------
22
Fugue
52.78
22%
16
- C2 -
-
1JV2
3
ITAV_HUMAN
A:
[1-956]
----------------
F
N
L
D
V
D
S
P
A
E
Y
S
--
G
P
E
G
S
Y
F
G
F
A
V
D
F
F
V
P
S
ASSRM
F
L
L
V
G
A
P
K
ANT
T
Q
P
G
I
V
E
G
G
Q
V
L
K
C
D
W
S
S
T
R
R
C
Q
P
I
E
F
D
A
T
G
N
R
D
Y
A
K
DDPLEFKSH
Q
W
F
G
A
S
V
R
S
K
Q
D
K
I
L
A
C
A
P
L
Y
H
W
R
T
E
M
K
Q
ER
E
P
V
G
T
C
F
L
Q
D
G
T
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
Y
A
P
C
R
S
Q
D
I
D
A
D
G
Q
G
F
C
Q
G
G
F
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T
K
A
D
R
V
L
L
G
G
P
G
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F
Y
W
Q
G
Q
L
I
-
S
D
Q
V
A
E
IVSKYDPNVYSIK
Y
N
N
Q
L
A
T
R
T
A
Q
A
I
F
D
D
S
Y
L
G
Y
S
V
A
V
GD
F
-
N
G
D
G
I
D
D
F
V
S
G
V
P
R
A
A
R
T
L
G
M
V
Y
I
Y
D
--
G
K
N
M
--
S
S
L
Y
N
F
T
G
E
Q
M
A
A
Y
F
G
F
S
V
A
A
T
D
I
N
G
D
D
Y
A
D
V
F
-
I
G
A
P
L
F
M
D
R
G
S
D
G
K
L
Q
EVGQ
V
S
V
S
L
Q
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A
S
G
D
F
Q
T
T
K
L
N
G
F
E
--
V
F
A
R
F
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S
A
I
A
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L
G
D
L
D
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D
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F
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A
A
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Y
G
G
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K
K
G
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Y
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-
T
G
L
N
A
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A
A
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F
G
Y
S
M
K
G
A
T
D
I
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K
N
G
Y
P
D
L
I
V
G
A
F
G
VD
R
A
I
L
Y
R
A
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V
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V
N
A
G
L
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Y
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S
I
L
N
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D
N
K
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C
S
L
P
G
T
A
L
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V
S
C
F
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R
F
C
L
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A
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-
G
K
G
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L
P
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K
L
N
F
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L
L
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L
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A
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L
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GG
L
M
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C
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A
Y
L
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FR
D
K
L
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-
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A
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G
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A
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A
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F
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V
V
R
N
N
E
A
L
A
R
L
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C
--------
A
F
K
T
E
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Q
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V
