@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NAKD2_HUMAN: (2020-02-01 )
MTCYRGFLLGSCCRVAGGRAAALRGPGAGGPAARPRLGGDGGGRRHLGQGQPRELAGCGSRADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRNEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIRLYLEGTGINPVPVDLHEQQLSLNQHNRALNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRQGNLSLPLNRELVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ
Atome Classification :
(20 SA)
.........10..--......20........30......-..40........50........60........70..-...-...80........90........100-.......110...-.....----120.......130..---.....--140..-----------.....150--........-160.......170-----...--..-.-----...-180-----------------........190.......200.......210.......220.......230.---......240......---------.250.........260.......270........280.......290.......300.--.....------.310.......320--------------.......330.......340......-.---.350-..---...--..-------360-----....-----.....370...----....380.......390...----....400.------.-.----....410...-....420.......430-----.----------........440
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
C
Y
R
G
F
L
L
G
S
C
C
--
R
VAGG
R
A
A
A
LRGPGAGGPAARPRL-GGDGGGRRHLGQGQ
P
R
E
L
AGCGSRADGGFRP
S
R
V
V
V
-
V
A
K-TT
R
Y
E
F
E
Q
Q
R
Y
R
YAEL
S
E
E
D
L
K
Q
L
L
A
-LKGS
S
Y
S
G
L
-
L
E
R
-HHIH
T
----
K
N
V
E
H
I
I
D
S
L
R
NEG
I
---
E
V
R
L
V
--KRREY-----------
D
E
E
T
V
R
W
---
A
D
A
V
I
AAG-GD
G
T
M
L
L
A
A
S
K
-------
V
L
D
--RL-
K
-----
P
V
I-GV------------------NTDPERSEG
H
L
C
L
P
V
RYT
H
S
F
P
E
A
L
Q
K
F
YR
G
E
F
R
W
L
W
R
Q
R
I
R
L
Y
L
EGTGINP---VPV
D
L
H
E
Q
Q
LSLNQH---------NR--ALNIERAHDERSEASGP
Q
L
L
-
P
V
R
A
L
N
E
V
F
IGESLSSRA
S
Y
Y
E
I
SVDDGPW
E
K
Q
--KSSGL------
N
L
CTGTGS
K
A
W
S
F
N
--------------
I
N
R
V
A
T
Q
A
V
E
D
V
L
N
I
A
K
RQ-GNLSLP-L---
N
R
E
L
-
V
E
---
K
V
T
--
N
E
-------Y-------
N
E
SL-----LYSPEE
P
K
I
L
F
----
S
I
R
E
P
I
A
N
R
V
F
S
S
S
R
Q
R
C
F
S
----S
K
V
C
V
R
SR------C-W----
D
A
C
M
V
V
DGGT-SFEFNDG
A
I
A
S
MMIN-------K----------
E
D
E
L
R
T
V
LLEQ
25
HHSearch
75.03
22%
-67
- C5 -
-
1U0T
-
NADK_MYCTU
B:
[5-284]
-----------------------------------------------------------------------
R
S
V
L
L
-
V
V
H
-
T
G
R
D
E
A
T
--
E
--
T
----
A
R
R
V
E
K
V
L
G
-
D
N
K
I
A
L
R
V
L
-
S
-----------------------------------------
A
-----------
D
Q
H
A
A
D
G
---
C
E
L
V
L
V
L
G
-
G
D
G
T
F
L
R
A
A
E
L
-------
A
R
N
--
A
S
-
I
-----
P
V
L
-
G
V
------------------
N
L
---
G
R
I
G
F
L
A
E
A
--
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
E
D
R
L
T
L
D
V
V
V
R
Q
G
G
--------------------------------------------------
R
I
V
N
-
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
--
G
C
D
G
V
------
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
--------------
A
G
------------------
G
P
V
L
W
P
D
L
---
E
A
I
L
-
V
