@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MDC1_HUMAN: (2020-02-01 )
MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQLPAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQAFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900--.------...---...1910.-.....--1920------------------------.........1930--.........1940......1950......1960......1970.....---.1980-....------------....1990--------.--..--......2000...-.--.-.2010.---------.......2020------......2030------.----------.----------.----------------....-2040...---...2050..-----......2060......2070-.-.-....2080......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEDTQAIDWDVE
E
E
E
E
T
EQSSE
S
L
R
CNVEPV
G
R
L
H
I
FSGAHGPEKDF
P
L
H
L
G
K
N
V
VGRMPDC
S
V
ALPFPSISKQH
A
E
I
E
I
L
AWDKA
P
I
L
R
D
CGSLNGTQILRPPKVLSPGVSHRLR
D
Q
E
L
I
L
F
A
D
L
L
C
Q
Y
H
RLDVSLPFVSRGPLTVEETPRVQGETQP
Q
R
L
L
L
AEDS
E
E
E
V
D
F
L
S
E
R
R
M
V
K
KSRTTSS
S
V
I
VPESDEEGHSPVLGGLGPP
F
A
F
NLNSDT
D
V
E
EGQQPA
T
E
E
A
S
S
A
ARRG
A
T
V
EAKQSE
A
E
V
V
T
E
I
Q
LEKDQ
P
L
V
KERDNDT
K
V
KRGAGNGV
V
P
AG
V
I
L
ERSQPPGEDSDTDVDDDSRPPGRPA
E
V
H
L
ERAQPFGFIDSDTDAEEERIPATP
V
V
I
PMKK
R
K
I
F
HGVGTRGPGAP
G
L
A
H
L
Q
E
SQAGSDTDVEEGKAPQAVPLEKSQ
A
S
M
V
INSDTD
D
E
E
E
V
S
A
A
L
T
L
A
H
LKESQPAIWNRD
A
E
E
DM
P
Q
R
V
V
L
L
QRSQTTTERDSDTDV
E
E
EELPV
E
N
R
E
A
V
L
K
D
H
T
K
I
R
A
L
V
R
AHSEKDQPPFGDSDDSVEADKSSP
G
I
H
L
ERSQAS
T
T
V
D
I
N
T
Q
V
EKEVPPG
S
A
I
I
H
I
K
K
H
Q
V
S
VEGTNQTD
V
K
AVGGP
A
K
L
L
V
V
S
L
E
EAWPLHGDCET
D
A
EEGT
S
L
T
A
S
V
V
A
D
V
R
K
SQLPAEGDA
G
A
E
W
A
A
A
V
L
K
Q
E
R
A
H
EVGAQGGP
P
V
A
Q
V
E
QDLPISREN
L
T
D
L
V
V
DTDTLGESTQPQREGAQVPTGR
E
R
E
Q
HVGGTKDSEDNYGDSED
L
D
L
Q
A
T
Q
C
F
L
ENQ
G
L
E
A
V
Q
SMEDEPT
Q
A
F
M
LT
P
P
Q
ELGPSHCSFQTTGTLDE
P
W
E
V
LATQP
F
C
LRESEDSETQP
F
D
T
H
L
E
AYGPCLSPPRAIPGDQHPESPVHTEPMGIQGR
G
R
Q
T
V
D
K
V
MGI
P
K
E
T
A
E
RVGPERGP
L
E
R
E
T
E
K
LLPERQTDVT
G
E
E
E
L
TKGK
Q
D
R
E
Q
K
Q
L
L
A
R
D
T
Q
RQESDKNGESASPERDRE
S
L
K
V
E
I
E
T
S
E
E
I
Q
E
K
Q
V
Q
K
QTL
P
S
K
A
F
E
R
E
V
ERPVANREC
D
P
A
E
L
E
E
K
V
P
K
V
I
L
ERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVS
P
R
R
H
QKGLLNCKMP
P
A
E
K
A
S
R
I
R
A
A
E
K
VSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPP
P
L
L
S
P
L
LPSI
K
P
T
V
R
K
T
RQDGSQEAPEAPLSSELEPFHPKP
K
I
R
TRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPT
S
Q
A
T
RSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEP
T
S
Q
V
T
RGRKSRSSVKTPETVVP
T
A
L
E
LQPSTSTDRPVTSEPT
S
Q
A
TRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPT
Y
Q
ATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAP
E
L
Q
I
STSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPT
S
R
ATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRN
Q
L
VTPEPTS
R
A
T
R
CRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVT
P
K
L
T
S
R
A
T
RRKTNRSSVKTPKPVEPAASDLEPFTPTDQSV
T
P
E
A
I
AQGGQSKTLRSST
V
R
AMPVPTTPEFQSPVTTDQPISPEPIT
Q
P
S
C
I
K
R
Q
RAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGA
V
R
A
A
E
S
LTAIPEPASP
Q
L
L
ETPI
H
A
S
Q
I
Q
KVEPAGRSRFTPELQPK
A
S
Q
S
R
K
RSLATMDSPPHQKQPQRGEVS
Q
K
T
V
I
I
KEEEEDTAEKPGKEEDVVTPKPGKRKRD
Q
A
EEEPNRI
P
S
R
S
L
R
R
TKLNQESTA
P
K
V
L
F
T
G
VVD---A------RG
E
---
R
A
V
L
A
LGG-SLAGS--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
LGRG
I
P
I
L
S
L
D
W
L
HQSRKAGFFLPPD
E
Y
VVTD
P
E
QEKN---FGF---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
LLEG
Y
E
I
Y
VTPG-V--Q-PPP--P---------
Q
M
G
E
I
I
S
CCGG------TYLPSMPRS-------Y----------K----------P----------------
Q
R
V
V
-
I
TCPQDF---PHCS-I-PL-----RVGLPLL
S
P
E
F
L
L
T
G
V
L
KQE-A-K-PE
A
F
V
L
SPLEMSST
37
HHSearch
95.81
99%
-142
- C1 -
-
3K05
3
B:
[2-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
D
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
L
E
M
S
S
T
21
Fugue
95.07
100%
-150
- C1 -
-
2ADO
-
MDC1_HUMAN
A:
[1892-2085]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
T
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
L
E
----
4
PsiBlast_PDB
95.07
100%
-150
- C1 -
-
2ADO
-
MDC1_HUMAN
A:
[1892-2085]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
T
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
L
E
----
2
PsiBlast_PDB
95.02
98%
-139
- C1 -
-
2AZM
-
MDC1_HUMAN
A:
[9-201]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
T
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
------
3
PsiBlast_PDB
94.80
99%
-147
- C1 -
-
3K05
2
MDC1_HUMAN
A:
[2-194]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
D
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
------
1
PsiBlast_PDB
93.86
100%
-149
- C- -
-
2ETX
-
MDC1_HUMAN
A:
[1892-2085]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
K
V
L
F
T
G
V
V
D
---
A
------
R
G
E
---
R
A
V
L
A
L
G
G
-
S
L
A
G
S
--
A
---------------------------
A
E
A
S
H
L
V
T
D
R
-----
I
R
R
T
V
K
F
L
C
A
L
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
R
K
A
G
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
---
F
G
F
---
S
L
Q
D
------------
A
L
S
R
A
-----------
R
--
E
R
--
R
L
L
E
G
Y
E
I
Y
V
T
P
G
-
V
--
Q
-
P
P
P
--
P
---------
Q
M
G
E
I
I
S
C
C
G
G
------
T
Y
L
P
S
M
P
R