V
C
D
L
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N
P
-
M
K
A
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PIPNWEHK
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-
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N
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A
M
L
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L
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Y
K
Y
N
N
N
T
L
L
Y
I
L
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Y
D
I
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P
--
M
N
C
T
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M
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-
I
N
P
L
R
I
K
I
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S
L
D
I
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C
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A
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C
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R
L
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A
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L
L
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F
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-
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H
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S
T
L
V
T
T
N
V
T
--------------------------------------------------
W
G
I
Q
7
PsiBlast_PDB
50.44
37%
9
- C2 -
-
5E6R
1
ITAL_HUMAN
A:
[1-590]
----------------
Y
N
L
D
V
R
G
A
R
S
F
S
PP
R
A
G
R
-
H
F
G
Y
R
V
L
Q
V
-
G
N
-----
G
V
I
V
G
A
P
G
---
E
---
G
N
S
T
G
S
L
Y
Q
C
Q
S
-
G
T
G
H
C
L
P
V
T
L
R
-
G
S
N
Y
T
S
K
Y
---------
L
G
M
T
L
A
T
D
P
T
D
G
S
I
L
A
C
D
P
G
L
S
R
T
C
D
Q
N
T
--
Y
L
S
G
L
C
Y
L
F
R
Q
N
L
Q
G
P
M
L
Q
G
R
P
G
F
Q
E
C
I
K
G
N
V
D
L
V
F
L
F
D
G
S
M
S
L
Q
P
D
E
F
Q
K
I
L
D
F
M
K
D
V
M
K
K
L
S
N
T
S
Y
Q
F
A
A
V
Q
F
S
T
S
Y
K
T
E
F
D
F
S
D
Y
V
K
W
K
D
P
D
A
L
L
K
H
V
K
H
M
L
L
L
T
N
T
F
G
A
I
N
Y
V
A
T
E
V
F
R
E
E
L
G
A
R
P
D
A
T
K
V
L
I
I
I
T
D
G
E
A
T
D
S
--
G
N
I
D
A
A
K
D
-----
I
I
R
Y
I
I
G
I
G
K
H
F
Q
T
K
E
S
Q
E
T
L
H
K
F
A
S
K
P
A
S
E
F
V
K
I
L
D
T
F
E
K
L
K
D
L
F
T
E
L
Q
K
K
I
---------
D
L
T
S
F
N
M
E
L
S
S
S
G
I
S
A
D
L
S
R
G
H
A
-
V
V
G
A
V
G
A
K
D
W
A
G
G
F
L
D
L
K
A
D
L
Q
-------------
D
D
T
F
I
G
N
E
P
L
T
P
E
V
R
A
G
Y
L
G
Y
T
V
T
W
--
L
P
S
R
Q
K
T
S
L
L
A
S
G
A
P
R
Y
Q
H
-
M
G
R
V
L
L
F
Q
EP
Q
G
G
G
H
W
S
Q
V
Q
T
I
H
G
T
Q
I
G
S
Y
F
G
G
E
L
C
G
V
D
V
D
Q
D
G
E
T
E
L
L
L
I
G
A
P
L
F
Y
G
E
Q
R
G
G
R
V
F
----
I
--
Y
Q
R
R
Q
L
G
F
E
E
V
S
E
L
Q
G
D
P
G
Y
P
L
G
R
F
G
E
A
I
T
A
L
T
D
I
N
G
D
G
L
V
D
V
A
V
G
A
P
-
L
E
E
--
Q
G
A
V
Y
I
F
N
G
R
H
G
-
G
L
S
P
Q
P
S
Q
R
I
E
G
T
Q
V
L
S
G
I
Q
-
W
F
G
R
S
I
H
G
V
K
D
L
E
G
D
G
L
A
D
V
A
V
G
A
E
S
--
Q
M
I
V
L
S
S
R
P
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
50.30
37%
11
- C2 -
-
5E6S
1
ITAL_HUMAN
A:
[1-589]
----------------
Y
N
L
D
V
R
G
A
R
S
F
S
PP
R
A
G
R
-
H
F
G
Y
R
V
L
Q
V
-
G
N
-----
G
V
I
V
G
A
P
G
---
E
---
G
N
S
T
G
S
L
Y
Q
C
Q
S
-
G
T
G
H
C
L
P
V
T
L
R
-
G
S
N
Y
T
S
K
Y
---------
L
G
M
T
L
A
T
D
P
T
D
G
S
I
L
A
C
D
P
G
L
S
R
T
C
D
Q
N
T
--
Y
L
S
G
L
C
Y
L
F
R
Q
N
L
Q
G
P
M
L
Q
G
R
P
G
F
Q
E
C
I
K
G
N
V
D
L
V
F
L
F
D
G
S
M
S
L
Q
P
D
E
F
Q
K
I
L
D
F
M
K
D
V
M
K
K
L
S
N
T
S
Y
Q
F
A
A
V
Q
F
S
T
S
Y
K
T
E
F
D
F
S
D
Y
V
K
W
K
D
P
D
A
L
L
K
H
V
K
H
M
L
L
L
T
N
T
F
G
A
I
N
Y
V
A
T
E
V
F
R
E
E
L
G
A
R
P
D
A
T
K
V
L
I
I
I
T
D
G
E
A
T
D
S
--
G
N
I
D
A
A
K
D
-----
I
I
R
Y
I
I
G
I
G
K
H
F
Q
T
K
E
S
Q
E
T
L
H
K
F
A
S
K
P
A
S
E
F
V
K
I
L
D
T
F
E
