@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : C7PUJ6_CHIPD: (2019-01-27 )
MSFQFQEVFPAERTAAINVAIETAFGGAKLEDVNLLTGGLSTAPVYKLTVDNRPYVMKLDVLHVAATVDLSEKVALAAQAGIAPALLYRNVESGITISDFVENKPIRSIFTGEVLADRLAGAVKKIHAVPYTIPGDDLKATIDHILTGFRQTNILSGEIPDECLRRYAEVREIYPWQDTDKVFSHNDLNPSNILCDGQDIWVIDWNTAFVNDRYVDLAGVANFFIHMPEQEAVFLKAYFGDELDEYKKARFYVMRQISRIIYALMMLHLAAKAKPADYKHDQDVAGVLLRDVGPAIGAGKLSLATYEGQFMYGKALMHEAVQQMRTARFEASLAMLKG
Atome Classification :
(21 SA)
-----------------------------.........10........20.....----.-.------.30......-..40........50.---------.----------..---------.....---60.-..--.--..-.--.70........-80--..-.-......90.-------..------.....100..-..-...---------110--.-----------.--.....---..120......--.-----130.-....---------------.---------------..140.......150----------...-----------...--..------.------------160-----..-.....170..------.--..---..180.......190....---.-------.-.200---.-......210.......220-...---------.------------------.------------------..230.......240.--------------.----------.....250.......260.......270.......280.......290.-----......300.......310.......320.......330......-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------MSF
Q
F
Q
EVFPAER
T
A
A
I
N
V
A
I
E
TAFG----G-
A
------
K
L
E
D
V
N
L
LT-GGLSTA
P
V
Y
K
L
T
V-D---------N----------R
P
---------
Y
V
M
K
L
---
D
V
L
-
H
V
--
A
--
A
T-V--D
L
S
E
K
V
A
L
A
A
Q-A---G
I
-
A
-
P
A
L
L
Y
R
NVE-------SG------
I
T
I
S
D
F
VENK-P
I
-
R
S
I---------F----
T
-----------
G
--
E
V
L
A
D
---
R
L
A
G
A
V
K
K
I
H
A--V-----PY-T-IP
G
D
---------------
D
---------------
L
K
A
T
I
D
H
I
L
T
G
F
R
------------QTN-----------ILS--GE------I------------
P
D
E
-----
C
L
-
R
R
Y
A
E
V
R
EIY------P--WQ---DTDKVFSHNDL
N
P
S
N
I
L
CD---G-------
Q
-
D
I
W
V
---
I
-DWN
T
A
F
VNDRY
V
D
L
A
G
V
A
N
-
F
F
I
---------H------------------M------------------PEQ
E
A
V
F
L
K
A
Y
FGD
E
L
--------------
D
----------
E
Y
K
K
A
R
F
Y
V
M
R
Q
I
S
R
I
I
Y
A
L
M
M
L
H
L
AAKAKPADYKH
D
Q
D
V
A
G
V
L
L
R
DVG-----PAIGAG
K
L
S
L
A
TYE
G
Q
F
M
Y
G
K
A
L
M
H
E
A
V
Q
Q
M
R
T
A
R
F
E
A
S
L
AMLKG-----
57
HHSearch
80.62
18%
-31
- C4 -
-
1NW1
-
CKA2_CAEEL
B:
[54-398]
-------------------------------------------
E
R
A
H
M
L
C
A
R
F
L
G
----
G
-
A
WKTVPL
E
H
L
R
I
S
R
I
K
-
G
G
M
S
N
-
M
L
F
L
C
R
L
-
S
EVYPPIRNE
P
----------
N
K
---------
V
L
L
R
V
---
Y
F
N
-
P
E
--
T
E
-
S
H
-
L
V
-
A
E
S
V
I
F
T
L
L
S
E
-
R
---
H
L
-
G
-
P
K
L
Y
G
I
F
S
---------
G
------
G
R
L
E
E
Y
I
P
S
R
-
P
L
-
S
C
H
---------
E
----
I
S
----------
L
--