V
---
P
N
N
AH
A
L
-------
F
-------
G
R
P
M
-----
V
T
S
P
E
A
T
I
A
--------------------------------
I
E
I
E
A
D
------
G
-
H
----
D
A
L
V
F
C
D
G
R
R
-
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
-------
V
----------
T
-
S
V
K
W
A
R
L
--
26
HHSearch
73.89
22%
-60
- C5 -
-
1U0R
-
NADK_MYCTU
D:
[3-284]
---------------------------------------------------------------------
A
H
R
S
V
L
L
-
V
V
H
-
T
G
---
A
T
--
E
--
T
----
A
R
R
V
E
K
V
L
G
-
D
N
K
I
A
L
R
V
L
-
S
A
E
-
A
V
D
R
G
----
S
-
L
H
L
A
P
D
D
M
R
A
M
G
V
---
E
I
E
V
V
--
D
---
A
-----------
D
Q
H
A
A
D
G
---
C
E
L
V
L
V
L
G
-
G
D
G
T
F
L
R
A
A
E
L
-------
A
R
N
--
A
S
-
I
-----
P
V
L
-
G
V
------------------
N
L
---
G
R
I
G
F
L
A
E
A
--
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
E
D
R
L
T
L
D
V
V
V
R
Q
G
G
--------------------------------------------------
R
I
V
N
-
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
--
G
C
D
G
V
------
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
--------------
A
G
------------------
G
P
V
L
W
P
D
L
---
E
A
I
L
-
V
V
---
P
N
N
AH
A
L
-------
F
-------
G
R
P
M
-----
V
T
S
P
E
A
T
I
A
--------------------------------
I
E
I
E
A
D
------
G
-
H
----
D
A
L
V
F
C
D
G
R
R
-
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
-------
V
----------
T
-
S
V
K
W
A
R
L
--
24
HHSearch
71.79
16%
0
- C- -
-
3AFO
3
POS5_YEAST
A:
[31-340]
------------------------------------------------------------
K
L
Q
S
L
I
W
Q
N
P
L
Q
N
V
Y
I
-
T
K
K
-
P
W
T
P
S
T
-
R
---
E
A
----
M
V
E
F
I
T
H
L
H
-
E
S
Y
P
E
V
N
V
I
-
V
Q
P
-
D
V
A
E
E
-----
I
S
Q
D
F
K
S
P
L
E
N
D
P
N
---
R
P
H
I
L
---
Y
T
G
P
-----------
E
Q
D
I
V
N
R
---
T
D
L
L
V
T
L
G
-
G
D
G
T
I
L
H
G
V
S
M
-------
F
G
N
--
T
Q
V
P
-----
P
V
L
-
A
F
------------------
A
L
---
G
T
L
G
F
L
S
P
F
-
D
-
F
K
E
H
K
K
V
F
Q
E
V
I
S
S
R
A
K
C
L
H
R
T
R
L
E
C
H
L
K
K
K
D
S
-------------------------------------------------
N
S
S
I
-
V
T
H
A
M
N
D
I
F
L
H
R
G
N
S
P
H
L
T
N
L
D
I
F
I
D
G
E
F
L
T
R
T
--
T
A
D
G
V
------
A
L
A
T
P
T
G
S
T
A
Y
S
L
S
--------------
A
G
------------------
G
S
I
V
S
P
L
V
---
P
A
I
L
-
M
T
---
P
I
C
PR
S
L
-------
S
-------
F
R
P
L
-----
I
L
P
H
S
S
H
I
R
I
--------------------------------
K
I
G
S
K
LNQKPV
N
-
S
----
V
V
K
L
S
V
D
G
I
P
-
Q
Q
D
L
D
V
G
D
E
I
Y
V
I
N
E
-----------------------------
21
HHSearch
66.04
18%
4
- C5 -
-
3PFN
-
NADK_HUMAN
A:
[30-344]
--------------------------------------------------------------
Q
R
L
T
W
N
K
S
P
K
S
V
L
V
-
I
K
K
-
M
R
D
-
A
S
L
L
Q
---
P
----
F
K
E
L
C
T
H
L
M
-
E
E
N
M
I
V
Y
V
E
-
K
K
V
-
L
E
D
P
A
IASD
E
S
F
G
A
V
K
K
K
F
C
--------
T
F
R
E
-----
D
------------
Y
D
D
I
S
N
Q
---
I
D
F
I
I
C
L
G
-
G
D
G
T
L
L
Y
A
S
S
L
-------
F
Q
G
--
S
V
-
P
-----
P
V
M
-
A
F
------------------
H
L
---
G
S
L
G
F
L
T
P
F
S
