@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PI42A_HUMAN: (2020-02-02 )
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80......----..90........100.......110.......120.......130.......140.......150.......160....-.-..170.......180.......190.......200.......210.......220.......230.......240........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MATPGNL
G
S
S
V
L
A
SKTK
T
K
K
K
H
F
V
A
Q
K
V
K
L
FRAS
D
P
L
L
S
V
L
M
W
GVNHSINELSH
V
Q
I
P
V
M
LMPDD
F
K
A
Y
S
K
I
KVDNHLFNKENMPSH----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
RFGI
D
D
Q
D
F
Q
N
S
LTRSAPLPN
D
S
Q
ARSG
A
R
FHTSYD
K
R
Y
I
I
K
TI
T
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
Y
I
-
V
-
E
CH
G
I
T
L
L
P
Q
F
L
G
M
Y
R
LNVD
G
V
E
I
Y
V
I
V
T
R
N
V
F
S
H
R
L
S
V
Y
R
KYDLKGSTVAREAS
D
K
E
K
A
KELPTLKDNDFINE-G
Q
K
I
Y
IDDNN
K
K
V
F
L
E
K
L
K
K
D
V
E
F
L
A
Q
L
K
LM
D
Y
S
L
L
V
G
IH
D
V
E
R
A
E
Q
E
EVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNI
D
V
Y
G
I
K
CHENSPR
K
E
V
Y
F
M
A
I
I
D
I
L
T
HY
D
A
K
K
K
A
A
H
A
A
K
T
V
KHGAGAE
I
S
TV
N
P
E
Q
Y
S
K
R
F
L
D
F
I
G
H
ILT
1
PsiBlast_PDB
97.06
98%
-111
- C5 -
-
2YBX
-
PI42A_HUMAN
A:
[20-394]
------------------------------
F
Q
S
M
D
P
L
L
S
V
L
M
W
G
V
N
H
S
I
N
E
L
S
H
V
Q
I
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
M
P
S
H
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
F
Q
N
S
L
T
R
S
A
P
L
P
N
D
-----
G
A
R
F
H
T
S
Y
D
K
R
Y
I
I
K
T
I
T
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
Y
I
-
V
-
E
C
H
G
I
T
L
L
P
Q
F
L
G
M
Y
R
L
N
V
D
G
V
E
I
Y
V
I
V
T
R
N
V
F
S
H
R
L
S
V
Y
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
E
L
P
T
L
K
D
N
D
F
I
N
E
-
G
Q
K
I
Y
I
D
D
N
N
K
K
V
F
L
E
K
L
K
K
D
V
E
F
L
A
Q
L
K
L
M
D
Y
S
L
L
V
G
I
H
D
V
E
R
A
E
Q
E
E
V
E
C
--------------------------------
P
L
A
P
G
E
F
D
P
N
I
D
V
Y
G
I
K
C
H
E
N
S
P
R
K
E
V
Y
F
M
A
I
I
P
I
L
T
H
Y
D
A
K
K
-------------------
V
N
P
E
Q
Y
S
K
R
F
L
D
F
I
G
H
I
L
-
14
PsiBlast_PDB
91.92
77%
-113
- C5 -
-
3X05
2
PI42B_HUMAN
A:
[10-393]
---------------------------
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
--------
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
M
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
P
-----------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
6
PsiBlast_PDB
90.67
78%
-105
- C5 -
-
3X03
2
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
S
-------
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
-------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
5
PsiBlast_PDB
90.63
78%
-110
- C5 -
-
3X02
4
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
-
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
-----------------------------
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
P
------------------------
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
7
PsiBlast_PDB
90.36
78%
-115
- C5 -
-
3X04
3
PI42B_HUMAN
A:
[10-393]
---------------------------
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
------------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
--------------------------
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
13
PsiBlast_PDB
90.31
77%
-111
- C5 -
-
3X0A
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
L
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
P
------------------------
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
8
PsiBlast_PDB
90.19
77%
-117
- C5 -
-
3X07
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
----------
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
A
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
-
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
---------------------------
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
10
PsiBlast_PDB
90.17
77%
-118
- C5 -
-
3X0B
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
--------
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
--
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
A
D
I
L
T
------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
11
PsiBlast_PDB
90.15
77%
-110
- C5 -
-
3X0C
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
A
D
I
L
T
------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
4
PsiBlast_PDB
89.78
78%
-111
- C5 -
-
3X01
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
S
--------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
