@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2535_HUMAN: (2020-02-03 )
MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDAQGKGLMYRGILDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRSLYYTDTK
Atome Classification :
(20 SA)
--------------------.........10.--.......----------20........30...--...--..40........50........60........70...--------.....80-------.---......---.90......---...100.....-...110.......120.......130.......140...-....150.......----160--........170...-------....180...-.-----...190....-...200---........210...-------------....220--....----.-....---230.......240.....-----..250.......260.......270....-...280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------
M
D
F
L
M
S
G
L
A
AC
G
--
A
C
VFTN
P
----------
L
E
V
V
K
T
R
M
Q
L
QGELQ--AP
G
--
T
Y
Q
R
H
Y
R
N
V
F
H
A
F
I
T
IGKV
D
G
L
A
A
L
Q
KG
L
A
P
A
L
L
Y
Q
F
--------
L
MNGIRL-------G---TYGLAE---AG-
G
Y
L
HTA---EGTHS-P
A
R
S
A
-
A
A
G
A
M
A
G
V
M
G
A
Y
LGS
P
I
Y
M
V
K
T
H
L
Q
A
Q
A
A
S
E
I
AVG
H
Q
Y
K
-HQ
G
M
F
Q
A
L
T
E
I
G
Q
K----HG---
L
V
G
L
W
R
G
A
LGGL
P
R
-------
V
I
VGSS
T
Q
L
C
-
T
-----FS
S
T
K
D
L
L
S
Q-WEIF-P---PQ
S
W
K
L
A
L
V
A
A
M
M
S
-------------
G
I
A
V
V
----LAMA----
P
-
F
D
V
A
---
C
T
R
LYNQPTDAQGK
G
L
M
Y
-----
R
G
I
L
D
A
L
L
Q
T
ARTE
G
I
F
G
M
Y
K
GIG
A
S
Y
FR-L
G
P
H
T
I
L
S
L
F
F
W
D
Q
L
R
S
L
YYTDTK
2
PsiBlast_PDB
74.78
23%
-42
- C3 -
-
4C9J
4
ADT3_YEAST
A:
[29-317]
--------------------
I
N
F
L
M
G
G
V
S
A
A
I
--
A
K
T
A
A
S
P
----------
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
--
K
Q
G
--
T
L
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
PTQALNFA
F
K
D
K
I
K
L
-----------
M
F
G
F
K
K
---
E
E
-
G
Y
G
K
W
F
---
A
G
-------
N
L
-
A
S
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
-----
A
R
------
Q
F
N
G
L
T
D
V
Y
K
K
TLKS
D
G
---
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
F
D
S
L
K
--------------------------
F
L
L
-------------
G
W
V
V
T
----
T
G
A
S
TCSY
P
-
L
D
T
V
---
R
R
R
M
M
M
----
T
S
G
Q
A
V
K
Y
-----
N
G
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
M
--
Y
D
Q
L
Q
M
I
L
F
----
7
PsiBlast_PDB
73.82
22%
-35
- C3 -
-
2C3E
4
ADT1_BOVIN
A:
[10-293]
---------------------
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
A
P
----------
I
E
R
V
K
L
L
L
Q
V
Q
-
H
A
S
--
K
Q
I
--
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
FKD
K
Y
K
Q
I
F
---
L
G
-
G
V
D
R
H
K
---
Q
F
W
R
Y
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
A
---
Q
R
E
-
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-------
I
I
I
Y
R
A
A
Y
F
G
-
V
-----
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
H
-
I
---
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
-------------
G
--------
L
V
S
Y
----
P
-
F
D
T
V
---
R
R
R
M
M
M
Q
-
S
G
R
K
G
A
D
I
M
Y
-----
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
L
V
L
Y
--
D
E
I
---------
8
PsiBlast_PDB
73.62
23%
-70
- C3 -
-
6GCI
6
?