--
F
E
N
F
Q
S
Q
V
T
Q
V
I
E
G
N
A
A
V
V
L
R
S
R
L
K
V
R
V
V
-----------------------------------------------------
K
Q
A
M
-
Q
Y
Q
V
L
N
E
V
V
I
D
R
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
--
Q
G
D
G
V
------
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
--------------
A
G
------------------
A
S
M
I
H
P
N
V
---
P
A
I
M
-
I
T
---
P
I
C
PH
S
L
-------
S
-------
F
R
P
I
-----
V
V
P
A
G
V
E
L
K
--------------------------------
I
M
L
S
P
E
A-----
R
-
N
----
T
A
W
V
S
F
D
G
R
K
-
R
Q
E
I
R
H
G
D
S
I
S
I
T
T
S
-------
C
----------
Y
-
P
L
P
S
I
C
V
--
23
HHSearch
62.64
23%
-75
- C5 -
-
1Z0S
3
NADK_ARCFU
A:
[41-264]
------------------------------------------------------------------------------------------------------------------------------------
H
V
K
R
I
E
E
A
L
K
R
L
E
V
---
E
V
E
L
F
--
N
Q
--------------
P
S
E
E
L
E
N
---
F
D
F
I
V
S
V
G
-
G
D
G
T
I
L
R
I
L
Q
K
-------
L
K
---
R
C
-
P
-----
P
I
F
-
G
I
------------------
N
T
---
G
R
V
G
L
L
T
H
A
S
--
P
E
N
F
E
V
E
L
K
K
A
V
E
-
K
F
E
V
E
R
F
P
R
V
S
C
S
A
M
--------------------------------------------------------
P
-
D
V
L
A
L
N
E
I
A
V
L
S
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
E
V
D
R
I
--
R
C
D
G
F
------
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
--------------
A
G
------------------
G
P
V
V
E
P
Y
L
---
E
C
F
I
-
L
I
---
P
I
A
PF
R
F
-------
G
-------
W
K
P
Y
-----
V
V
S
M
E
R
K
I
----------------------------------
E
V
I
A
---------
E
----
K
A
I
V
V
A
D
G
Q
K
-
S
V
D
--
F
D
G
E
I
T
I
E
K
S
-------
E
----------
F
-
P
A
V
F
F
K
N
E
-
46
Fugue
61.45
22%
35
- C6 -
-
4B46
1
CETZ1_HALVD
A:
[1-367]
M
K
L
A
M
I
G
F
G
Q
A
G
G
--
K
V
V
D
K
F
V
E
Y
D
R
E
R
N
A
G
--
I
V
R
A
A
V
-
A
V
N
S
A
K
A
D
L
L
G
L
K
N
I
P
-------------
K
D
Q
R
V
L
I
G
Q
S
R
-
V
K
G
H
G
V
G
A
D
N
E
L
G
A
E
I
A
E
E
D
-------------------------
I
----
D
E
V
Q
G
A
I
D
S
I
P
V
H
E
V
---
D
--------------------------------
A
F
L
V
V
S
G
L
-
G
G
G
T
G
S
G
G
A
P
V
-------
L
A
K
--
H
L
-
K
RIYTE
P
V
Y
-
G
L
------------------
G
I
L
P
G
S
D
E
G
-----
G
I
Y
T
L
N
A
A
R
S
F
Q
T
F
V
R
E
------------------
V
D
N
---
L
L
V
-
F
D
N
D
A
W
R
K
T
G
E
---------
S
V
--
Q
G
G
Y
D
E
I
N
E
E
I
V
N
R
F
G
V
L
F
G
-
S
V
----------------------
V
D
S
S
E
I
I
N
T
--
L
A
G
G
G
------
V
S
T
V
G
Y
A
S
E
G
------------------
V
T
A
H
T
T
N
R
I
T
S
L
V
R
K
A
A
L
--
G
R
L
T
L
P
-
C
---
E
I
E
G
-
A
E
-----------------------------------------
R
A
L
L
----
V
L
A
G
P
P
E
H
----------
L
N
----
R
K
G
I
E
R
G
R
------
K
-
W
IEEQ
T
G
S
M
E
V
R
G
G
D
-
Y
P
I
P
G
A
E
K
V
A
G
V
I
L
L
SGVTNVP
R
----------
I
K
E
L
Q
Q
V
A
I
E
A
27
HHSearch
61.39
22%
-81
- C5 -
-
1SUW
2
NADK_ARCFU
B:
[14-234]
--------------------------------------------------------------------------------------------------------------------------------------