S
-------
Y
----------
K
----------
P
----------------
Q
R
V
V
-
I
T
C
P
Q
D
F
---
P
H
C
S
-
I
-
P
L
-----
R
V
G
L
P
L
L
S
P
E
F
L
L
T
G
V
L
K
Q
E
-
A
-
K
-
P
E
A
F
V
L
S
P
L
E
----
40
HHSearch
70.90
33%
-45
- C1 -
-
3SQD
-
PAXI1_HUMAN
A:
[13-218]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
L
T
P
F
V
L
F
T
G
F
E
P
---
V
QVQ---
Q
Y
I
---
K
K
L
Y
I
L
G
G
-
E
V
A
E
S
--
A
---------------------------
Q
K
C
T
H
L
I
A
S
K
-----
V
T
R
T
V
K
F
L
T
A
I
S
V
V
K
H
I
V
T
P
E
W
L
E
E
C
F
R
C
Q
K
F
I
D
E
Q
N
Y
I
L
R
D
A
E
A
E
V
L
---
F
S
F
---
S
L
E
E
------------
S
L
K
R
A
-----------
H
--
V
S
--
P
L
F
K
A
K
Y
F
Y
I
T
P
G
-
I
--
C
-
P
S
L
--
S
---------
T
M
K
A
I
V
E
C
A
G
G
------
K
V
L
S
K
Q
P
S
F
-------
R
KLMEHKQNSS
L
----------
S
----------------
E
I
I
L
-
I
S
C
E
N
D
L
---
H
L
C
R
-
E
-
Y
F
-----
A
R
G
I
D
V
H
N
A
E
F
V
L
T
G
V
L
T
Q
T
-
L
-
D
-
Y
E
S
Y
K
F
--------
12
PsiBlast_PDB
70.78
32%
-39
- C1 -
-
3SQD
-
PAXI1_HUMAN
A:
[10-216]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
E
L
T
-
P
F
V
L
F
T
G
F
E
P
---
V
------
Q
V
Q
QYI
K
K
L
Y
I
L
G
G
-
E
V
A
E
S
--
A
---------------------------
Q
K
C
T
H
L
I
A
S
K
-----
V
T
R
T
V
K
F
L
T
A
I
S
V
V
K
H
I
V
T
P
E
W
L
E
E
C
F
R
C
Q
K
F
I
D
E
Q
N
Y
I
L
R
D
A
E
A
E
V
L
---
F
S
F
---
S
L
E
E
------------
S
L
K
R
A
-----------
H
--
V
S
--
P
L
F
K
A
K
Y
F
Y
I
T
P
G
-
I
--
C
-
P
S
L
--
S
---------
T
M
K
A
I
V
E
C
A
G
G
------
K
V
L
S
K
Q
P
S
F
-------
R
----------
K
LMEHKQNSSL
S
----------------
E
I
I
L
-
I
S
C
E
N
D
L
---
H
L
C
R
-
E
-
Y
F
-----
A
R
G
I
D
V
H
N
A
E
F
V
L
T
G
V
L
T
Q
T
-
L
-
D
-
Y
E
S
Y
----------
41
HHSearch
70.45
33%
-40
- C1 -
-
3SQD
-
B:
[15-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
F
V
L
F
T
G
F
E
P
---
V
QVQ---
Q
Y
I
---
K
K
L
Y
I
L
G
G
-
E
V
A
E
S
--
A
---------------------------
Q
K
C
T
H
L
I
A
S
K
-----
V
T
R
T
V
K
F
L
T
A
I
S
V
V
K
H
I
V
T
P
E
W
L
E
E
C
F
R
C
Q
K
F
I
D
E
Q
N
Y
I
L
R
D
A
E
A
E
V
L
---
F
S
F
---
S
L
E
E
------------
S
L
K
R
A
-----------
H
--
V
S
--
P
L
F
K
A
K
Y
F
Y
I
T
P
G
-
I
--
C
-
P
S
L
--
S
---------
T
M
K
A
I
V
E
C
A
G
G
------
K
V
L
S
K
Q
P
S
F
-------
R
KLMEHKQNSS
L
----------
S
----------------
E
I
I
L
-
I
S
C
E
N
D
L
---
H
L
C
R
-
E
-
Y
F
-----
A
R
G
I
D
V
H
N
A
E
F
V
L
T
G
V
L
T
Q
T
-
L
-
D
-
Y
E
S
Y
K
F
--------
39
HHSearch
65.41
28%
-75
- C1 -
-
3L41
-
A:
[7-213]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
Y
I
T
F
T
G
Y
D
K
---
K
------
P
S
I
---
D
N
L
K
K
L
D
M
-
S
I
T
S
N
--
P
---------------------------
S
K
C
T
H
L
I
A
P
R
-----
I
L
R
T
S
K