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
--
L
-----
E
V
-
P
-
I
W
K
E
PD-------------
Y
---------------
L
C
E
A
L
Q
R
W
L
K
Q
L
T
------------
G
T
V
DAE
H
R
F
-----
D
L
P
--
E
E
CGVSSV
N
------------
C
L
D
-----
L
A
-
R
E
L
E
F
L
R
A
H
I
------
S
--
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
---------
R
L
V
L
---
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-
E
W
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
---------------------------------------------------------------------------
56
HHSearch
79.76
18%
-32
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[54-398]
-------------------------------------------
E
R
A
H
M
L
C
A
R
F
L
G
----
G
-
A
WKTVPL
E
H
L
R
I
S
R
I
K
-
G
G
M
S
N
-
M
L
F
L
C
R
L
-
S
EVYPPIRNE
P
----------
N
K
---------
V
L
L
R
V
---
Y
F
N
-
P
E
--
T
E
-
S
H
-
L
V
-
A
E
S
V
I
F
T
L
L
S
E
-
R
---
H
L
-
G
-
P
K
L
Y
G
I
F
S
---------
G
------
G
R
L
E
E
Y
I
P
S
R
-
P
L
-
S
C
H
---------
E
----
I
S
----------
L
--
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
--
L
-----
E
V
-
P
-
I
W
K
E
PD-------------
Y
---------------
L
C
E
A
L
Q
R
W
L
K
Q
L
T
------------
G
T
V
DAE
H
R
F
-----
D
L
P
--
E
E
CGVSSV
N
------------
C
L
D
-----
L
A
-
R
E
L
E
F
L
R
A
H
I
------
S
--
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
---------
R
L
V
L
---
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-
E
W
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
---------------------------------------------------------------------------
68
HHSearch
77.25
16%
-8
- C4 -
-
5FTG
11
CHKA_HUMAN
A:
[8-351]
-----------------------------------------
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
----
G
A
W
RGLRE-
D
E
F
H
I
S
V
I
R
-
G
G
L
S
N
-
M
L
F
Q
C
S
L
-
P
---------
D
TTATLGDEP-
R
K
---------
V
L
L
R
L
---
Y
G
---------
E
A
-
M
V
-
L
E
S
V
M
F
A
I
L
A
E
-
R
---
S
L
-
G
-
P
K
L
Y
G
I
F
P
Q
---------------
G
R
L
E
Q
F
I
P
S
R
-
R
L
-
D
T
E
---------
E
----
L
S----------
L
--
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
--
M
-----
K
M
-
P
-
F
N
K
E
---------------
P
KW-------------
L
F
G
T
M
E
K
Y
L
K
E
V
L
------------
R
I
K
FTE
E
S
R
I
K
---
K
L
H
--
K
L
------
L
------------
S
Y
N
-----
L
P
-
L
E
L
E
N
L
R
S
L
L
------
E
--
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
GRENSEK
Q
-
K
L
M
L
---
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
-
E
W
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
----------------------------------------------------------------------------
54
HHSearch
76.58
19%
-9
- C4 -
-
3DXQ
-
?