K
R
I
E
E
A
L
K
R
L
E
V
---
E
V
E
L
F
--
N
Q
P
--------------
S
E
E
L
E
N
---
F
D
F
I
V
S
V
G
-
G
D
G
T
I
L
R
I
L
Q
K
-------
L
K
---
R
C
-
P
-----
P
I
F
-
G
I
------------------
N
T
---
G
R
V
G
L
L
T
H
A
S
--
P
E
N
F
E
V
E
L
K
K
A
V
E
-
K
F
E
V
E
R
F
P
R
V
S
C
S
A
M
--------------------------------------------------------
P
-
D
V
L
A
L
N
E
I
A
V
L
S
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
E
V
D
R
I
--
R
C
D
G
F
------
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
--------------
A
G
------------------
G
P
V
V
E
P
Y
L
---
E
C
F
I
-
L
I
---
P
I
A
PF
R
F
-------
G
-------
W
K
P
Y
-----
V
V
S
M
E
R
K
----------------------------------
I
E
V
I
A
---------
E
----
K
A
I
V
V
A
D
G
Q
K
-
S
V
D
--
F
D
G
E
I
T
I
E
K
S
-------
E
----------
F
-
P
A
V
F
F
K
N
--
43
Fugue
61.07
18%
15
- C5 -
-
3PFN
-
NADK_HUMAN
A:
[6-361]
-----------------------
T
T
F
G
P
K
A
C
V
L
Q
N
P
Q
T
I
M
H
I
Q
D
P
A
S
Q
R
L
T
W
N
K
S
---------------
P
K
S
V
L
V
-
I
K
K
M
R
D
------------
A
S
L
L
Q
P
F
K
E
L
C
T
-
H
-------
L
M
E
E
N
M
I
V
Y
V
E
----
K
K
V
L
E
D
P
A
I
A
S
D
E
S
F
---
G
A
V
K
K
--
K
F
C
T
F
-----------
R
E
D
Y
D
D
I
SNQ
I
D
F
I
I
C
L
G
-
G
D
G
-
T
L
L
Y
A
S
S
-------
L
F
Q
--
G
S
-
V
-----
P
P
V
M
A
F
------------------
H
L
G
---
S
L
G
F
L
-
T
P
F
S
F
E
N
-
F
Q
S
Q
V
T
Q
V
I
E
G
N
A
A
V
V
L
R
S
R
L
K
V
R
V
V
K
Q
A
M
------------------------------------------------------
Q
Y
Q
V
L
N
E
V
V
I
D
R
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
--
Q
G
D
G
V
------
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
--------------
A
G
------------------
A
S
I
H
P
N
-
V
---
P
A
I
I
-
T
P
---
I
C
P
--
H
S
-------
L
-------
S
F
R
P
-----
I
V
V
P
A
G
V
E
L
K
I
----
L
S
P
E
A
R
N
T
A
W
V
S
F
D
G
R
K
R
Q
E
IRHG
D
S
I
S
I
T
T
S
------
C
-
Y
----
P
L
P
S
I
C
V
R
D
P
-
V
S
D
W
F
E
S
L
A
Q
C
------------------------------
L
H
H
42
Fugue
60.61
19%
-18
- C5 -
-
2AN1
-
NADK_SALTY
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------
H
F
-
K
C
I
-
G
I
V
G
H
----
T
T
H
E
M
L
Y
R
W
L
C
D
Q
G
Y
---
E
V
I
V
E
--
Q
Q
I
A
H
ELQLKNVPTGT
L
A
E
I
G
Q
Q
---
A
D
L
A
V
V
V
G
-
G
D
G
N
M
L
G
A
A
R
T
-------
L
A
R
--
Y
D
-
I
-----
N
V
I
-
G
I
------------------
N
R
G
N
L
G
F
-----
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
E
K
R
F
L
L
E
A
Q
V
C
Q
Q
R
-------------------------------------------------------
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
--
R
S
D
G
L
------
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
AGGPILTPSLDAIT
L
V
P
M
F
P
H
T
L
S
A
R
P
L
V
I
N
S
S
-
S
T
I
R
L
R
-
F
---
S
H
D
L
-
E
I
---
S
C
D
--
S
Q
-------
I
-------
A
L
P
I
QEGED
V
L
I
R
R
C
D
Y
H
L
N
----
L
I
H
P
K
D
Y
S
Y
F
N
T
L
S
T
K
L
G
W
S
----
K
K
L
F
------------------------------------------------------------------------
28