A:
[17-306]
--------------------
V
D
F
L
M
G
G
V
S
A
A
V
--
S
K
T
A
A
A
P
----------
I
E
R
I
K
L
L
V
Q
N
Q
D
E
M
I
--
K
A
G
--
R
L
D
R
R
Y
N
G
I
I
D
C
F
R
R
T
T
A
D
E
G
L
M
A
L
W
R
G
N
T
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
R
D
K
F
K
---
A
M
F
G
Y
K
K
D
K
---
D
G
Y
A
K
W
M
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
N
D
A
K
S
A
K
G
G
G
A
R
-
Q
-
F
N
G
L
I
D
V
Y
R
K
T
L
A
S
----
D
G
---
I
A
G
L
Y
R
G
F
G
P
S
V
A
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
Y
D
S
I
K
P
V
V
-----
L
V
-
G
---
P
L
A
N
N
--
F
L
A
S
F
L
L
-------------
G
W
C
V
T
TGAG
I
A
S
Y
----
P
-
L
D
T
V
---
R
R
R
M
M
M
----
T
S
----
K
Y
-----
K
S
S
I
D
A
F
R
Q
I
I
A
K
E
G
V
K
S
L
F
K
G
A
G
A
N
I
L
R
G
V
A
G
A
G
V
L
S
I
Y
--
D
Q
L
K
I
L
L
F
----
18
HHSearch
73.09
21%
-63
- C3 -
-
6GCI
6
?
A:
[18-306]
---------------------
D
F
L
M
G
G
V
S
A
A
V
--
S
K
T
A
A
A
P
----------
I
E
R
I
K
L
L
V
Q
N
Q
D
E
M
I
--
K
A
G
--
R
L
D
R
R
Y
N
G
I
I
D
C
F
R
R
T
T
A
D
E
G
L
M
A
L
W
R
G
N
T
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
R
D
K
F
K
---
A
M
-
F
G
Y
K
K
D
KD-
G
Y
A
K
W
-
M
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
N
D
A
K
S
A
K
G
G
-
G
A
R
Q
-
F
N
G
L
I
D
V
Y
R
K
T
L
A
S
----
D
G
---
I
A
G
L
Y
R
G
F
G
P
S
V
A
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
Y
D
S
I
K
P
V
V
L
V
-
G
P
L
------
A
N
N
F
L
A
S
F
L
L
G
W
C
V
-------------
T
T
G
A
G
----
I
A
S
Y
----
P
-
L
D
T
V
---
R
R
R
M
M
M
T
S
--------
K
Y
-----
K
S
S
I
D
A
F
R
Q
I
I
A
K
E
G
V
K
S
L
F
K
G
A
G
A
N
I
L
R
-
G
V
A
G
A
G
V
-
L
S
I
Y
D
Q
L
K
I
L
L
F
----
6
PsiBlast_PDB
71.10
22%
-27
- C3 -
-
1OKC
10
ADT1_BOVIN
A:
[10-293]
---------------------
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
A
P
----------
I
E
R
V
K
L
L
L
Q
V
Q
-
H
A
S
--
K
Q
I
--
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
FKD
K
Y
K
Q
I
F
---
L
G
-
G
V
D
R
H
K
---
Q
F
W
R
Y
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
A
---
Q
R
E
-
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-------
I
I
I
Y
R
A
A
Y
F
G
-
V
-----
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
H
-
I
---
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
-------------
G
--------
L
V
S
Y
----
P
-
F
D
T
V
---
R
R
R
M
M
M
Q
-
S
G
R
K
G
A
D
I
M
Y
-----
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
L
V
L
Y
--
D
E
I
---------
19
HHSearch
70.51
21%
-60
- C3 -
-
4C9G
5
ADT2_YEAST
A:
[26-309]
---------------------
D
F
L
M
G
G
V
S
A
A
V
--
A
K
T
A
A
S
P
----------
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
--
K
Q
G
--
T
L
D
R
K
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
K
D
K
I
K
---
A
M
-
F
G
F
K
K
E
E--
G
Y
A
K
W
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
---------
R
Q
-
