@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PERM_HUMAN: (2020-02-02 )
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320--.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570....-...580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGV
P
F
F
S
S
L
R
C
M
V
DLGPCWAG
G
L
T
A
E
M
K
L
L
L
A
L
A
G
L
L
A
I
LATPQPSEGAAP
A
V
L
GEV
D
T
S
L
V
L
S
S
M
E
E
A
K
Q
L
V
D
K
A
Y
K
E
R
R
E
S
I
K
Q
R
L
RSGSA
S
P
M
E
L
L
S
Y
F
KQ
P
V
A
A
T
R
T
A
V
R
A
A
D
Y
L
H
V
A
L
D
L
L
E
R
K
L
R
S
L
W
RRPFN
V
T
DVLTPA
Q
L
N
V
LSKSSGCAYQDVGVTCPEQDKYR
T
I
T
GMCNNRRSPTLGASN
R
A
F
V
R
WLPAEYEDGFSLPYGWTPGVKRNG
F
P
V
A
L
A
R
A
VS
N
E
I
V
RFPTDQLT
P
D
Q
E
RS
L
M
F
M
Q
W
G
Q
L
L
DHDLDFTPEPAAR
A
S
F
V
TGVNCE
T
S
CVQQPPC
F
P
L
KIPPNDPRIKNQAD
C
I
P
F
F
RSCPACPGS--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
MVYGSE
E
P
L
A
R
N
L
R
N
M
S
N
QL
G
L
L
A
V
N
Q
RFQDNG
R
A
LLPFDNLHDDPCLLTNRSAR
I
P
C
F
LAGDTRSSEM
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
SLNPRW
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
YRDYLPLVL
G
P
T
A
M
R
K
Y
L
P
T
YRSYNDSV
D
P
R
I
A
N
V
F
T
N
A
F
RY
G
H
T
L
I
Q
P
F
M
F
R
LDNRYQPMEPNPRV
P
L
S
R
V
F
F
A
S
W
R
V
VLEGG
I
D
P
I
L
R
G
L
MAT
P
A
KLNRQNQI
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
IGLDLPALNMQRSRDHGLP
G
Y
N
A
W
R
R
FCGLPQ
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
QYGTPN
N
I
D
I
W
MGGV
S
E
P
L
K
RKGR
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
KLRDGDR
F
W
WENEG
V
F
S
M
Q
Q
R
Q
A
L
A
Q
ISL
P
R
I
I
CDNTG
I
T
T
VSKN
N
I
F
MSNSYPRDFVNCSTLPALNLASWREAS
21
HHSearch
95.96
100%
-59
- C3 -
-
5MFA
15
?
A:
[109-696]
------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
A
Y
Q
D
V
G
V
T
C
P
E
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
A
A
R
A
S
F
V
T
G
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
-
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
2
PsiBlast_PDB
95.76
99%
-59
- C3 -
-
5MFA
15
?
A:
[109-696]
------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
A
Y
Q
D
V
G
V
T
C
P
E
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
A
A
R
A
S
F
V
T
G
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
-
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
4
PsiBlast_PDB
95.32
99%
-63
- C3 -
-
6AZP
4
?