HHSearch
59.28
22%
-52
- C5 -
-
2AN1
-
NADK_SALTY
B:
[61-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
Q
---
A
D
L
A
V
V
V
G
-
G
D
G
N
M
L
G
A
A
R
T
-------
L
A
R
--
Y
D
-
I
-----
N
V
I
-
G
I
------------------
N
R
---
G
N
L
G
F
L
T
D
L
D
--
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
E
K
R
F
L
L
E
A
Q
V
C
Q
Q
D
--------------------------------------------------
R
Q
K
R
-
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
--
R
S
D
G
L
------
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
--------------
A
G
------------------
G
P
I
L
T
P
S
L
---
D
A
I
T
-
L
V
---
P
M
F
PH
T
L
-------
S
-------
A
R
P
L
-----
V
I
N
S
S
S
T
I
-------
R
-------------------------
L
R
F
S
H
R
------
R
-
S
----
D
L
E
I
S
C
D
S
Q
I
-
A
L
P
I
Q
E
G
E
D
V
L
I
R
R
C
-------
D
----------
Y
-
H
L
N
L
I
H
P
--
22
HHSearch
59.07
25%
-38
- C5 -
-
1YT5
-
NADK_THEMA
A:
[38-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
V
T
---
A
D
L
I
V
V
V
G
-
G
D
G
T
V
L
K
A
A
K
K
-------
A
A
---
D
G
-
T
-----
P
M
V
-
G
F
------------------
K
A
---
G
R
L
G
F
L
T
S
Y
T
--
L
D
E
I
D
R
F
L
E
D
L
R
N
W
N
F
R
E
E
T
R
W
F
I
Q
I
E
S
E
-------------------------------------------------------
L
G
-
N
H
L
A
L
N
D
V
T
L
E
R
D
L
S
G
K
M
V
E
I
E
V
E
V
E
H
H
S
S
M
W
F
--
F
A
D
G
V
------
V
I
S
T
P
T
G
S
T
A
Y
S
L
S
--------------
I
G
------------------
G
P
I
I
F
P
E
C
---
E
V
L
E
-
I
S
---
P
I
A
PQ
F
F
-------
L
-------
T
R
S
V
-----
V
I
P
S
N
F
K
V
----------------------------------
V
V
E
S
Q
--------
R
----
D
I
N
M
L
V
D
G
V
L
-
T
G
---
K
T
K
R
I
E
V
K
K
S
-------
R
----------
R
-
Y
V
R
I
L
R
P
--
41
Fugue
56.66
18%
-57
* C5 *
-
1SUW
2
NADK_ARCFU
A:
[1-249]
----------------------------------------------------------------------------------------------------------------
M
R
A
A
V
-
V
Y
K
-
T
---
D
----
G
H
V
K
R
I
E
E
A
L
K
R
L
E
V
---
E
V
E
L
F
--
N
---
Q
-----------
P
S
E
E
L
E
N
---
F
D
F
I
V
S
V
G
-
G
D
G
T
I
L
R
I
L
-
Q
-------
K
L
K
--
R
C
-
P
-----
P
I
F
-
G
I
------------------
N
T
G
---
R
V
G
L
L
------------------------------------------------
T
H
A
S
P
E
N
F
E
V
E
---------
L
K
--
K
A
V
E
K
F
E
V
E
R
F
P
R
V
S
C
S
A
M
P
-
D
V
L
A
L
N
E
I
A
V
L
S
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
E
V
D
R
I
--
R
C
D
G
F
------
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
AGGPVVEPYLECFI
L
I
P
I
A
P
F
R
F
G
W
K
P
Y
V
V
S
M
E
-
R
K
I
E
V
I
-
A
---
E
K
A
I
-
V
V
ADG
Q
K
S
--
V
D
-------
F
-------
D
G
E
I
-----
T
I
E
K
S
E
F
P
A
V
F
FKNE
K
R
F
R
N
L
F
G
K
V
R
S
I
G
--------------------------------------------------------------------------------------
54
Fugue
55.80
17%
-60
* C3 *
-
4MND
3
DIPPS_ARCFU
A:
[40-457]
--
L
M
K
A
V
I
L
A
A
---------------
G
L
G
G
G
V
P
K
P
L
V
R
V
-
G
G
C
E
I
I
L
R
T
M
K
L
L
S
P
H
--------------
V
S
E
F
I
I
-
V
