@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KIN17_HUMAN: (2020-02-01 )
MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGSSASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTHLETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRVEGIQYEDISKLA
Atome Classification :
(20 SA)
--------------------........----.10........20--...-...-----...30..-----.-------------.....40.--.....-..50------...--.-....60...--------.....70........80..-......90........100.......110..-......120..-----.....-----------------130.......140...------....150...--...-.160....--...---170.-------......180.-.---.-....190........200-.......210.------------.....--.220.......230.......240......-------.250.....--..260--.-......270.......280.------......290....---------------...300.-......310.....-...320-........----330..--.....340.......----------350......-.360--------------.-.-.-...----.370..--.--...------------.380...------------------------------....390.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------MGKSDFL
T
----
P
K
A
I
A
N
R
I
K
S
K
G
---
L
Q
K
-
L
R
W
-----
Y
C
Q
M
C
Q
K
-----Q-------------CRDENG
F
K
--
C
H
CMS-ESHQ------
R
Q
L
--
L
-
L
ASE
N
P
Q
Q
F
--------
M
D
Y
F
S
E
E
F
R
N
D
F
L
E
L
L
R
R
R-FGT
K
R
VHNN
I
V
Y
N
E
Y
I
S
H
R
E
H
I
HMNA
T
Q
-
W
E
-
T
L
T
D
F
T
K
W
LGR-----EGLCK-----------------VDETPKG
W
Y
I
Q
Y
IDR
D
------
P
E
T
I
R
R
Q
L
E
L
--
E
K
K
-KKQDLD
D
E
--
E
K
T
---
A
K
F
I
-------
E
E
Q
V
R
RGLEG-K---E-QEVP
T
-
F
T
E
LSRENDE
E
K
-
V
T
F
N
LSKGACS------------SSGAT--SSKSSTL
G
P
S
A
L
K
TIGSSASVKRKESSQSS-------
T
Q
S
K
E
K
K
K
K
--
K
S
A
L
D
--
E
-
I
M
E
I
E
E
E
K
K
R
TARTDYWL
Q
P
------
E
I
I
V
K
I
I
T
K
K
L
G
E
---------------
K
Y
H
K
K
K
A
-
I
V
K
E
V
I
D
-
K
Y
T
A
V
V
-
K
MIDS--GD
K
L
KL
D
Q
----
T
H
L
E
T
--VIPAPG
K
R
I
L
V
L
NGG----------YRGNEG
T
L
E
-
S
INE--------------K-T-
F
-
S
A
T
----
I
V
I
ETG--P--LKG------------RRVEGI
Q
------------------------------
Y
E
D
I
S
KLA
44
Fugue
86.30
100%
-66
- C4 -
-
2CKK
-
A:
[8-127]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
R
T
D
Y
W
L
Q
P
------
E
I
I
V
K
I
I
T
K
K
L
G
E
---------------
K
Y
H
K
K
K
A
-
I
V
K
E
V
I
D
-
K
Y
T
A
V
V
-
K
M
I
D
S
--
G
D
K
L
K
L
D
Q
----
T
H
L
E
T
--
V
I
P
A
P
G
K
R
I
L
V
L
N
G
G
----------
Y
R
G
N
E
G
T
L
E
-
S
I
N
E
--------------
K
-
T
-
F
-
S
A
T
----
I
V
I
E
T
G
--
P
--
L
K
G
------------
R
R
V
E
G
I
Q
------------------------------
Y
E
D
I
S
K
L
A
20
HHSearch
86.30
100%
-66
- C4 -