A:
[1-577]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
E
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
A
A
R
A
S
F
V
T
G
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
--
1
PsiBlast_PDB
95.03
100%
-62
- C3 -
-
6BMT
4
PERM_HUMAN
A:
[166-744]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
P
E
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
A
A
------
G
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
3
PsiBlast_PDB
94.72
99%
-61
- C3 -
-
5UZU
5
PERM_HUMAN
A:
[1-578]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
E
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
A
A
R
A
S
F
V
T
G
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
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M
P
E
L
T
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M
H
T
L
L
L
R
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H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
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L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
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F
T
N
A
F
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Y
G
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F
M
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N
R
Y
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V
P
L
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F
A
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W
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V
L
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G
G
I
D
P
I
L
R
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L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
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W
W
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N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
11
PsiBlast_PDB
82.21
99%
-85
- C3 -
-
3ZS0
4
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
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D
T
R
S
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M
P
E
L
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T
L
L
L
R
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H
N
R
L
A
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L
K
S
L
N
P
R
W
D
G
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R
L
Y
Q
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A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
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P
N
P
R
V
P
L
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R
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F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
18
PsiBlast_PDB
81.93
99%
-85
- C3 -
-
1D5L
2
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
20
PsiBlast_PDB
81.80
99%
-85
- C3 -
-
1DNW
4
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
16
PsiBlast_PDB
81.80
99%
-82
- C3 -
-
1D2V
2
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
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L
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D
D
P
C
L
L
T
N
R
S
A
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A
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D
T
R
S
S
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M
P
E
L
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M
H
T
L
L
L
R
E
H
N
R
L
A
T
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L
K
S
L
N
P
R
W
D
G
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R
L
Y
Q
E
A
R
K
I
V
G
A
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V
Q
I
I
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Y
R
D
Y
L
P
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L
G
P
T
A
M
R
K
Y
L
P
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Y
R
S
Y
N
D
S
V
D
P
R
I
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F
T
N
A
F
R
Y
G
H
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F
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L
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N
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Y
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V
P
L
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F
F
A
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W
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V
V
L
E
G
G
I
D
P
I
L
R
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L
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A
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P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
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V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
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Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
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R
K
G
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L
L
A
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I
I
G
T
Q
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L
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D
G
D
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F
W
W
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N
E
G
V
F
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M
Q
Q
R
Q
A
L
A
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I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
12
PsiBlast_PDB
81.75
99%
-85
- C3 -
-
3ZS1
4
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
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F
L
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P
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T
L
L
L
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N
R
L
A
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L
K
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L
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P
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L
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A
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I
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Y
L
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L
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L
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P
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A
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Y
L
P
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Y
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Y
N
D
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I
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A
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D
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-
M
R
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L
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L
P
A
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R
S
R
D
H
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L
P
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Y
N
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L
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Q
P
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L
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L
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N
L
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A
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K
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N
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L
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A
L
A
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L
P
R
I
I
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N
T
G
I
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T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
10
PsiBlast_PDB
81.70
99%
-84
- C3 -
-
3F9P
3
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
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E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
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N
G
R
A
L
L
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F
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N
L
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C
L
L
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R
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A
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L
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P
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L
L
L
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L
K
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L
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A
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A
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Y
L
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A
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Y
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P
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M
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L
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A
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S
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Y
N
A
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L
P
Q
P
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L
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L
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N
L
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A
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K
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N
N
I
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I
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G
V
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P
L
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R
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L
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I
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L
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D
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W
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V
F
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A
L
A
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S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
15
PsiBlast_PDB
81.52
99%
-83
- C3 -
-
1CXP
3
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
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P
L
A
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N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
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F
Q
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N
G
R
A
L
L
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F
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N
L
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D
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L
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R
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A
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P
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L
L
L
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R
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L
K
S
L
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L
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A
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I
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A
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I
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R
D
Y
L
P
L
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L
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P
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A
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R
K
Y
L
P
T
Y
R
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Y
N
D
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D
P
R
I
A
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N
A
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Y
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N
R
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P
L
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A
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V
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G
G
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A
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A
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L
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Q
N
Q
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A
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D
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I
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R
L
F
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-
M
R
I
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L
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L
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A
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R
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R
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L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
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G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
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Y
G
T
P
N
N
I
D
I
W
M
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G
V
S
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P
L
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R
K
G
R
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G
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L
L
A
C
I
I
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T
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K
L
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D
G
D
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W
W
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N
E
G
V
F
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M
Q
Q
R
Q
A
L
A
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I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
14
PsiBlast_PDB
81.52
99%
-82
- C3 -
-
5WDJ
12
?