B:
[4-264]
-------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
----
L
-
A
------
G
Y
T
G
P
L
E
R
L
-
G
G
L
T
N
-
L
V
F
R
A
------------------------
G
D
---------
L
C
L
R
I
---
P
-----------
N
-
R
A
-
N
E
A
V
A
A
R
E
A
A
K
-
A
---
G
V
-
S
-
P
E
V
L
H
V
D
P
A
-------
T
G
------
V
M
V
T
R
Y
I
A
G
A
Q
T
M
-
S
P
E
---------
K
----
F
-----------
K
T
R
P
G
S
P
A
---
R
A
G
E
A
F
R
K
L
H
G
--
S
-----
G
A
-
V
-
F
P
F
R
F
--------------
E
---------------
L
F
A
M
I
D
D
Y
L
K
V
L
S
------------
T
K
N
-----------
V
T
L
--
P
A
------
G
------------
Y
H
D
-----
V
V
-
R
E
A
G
G
V
R
S
A
L
------
A
--
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
T
---
G
-------
E
-
R
M
W
I
---
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
-
E
G
K
---------
F
------------------
N
------------------
A
N
Q
D
E
E
L
M
R
A
Y
F
G
G
E
A
--------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
---------------------------------------------------------------------------
46
SP3
76.25
13%
-11
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
---------------------G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
GAWK
T
-
V
------
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
-
S
---------
E
VYPPIRNEP-
N
K
---------
V
L
L
R
V
---
Y
F
N
-
P
E
--
T
--
E
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
-
R
---
H
L
-
G
-
P
K
L
Y
G
I
--
F
-------
S
G
------
G
R
L
E
E
Y
I
P
S
R
-
P
L
-
S
C
H
---------
E
I
---
S
-----------
L
--
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
--
L
EV---
P
I
-
W
-
K
E
P
D
---------------
Y
---------------
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
P
E
E
C
-----------
G
V
S
--
S
V
------
N
------------
C
L
D
-----
L
A
-
R
E
L
E
F
L
R
A
H
I
------
S
--
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
-------
R
--
L
V
L
---
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-
E
W
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
-
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
----------------------------------------------
67
HHSearch
73.78
16%
-24
- C4 -
-
5FUT
10
CHKA_HUMAN
A:
[8-351]
-----------------------------------------
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
----
G
A
W
RGLRE-
D
E
F
H
I
S
V
I
R
-
G
G
L
S
N
-
M
L
F
Q
C
S
L
-
P
---------
D
TTATLGDEP-
R
K
---------
V
L
L
R
L
---
Y
G
-------G
A
E
A
-
M
V
-
L
E
S
V
M
F
A
I
L
A
E
-
R
---
S
L
-
G
-
P
K
L
Y
G
I
F
P
Q
---------------
G
R
L
E
Q
F
I
P
S
R
-
R
L
-
D
T
E
---------
E
----
L
S----------
L
--
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
--
M
-----
K
M
-
P
-
F
N
K
E
---------------
P
KW-------------
L
F
G
T
M
E
K
Y
L
K
E
V
L
------------
R
I
K
FTE
E
S
R
I
K
---
K
L
H
--
K
L
------
L
------------
S
Y
N
-----
L
P
-
L
E
L
E
N
L
R
S
L
L
------
E
--
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
GRENSEK
Q
-
K
L
M
L
---
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
-
E
W
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
----------------------------------------------------------------------------
36
Fugue
73.45
14%
-35
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-----------------------------
S
A
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
------------
G
------
I
R
V
D
S
G
L
T
P
-
L
N
S
Y
E
N
R
V
Y
Q
F
Q
D
-
E
---------
D
R---------
R
R
---------
F
V
V
K
F
---
Y
R
P
-
E
R
--
W
--
T
A
-
D
--
Q
I
L
E
E
H
Q
F
A
L
Q
-
L
---
V
N
-
D
-
E
V
P
V
A
A
P
V
A
-------
F
N
------
G
Q
T
L
L
N
H
Q
G
F
-
Y
F
-
A
V
F
PSVGGRQFE
A
----
D
-----------
N
--
I
D
Q
M
E
---
A
V
G
R
Y
L
G
R
M
H
Q
--
T
-----
G
R
-
K
-
Q
L
F
I
HRPTI----------
G
---------------
L
N
E
Y
L
I
E
P
R
K
L
F
E
------------
D
A
T
-----------
L
I
P
--
S
G
------
L
------------
K
A
A
-----
F
L
-
K
A
T
D
E
L
I
A
A
V
------
T
--
A
H
WRE
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
---
D
---------