--
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
---------------------------
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
9
PsiBlast_PDB
89.62
77%
-118
- C5 -
-
3X08
3
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
A
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
12
PsiBlast_PDB
89.52
77%
-110
- C5 -
-
3X09
3
PI42B_HUMAN
A:
[10-393]
---------------------------
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
L
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
--
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
-------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
15
PsiBlast_PDB
89.20
77%
-117
- C5 -
-
3X06
4
PI42B_HUMAN
A:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
M
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
----------------------------
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
-------------------------
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
37
Fugue
87.92
80%
-91
- C5 -
-
1BO1
-
PI42B_HUMAN
A:
[34-416]
----------------------------
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
----
I
N
S
D
S
Q
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
------------------------------
E
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
A
------------------
G
A
E
I
S
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
2
PsiBlast_PDB
86.97
78%
-90
- C5 -
-
1BO1
-
PI42B_HUMAN
A:
[34-416]
----------------------------
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
S
D
S
Q
----
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
-
E
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
Q
E
E
M
E
V
E
E
R
A
E
D
E
------------------------------
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
L
T
------------------
A
G
A
E
I
S
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
22
HHSearch
83.04
77%
-52
- C5 -
-
3X01
1
PI42B_HUMAN
B:
[9-393]
--------------------------
K
V
K
L
F
R
A
S
E
P
I
L
S
V
L
M
W
G
V
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
L
M
P
D
D
F
K
A
Y
S
K
I
K
V
D
N
H
L
F
N
K
E
N
L
P
S
R
----
F
K
F
K
E
Y
C
P
M
V
F
R
N
L
R
E
R
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
N
---------
R
F
L
T
T
Y
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
E
M
H
N
I
L
K
K
Y
H
Q
F
I
-
V
E
C
H
G
N
-
T
L
L
P
Q
F
L
G
M
Y
R
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
K
-----
R
E
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
N
E
-
G
Q
-
L
H
V
G
--
S
K
K
N
F
L
E
K
L
K
R
D
V
E
F
L
A
Q
L
K
I
M
D
Y
S
L
L
V
G
I
H
D
V
D
R
A
E
-------------------------------------
R
F
F
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
S
P
-
K
E
V
Y
F
M
A
I
I
D
I
L
---------------------------
N
P
E
Q
Y
S
K
R
F
N
E
F
M
S
N
I
L
T
16
PsiBlast_PDB
71.53
64%
-145
- C5 -
-
2GK9
-
PI42C_HUMAN
A:
[45-417]
----------------------------------
D
P
L
V
G
V
F
L
W
G
V
A
H
S
I
N
E
L
S
Q
V
P
P
P
V
M
L
L
P
D
D
F
K
A
S
S
K
I
K
V
N
N
H
L
F
H
R
E
N
L
P
S
H
----
F
K
F
K
E
Y
C
P
Q
V
F
R
N
L
R
D
R
F
G
I
D
D
Q
D
Y
L
V
S
L
T
R
N
P
P
--
S
E
S
E
------
F
L
I
S
Y
D
R
T
L
V
I
K
E
V
S
S
E
D
I
A
D
M
H
S
N
L
S
N
Y
H
Q
Y
I
-
V
-
K
C
H
G
N
T
L
L
P
Q
F
L
G
M
Y
R
V
S
V
D
N
E
D
S
Y
M
L
V
M
R
N
M
F
S
H
R
L
P
V
H
R
K
Y
D
L
K
G
-----------------
T
L
R
D
M
D
--
N
K
-
N
Q
K
V
Y
I
----
K
K
I
F
L
E
K
L
K
R
D
V
E
F
L
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
D
I
-------------------------------------------------------------------
E
V
Y
F
M
G
L
I
D
I
L
---------------------------
H
P
E
Q
Y
A
K
R
F
L
D
F
I
T
----
23
HHSearch
68.41
65%
-81
- C5 -
-
2GK9
-
PI42C_HUMAN
B:
[45-417]
----------------------------------
D
P
L
V
G
V
F
L
W
G
V
A
H
S
I
N
E
L
S
Q
V
P
P
P
V
M
L
L
P
D
D
F
K
A
S
S
K
I
K
V
N
N
H
L
F
H
R
E
N
L
P
S
H
----
F
K
F
K
E
Y
C
P
Q
V
F
R
N
L
R
D
R
F
G
I
D
D
Q
D
Y
L
V
S
L
T
R
N
P
P
S
--
E
S
E
-----
R
F
L
I
S
Y
D
R
T
L
V
I
K
E
V
S
S
E
D
I
A
D
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
-
C
H
G
N
-
T
L
L
P
Q
F
L
G
M
Y
R
V
S
V
D
N
E
D
S
Y
M
L
V
M
R
N
M
F
S
H
R
L
P
V
H
R
K
Y
D
L
K
G
-----------------
T
L
R
D
M
D
F
L
N
K
-
N
Q
K
V
Y
I
G
E
E
E
K
K
I
F
L
E
K
L
K
R
D
V
E
F
L
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
D
I
-------------------------------------------------------------------
E
V
Y
F
M
G
L
I
D
I
L
---------------------------
H
P
E
Q
Y
A
K
R
F
L
D
F
I
T
----
20
PsiBlast_PDB
66.57
31%
-14
- C5 -
-
5E3T
1
?