-
2CKK
-
A:
[8-127]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
R
T
D
Y
W
L
Q
P
------
E
I
I
V
K
I
I
T
K
K
L
G
E
---------------
K
Y
H
K
K
K
A
-
I
V
K
E
V
I
D
-
K
Y
T
A
V
V
-
K
M
I
D
S
--
G
D
K
L
K
L
D
Q
----
T
H
L
E
T
--
V
I
P
A
P
G
K
R
I
L
V
L
N
G
G
----------
Y
R
G
N
E
G
T
L
E
-
S
I
N
E
--------------
K
-
T
-
F
-
S
A
T
----
I
V
I
E
T
G
--
P
--
L
K
G
------------
R
R
V
E
G
I
Q
------------------------------
Y
E
D
I
S
K
L
A
1
PsiBlast_PDB
86.10
100%
-66
- C4 -
-
2CKK
-
A:
[8-127]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
R
T
D
Y
W
L
Q
P
------
E
I
I
V
K
I
I
T
K
K
L
G
E
---------------
K
Y
H
K
K
K
A
-
I
V
K
E
V
I
D
-
K
Y
T
A
V
V
-
K
M
I
D
S
--
G
D
K
L
K
L
D
Q
----
T
H
L
E
T
--
V
I
P
A
P
G
K
R
I
L
V
L
N
G
G
----------
Y
R
G
N
E
G
T
L
E
-
S
I
N
E
--------------
K
-
T
-
F
-
S
A
T
----
I
V
I
E
T
G
--
P
--
L
K
G
------------
R
R
V
E
G
I
Q
------------------------------
Y
E
D
I
S
K
L
A
43
Fugue
74.65
99%
-98
- C3 -
-
2V1N
-
KIN17_HUMAN
A:
[1-111]
-------------------------------------------------------------------------------------------------------
G
Q
------
R
Q
L
--
L
-
L
A
S
E
N
P
Q
Q
F
--------
M
D
Y
F
S
E
E
F
R
N
D
F
L
E
L
L
R
R
R
-
F
G
T
K
R
V
H
N
N
I
V
Y
N
E
Y
I
S
H
R
E
H
I
H
M
N
A
T
Q
-
W
E
-
T
L
T
D
F
T
K
W
L
G
R
-----
E
G
L
C
K
-----------------
V
D
E
T
P
K
G
W
Y
I
Q
Y
I
D
R
D
------
P
E
T
I
R
R
Q
L
E
L
--
E
K
K
-
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.47
100%
-98
- C3 -
-
2V1N
-
KIN17_HUMAN
A:
[2-111]
--------------------------------------------------------------------------------------------------------
Q
------
R
Q
L
--
L
-
L
A
S
E
N
P
Q
Q
F
--------
M
D
Y
F
S
E
E
F
R
N
D
F
L
E
L
L
R
R
R
-
F
G
T
K
R
V
H
N
N
I
V
Y
N
E
Y
I
S
H
R
E
H
I
H
M
N
A
T
Q
-
W
E
-
T
L
T
D
F
T
K
W
L
G
R
-----
E
G
L
C
K
-----------------
V
D
E
T
P
K
G
W
Y
I
Q
Y
I
D
R
D
------
P
E
T
I
R
R
Q
L
E
L
--
E
K
K
-
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
74.25
100%
-102
- C3 -
-
2V1N
-
KIN17_HUMAN
A:
[2-110]
--------------------------------------------------------------------------------------------------------
Q
------
R
Q
L
--
L
-
L
A
S
E
N
P
Q
Q
F
--------
M
D
Y
F
S
E
E
F
R
N
D
F
L
E
L
L
R
R
R
-
F
G
T
K
R
V
H
N
N
I
V
Y
N
E
Y
I
S
H
R
E
H
I
H
M
N
A
T
Q
-
W
E
-
T
L
T
D
F
T
K
W
L
G
R
-----
E
G
L
C
K
-----------------
V
D
E
T
P
K
G
W
Y
I
Q
Y
I
D
R
D
------
P
E
T
I
R
R
Q
L
E
L
--
E
K
K
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
64.08
19%
62
- C5 -
-
5D2E
3
?