G
P
M
F
---
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
---------
E
------------------
Q
------------------
R
M
Q
L
E
T
I
I
E
A
Y
--
E
E
F
--------------
S
----------
E
F
D
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
W
A
D
P
A
F
P
K
N
F
------------------------
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
P
M
Y
--------
32
Fugue
73.05
15%
11
- C4 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VS
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
----
P
-
N
------
E
V
D
S
L
E
F
Q
I
-
I
N
G
-
T
N
I
L
I
K
V
K
D
-
M
---------
S
----------
K
Q
---------
A
K
Y
L
I
---
R
L
Y
G
P
T
--
D
--
E
I
-
I
--
N
R
E
R
E
K
K
I
S
C
I
-
L
Y
NK
N
I
-
A
-
K
K
-
I
Y
V
F
F
T
-------
N
G
-------
R
I
E
E
F
M
D
G
Y
-
A
L
S
R
E
D
---------
I
----
K
-----------
N
--
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
--
I
-----
K
L
-
N
-
E
N
L
Y
---------------
K
E
L
Q
V
T
QKVPGTRPSF
L
W
N
T
I
W
K
Y
F
H
L
L
N
------------
E
E
R
K
KICSFDAKA
N
I
L
K
--
L
I
------
D
------------
F
D
V
-----
L
R
-
D
S
I
V
E
V
E
S
L
C
------
K
--
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VGE
G
-------
D
-
S
I
S
F
---
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-
E
Y
A
---------
G
------------------
F
NCDWDLTPS---------
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
---------------------------
D
E
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
F
D
--------------------------------
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
--------------
31
Fugue
70.47
13%
-44
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------G
M
K
E
L
L
S
T
MDLD
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
----
T
-
V
------
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
-
S
---------
E
----------
V
Y
PPIRNEPN
K
V
L
L
R
V
---
Y
F
N
-
P
E
--
T
--
E
S
-
H
--
L
V
A
E
S
V
I
F
T
L
L
-
S
---
E
R
-
H
-
L
G
P
K
L
Y
G
I
F
-------
S
G
------
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
---------
I
----
S
-----------
L
--
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
LE
V
-----
P
I
-
W
-
K
E
P
D
---------------
Y
---------------
L
C
E
A
L
Q
R
W
L
K
Q
L
T
------------
G
T
V
-----------
D
A
E
--
H
R
------
F
D
L
PEECGVSSVN
C
L
D
-----
L
A
-
R
E
L
E
F
L
R
A
H
I
------
S
--
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
-----------
K
-
R
L
V
L
---
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-
E
W
T
----------------------------------------------------------
I
D
Y
D
I
--------------
D
----------
E
A
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
-----
P
F
V
P
V
S
H
F
F
W
G
V
W
-
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
78
HHSearch
70.10
20%
-47
- C4 -
-
5IGI
3
?
A:
[6-283]
---------------------------------------
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
----
L
-
K
------
L
H
G
P
L
T
V
N
E
-
L
G
L
D
Y
-
R
I
V
I
A
T
V
-
D
D--------
G
----------
R
R
---------
W
V
L
R
I
---
P
R
R
-
A
E
--
V
S
-
A
K
-
V
E
-
P
E
A
R
V
L
A
M
L
K
N
-
R
L--
P
F
A
V
-
P
D
W
R
V
A
N
A
E
L
V
A
Y
PML
E
D
------
S
T
A
-
V
I
Q
P
G
S
-
S
T
-
P
D
W
---------
V
VPQ-
D
-----------
S
--
E
V
F
A
E
---
S
F
A
T
A
L
A
A
L
H
A
--
V
-----
P
I
-
S
-
A
A
V
D
---------------
A
GMLIRT
P
T
Q
------
A
R
Q
K
V
A
D
D
V
D
R
V
R
------------
R
E
F
-----------
V
V
N
--
D
K
------
R
------------
L
H
R
-----
W
Q
-
R
W
L
D
D
----
D
------
S
--
S
W
---
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
---
N
T------
E
R
V
S
G
M
---
I
-
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
-
V
F
-----------------------------
G
------------------
E
E
G
L
A
K
L
L
L
T
Y
E
A
A
G
G
--------------
R
V
W
--------
P
R
L
A
H
H
I
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
D
--------------------------------------------------------------------------------
55
HHSearch
69.62
19%
-6
- C- -
-
3DXQ
-
?