F
L
C
S
I
P
Y
G
P
C
V
V
T
M
D
W
I
N
S
C
L
K
T
H
E
I
V
D
E
E
P
Y
L
L
N
D
P
E
K
E
L
E
---
L
G
C
---
T
L
E
S
------------
A
L
K
R
A
-----------
R
AQ
G
P
--
S
L
L
E
D
Y
V
V
Y
L
T
S
K
-
T
VA
P
-
E
N
V
--
P
---------
A
V
I
S
I
V
K
S
N
G
G
------
V
C
S
T
L
N
V
Y
N
KRLARHL
E
----------
D
----------
G
----------------
N
V
V
L
-
I
T
C
N
E
D
S
---
H
I
W
T
-
N
-
F
L
DNASQ
N
K
T
I
F
L
Q
N
Y
D
W
L
I
K
T
V
L
R
Q
E
-
I
-
D
V
N
D
R
I
A
---------
51
HHSearch
56.62
14%
-39
- C1 -
-
2NTE
3
BARD1_HUMAN
A:
[2-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
L
I
G
S
G
L
S
S
---
E
QQK---
M
L
S
---
E
L
A
V
I
L
K
A
-
K
K
Y
T
E
--
F
D--------------------------
S
T
V
T
H
V
V
V
P
G
DA---
V
Q
S
T
L
K
C
M
L
G
I
L
N
G
C
W
I
L
K
F
E
W
V
K
A
C
L
R
R
K
V
C
E
Q
E
E
K
Y
E
I
P
E
G
P
R
R
S
R
----------
L
---------------
N
R
E
Q
-----------
L
--
L
P
--
K
L
F
D
G
C
Y
F
Y
L
W
G
T
F
K
--
H
-
H
P
K
--
D
---------
N
L
I
K
L
V
T
A
G
G
G
------
Q
I
L
S
R
K
P
K
P
-------
D
SDVTQ-----
T
----------
I
NTVAYHARPDSDQRFC
T
Q
Y
I
-
I
Y
E
D
L
C
N
---
Y
H
P
E
-
R
-
V
R
-----
Q
G
K
V
W
K
A
P
S
S
W
F
I
D
C
V
M
S
F
E
-
L
-
L
---------------
44
HHSearch
56.26
15%
-46
- C1 -
-
3AL2
-
A:
[8-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
I
F
Q
L
S
S
L
N
P
QER
I
------
D
Y
C
---
H
L
I
E
K
L
G
G
-
L
V
I
E
K
QC
F
D--------------------------
P
T
C
T
H
I
V
V
G
H
-----
P
L
R
N
E
K
Y
L
A
S
V
A
A
G
K
W
V
L
H
R
S
Y
L
E
A
C
R
T
A
G
H
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
L
D
V
LTG
I
N
V
QQR
R
L
A
L
------------
A
A
M
R
W
RKKIQQRQESG
I
--
V
E
--
G
A
F
S
G
W
K
V
I
L
H
V
D
----
Q
-
S
R
E
--
A
---------
G
F
K
R
L
L
Q
S
G
G
A
------
K
V
L
P
G
H
S
V
P
L------
F
----------
K
----------
E
----------------
A
T
H
L
-
F
S
D
L
--
G
---
V
N
I
A
-
E
-
A
A
-----
A
Q
N
V
Y
C
L
R
T
E
Y
I
A
D
Y
L
M
Q
E
S
P
P
-
H
-
V
E
N
Y
C
L
P
E
------
54
HHSearch
56.10
18%
-24
- C1 -
-
2VXC
-
B:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
D
D
C
V
F
A
F
S
G
P
V
H
---
E
DAYDRS
A
L
E
---
T
V
V
Q
D
H
G
G
-
L
V
L
D
T
--
G
LRPLFNDPFKSKQKKLRHLKPQKRSKS
W
N
Q
A
F
V
V
S
D
T
-----
F
S
R
K
V
K
Y
L
E
A
L
A
F
N
I
P
C
V
H
P
Q
F
I
K
Q
C
L
K
M
N
R
V
V
D
F
S
P
Y
L
L
A
S
G
-
Y
S
H
R
---
L
D
C
---
T
L
S
Q
RIEPFDTTDSLY
D
R
L
L
A
-----------
R
--
K
G
--
P
L
F
G
K
K
I
L
F
I
I
P
-------------NTEQGQKAL
A
H
V
Y
H
A
L
A
L
G
A
------
D
V
E
I
R
P
N
V
A
-------
H
----------
L
----------
E
----------------
C
D
L
I
-
L
T
M
D
G
N
---------
I
-
V
D
-----
E
T
N
C
P
V
V
D
P
E
W
I
V
E
C
L
I
S
Q
S
-
D
-
I
---------------
5
PsiBlast_PDB
56.06
99%
-118
- C3 -
-
3UOT
-
?