B:
[2-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
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R
S
A
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F
L
A
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D
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P
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L
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M
H
T
L
L
L
R
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H
N
R
L
A
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L
K
S
L
N
P
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W
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R
L
Y
Q
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A
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K
I
V
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A
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Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
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F
T
N
A
F
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Y
G
H
T
L
I
Q
P
F
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N
R
Y
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P
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P
L
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A
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V
L
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G
G
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D
P
I
L
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L
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A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
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V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
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T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
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R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
13
PsiBlast_PDB
81.52
99%
-84
- C3 -
-
4C1M
5
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
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D
D
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C
L
L
T
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R
S
A
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L
L
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N
R
L
A
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L
K
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L
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A
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I
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A
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Y
L
P
L
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L
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P
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A
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Y
L
P
T
Y
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Y
N
D
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D
P
R
I
A
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N
A
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L
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I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
7
PsiBlast_PDB
81.40
99%
-84
- C3 -
-
5QJ3
14
?
B:
[3-466]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
--
9
PsiBlast_PDB
81.32
100%
-90
- C3 -
-
1MHL
3
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
19
PsiBlast_PDB
81.26
99%
-83
- C3 -
-
1DNU
6
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
17
PsiBlast_PDB
81.10
99%
-83
- C3 -
-
1D7W
2
?
C:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
5
PsiBlast_PDB
81.08
100%
-86
- C3 -
-
4EJX
3
?
D:
[1-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
A
-
6
PsiBlast_PDB
81.05
99%
-88
- C3 -
-
5QJ2
12
?
B:
[2-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
R
E
--
23
HHSearch
80.20
56%
-7
- C3 -
-
3R4X
10
PERL_BOVIN
A:
[4-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
C
G
A
P
V
P
L
V
K
C
D
E
N
S
P
Y
R
T
I
T
G
D
C
N
N
R
R
S
P
A
L
G
A
A
N
R
A
L
A
R
W
L
P
A
E
Y
E
D
G
L
A
L
P
F
G
W
T
Q
R
K
T
R
N
G
F
R
V
P
L
A
R
E
V
S
N
K
I
V
G
Y
L
D
E
E
G
V
L
D
Q
N
R
S
L
L
F
M
Q
W
G
Q
I
V
D
H
D
L
D
F
A
P
E
T
E
L
G
S
N
E
H
S
K
T
Q
C
E
E
Y
C
I
Q
G
D
N
C
F
P
I
M
F
P
K
N
D
P
K
L
K
T
Q
G
K
C
M
P
F
F
R
A
G
F
V
C
P
T
P
PY
Q
S
L
A
R
E
Q
I
N
A
V
T
S
F
L
D
A
S
L
V
Y
G
S
E
P
S
L
A
S
R
L
R
N
L
S
S
P
L
G
L
M
A
V
N
Q
E
A
W
D
H
G
L
A
Y
L
P
F
N
N
K
K
P
S
P
C
E
F
I
N
T
T
A
R
V
P
C
F
L
A
G
D
F
R
A
S
E
Q
I
L
L
A
T
A
H
T
L
L
L
R
E
H
N
R
L
A
R
E
L
K
K
L
N
P
H
W
N
G
E
K
L
Y
Q
E
A
R
K
I
L
G
A
F
I
Q
I
I
T
F
R
D
Y
L
P
I
V
L
G
S
E
M
Q
K
-
W
I
P
P
Y
Q
G
Y
N
N
S
V
D
P
R
I
S
N
V
F
T
F
A
F
R
F
G
H
M
E
V
P
S
T
V
S
R
L
D
E
N
Y
Q
P
W
G
P
E
A
E
L
P
L
H
T
L
F
F
N
T
W
R
I
I
K
D
G
G
I
D
P
L
V
R
G
L
L
A
K
K
S
K
L
M
N
Q
D
K
M
V
T
S
E
L
R
N
K
L
F
Q
P
T
H
K
I
H
G
F
D
L
A
A
I
N
L
Q
R
C
R
D
H
G
M
P
G
Y
N
S
W
R
G
F
C
G
L
S
Q
P
K
T
L
K
G
L
Q
T
V
L
K
N
K
I
L
A
K
K
L
M
D
L
Y
K
T
P
D
N
I
D
I
W
I
G
G
N
A
E
P
M
V
E
R
G
R
V
G
P
L
L
A
C
L
L
G
R
Q
F
Q
Q
I
R
D
G
D
R
F
W
W
E
N
P
G
V
F
T
E
K
Q
R
D
S
L
Q
K
V
S
F
S
R
L
I
C
D
N
T
H
I
T
K
V
P
L
-
H
A
F
Q
A
N
N
Y
P
H
D
F
V
D
C
S
T
V
D
K
L
D
L
S
P
W
A
S
R
E
8
PsiBlast_PDB
79.42
100%
-87
- C3 -
-
1MYP
1
?