A
S
-
R
Y
A
D
D
I
D
A
-
F
L
K
D
K
G
F
N
Y
K
I
V
R
H
D
R
P
-
E
K
G
N
G
Y
S
L
L
-
V
A
K
-
N
H
V
E
D
----
R
F
I
L
T
M
G
D
H
V
Y
S
---------------
Q
Q
F
-----------
I
E
K
A
V
R
G
---
E
G
V
I
A
D
R
E
-
P
R
F
V
D
I
G
E
A
T
K
-------
I
R
V
--
E
D
-
G
-----
R
V
A
-
K
I
------------------
G
K
D
L
R
E
F
D
C
V
D
T
G
F
F
V
L
D
D
S
I
F
E
H
A
E
K
L
R
D
R
E
E
I
P
L
S
E
I
V
K
L
A
R
L
P
V
T
Y
V
D
G
ELW
M
D
V
D
T
K
E
D
V
R
R
A
N
R
A
LVSAAVGDG
F
I
--
S
R
K
I
N
R
K
I
S
T
R
I
S
A
A
I
V
N
K
V
N
P
N
Q
M
T
L
I
S
F
L
V
G
A
F
S
A
L
A
S
F
F
--
S
I
P
L
A
G
L
L
Y
Q
--
F
S
S
I
L
------
D
G
C
D
G
E
I
A
R
A
-
S
L
K
--------------
M
S
K
K
G
G
Y
V
D
S
I
L
D
R
F
V
D
F
L
-
F
L
A
I
I
A
-
L
LYP
K
T
A
T
-
V
A
---
M
F
A
--
I
F
-------
G
-------
S
V
M
V
-----
S
Y
T
S
E
K
Y
K
A
E
F
----
G
E
S
I
R
V
L
N
Y
I
P
G
K
R
D
E
R
I
F
L
----
I
M
I
F
C
L
L
S
-----------------
A
I
S
L
Q
W
-
I
F
W
M
F
L
F
V
A
A
I
S
L
T
R
-------
V
----------
V
V
T
L
L
A
V
L
V
S
-
29
HHSearch
51.86
22%
-58
- C5 -
-
2AN1
-
NADK_SALTY
A:
[61-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
Q
---
A
D
L
A
V
V
V
G
-
G
D
G
N
M
L
G
A
A
R
T
-------
L
A
R
--
Y
D
-
I
-----
N
V
I
-
G
I
------------------
N
R
---
G
N
L
G
F
L
T
D
L
D
--
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
E
K
R
F
L
L
E
A
Q
V
C
Q
Q
------------------------------------------------------
R
-
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
--
R
S
D
G
L
------
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
--------------
A
G
------------------
G
P
I
L
T
P
S
L
---
D
A
I
T
-
L
V
---
P
M
F
PH
T
L
-------
S
-------
A
R
P
L
-----
V
I
N
S
S
S
T
I
-------
R
-------------------------
L
R
F
S
H
--------------
D
L
E
I
S
C
D
S
Q
I
-
A
L
P
I
Q
E
G
E
D
V
L
I
R
R
C
-------
D
----------
Y
-
H
L
N
L
I
H
P
--
30
HHSearch
51.77
18%
6
- C5 -
-
2I2A
2
NADK1_LISMO
A:
[18-248]
--------------------------------------------------------------------------------------------------------------------------------------
L
N
M
I
A
G
F
G
E
Y
D
M
---
E
Y
------------------------
D
D
V
E
---
P
E
I
V
I
S
I
G
-
G
D
G
T
F
L
S
A
F
H
Q
-------
Y
E
E
RL
D
E
-
I
-----
A
F
I
-
G
I
------------------
H
T
---
G
H
L
G
F
Y
A
D
W
--
R
P
A
E
A
D
K
L
V
K
L
L
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
I
-------------------------------------------------
G
K
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
S
S
--
G
G
P
F
V
V
D
V
V
I
N
D
I
H
F
E
R
F
--
R
G
D
G
L
------
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
--------------
L
G
------------------
G
A
L
M
H
P
S
I
---
E
A
M
Q
-
L
T
---
E
M
A
--
S
I
NNRVYRT
I
-------
G
S
P
L
-----
V
F
P
K
H
H
----------------------------------
V
V
S
L
Q
P
V
------
N
D
K
----
D
F
Q
I
S
V
D
H
L
S
-
I
L
-
H
R
D
V
Q
E
I
R
Y
E
V
S
-------
A
----------
K
-
K
I
H
F
A
R
F
--
50
Fugue
50.45
15%
22
* C4 *
-
4WL2
-
?
