@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A0AWX6_ARTS2: (2019-01-25 )
MDESGGEARAYMLGSGIVVKTQRPHRLRPRTSLEKEAHVLSLLAGPLAGRIPRLFGYGREDTAAGPVEFLVMSRIRGCAALHAGLPAREALLASLADVLRSVHAADVTGLRDSGLLPADVDSAALRGRLQLGFADACDGFAAHRDRYAGAGAPERIAIAAVDALAGLTDESPVLLHSNPGPTHVFVGDGGLCTGLIDFGDAYASHPALDLRSWPDPADRIVLHEAYTGGRPTTRGFDAVWTVVMILADLNAMLHRADLAEAAGRDLALRLAQL
Atome Classification :
(26 SA)
----------------------.....-....10..---......20........30........40.....--.--..50........60........70........80..-----.-----.-----.-----..--.90........100.......110....----...120.......130.......140......-.150.......160..--..---...170.......180..-....---.190.......200.......210--...-------.--....220.....-----..230-.--......240.......250.--......260..-------.....270.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------MDESG-GE
A
R
A
Y
M
L---GS
G
I
V
V
KTQRPHRLRPRTS
L
E
K
E
A
H
V
L
S
L
L
A
G
P
--
L
--AGRI
P
R
L
FGYGREDTAA
G
P
V
E
F
L
V
M
S
R
I
R
G
C
A
A
L
HA-----G-----L-----
P
-----
A
R
--
E
A
L
L
A
S
L
A
D
V
L
R
S
V
H
A
A
DVTGLRDSGLL----PADV
D
S
A
A
LRG
R
L
QLGFADAC
D
G
F
A
A
H
R
D
RYA-GAGAP
E
R
I
A
I
A
A
V
D
A
L
--AG---LTDES
P
V
L
L
HSNPGP
T
H
V
-
F
VGD---GG
L
C
T
G
L
I
DF
G
D
A
YASHPALDLR---SWP-------D--PA
D
R
I
V
L
H
EAYT-----GGRPT-T--R
G
F
D
A
V
W
T
V
V
M
I
L
A
D
L
N
A
M
L
--
H
R
A
D
L
A
E
AA
G
R
-------
D
L
A
L
R
LAQL---
26
HHSearch
77.40
20%
-11
- C5 -
-
3TDW
1
?
A:
[29-281]
-------------------------
E
G
-
F
R
N
Y
A
I
L
V
---
N
G
D
W
V
F
R
F
P
K
S
Q
Q
--
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
--
V
--
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
S
---
D
G
N
P
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
-----
G
M
A
V
LP
D
-----
D
-----
A
K
--
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
-----
P
V
--------
T
N
L
K
N
K
I
L
L
L
S
E
A
V
E
D
Q
V
F
P
L
--
L
D
E
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
--
M
T
HPV
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
-
L
T
N
L
NSR
Q
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
---
Y
L
L
-------
E
DC
G
E
L
F
T
R
Q
V
M
A
Y
R
-----
G
E
V
D
L
-
D
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
--
R
A
R
---------------------------
3
PsiBlast_PDB
75.58
20%
-37
- C5 -
-
3SG8
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.14
20%
-39
- C5 -
-
5C4K
1
?
A:
[50-252]
-------------------------
K
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.70
20%
-34
- C5 -
-
6CD7
-
?
A:
[31-233]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.30
20%
-37
- C5 -
-
4N57
1
?
A:
[50-252]
-------------------------
K
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.07
20%
-34
- C5 -
-
3SG9
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.81
20%
-59
- C- -
-
4DBX
-
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.33
20%
-27
- C5 -
-
4DFB
1
?
A:
[51-255]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.27
20%
-32
- C5 -
-
4DTA
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
M
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
55
Fugue
73.06
17%
-1
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--AKMRIS
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
-
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
T
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
G
K
--
L
----
P
V
P
K
V
L
H
F
E
R
H
D
----
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-----
Y
-----
E
-----
D
EQ---
S
P
--
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
L
----
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
A
D
V
D
--------
C
E
N
W
E
-
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
--
T
E
---
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
----
D
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
---
F
C
V
-------
R
--
S
I
R
E
D
I
G
E
E
Q
Y
V
-----
E
L
F
F
D
-
L
--
L
G
I
K
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------
16
PsiBlast_PDB
72.86
20%
-31
- C5 -
-
4DE4
1
?