A:
[5-510]
-----------TMQIEQIVK
K
V
K
E
C
S
L
T
----
P
E
E
G
L
E
L
I
K
S
L
G
KTH
L
Y
E
-
M
V
W
-----
D
R
H
E
F
K
G
-----
S
KKFPHTKEPILFF
C
E
D
D
S
M
Y
T
--
V
M
K
R
Q
L
E
G
Y
E
------
A
P
F
--
I
-
Y
V
T
S
G
E
R
F
E
DCRNGRFT
M
N
F
T
K
G
E
D
Y
D
A
L
C
G
V
L
R
S
Q
N
I
R
P
R
H
I
I
H
F
L
A
A
G
L
F
K
N
T
E
D
A
M
R
K
Q
L
N
K
S
L
Y
-
S
L
F
Q
M
F
Q
A
F
M
A
-----
N
K
L
C
P
KAEILYLYENAEGEVQP
I
Y
N
A
V
E
S
F
L
K
T
V
Q
A
E
N
------
P
N
F
T
C
K
A
A
E
L
--
K
S
M
-
F
D
E
P
F
T
-
K
--
Q
H
I
---
A
D
V
I
-------
S
F
E
W
N
N
C
F
T
C
-
Y
---
E
-
P
R
H
Y
Y
-
K
R
Q
L
Q
R
V
K
K
S
F
S
-
V
K
K
N
---
G
V
Y
L
------------
I
T
G
G
------
A
G
G
L
G
Y
L
F
A
E
Y
L
A
K
Q
A
E
V
K
L
I
L
T
G
R
S
P
--------
A
S
R
E
T
A
Q
K
--
L
S
A
L
E
--
N
-
L
G
A
--
E
A
L
Y
V
P
A
D
I
S
K
E
K
E
T
------
D
A
L
I
K
Y
I
K
Q
T
F
G
E
LNGILHSAGLVKDAF
I
I
K
K
T
K
E
-
S
I
E
E
V
I
A
P
K
V
F
G
T
V
-
W
L
D
K
A
--
A
E
E
E
P
L
D
F
FVMF
S
S
L
S
A
--
V
L
P
N
A
G
Q
S
D
Y
A
F
A
N
G
CMDGFTQYRS
M
K
G
R
P
G
K
T
L
-
S
I
N
W
--------------
P
-
L
-
W
-
D
A
G
----
A
L
R
H
A
G
--
L
EL
L
S
A
------------
Q
A
G
L
A
A
F
------------------------------
Q
D
S
M
S
R
S
A
47
Fugue
62.81
13%
67
* C5 *
-
3S5W
3
PVDA_PSEAE
A:
[29-448]
-----------VVHDLIGVG
F
G
P
S
N
I
A
L
----
A
I
A
L
Q
E
R
A
Q
A
Q
G
---
A
L
E
-
V
L
F
-----
L
D
K
Q
G
D
Y
-----
R
-------------
W
H
G
N
T
L
V
S
--
Q
S
E
L
Q
-
I
S
F
L
------
K
D
L
VS
L
-
R
N
P
T
S
P
Y
S
F
--------
V
N
Y
L
H
K
H
D
R
-
L
V
D
F
I
N
L
G
T
-
F
Y
P
C
R
M
E
F
N
D
Y
L
R
W
V
A
S
H
F
Q
E
Q
S
R
Y
G
E
E
-
V
L
-
R
I
E
P
M
L
S
A
G
Q
V
-----
E
A
L
R
V
-----------------
I
S
R
N
A
D
G
E
E
L
V
R
T
T
R
A
LVVSPG
G
T
P
R
I
P
Q
V
F
R
--
A
L
K
-
G
D
G
R
V
F
H
H
--
S
Q
Y
---
L
E
H
M
-------
A
K
P
M
K
I
A
I
I
G
-
G
G--
Q
-
S
A
A
E
A
-
F
I
D
L
N
D
S
Y
P
S
V
Q
-
A
D
M
I
L
R
A
S
A
L
K
------------
P
A
D
D
S
--
P
F
V
N
E
V
F
A
P
K
F
T
D
L
I
Y
S
R
E
H
A
E
R
E
R
L
L
R
E
Y
-------
H
N
T
N
Y
S
V
V
D
--
T
D
L
I
E
--
R
-
I
Y
G
V
F
Y
R
Q
K
V
S
G
I
P
R
H
A
F
R
C
------
M
T
T
V
E
R
A
T
A
T
--------------------------------------------
A
Q
--
G
I
E
L
A
L
R
D
----
A
G
S
G
E
--
L
S
V
E
T
Y
D
A
V
I
L
A
T
G
Y
----------
E
R
Q
L
R
Q
L
L
E
-
P
L
A
E
YLGEIGRDYRLQTD
E
-
R
-
C
-
K
V
A
----
I
Y
A
Q
G
F
--
S
--
Q
A
S
HGLSDTLLSVLP
V
R
A
E
E
I
S
------------------------------
G
S
L
Y
Q
H
L
K
57
Fugue
56.58
17%
63
- C1 -
-
4R6I
1
ATXA_BACAN
A:
[5-478]
LTPISIEKEHIRLINLLHFI
N
E
Q
N
R
W
F
T
----
I
K
E
L
S
D
Y
L
Q
V
A
----
D
K
T
-
V
R
K
-----
Y
L
K
L
L
E
D
-----
E
IPPSWN-------
L
L
V
Q
K
G
K
G
--
I
Y
L
K
K
-
P
L
N
E
SLSFVE
S
K
I
--
L
-
R
K
S
L
N
L
Q
I
C
--------
E
E
L
V