A:
[1-346]
--
C
T
R
F
V
Y
L
D
P
H
N
PD
Y
P
I
T
A
R
S
M
D
W
A
D
D
T
E
T
N
L
W
I
F
P
Q
-----------------------
E
L
K
R
S
G
G
A
G
Q
Y
S
L
E
W
-
T
S
K
---------------------------------
Y
G
S
V
-
I
A
S
-
A
F
D
G
R
----
K
G
M
A
S
T
T
D
G
V
N
E
K
G
L
---
A
A
N
V
L
WL
A
E
S
E
Y
-----------
P
K
T
K
P
T
A
---
K
K
P
G
L
S
-------
V
A
A
W
A
Q
Y
-------
V
L
D
--
N
F
-
A
------------------------------------------------
T
V
D
E
A
V
K
S
L
Q
Q
E
K
F
I
L
V
-----------
T
K
Q
V
E
---
G
Q
K
R
L
A
T
L
H
L
S
L
S
---------------------------
D
S
S
G
D
------
S
A
I
I
E
Y
I
D
G
K
Q
V
I
H
H
S
K
N
Y
Q
V
M
T
N
S
P
T
F
D
Q
Q
--
L
T
L
N
A
------
Y
W
D
Q
I
G
G
N
V
M
L
P
G
T
---------------
N
R
A
A
D
R
F
V
R
A
S
F
Y
V
K
N
V
N
-
P
N
K
L
I
P
-
G
---
V
A
E
K
G
K
I
---
E
K
D
--
K
A
-------
D
-------
L
A
T
A
-----
F
S
I
I
R
N
A
S
V
P
Y
----
G
Y
S
L
P
D
M
P
N
I
-
A
S
T
R
W
R
T
V
V
DHKS
L
Q
Y
F
F
E
S
A
------
V
-
S
----
P
N
I
F
W
V
D
L
K
K
I
N
F
A
P
R
G
G
S
A
A
K
L
D
L
G
-------
P
NQSTIYSGQA
S
G
H
F
K
P
A
Q
P
F
E
31
HHSearch
49.74
18%
7
- C5 -
-
2I2C
2
NADK1_LISMO
A:
[18-248]
--------------------------------------------------------------------------------------------------------------------------------------
L
N
M
I
A
G
F
G
E
Y
D
M
---
E
Y
------------------------
D
D
V
E
---
P
E
I
V
I
S
I
G
-
G
D
G
T
F
L
S
A
F
H
Q
-------
Y
E
E
RL
D
E
-
I
-----
A
F
I
-
G
I
------------------
H
T
---
G
H
L
G
F
Y
A
D
W
--
R
P
A
E
A
D
K
L
V
K
L
L
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
I
-------------------------------------------------
G
K
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
S
S
--
G
G
P
F
V
V
D
V
V
I
N
D
I
H
F
E
R
F
--
R
G
D
G
L
------
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
--------------
L
G
------------------
G
A
L
M
H
P
S
I
---
E
A
M
Q
-
L
T
---
E
M
A
--
S
I
-------
N
NRVYRTI
G
S
P
L
-----
V
F
P
K
H
----------------------------------
H
V
V
S
L
Q
P
V
------
N
D
K
----
D
F
Q
I
S
V
D
H
L
S
-
I
L
-
H
R
D
V
Q
E
I
R
Y
E
V
S
-------
A
----------
K
-
K
I
H
F
A
R
F
--
53
Fugue
49.00
16%
-8
- C4 -
-
4XGC
-
ORC2_DROME
B:
[62-352]
---------------------------------------------------------------------------------------
E
G
S
I
N
A
I
M
E
E
Y
R
S
Y
F
P
K
W
M
C
-
I
L
N
E
G
F
N
I
L
-
L
---
Y
G
L
G
S
----
K
--
H
Q
L
L
Q
S
F
H
R
E
V
L
HKQ
T
V
L
V
V
--
N
G
F
F
P
-----------
S
L
T
I
K
D
M
---
L
D
S
I
T
S
D
I
L
D
A
G
I
S
P
A
N
P
H
E
-------
A
V
D
--
M
I
-
E
-----
E
E
F