A:
[51-253]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.53
20%
-34
- C5 -
-
5C4L
-
?
A:
[50-252]
-------------------------
K
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.47
20%
-30
- C5 -
-
4DFU
3
?
A:
[51-253]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.30
20%
-29
- C5 -
-
4DTB
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
Y
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
24
HHSearch
72.13
17%
-8
- C- -
-
3N4U
-
?
A:
[29-283]
------------------------
G
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
P
K
H
S
R
--
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
-
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
L
N
N
LP
K
-----
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
---
K
S
N
----
L
V
---
L
-----
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
R
E
--
L
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
--
L
E
NEI
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
-
L
F
D
T
E--
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
L
M
EDDEEY-
G
--
M
E
F
V
S
K
I
L
N
H
Y
K
-----
H
K
D
I
P
-
T
V
-
L
E
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
--
E
Y
G
---------------------------
8
PsiBlast_PDB
72.02
20%
-30
- C5 -
-
4DT8
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.01
20%
-32
- C- -
-
3N4U
-
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
56
Fugue
71.86
16%
-3
* C5 *
-
3HAM
3
?
A:
[1-299]
MVNLD
A
E
I
Y
E
H
L
N
K
Q
IKIN
E
L
R
Y
L
S
S
G
-
D
D
S
D
T
F
L
C
---
N
E
Q
Y
V
V
K
V
--
P
K
R
D
S
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K-
L
--
S
Y
Q
I
P
A
V
V
Y
Q
S
D
R
--------
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
-----
Q
-----
Y
-----
H
K
LS
E
K
E
K
--
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
----------
V
S
L
F
S
D
A
L
V
N
K
K
D
K
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
E
Q
L
L
-
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
A
V
---
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
R
----
N
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
CLL
D
C
S
-------
T
--
D
D
F
G
K
E
F
G
R
K
V
L
K
Y
Y
QH
K
A
P
E
V
-
A
--
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
-------
E
L
L
Q
T
Q
A
E
M
FIF
9
PsiBlast_PDB
71.71
20%
-27
- C5 -
-
4DT9
1
?
A:
[30-232]
-------------------------
E
G
-
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
-
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-----
L
-----
L
N
N
LP
K
Q
-----
S
Q
--
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D
F
R
E
K
I
N
E
D
N
K
K
I
K
K
L
L
S
---------------
R
E
L
-
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
--
E
N
EI-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
------------------------------------------------------------------------------------------
32
HHSearch
69.19
17%
6
- C5 -
-
3HAM
3
?
A:
[25-277]
------------------------
S
S
G
-
D
D
S
D
T
F
L
C
---
N
E
Q
Y
V
V
K
V
P
K
R
D
S
--
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K-
L
--
S
Y
Q
I
P
A
V
V
Y
Q
--------
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
K
L
S
-----
E
-----
K
-----
E
K
--
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
---
V
S
------
L
F
S
D
A
--
L
V
N
K
K
D
K
-
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
--
L
N
NAV
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
R
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
---
C
L
L
DCSTDDF
G
--
K
E
F
G
R
K
V
L
K
Y
Y
Q
-----
H
K
A
P
E
-
V
A
-
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
--
E
R
K
---------------------------
36
HHSearch
69.10
16%
-1
- C5 -
-
4DCA
1
?