F
K
K
N
S
Q
S
L
A
Q
K
L
H
L
Q
-
V
G
A
L
Y
P
I
I
N
Q
I
N
Y
D
I
Q
S
S
H
L
N
I
K
K
K
P
L
E
-
I
S
G
R
E
Q
D
V
R
V
F
L
M
------
R
L
Y
C
N
-----------------
I
--
P
N
D
Y
W
P
F
P
Y
I
N
--------
K
Q
N
I
T
D
L
I
N
K
--
E
K
I
L
N
V
Q
Y
T
Y
S
K
--
H
K
L
---
C
V
L
F
-------
A
I
T
I
S
R
L
L
S
G
-
N
---
T
I
D
N
V
S
G
-
L
I
L
V
N
K
N
D
D
H
Y
K
-
T
V
A
S
I
T
S
E
L
Q
N
------------
S
F
G
V
T
LH
E
T
E
I
S
F
L
A
L
A
L
L
L
S
L
G
N
S
I
S
N
K
T
L
T
S
Y
K
K
T
IPLAKEI
T
K
G
I
E
H
K
L
Q
LG
I
N
Y
D
E
--
S
-
F
L
T
Y
V
V
L
I
I
K
K
A
L
D
K
N
F
I
Q
Y
------
Y
N
Y
N
I
K
F
I
R
H
I
K
Q
---------------
R
H
P
N
T
F
N
-
T
I
Q
E
C
I
S
-
N
L
N
Y
T
V
Y
S
H
F
D
C
--
Y
E
I
S
L
L
------
T
H
F
E
T
QR
L
F
K
N
N
P
K
K
I
Y
V
Y
T
S
Q
----------
G
C
I
H
R
E
Y
I
S
-
A
L
L
E
--------------
K
-
R
-
Y
-
N
G
L
----
I
K
I
V
R
N
--
T
--
I
I
N
------------
L
T
N
E
S
L
Q
DEIDIIISNVNLPIKNIPIVQISEFPTERD
F
H
E
I
K
K
I
I
21
HHSearch
49.71
20%
-72
- C4 -
-
5OHQ
-
A:
[1-109]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
W
V
T
T
------
D
I
Q
V
K
V
R
D
T
Y
L
D
T
---------------
Q
V
V
G
Q
T
G
-
V
I
R
S
V
T
--
G
G
M
C
S
V
-
Y
L
K
D
S
--
E
K
V
V
S
I
S
S
----
E
H
L
E
P
--
I
T
P
T
K
N
N
K
V
K
V
I
L
G
E
----------
D
R
E
A
T
G
V
L
L
-
S
I
D
G
--------------
E
-
D
----
G
I
----
V
R
M
D
L
D
--
E
------------------
Q
L
K
I
L
N
------------------------------
L
R
F
L
G
K
L
L
51
Fugue
49.27
12%
45
- C3 -
-
1LRZ
-
FEMA_STAAU
A:
[1-412]
------------MKFTNLTA
K
E
F
G
A
F
T
D
----
S
M
P
Y
S
H
F
T
Q
T
V
G
---
H
Y
E
-
L
K
L
AEGYE
T
H
L
V
G
I
K
-----
N
-------------
N
N
N
E
V
I
A
A
--
C
L
L
T
A
-
V
P
V
M
------
K
V
F
--
K
-
Y
F
Y
S
N
R
G
P
V
--------
I
D
Y
E
N
Q
E
L
V
H
F
F
F
N
E
L
S
K
Y
-
V
K
K
H
R
C
L
Y
L
H
I
D
P
Y
L
P
Y
Q
Y
L
N
H
D
G
E
I
T
G
-
N
A
-
G
N
D
W
F
F
D
K
M
S
N
-----
L
G
F
----------------------
E
H
T
G
F
H
K
G
F
D
P
V
L
------
Q
I
R
Y
H
S
V
L
D
L
--
K
D
K
-
T
A
D
D
I
I
K
N
MD
G
L
R
---
K
R
N
T
-------
K
K
V
K
K
N
G
V
K
V
-
R
FLS
E
-
E
E
L
P
I
-
F
R
S
F
M
D
D
K
F
Y
Y
N
-
R
L
K
Y
Y
K
D
R
V
L
V
------------
P
L
A
Y
I
--
N
F
D
E
Y
I
K
E
L
N
E
E
R
D
I
L
N
K
D
L
N
K
A
L
K
D
I
E
K
R
-------
P
E
N
K
K
A
H
N
K
--
R
D
N
L
Q
--
Q
-
Q
L
D
A
N
E
Q
K
I
E
E
G
K
R
L
Q
E
E
H
G
NELPIS
A
G
F
F
F
I
N
P
F
E
V
V
Y
---------------
Y
A
G
G
T
S
N
-
A
F
R
H
F
A
G
-
S
Y
A
V
Q
W
-
E
M
I
N
Y
--
A
L
N
H
G
I
D
R
----
Y
N
F
Y
G
--
V
-----------
S
G
K
----------
F
T
E
D
A
E
D
A
G
-
V
V
K
F
--------------
K
-
K
G
Y
-
N
A
E
----
I
I
E
Y
V
G
--
D
--
F
I
K
------------
P
-
I
N
K
P
V
------------------------------
Y
A
A
Y
T
A
L
-
46
Fugue
48.35
16%
61
- C5 -
-
4D7E
1
?