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
----
D
G
---
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
Y
D
S
L
--------------------
L
A
S
F
L
L
G
W
V
V
-------------
T
T
G
A
S
----
T
C
S
Y
----
P
-
L
D
T
V
---
R
R
R
M
M
M
T
S
G
Q
----
A
V
K
Y
-----
D
G
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
-
G
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
--------
5
PsiBlast_PDB
70.29
22%
-30
- C3 -
-
4C9H
5
ADT2_YEAST
A:
[25-313]
--------------------
I
D
F
L
M
G
G
V
S
A
A
V
--
A
K
T
A
A
S
P
----------
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
--
K
Q
G
--
T
L
D
R
K
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
AFKDKIK
A
---
M
F
G
F
K
K
---
E
E
-
G
Y
A
K
W
F
---
A
G
-------
N
L
-
A
S
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
-------
A
R
-
Q
-
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
----
D
G
---
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
Y
D
S
L
K
-----------------------
L
A
S
F
L
L
-------------
G
W
V
V
T
----
T
G
A
S
TCSY
P
-
L
D
T
V
---
R
R
R
M
M
M
----
T
S
G
Q
A
V
K
Y
-----
D
G
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
I
S
M
Y
--
D
Q
L
Q
M
I
L
F
----
21
HHSearch
68.15
20%
-36
- C3 -
-
2C3E
4
ADT1_BOVIN
A:
[9-293]
--------------------
K
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
A
P
----------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
--
Q
I
---
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
K
D
K
Y
K
---
Q
I
-
F
L
G
G
V
D
RHK
Q
F
W
R
Y
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
---
A
Q
R
E
-
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-------
I
I
I
Y
R
A
A
Y
F
G
-
V
-----
Y
D
T
A
K
G
M
L
P
D
-
P
K
N
-------
V
H
I
I
V
S
W
M
I
A
Q
T
V
-------------
T
A
V
A
G
----
L
V
S
Y
----
P
-
F
D
T
V
---
R
R
R
M
M
M
Q
S
G
R
K
G
-
A
D
I
M
Y
-----
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-
G
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
---------
3
PsiBlast_PDB
67.53
23%
-40
- C3 -
-
4C9Q
5
ADT3_YEAST
A:
[29-317]
--------------------
I
N
F
L
M
G
G
V
S
A
A
I
--
A
K
T
A
A
S
P
----------
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
--
K
Q
G
--
T
L
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
PTQALNFA
F
K
D
K
I
K
L
-----------
M
F
G
F
K
K
----
E
-
G
Y
G
K
W
F
---
A
G
-------
N
L
-
A
S
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
-----
A
R
------
Q
F
N
G
L
T
D
V
Y
K
K
TLKS
D
G
---
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
F
D
S
L
K
P
L
--------------------
F
L
A
S
F
L
L
-------------
G
W
V
V
T
----
T
G
A
S
TCSY
P
-
L
D
T
V
---
R
R
R
M
M
M
----
T
S
G
Q
A
V
K
Y
-----
N
G
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
M
--
Y
D
Q
L
Q
M
I
L
F
----
34
Fugue
67.49
17%
-91
- C3 -
-
5B5Z
-
?