A:
[3-119]
------------------
Q
S
S
E
S
L
R
C
N
V
E
P
V
G
R
L
H
I
F
S
G
A
H
G
P
E
K
D
F
P
L
H
L
G
K
N
V
V
G
R
M
P
D
C
S
V
A
L
P
F
P
S
I
S
K
Q
H
A
E
I
E
I
L
A
W
D
K
A
P
I
L
R
D
C
G
S
L
N
G
T
Q
I
L
R
P
P
K
V
L
S
P
G
V
S
H
R
L
R
D
Q
E
L
I
L
F
A
D
L
L
C
Q
Y
H
R
L
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
55.58
19%
-20
- C1 -
-
3U3Z
2
A:
[10-198]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
R
T
L
V
M
T
S
M
P
S
---
E
KQN---
V
V
I
---
Q
V
V
D
K
L
K
G
F
S
I
A
P
D
--
V
C--------------------------
E
T
T
T
H
V
L
S
G
K
-----
P
L
R
T
L
N
V
L
L
G
I
A
R
G
C
W
V
L
S
Y
D
W
V
L
W
S
L
E
L
G
H
W
I
S
E
E
P
F
E
L
S
H
H
F
P
A
A
P
---
L
C
R
---
S
E
C
H
------------
L
S
A
G
P
-----------
Y
--
R
G
--
T
L
F
A
D
Q
P
V
M
F
V
S
P
A
S
--
S
-
P
P
V
--
A
---------
K
L
C
E
L
V
H
L
C
G
G
------
R
V
S
Q
V
P
R
-------------------------------
Q
----------------
A
S
I
V
-
I
G
P
Y
S
G
K
-----------
K
-----
K
A
T
V
K
Y
L
S
E
K
W
V
L
D
S
I
T
Q
H
K
-
V
C
A
-
P
E
N
Y
L
L
S
-------
7
PsiBlast_PDB
55.55
100%
-141
- C- -
-
3UNM
-
MDC1_HUMAN
A:
[29-133]
----------------------------
E
P
V
G
R
L
H
I
F
S
G
A
H
G
P
E
K
D
F
P
L
H
L
G
K
N
V
V
G
R
M
P
D
C
S
V
A
L
P
F
P
S
I
S
K
Q
H
A
E
I
E
I
L
A
W
D
K
A
P
I
L
R
D
C
G
S
L
N
G
T
Q
I
L
---
K
V
L
S
P
-
V
S
H
R
L
R
D
Q
E
L
I
L
F
A
D
L
L
C
Q
Y
H
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.78
100%
-132
- C3 -
-
3UMZ
-
MDC1_HUMAN
A:
[29-133]
----------------------------
E
P
V
G
R
L
H
I
F
S
G
A
H
G
P
E
K
D
F
P
L
H
L
G
K
N
V
V
G
R
M
P
D
C
S
V
A
L
P
F
P
S
I
S
K
Q
H
A
E
I
E
I
L
A
W
D
K
A
P
I
L
R
D
C
G
S
L
N
G
T
Q
I
L
R
P
P
K
V
L
S
P
G
V
S
H
R
L
R
D
Q
E
L
I
L
F
A
D
L
L
C
Q
Y
H
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.59
30%
-114
- C1 -
-
3L41
-
A:
[11-172]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
T
G
Y
D
K
---
K
------
P
S
I
---
D
N
L
K
K
L
D
M
-
S
I
T
S
N
--
P