A:
[1-413]
----------------------
M
E
T
L
L
V
VGAG
P
K
A
L
A
V
A
A
K
S
H
V
---
L
R
Q
-
L
G
L
SAP--
R
V
I
A
V
E
A
HAVGG
N
-------------
W
L
A
S
G
G
W
T
DG
R
H
R
L
G
-
T
S
P
E
------
K
D
I
-----
G
F
P
Y
H
S
T
W
--------
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
---
S
-
W
T
S
F
L
V
E
H
G
-
T
Y
A
E
W
I
D
R
G
R
----
P
S
P
Q
-
H
H
-
V
W
A
K
Y
L
Q
W
V
A
R
KIDLE
L
V
L
G
K
-----------------
V
R
T
I
R
Q
G
W
S
V
E
V
A
G
A
T
------
T
E
L
E
A
D
G
L
M
I
TG
P
G
Q
-
S
T
K
A
L
A
A
H
--
P
R
V
LSI
A
E
F
W
-------
D
L
A
G
K
R
K
L
------------
P
I
-
S
S
R
A
A
V
I
G
G
G
E
T
-
A
G
S
A
L
D
E
L
V
----------------
R
H
E
--
M
L
T
I
S
V
I
S
P
M
A
S
Y
F
E
N
S
L
F
S
D
P
T
K
W
N
A
L
S
I
-------
Q
E
R
R
D
V
I
R
R
--
T
D
--
R
--
G
-
V
F
S
V
R
V
Q
E
S
L
L
G
D
N
R
V
H
H
L
Q
------
G
R
V
T
R
I
V
G
Q
G
D
G
V
---------------
A
V
T
L
R
N
E
-
M
R
A
D
Q
V
H
-
N
F
D
L
V
V
-
D
A
T
G
G
--
Q
P
L
W
F
L
D
L
------------
F
D
S
E
S
A
D
L
L
E
L
A
V
G
----------
G
P
L
T
Q
Q
R
I
E
-
S
S
I
G
--------------
Y
-
D
-
L
-
A
V
T
----
G
L
G
A
K
L
YL
P
--
N
M
A
------------
A
L
A
Q
G
P
G
------------------------------
F
P
N
L
S
C
L
G
56
Fugue
45.07
13%
42
- C2 -
-
5LOI
-
?
A:
[2-459]
--------------------------------
P
D
F
L
K
L
F
L
N
H
T
P
---
T
F
D
M
F
S
R
-----
F
C
F
--------------------------
P
S
D
P
E
--
R
S
L
A
S
-
I
V
L
Q
------
K
L
P
--
Q
M
G
S
P
G
D
P
T
S
L
--------
L
V
D
F
A
D
T
L
I
D
L
W
H
Q
C
L
S
E
R
-
Y
-
Y
G
P
I
Y
H
L
V
S
L
L
L
Y
T
L
D
L
N
A
V
E
V
A
P
H
I
-
L
S
-
S
L
I
P
V
C
A
T
T
C
R
-----
L
V
A
L
P
-----------------
R
L
N
S
A
D
G
----
D
L
S
G
H
------
P
D
A
V
V
R
Q
L
C
L
--
N
I
D
-
V
T
Q
C
L
S
V
L
--
Y
L
A
---
A
S
G
C
LPQPLPQ
D
T
P
Q
L
E
F
W
K
T
M
E
---
L
-
D
F
V
L
T
M
L
S
P
K
N
P
E
E
D
W
S
A
M
I
L
L
R
T
S
V
A
P
H
S
IGPIPSSATNST
N
R
R
S
E
--
A
K
N
A
D
A
V
A
A
T
L
I
D
C
V
S
S
F
L
C
E
P
P
K
W
A
T
P
R
S
---------
A
K
E
I
A
A
R
--
L
A
A
L
R
TL
A
M
F
A
T
G
H
F
G
A
R
Q
I
A
E
S
D
V
A
I
P
R
LV----
T
V
L
C
W
A
L
D
R
L
Y
D
S
---------------
D
L
P
P
D
S
S
M
L
L
H
Q
I
I
A
-
Q
G
T
R
L
L
-
H
F
L
V
T
---
D
H
R
T
S
D
A
----
A
N
I
S
T
--
K
L
A
A
S
-------
H
G
G
----------
S
Q
R
Y
F
L
T
L
A
-
R
L
N
F
--------------
A
-
E
----
E
D
----
L
V
L
E
A
G
--
I
--
D
A
E
------------
T
V
E
L
A
H
E
------------------------------
L
L
E
L
A
V
T
P
45
Fugue
42.15
26%
-30
- C4 -
-
4YTL
-
SPT5_YEAST
A:
[1-99]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