A:
[15-277]
---------------------
N
V
T
L
T
A
V
K
K
A
------
F
P
D
A
----------
L
T
N
A
E
L
V
A
M
V
S
K
R
L
S
--
Q
F
G
---
Y
H
K
Y
N
T
L
L
A
T
S
L
C
S
---
D
E
V
T
R
P
L
E
Q
D
F
G
E
V
Y
G
K
H
F
--------
T
M
G
G
L
-----------------------
A
-
G
F
P
F
------------
G
G
L
T
-
G
F
G
A
M
A
G
A
I
P
D
G
-
G
S
C
L
L
I
Y
G
S
H
V
G
V
S
----------------------------------------
W
E
G
K
W
G
T
V
A
R
-------
R
G
R
E
K
G
G
A
C
C
G
S
-----
A
V
A
A
A
Q
A
V
T
Q
-
A
Y
Q
A
-
T
---
P
L
D
A
Q
Q
G
Y
V
R
D
M
L
R
-------------
P
Y
A
A
T
----
L
S
E
A
----
E
---
D
V
---
M
V
T
L
P
V
S
V
Y
D
A
Q
Q
K
--
L
V
-----
T
R
I
L
D
E
G
S
N
H
I
D
G
D
G
Q
I
A
V
V
G
G
I
Q
I
N
T
P
K
E
M
S
D
F
F
V
V
R
R
F
C
I
R
D
S
S
G
N
M
V
E
N
F
M
22
HHSearch
66.88
20%
-33
- C3 -
-
1OKC
10
ADT1_BOVIN
A:
[9-293]
--------------------
K
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
A
P
----------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
--
Q
I
---
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
K
D
K
Y
K
---
Q
I
-
F
L
G
G
V
D
RHK
Q
F
W
R
Y
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
---
A
Q
R
E
-
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-------
I
I
I
Y
R
A
A
Y
F
G
-
V
-----
Y
D
T
A
K
G
M
L
P
D
-
P
K
N
-------
V
H
I
I
V
S
W
M
I
A
Q
T
V
-------------
T
A
V
A
G
----
L
V
S
Y
----
P
-
F
D
T
V
---
R
R
R
M
M
M
Q
S
G
R
K
G
-
A
D
I
M
Y
-----
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-
G
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
---------
4
PsiBlast_PDB
66.58
22%
-35
- C3 -
-
4C9G
5
ADT2_YEAST
A:
[25-309]
--------------------
I
D
F
L
M
G
G
V
S
A
A
V
--
A
K
T
A
A
S
P
----------
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
--
K
Q
G
--
T
L
D
R
K
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
AFKDKIK
A
---
M
F
G
F
K
K
---
E
E
-
G
Y
A
K
W
F
---
A
G
-------
N
L
-
A
S
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
--------
R
-
Q
-
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
----
D
G
---
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
-------
I
V
V
Y
R
G
L
Y
F
G
-
M
-----
Y
D
S
L
------------------------
L
A
S
F
L
L
-------------
G
W
V
V
T
----
T
G
A
S
TCSY
P
-
L
D
T
V
---
R
R
R
M
M
M
----
T
S
G
Q
A
V
K
Y
-----
D
G
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
I
S
M
Y
--
D
Q
L
Q
--------
29
Fugue
66.18
20%
-19
- C3 -
-
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------DQALSFL
K
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
A
P
----------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
---
Q
I
--
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
--------
P
T
Q
A
L
N
F
-------
A
---
F
K
D
K
Y
K
QIF
L
G
-
G
V
D
R
H
K
---
Q
F
W
R
Y
-
F
A
G
N
L
-
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
---
A
A
Q
R
E
-