A:
[3-364]
--------------------------------
T
S
S
A
L
K
G
A
I
Q
L
G
I
T
H
S
V
G
S
L
S
Q
K
P
E
R
D
V
L
M
-
Q
D
F
E
V
V
E
S
I
F
F
P
S
Q
--
G
S
S
S
T
P
G
H
HHGD
F
K
F
K
T
Y
A
P
I
A
F
R
Y
F
R
E
M
F
G
I
R
P
D
D
Y
L
Y
S
L
C
N
E
P
L
I
E
L
S
N
----
G
S
L
F
Y
V
S
S
D
D
E
F
I
I
K
T
V
Q
H
K
E
A
E
F
L
Q
T
L
L
P
G
Y
F
M
N
L
-
N
-
Q
-
N
M
R
T
L
L
P
K
F
Y
G
L
Y
C
V
Q
A
D
G
K
N
I
R
I
V
V
M
N
N
L
L
P
R
A
V
P
M
H
L
K
F
D
L
K
G
S
T
Y
K
R
R
A
S
P
K
E
R
S
K
G
V
P
T
Y
K
D
L
D
F
M
Q
D
M
P
E
G
I
L
L
E
N
D
H
Y
T
A
L
S
R
T
M
Q
R
D
C
R
V
L
Q
S
F
K
I
M
D
Y
S
L
L
V
G
I
H
I
L
H
-----------------------------------------------------
M
G
G
I
P
A
F
N
S
K
G
E
R
L
L
V
F
I
G
I
I
D
I
L
Q
S
Y
R
--------------------
S
V
H
R
P
S
F
Y
A
D
R
F
Q
K
F
M
-----
18
PsiBlast_PDB
65.79
31%
-5
- C5 -
-
6CMW
1
?
A:
[13-374]
--------------------------------
T
S
S
A
L
K
G
A
I
Q
L
G
I
T
H
S
V
G
S
L
S
Q
K
P
E
R
D
V
L
M
-
Q
D
F
E
V
V
E
S
I
F
F
P
S
Q
--
G
S
S
S
T
P
G
H
HHGD
F
K
F
K
T
Y
A
P
I
A
F
R
Y
F
R
E
M
F
G
I
R
P
D
D
Y
L
Y
S
L
C
N
E
P
L
I
E
L
S
N
P
G
A
S
G
S
L
F
Y
V
S
S
D
D
E
F
I
I
K
T
V
Q
H
K
E
A
E
F
L
Q
T
L
L
P
G
Y
F
M
N
L
-
N
-
Q
-
N
M
R
T
L
L
P
K
F
Y
G
L
Y
C
V
Q
A
D
G
K
N
I
R
I
V
V
M
N
N
L
L
P
R
A
V
P
M
H
L
K
F
D
L
K
G
S
T
Y
K
R
R
A
S
P
K
E
R
S
K
G
V
P
T
Y
K
D
L
D
F
M
Q
D
M
P
E
G
I
L
L
E
N
D
H
Y
T
A
L
S
R
T
M
Q
R
D
C
R
V
L
Q
S
F
K
I
M
D
Y
S
L
L
V
G
I
H
I
L
H
-----------------------------------------------------
M
G
G
I
P
A
F
N
S
K
G
E
R
L
L
V
F
I
G
I
I
D
I
L
Q
S
Y
R
------------------
T
V
S
V
H
R
P
S
F
Y
A
D
R
F
Q
K
F
M
-----