P
------
G
D
R
I
E
V
L
N
---
G
E
---------------
Q
-
R
G
S
K
G
-
I
V
T
R
T
-
T
-
K
D
I
A
T
I
-
K
L
N
G
F
--
T
T
P
L
E
F
P
I
----
S
T
L
R
K
--
I
F
E
-
P
G
D
H
V
T
V
I
N
G
E
----------
H
Q
G
D
A
G
L
V
L
M
V
E
Q
G
--------------
Q
V
T
-
F
M
S
T
Q
TSRE
V
T
I
T
A
N
--
N
--
L
S
K
---------------------------------------------------------
24
HHSearch
40.38
23%
-43
- C4 -
-
4YTL
-
SPT5_YEAST
A:
[3-77]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
G
D
R
I
E
V
L
N
----
G
---------------
E
Q
R
G
S
K
G
-
I
V
T
R
T
T
--
K
D
I
A
T
I
-
K
L
N
G
F
--
T
T
P
L
E
F
P
I
----
S
T
L
R
K
---
I
F
E
P
G
D
H
V
T
V
I
N
G
E
----------
H
Q
G
D
A
G
L
V
L
-
M
V
E
Q
--------------
G
-----------------------------------------------------------------------------------
42
HHSearch
39.30
13%
-118
- C4 -
-
2DO3
-
SPT5H_HUMAN
A:
[460-519]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
F
P
A
----
Q
E
L
R
K
---
Y
F
K
M
G
D
H
V
K
V
I
A
G
R
----------
F
E
G
D
T
G
L
I
V
-
R
V
E
E
--------------
N
-----
F
V
I
----
L
F
S
D
L
T
-------
M
------------
H
E
L
-
K
V
L
------------------------------
P
R
D
L
Q
---
40
HHSearch
36.89
21%
-83
- C4 -
-
6A7K
1
?
B:
[6-62]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
T
I
L
P
------
G
M
T
V
K
V
T
N
P
--
N
D
---------------
T
Y
Y
Q
F
Q
G
-
I
V
Q
R
I
T
D
-
G
K
V
A
-
V
-
L
F
E
G
G
NW
D
K
L
V
T
F
Q
A
----
S
E
L
E
P
--
V
----------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
34.67
21%
-74
- C4 -
-
6A7K
1
?
A:
[6-62]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
T
I
L
P
------
G
M
T
V
K
V
T
N
P
--
N
D
---------------
T
Y
Y
Q
F
Q
G
-
I
V
Q
R
I
T
D
-
G
K
V
A
-
V
-
L
F
E
G
G
NW
D
K
L
V
T
F
Q
A
----
S
E
L
E
P
--
V
----------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
34.44
17%
-105
- C4 -
-
5XOG
-
?
W:
[20-65]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
K
T
V
K
I
R
Q
G
G
----------
Y
K
G
K
I
G
I
V
K
-
E
A
N
G
--------------
D
-----
R
F
R
----
V
E
L
H
N
P
--
N
-----------------
K
T
I
-
P
I
P
------------------------------
C
S
F
L
L
---
36
HHSearch
34.30
31%
-57
- C4 -
-
4YTL
-
SPT5_YEAST
A:
[3-50]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
D
R
I
E
V
L
N
G
E
----------
Q
R
G
S
K
G
I
V
T
-
R
T
T
K
--------------
D
-----
I
A
T
----
I
K
L
N
G
F
--
T
-----------------
T
P
L
-
E
F
P
------------------------------
I
S
T
L
R
K
I
-