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-------
I
I
I
Y
R
A
A
Y
F
G
-
V
-----
Y
D
T
A
K
G
M
L
P
D
-
P
K
-------
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
-------------
T
A
V
A
G
----
L
V
S
Y
----
P
-
F
D
T
V
---
R
R
R
M
M
M
Q
-
S
G
R
K
G
A
D
I
M
Y
-----
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
----------
30
Fugue
60.37
19%
-58
- C3 -
-
4S1B
2
PGPH_LISM4
A:
[5-220]
--------------------------------------------------------
H
P
L
L
K
K
I
L
M
K
--
A
P
G
--
T
Y
H
H
---
S
M
M
V
A
N
L
A
E
A
C
A
D
K
I
G
A
N
S
L
L
V
R
V
G
C
F
Y
H
-----------------------------
D
I
G
K
---
T
L
-
R
P
P
Y
F
V
---
E
N
Q
I
N
-
P
H
D
R
L
-
T
P
E
Q
S
R
D
I
I
L
S
H
T
K
D
G
A
E
I
L
K
E
N
H
M
P
Q
P
I
I
D
I
A
L
Q
H
----------------------
H
G
TTL
L
K
Y
F
Y
F
K
A
K
E
T
N
P
D
-------
V
----
K
E
A
D
Y
-
R
-----
Y
S
G
P
K
---------------
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
-------------
V
E
A
A
V
----
R
S
S
-------------------
T
E
P
T
M
A
K
I
T
E
I
I
D
-----
G
I
I
K
D
R
F
L
D
--------
G
Q
F
T
E
C
D
I
T
----
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
Q
R
I
Q
1
PsiBlast_PDB
56.26
27%
-39
- C3 -
-
2LCK
-
UCP2_MOUSE
A:
[15-295]
--------------------
V
K
F
L
G
A
G
T
A
A
C
I
--
A
D
L
I
T
F
P
----------
L
D
T
A
K
V
R
L
Q
I
Q
G
E
S
Q
GL
V
R
T
--
A
A
S
A
Q
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
--------
S
F
A
S
V
R
I
-------
G
---
L
Y
---
D
---
S
V
-
K
Q
F
Y
T
K
---
G
S
E
H
A
-
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
----
G
G
G
R
R
-
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
----
E
G
---
I
R
G
L
W
K
G
T
S
P
N
V
A
R
-------
N
A
I
V
N
C
A
E
L
V
-
T
-----
Y
D
L
I
K
D
T
L
L
K
-
A
N
L
M
-----
T
D
D
L
P
C
H
F
T
S
A
F
G
A
-------------
G
F
C
T
T
----
V
I
A
S
----
P
-
V
D
V
V
---
K
T
R
Y
M
N
---
S
A
L
G
Q
---
Y
-----
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
-
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
--------
25
HHSearch
55.89
19%
-40
* C3 *
-
2C3E
4
ADT1_BOVIN
A:
[4-203]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
-
F
L
K
D
F
-
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
Q
I
S
-
A
E
K
Q
-
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
----
Q
G
---
F
L
S
F
W
R
G
N
L
A
N
V
I
R
-------
Y
F
P
T
Q
A
L
N
F
A
-
F
-----
K
D
K
Y
K
Q
I
F
L
G
-
G
V
D
R
-
H
KQF
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
-------------
G
A
T
S
L
----
C
F
V
Y
----
P
-
L
D
F
A
---
R
T
R
L
A
A
D
V
G
K
G
A
-
A
Q
R
E
F
-----
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
D
---
37
Fugue
55.38
13%
-28
- C4 -
-
2GEK
1
PIMA_MYCS2
A:
[21-393]
MRIGMVCPYSFDVPGGVQSH
V
L
Q
L
A
E
V
L
R
D
A
G
HE
V
S
V
L
A
P
A
SPHVKLPDYV
V
S
G
G
K
A
V
F
G
P
A
T
H
R
K
--
V
K
K
--
W
I
A
E
G
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
L
A
L
Q
A
A
E
G
P
I
V
A
T
F
H