-
A
L
-----------------------
I
P
E
T
H
L
F
L
I
V
H
N
L
D
G
A
M
L
R
N
V
K
A
Q
A
I
L
S
R
L
A
R
I
P
N
I
H
L
L
A
S
I
D
H
I
N
----
T
P
L
L
W
D
Q
G
K
L
C
S
F
N
F
---------
S
W
WD
C
T
T
M
L
P
Y
T
N
E
T
A
F
E
N
S
L
L
V
L
-
A
L
S
S
M
R
S
V
F
S
S
L
T
T
N
S
R
G
I
Y
M
L
I
V
K
Y
Q
L
K
-
N
K
G
--
N
A
T
G
M
PFRDLY
S
S
C
R
E
A
F
L
V
S
S
D
L
A
--------------
L
R
A
Q
L
T
E
F
L
D
H
K
L
V
K
S
K
R
S
S
E
Q
L
T
I
P
-
I
---
D
G
A
L
-
L
Q
---
Q
F
L
--
E
E
-------
Q
-------
E
---------------------------------------------------------------------------------------------------------------------------
56
Fugue
47.77
15%
-8
- C1 -
-
3AQB
-
HEXB_MICLU
B:
[5-325]
--
S
Y
K
A
F
L
N
P
Y
I
I
--
E
V
E
K
R
L
Y
E
C
I
Q
S
D
S
E
T
I
N
K
A
A
H
H
I
-
L
S
S
G
G
K
R
---------------------
V
R
P
M
F
V
L
L
-
S
G
F
-
L
N
D
T
Q
-----------
K
D
D
L
I
R
T
A
V
S
-
L
E
L
V
H
M
A
S
L
-
V
H
D
-
D
Y
I
D
----------------------------------------------
N
S
D
M
R
R
G
---
N
T
S
V
H
I
A
F
-
D
K
D
T
A
I
R
T
G
H
F
-------
L
L
A
--
R
A
-
L
-----
Q
N
I
-
A
T
------------------
I
N
N
-----------
S
K
F
H
Q
I
F
S
K
T
I
L
E
V
C
F
G
E
F
D
Q
M
A
D
R
-----------
F
N
---
Y
P
V
S
-
F
T
A
Y
L
R
R
I
N
R
---------
K
T
--
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
-
S
T
Y
H
I
K
Q
--
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
LG
K
P
V
G
S
------
D
I
R
N
G
H
--------------------------
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
Q
-
D
D
---
D
-
K
---
L
E
A
V
-
V
K
---
H
L
T
--
S
T
-------
S
-------
D
----------
D
E
V
Y
Q
Y
I
V
S
----
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
----
A
K
Y
H
L
S
----------------------------
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
-------
I
----------
H
E
K
M
L
K
R
V
Y
--
44
Fugue
44.88
15%
6
- C2 -
-
1FYE
-
PEPE_SALTY
A:
[1-229]
-----------------------------------------------------------------------
M
E
L
L
L
-
L
S
N
-
S
T
-----
L
P
G
K
A
W
L
E
H
A
L
P
L
I
A
N
Q
L
N
G
R
R
S
A
V
F
I
P
F
-
A
G
V
-
T
Q
T
W
D
----
E
Y
T
D
K
T
A
E
V
L
A
P
L
G
V
---
N
V
T
G
I
--
H
R
V
A
D
-----------
P
L
A
A
I
E
K
---
A
E
I
I
I
V
G
G
-
G
N
T
F
Q
L
L
K
E
S
R
ERGLLAP
M
A
D
--
R
V
-
K
RGA--
L
Y
I
-
G
W
SAGANLACPTIRTTNDMP
I
V
D
P
N
G
F
D
A
L
D
L
F
P
L
Q
I
N
P
H
F
T
N
T
R
E
Q
R
I
R
E
L
L
V
V
A
P
E
L
T
V
I
G
L
P
E
G
N
--------
W
I
Q
V
S
N
G
Q
A
V
L
G
G
P
---------
N
T
--
T
W
V
F
K
A
G
E
E
A
V
A
L
E
A
G
H
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------