C:
[2-463]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
C
E
T
S
C
V
Q
Q
P
P
C
F
P
L
K
I
P
P
N
D
P
R
I
K
N
Q
A
D
C
I
P
F
F
R
S
C
P
A
C
P
G
S
--
N
I
T
I
R
N
Q
I
N
A
L
T
S
F
V
D
A
S
M
V
Y
G
S
E
E
P
L
A
R
N
L
R
N
M
S
N
Q
L
G
L
L
A
V
N
Q
R
F
Q
D
N
G
R
A
L
L
P
F
D
N
L
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
C
F
L
A
G
D
T
R
S
S
E
M
P
E
L
T
S
M
H
T
L
L
L
R
E
H
N
R
L
A
T
E
L
K
S
L
N
P
R
W
D
G
E
R
L
Y
Q
E
A
R
K
I
V
G
A
M
V
Q
I
I
T
Y
R
D
Y
L
P
L
V
L
G
P
T
A
M
R
K
Y
L
P
T
Y
R
S
Y
N
D
S
V
D
P
R
I
A
N
V
F
T
N
A
F
R
Y
G
H
T
L
I
Q
P
F
M
F
R
L
D
N
R
Y
Q
P
M
E
P
N
P
R
V
P
L
S
R
V
F
F
A
S
W
R
V
V
L
E
G
G
I
D
P
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
N
Q
I
A
V
D
E
I
R
E
R
L
F
E
Q
V
-
M
R
I
G
L
D
L
P
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
G
L
P
Q
P
E
T
V
G
Q
L
G
T
V
L
R
N
L
K
L
A
R
K
L
M
E
Q
Y
G
T
P
N
N
I
D
I
W
M
G
G
V
S
E
P
L
K
R
K
G
R
V
G
P
L
L
A
C
I
I
G
T
Q
F
R
K
L
R
D
G
D
R
F
W
W
E
N
E
G
V
F
S
M
Q
Q
R
Q
A
L
A
Q
I
S
L
P
R
I
I
C
D
N
T
G
I
T
T
V
S
K
N
N
I
F
M
S
N
S
Y
P
R
D
F
V
N
C
S
T
L
P
A
L
N
L
A
S
W
----
31
Fugue
17.84
95%
34
- C3 -
-
1MHL
1
PERM_HUMAN
A:
[3-106]
------------------------------------------------------------------
C
P
E
--
Q
D
K
Y
R
T
I
T
G
M
C
N
N
R
R
S
P
T
L
G
A
S
N
--------------------------------------------------------------------------------------------------
R
A
F
V
R
W
L
P
A
E
Y
E
D
G
F
S
L
P
Y
G
W
T
P
G
V
K
R
N
G
F
P
V
A
L
A
R
A
V
S
N
E
I
V
R
F
P
T
D
Q
L
T
P
D
Q
E
R
S
L
M
F
M
Q
W
G
Q
L
L
D
H
D
L
D
F
T
P
E
P
--------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------