--------
T
S
T
T
K
S
L
-------
T
---
L
S
V
F
Q
G
--------
I
L
R
P
---
Y
H
E
K
I
-
I
G
R
I
A
-
V
S
D
L
A
R
R
W
Q
M
E
A
L
G
S
D
A
V
E
I
P
N
G
V
D
V
A
S
F
A
D
A
P
L
L
D
G
Y
P
R
E
G
R
T
V
L
F
L
G
R
Y
D
E
P
----
R
K
---
G
M
A
V
L
L
A
A
L
P
K
L
V
A
RFPDVEI
L
I
V
G
R
G
D
E
D
E
-
L
-----
R
E
Q
A
G
D
L
A
G
H
-
L
R
F
L
-
G
---
Q
V
D
D
A
T
K
A
S
A
M
R
S
A
DVYCAPHLGGESF
G
I
V
L
V
----
E
A
M
A
AGT-
A
-
V
V
A
S
---
D
L
D
A
F
R
R
V
L
A
D
G
D
A
G
R
L
V
PVDDA
D
G
M
A
A
A
L
I
G
I
L
E
D
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
H
-
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
K
20
HHSearch
55.00
27%
-44
- C3 -
-
2LCK
-
UCP2_MOUSE
A:
[15-301]
--------------------
V
K
F
L
G
A
G
T
A
A
C
I
--
A
D
L
I
T
F
P
----------
L
D
T
A
K
V
R
L
Q
I
Q
G
E
S
Q
--
G
L
V
RT
A
A
S
A
Q
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
--------
S
F
A
S
V
R
I
-------
G
---
L
Y
D
S
V
K
---
Q
F
-
Y
T
K
G
-----
S
E
H
A
G
-
I
G
S
R
L
-
L
A
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
----
G
G
R
R
-
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
----
E
G
---
I
R
G
L
W
K
G
T
S
P
N
V
A
R
-------
N
A
I
V
N
C
A
E
L
V
-
T
-----
Y
D
L
I
K
D
T
L
L
K
-
A
N
L
M
-----
T
D
D
L
P
C
H
F
T
S
A
F
G
A
-------------
G
F
C
T
T
----
V
I
A
S
----
P
-
V
D
V
V
---
K
T
R
Y
M
N
S
A
L
------
G
Q
Y
-----
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
-
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
--
40
Fugue
54.86
16%
-56
- C4 -
-
5JJO
-
?
A:
[4-268]
--------------------------------------
L
R
P
----------
F
I
C
V
N
E
K
D
H
L
P
S
L
D
P
--
Q
A
D
--
A
W
Y
R
E
A
V
A
L
A
K
P
D
-
T
L
R
P
W
D
R
I
V
D
L
Y
S
K
A
V
E
R
G
H
W
K
A
--------
M
H
N
L
A
S
L
-------
Y
---
R
T
G
W
K
D
---
T
Q
-
K
A
L
D
L
Y
---
Q
K
M
I
D
-
L
K
V
P
Q
-
G
F
Y
D
M
A
A
M
I
G
--------------
N
R
A
G
V
K
N
P
A
T
D
G
L
-----
T
F
L
D
K
A
A
S
L
G
N
P
----
P
A
---
L
T
E
L
G
R
L
Y
I
Y
V
A
G
Q
-------
D
E
L
G
L
K
Y
T
N
C
-
A
AGQGY
A
P
A
N
Y
E
L
A
M
Y
-
Y
R
L
V
-
A
HNY
P
K
A
A
G
Y
Y
L
L
A
A
S
Q
G
-------------
N
D
D
A
A
----
F
F
M
S
----
G
V
F
D
K
T
SPD
V
D
R
M
W
Y
A
P
D
E
K
L
H
K
--
L
Y
-----
D
G
I
Y
D
Q
L
A
A
D
P
D
L
-----
R
F
P
N
L
I
K
D
H
-
P
-
L
P
P
H
P
-------
T
Q
G
Y
D
A
D
R
P
D
--
23
HHSearch
54.72
19%
-73
- C3 -
-
4C9G
5
ADT2_YEAST
A:
[24-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
F
-
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
K
Q
G
T
L
D
R
K
-
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
----
E
G
---
V
I
S
F
W
R
G
N
T
A
N
V
I
R
-------
Y
F
P
T
Q
A
L
N
F
A
-
F
-----
K
D
K
I
K
A
M
F
G
F
-
K
K
E
E
G
Y
---
A
K
W
F
A
G
N
L
A
S
G
G
A
A
-------------
G
A
L
S
L
----
L
F
V
Y
----
S
-
L
D
Y
A
---
R
T
R
L
A
A
D
S
-------
R
Q
F
-----
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
-
I
V
V
Y
R
G
L
Y
F
G
M
Y
D
S
L
K
P
L
L
L
T
---