K
L
K
D
L
F
T
E
L
Q
K
K
I
----------
L
T
S
F
N
M
E
L
S
S
S
G
I
S
A
D
L
S
R
G
H
A
-
V
V
G
A
V
G
A
K
D
W
A
G
G
F
L
D
L
K
A
D
L
Q
-------------
D
D
T
F
I
G
N
E
P
L
T
P
E
V
R
A
G
Y
L
G
Y
T
V
T
W
--
L
P
S
R
Q
K
T
S
L
L
A
S
G
A
P
R
Y
Q
H
-
M
G
R
V
L
L
F
Q
EP
Q
G
G
G
H
W
S
Q
V
Q
T
I
H
G
T
Q
I
G
S
Y
F
G
G
E
L
C
G
V
D
V
D
Q
D
G
E
T
E
L
L
L
I
G
A
P
L
F
Y
G
E
Q
R
G
G
R
V
F
----
I
--
Y
Q
R
R
Q
L
G
F
E
E
V
S
E
L
Q
G
D
P
G
Y
P
L
G
R
F
G
E
A
I
T
A
L
T
D
I
N
G
D
G
L
V
D
V
A
V
G
A
P
-
L
E
E
--
Q
G
A
V
Y
I
F
N
G
-
H
G
-
G
L
S
P
Q
P
S
Q
R
I
E
G
T
Q
V
L
S
G
I
Q
-
W
F
G
R
S
I
H
G
V
K
D
L
E
G
D
G
L
A
D
V
A
V
G
A
E
S
--
Q
M
I
V
L
S
S
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
50.20
37%
9
- C2 -
-
5E6U
1
ITAL_HUMAN
A:
[1-591]
----------------
Y
N
L
D
V
R
G
A
R
S
F
S
PP
R
A
G
R
-
H
F
G
Y
R
V
L
Q
V
-
G
N
-----
G
V
I
V
G
A
P
G
---
E
---
G
N
S
T
G
S
L
Y
Q
C
Q
S
-
G
T
G
H
C
L
P
V
T
L
R
-
G
S
N
Y
T
S
K
Y
---------
L
G
M
T
L
A
T
D
P
T
D
G
S
I
L
A
C
D
P
G
L
S
R
T
C
D
Q
N
T
--
Y
L
S
G
L
C
Y
L
F
R
Q
N
L
Q
G
P
M
L
Q
G
R
P
G
F
Q
E
C
I
K
G
N
V
D
L
V
F
L
F
D
G
S
M
S
L
Q
P
D
E
F
Q
K
I
L
D
F
M
K
D
V
M
K
K
L
S
N
T
S
Y
Q
F
A
A
V
Q
F
S
T
S
Y
K
T
E
F
D
F
S
D
Y
V
K
W
K
D
P
D
A
L
L
K
H
V
K
H
M
L
L
L
T
N
T
F
G
A
I
N
Y
V
A
T
E
V
F
R
E
E
L
G
A
R
P
D
A
T
K
V
L
I
I
I
T
D
G
E
A
T
D
S
--
G
N
I
D
A
A
K
D
-----
I
I
R
Y
I
I
G
I
G
K
H
F
Q
T
K
E
S
Q
E
T
L
H
K
F
A
S
K
P
A
S
E
F
V
K
I
L
D
T
F
E
K
L
K
D
L
F
T
E
L
Q
K
K
I
--------
Q
D
L
T
S
F
N
M
E
L
S
S
S
G
I
S
A
D
L
S
R
G
H
A
-
V
V
G
A
V
G
A
K
D
W
A
G
G
F
L
D
L
K
A
D
L
Q
-------------
D
D
T
F
I
G
N
E
P
L
T
P
E
V
R
A
G
Y
L
G
Y
T
V
T
W
--
L
P
S
R
Q
K
T
S
L
L
A
S
G
A
P
R
Y
Q
H
-
M
G
R
V
L
L
F
Q
EP
Q
G
G
G
H
W
S
Q
V
Q
T
I
H
G
T
Q
I
G
S
Y
F
G
G
E
L
C
G
V
D
V
D
Q
D
G
E
T
E
L
L
L
I
G
A
P
L
F
Y
G
E
Q
R
G
G
R
V
F
----
I
--
Y
Q
R
R
Q
L
G
F
E
E
V
S
E
L
Q
G
D
P
G
Y
P
L
G
R
F
G
E
A
I
T
A
L
T
D
I
N
G
D
G
L
V
D
V
A
V
G
A
P
-
L
E
E
--
Q
G
A
V
Y
I
F
N
G
R
H
G
-
G
L
S
P
Q
P
S
Q
R
I
E
G
T
Q
V
L
S
G
I
Q
-
W
F
G
R
S
I
H
G
V
K
D
L
E
G
D
G
L
A
D
V
A
V
G
A
E
S
--
Q
M
I
V
L
S
S
R
P
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
39.27
100%
-119
- C2 -
-
1NA5
-
ITAM_HUMAN
A:
[130-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
I
F
A
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
39.15
100%
-123
- C2 -
-
1JLM
-
ITAM_HUMAN
A:
[6-192]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
I
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
39.11
100%
-123
- C2 -
-
3Q3G
1
ITAM_HUMAN
G:
[1-189]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
I
F
A
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
38.61
99%
-126
- C2 -
-
3QA3
3
ITAM_HUMAN
G:
[1-187]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
G
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
37.85
98%
-115
- C2 -
-
4XW2
1
ITAM_HUMAN
A:
[9-192]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
37.57
100%
-112
- C2 -
-
1IDO
-
ITAM_HUMAN
A:
[6-189]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
37.51
98%
-117
- C2 -
-
1N9Z
-
ITAM_HUMAN
A:
[5-188]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
37.45
99%
-108
- C2 -
-
1M1U
-
ITAM_HUMAN
A:
[12-195]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
S
K
T
L
F
S
L
M
Q
Y
S
E
E
F
R
I
H
F
T
F
K
E
F
Q
N
N
P
N
P
R
S
L
V
K
P
I
T
Q
L
L
G
R
T
H
T
A
T
G
I
R
K
V
V
R
E
L
F
N
I
T
N
G
A
R
K
N
A
F
K
I
L
V
V
I
T
D
G
E
K
F
G
D
P
L
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
F
R
S
E
K
S
R
Q
E
L
N
T
I
A
S
K
P
P
R
D
H
V
F
Q
V
N
N
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------