A:
[4-264]
-------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
----
L
-
A
------
G
Y
T
G
P
L
E
R
L
-
G
G
L
T
N
-
L
V
F
R
A
------------------------
G
D
---------
L
C
L
R
I
---
P
G
K
-----
Y
--
I
N
-
R
A
-
N
E
A
V
A
A
R
E
A
A
K
-
A
---
G
V
-
S
-
P
E
V
L
H
V
D
P
A
-------
T
G
------
V
M
V
T
R
Y
I
A
G
A
Q
T
M
-
S
P
E
---------
K
----
F
-----------
K
T
R
P
G
S
P
A
---
R
A
G
E
A
F
R
K
L
H
G
--
S
-----
G
A
-
V
-
F
P
F
R
F
--------------
E
---------------
L
F
A
M
I
D
D
Y
L
K
V
L
S
--------------
N
-----------
V
T
L
--
P
A
------
G
------------
Y
H
D
-----
V
V
-
R
E
A
G
G
V
R
S
A
L
------
A
--
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
T
---
G
-------
E
-
R
M
W
I
---
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
-
E
G
K
---------
F
------------------
N
------------------
A
N
Q
D
E
E
L
M
R
A
Y
F
G
G
E
A
--------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
---------------------------------------------------------------------------
58
HHSearch
68.93
18%
7
* C4 *
-
4R7B
-
?
A:
[20-280]
----------------------------------------
H
M
E
K
I
I
K
E
K
I
S
S
L
L
S
----
Q
E
E
------
E
V
L
S
V
E
Q
L
--
G
G
M
T
N
-
Q
N
Y
L
A
K
T
-
T
---------
N
----------
K
Q
---------
Y
I
V
K
F
---
F
G
K
-
G
T
--
E
KL
I
N
-
R
Q
-
D
E
K
Y
N
L
E
L
L
K
D
-
L
---
G
L
D
V
-
K
N
Y
L
-
F
D
I
E
-------
A
G
------
I
K
V
N
E
Y
I
E
S
A
I
T
L
-
D
S
T
---------
S
----------------
I
--
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
H
T
--
S
-----
A
K
-
E
-
L
R
G
E
F--------------
A
---------------
P
F
E
E
I
K
K
Y
E
S
L
I
E
------------
E
Q
-------------
I
P
--
Y
A
------
N
------------
Y
E
S
-----
V
R
-
N
A
V
F
S
L
E
K
R
L
------
A
--
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
---
P
Q------
G
-
R
L
Y
L
---
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
-
E
S
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
S
D
Q
T
-------------------------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-----------------------------------------------------------------------------
59
HHSearch
68.42
18%
4
- C4 -
-
4R78
2
?
A:
[20-280]
----------------------------------------
H
M
E
K
I
I
K
E
K
I
S
S
L
L
S
----
Q
E
E
------
E
V
L
S
V
E
Q
L
--
G
G
M
T
N
-
Q
N
Y
L
A
K
T
-
T
---------
N
----------
K
Q
---------
Y
I
V
K
F
---
F
G
K
-
G
T
--
E
KL
I
N
-
R
Q
-
D
E
K
Y
N
L
E
L
L
K
D
-
L
---
G
L
D
V
-
K
N
Y
L
-
F
D
I
E
-------
A
G
------
I
K
V
N
E
Y
I
E
S
A
I
T
L
-
D
S
T
---------
S
----------------
I
--
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
H
T
--
S
-----
A
K
-
E
-
L
R
G
E
F
--------------
A
---------------
P
F
E
E
I
K
K
Y
E
S
L
I
E
------------
E
Q
-------------
I
P
--
Y
A
------
N
------------
Y
E
S
-----
V
R
-
N
A
V
F
S
L
E
K
R
L
------
A
--
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
---
P
Q------
G
-
R
L
Y
L
---
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
-
E
S
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
S
D
Q
T
-------------------------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-----------------------------------------------------------------------------
77
HHSearch
68.33
20%
-46
- C4 -
-
5IGH
-
?