---------------------------
S
K
C
T
H
L
I
A
P
R
-----
I
L
R
T
S
K
F
L
C
S
I
P
Y
G
P
C
V
V
T
M
D
W
I
N
S
C
L
K
T
H
E
I
V
D
E
E
P
Y
L
L
N
D
P
E
K
E
L
E
---
L
G
C
---
T
L
E
S
------------
A
L
K
R
A
-----------
R
--
A
Q
GP
S
L
L
E
D
Y
V
V
Y
L
T
S
K
-
T
--
V
-
A
P
E
NV
P
---------
A
V
I
S
I
V
K
S
N
G
G
VCSTLN
V
Y
N
K
R
L
A
R
H
-------
L
----------
E
----------
D
----------------
G
N
V
V
L
I
T
C
N
E
D
---------------------------------------------------------
50
HHSearch
54.45
16%
1
- C1 -
-
4Y2G
-
BRCA1_HUMAN
A:
[1646-1857]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
K
R
M
S
M
V
V
S
G
L
T
P
---
E
EFM---
L
V
Y
---
K
F
A
R
K
H
H
I
-
T
L
T
N
L
--
I
T--------------------------
E
E
T
T
H
V
V
M
K
T
DAEFV
C
E
R
T
L
K
Y
F
L
G
I
A
G
G
K
W
V
V
S
Y
F
W
V
T
Q
S
I
K
E
R
K
M
L
N
E
H
D
F
E
V
R
G
D
V
V
N
G
R
---
N
H
Q
---
G
P
K
R
------------
A
R
-
E
S
-----------
Q
--
D
R
--
K
I
F
R
G
L
E
I
C
C
Y
G
P
-
F
--
T
N
M
P
T
--
D
---------
Q
L
E
W
M
V
Q
L
C
G
A
------
S
V
V
K
E
L
S
S
F
-------
T
LGT-------
G
----------
V
----------------
H
P
I
V
-
V
V
Q
P
D
A
W
TED
N
G
F
H
-
A
I
G
Q
-----
M
C
E
A
P
V
V
T
R
E
W
V
L
D
S
V
A
L
Y
Q
-
C
Q
E
-
L
D
T
Y
L
I
P
Q
------
49
HHSearch
54.38
17%
12
- C1 -
-
4IGK
2
BRCA1_HUMAN
A:
[3-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
M
S
M
V
V
S
G
L
T
P
---
E
EFM---
L
V
Y
---
K
F
A
R
K
H
H
I
-
T
L
T
N
L
--
I
T--------------------------
E
E
T
T
H
V
V
M
K
T
DAEFV
C
E
R
T
L
K
Y
F
L
G
I
A
G
G
K
W
V
V
S
Y
F
W
V
T
Q
S
I
K
E
R
K
M
L
N
E
H
D
F
E
V
R
G
D
V
V
N
G
R
---
N
H
Q
---
G
P
K
R
------------
A
-
R
E
S
-----------
Q
--
D
R
--
K
I
F
R
G
L
E
I
C
C
Y
G
P
-
F
T-
N
-
M
P
T
--
D
---------
Q
L
E
W
M
V
Q
L
C
G
A
------
S
V
V
K
E
L
S
S
F
TLG----
T
----------
G
----------
V
----------------
H
P
I
V
-
V
V
Q
P
D
A
W
---
N
G
F
H
A
I
-
G
Q
-----
M
C
E
A
P
V
V
T
R
E
W
V
L
D
S
V
A
L
Y
Q
C
Q
-
E
-
L
D
T
Y
L
I
P
Q
------