A:
[47-298]
-------------------------
S
G
-
D
D
S
D
T
F
L
C
---
N
E
Q
Y
V
V
K
V
P
K
R
D
S
--
V
R
I
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
C
K-
L
--
S
Y
Q
I
P
A
V
V
Y
Q
--------
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
-----
Q
Y
H
K
LS
E
-----
K
-----
E
K
--
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
---
V
S
-----
L
F
S
D
-
A
L
V
--
N
K
K
D
K
-
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
--
L
S
NAV
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
R
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
---
C
L
L
D
CSTDDF
G
--
K
E
F
G
R
K
V
L
K
Y
Y
Q
-----
H
K
A
P
E
-
V
A
-
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
--
E
R
K
---------------------------
45
SP3
68.89
15%
-8
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---AKMRIS
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
T
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
G
K
--
L
--
P
V
--
P
K
V
L
H
F
E
R
H
D
G
----
W
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-----
Y
-----
E
-----
D
-----
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
----------
S
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
A
D
V
D
C
--
E
N
W
E
-
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
--
T
E
---
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
D
---
G
-
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
------------------------------------------------
Y
D
I
A
F
C
V
R
S
I
R
E
D
I
G
E
E
Q
--
Y
V
E
L
F
F
D
L
L
G
I
KPD
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F--
28
HHSearch
67.92
15%
-19
- C5 -
-
5IQI
1
AACA_STAAU
C:
[35-285]
------------------------
G
S
G
-
Y
D
S
V
A
Y
L
V
---
N
N
E
Y
I
F
K
T
K
F
S
T
N
--
K
K
K
G
F
A
K
E
K
A
I
Y
N
F
L
N
T
N
LE
T
--
N
V
K
I
P
N
I
E
Y
S
Y
I
S
----
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
-----
I
Y
S
T
MS
E
-----
E
-----
E
Q
--
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
---
S
E
C
----
T
I
D
N
-
K
Q
---
N
V
L
E
E
-
Y
I
L
L
R
E
T
I
Y
N
D
L
------
T
D
I
E
K
D
Y
I
E
S
F
M
E
R
L
--
N
A
TT-
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
-
L
L
D
G
---
N
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
---
Y
L
L
EDSEEEI
G
--
T
N
F
G
E
D
I
L
R
M
Y
G
-----
N
I
D
I
E
K
A
--
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
--
K
N
----------------------------
31
HHSearch
67.47
16%
-15
- C5 -
-
5IQC
2
AACA_STAAU
A:
[35-285]
------------------------
G
S
G
-
Y
D
S
V
A
Y
L
V
---
N
N
E
Y
I
F
K
T
K
F
S
T
N
--
K
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
N
--
L
ET
N
V
K
I
P
N
I
E
Y
S
Y
I
S
----
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
-----
I
Y
S
T
MS
E
-----
E
-----
E
Q
--
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
---
S
E
C
----
T
I
D
-
N
K
Q
N
---
V
L
E
E
-
Y
I
L
L
R
E
T
I
Y
N
D
L
T
------
D
I
E
K
D
Y
I
E
S
F
M
E
R
L
--
N
A
TT-
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
-
L
L
D
G
---
N
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
---
Y
L
L
EDSEEEI
G
--
T
N
F
G
E
D
I
L
R
M
Y
G
-----
N
I
D
I
E
K
A
--
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
--
K
N
----------------------------
39
HHSearch
64.34
16%
6
- C5 -
-
3TM0
2
KKA3_ENTFL
A:
[24-260]
-------------------------
G
M
-
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
T
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
G
------
K
L
P
V
P
K
V
L
H
F
E
R
H
----
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-----
Y
-----
E
DE---
Q
-----
S
P
--
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
---
P
Y
T
----
N
S
---
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
A
D
V
D
C
E
--
N
W
--
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
--
K
T
E
--
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
---
F
C
V
R
S
I
R
E
D
I
G
E-
E
Q
Y
V
E
L
F
F
D
L
L
G
-----
I
K
--
P
-
D
--
W
E
K
I
K
Y
Y
I
L
L
D
-----------------------------------------
40
HHSearch
63.86
16%
8
- C5 -
-
1L8T
2
KKA3_ENTFL
A:
[24-260]
-------------------------
G
M
-
S
P
A
K
V
Y
K
L
VGE
N
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
T
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
G
------
K
L
P
V
P
K
V
L
H
F
E
R
H
----
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-----
Y
-----
E
DE---
Q
-----
S
P
--
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
---
P
Y
T
----
N
S
---
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
A
D
V
D
C
E
--
N
W
--
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
--
K
T
E
--
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
---
F
C
V
R
S
I
R
E
D
I
G
E-
E
Q
Y
V
E
L
F
F
D
L
L
G
-----
I
K
--
P
-
D
--
W
E
K
I
K
Y
Y
I
L
L
D
-----------------------------------------