A:
[6-283]
---------------------------------------
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
----
L
-
K
------
L
H
G
P
L
T
V
N
E
-
L
G
L
D
Y
-
R
I
V
I
A
T
V
-
D
D--------
G
----------
R
R
---------
W
V
L
R
I
---
P
R
R
-
A
E
--
V
S
-
A
K
-
V
E
-
P
E
A
R
V
L
A
M
L
K
N
-
R
L--
P
F
A
V
-
P
D
W
R
V
A
N
A
E
L
V
A
Y
P
ML
E
D
------
S
T
A
M
V
I
Q
P
G
S
-
S
T
-
P
D
W
---------
V
V
P
Q-
D
-----------
S
--
E
V
F
A
E
---
S
F
A
T
A
L
A
A
L
H
A
--
V
-----
P
I
-
S
-
A
A
V
D
---------------
A
G
M
L
I
R
T
P
T
Q
------
A
R
Q
K
V
A
D
D
V
D
R
V
R
------------
R
E
F
-----------
V
V
N
--
D
K
------
R
------------
L
H
R
-----
W
Q
-
R
W
L
D
D
----
D
------
S
--
S
W
---
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
---
N
T------
E
R
V
S
G
M
---
I
-
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
-
V
F
-----------------------------
G
------------------
E
E
G
L
A
K
L
L
L
T
Y
E
A
A
G
G
--------------
R
V
W
--------
P
R
L
A
H
H
I
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
D
--------------------------------------------------------------------------------
63
HHSearch
68.03
18%
-25
- C4 -
-
2QG7
-
?
D:
[110-433]
---------------------------------------------------------------------
S
L
E
F
Q
I
I
N
-
G
G
-
T
N
-
I
L
I
K
V
K
D
-
M
SK-------
Q
----------
A
K
---------
Y
L
I
R
L
---
Y
G
P
-
K
T
--
D
---
N
-
R
E-
R
E
K
K
I
S
C
I
L
Y
N
-
K
---
N
I
-
A
-
K
K
I
Y
V
F
F
T
N
---------------
G
R
I
E
E
F
M
D
G
Y
-
A
L
-
S
R
E
---------
D
----
I
K----------
N
--
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
--
I
-----
K
L
-
N
-
E
N
L
Y
KELQVTQKVPGTRPS
F
---------------
L
W
N
T
I
W
K
Y
F
H
L
L
N
------------
E
E
R
KKICSFDAKAN
I
L
K
--
L
I
------
D
------------
F
D
V
-----
L
R
-
D
S
I
V
E
V
E
S
L
C
------
K
--
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
---
V
G------
D
-
S
I
S
F
---
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-
E
Y
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
D
--------------
E
ELI-------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
---------------------------------------------------------------------------
62
HHSearch
68.03
18%
-23
- C4 -
-
2QG7
-
?
E:
[110-433]
---------------------------------------------------------------------
S
L
E
F
Q
I
I
N
-
G
-
I
T
N
-
I
L
I
K
V
K
D
-
M
SK-------
Q
----------
A
K
---------
Y
L
I
R
L
---
Y
G
P
-
K
T
--
D
EI
I
N
-
R
E-
R
E
K
K
I
S
C
I
L
Y
N
-
K
---
N
I
-
A
-
K
K
I
Y
V
F
F
T
N
---------------
G
R
I
E
E
F
M
D
G
Y
-
A
L
-
S
R
E
---------
D
----
I
K----------
N
--
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
--
I
-----
K
L
-
N
-
E
N
L
Y
KELQVTQKVPGTRPS
F
---------------
L
W
N
T
I
W
K
Y
F
H
L
L
N
------------
E
E
R
KKICSFDAKAN
I
L
K
--
L
I
------
D
------------
F
D
V
-----
L
R
-
D
S
I
V
E
V
E
S
L
C
------
K
--
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
---
V
GG-----
D
-
S
I
S
F
---
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-
E
Y
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
D
--------------
E
ELI-------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
---------------------------------------------------------------------------
61
HHSearch
67.08
15%
-31
- C4 -
-
3C5I
3
?
D:
[11-332]
---------------------------------------
L
T
D
P
L
Y
I
K
K
I
C
L
E
K
V
P
----
E
-
W
NHFTE-
D
N
L
R
V
K
Q
I
L
---
L
T
N
-
Q
L
F
E
V
G
L
-
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
---------
V
L
F
R
I
---
Y
G
K
-
H
V
DE
L
--
Y
N
-
T
I
-
S
E
F
E
V
Y
K
T
M
S
K
-
Y
---
K
I
-
A
-
P
Q
L
L
N
T
F
---------
N
G
------
G
R
I
E
E
W
L
Y
G
D
-
P
L
-
R
I
D
---------
D
L
---
K
-----------
N
--
P
T
I
L
I
---
G
I
A
N
V
L
G
K
F
H
T
--
L
-----
S
R
-
K
-
R
H
L
P
---------------
E
HWDRTP
C
--------
I
F
K
M
M
E
K
W
K
N
Q
L
F
------------
K
Y
K
-----------
N
I
E
KY
N
C
------
D
------------
I
H
K
-----
Y
I
-
K
E
S
D
K
F
I
K
F
M
K
V
Y
S
KS
D
--
N
L
---
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
---
N
-------
K
-
C
L
R
L
---
I
-
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
-
E
T
S
---------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
E
N
R
K
L
F
I
T
A
Y
L
S
N
Y
L
DKVVP---------
T
P
K
L
I
------
D
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
----------------------------------------------------------------------------
2
PsiBlast_PDB
64.06
26%
6
- C- -
-
4H05
-
?
A:
[23-244]
-------------------------------------------------------------------------------
G
A
S
G
A
G
V
Y
R
L
R
G
-
G
---------
G
----------
R
E
---------
L
F
V
K
V
---
A
A
L
-
G
A
--
G
V
-
G
L
-
L
--
G
E
A
E
R
L
V
W
L
A
E
-
V
---
G
I
-
P
----
V
P
R
V
V
E
-------
G
G
G
D
ER
V
A
W
L
V
T
E
A
V
P
G
R
-
P
A
-
S
A
R
---------
W
----
P
-----------
R
--
E
Q
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
--
L
-----
D
W
-
E
R
C
P
F
D
R--------------
S
---------------
L
A
V
T
V
P
Q
A
A
R
A
V
A
------------
E
G
S
-----------
V
D
L
--
E
D
------
L
------------
D
E
E
RKGWS
G
E
-
R
L
L
A
E
L
E
R
T
R
------
P
---
A
---
D
E
D
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
---
P
-------
R
-
T
C
E
V
TGL
I
-
D
V
G
R
V
G
R
A
D
R
H
S
D
L
A
L
V
L
R
-
E
L
A
---------
H
------------------
E
EDPWFG------------
P
E
C
S
A
A
F
L
R
E
Y
--------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
62.75
18%
-63
- C4 -
-
5UXD
2
?
A:
[5-253]
----------------------------------------
E
D
L
D
A
L
L
D
L
A
A
R
H
G
L
----
D
-
L
------
D
G
G
T
L
R
T
E
E
-
I
G
L
D
F
-
R
V
A
F
A
R
A
H
D
---------
G
----------
G
D
---------
W
V
L
R
L
---
P
R
R
-
P
D
--
V
--
L
E
R
A
A
-
V
E
G
R
L
L
A
M
L
A
P
H
L
---
D
V
A
V
-
P
D
W
R
I
S
T
---------
S
E
------
L
I
A
Y
P
L
L
P
G
S
-
P
G
-
L
T
V
---------
A
----
A
DG
E
V
S
W
HVDMA
S
--
T
V
Y
A
R
---
S
L
G
S
V
V
A
Q
L
H
A
--
V
-----
D
A
-
E
-
A
A
A
A
---------------
T
G
I
E
V
R
S
P
A
Q
------
V
R
G
A
W
R
Q
D
L
A
R
V
G
------------
A
E
F
-----------
E
I
------------------------
A
P
A
-----
L
R
-
E
R
W
E
A
W
L
A
D
D
------
G
--
C
W
---
P
G
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
---
D
E------
R
-
I
T
A
V
---
L
-
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
-
S
-----------
A
------------------
P
------------------
S
A
I
F
E
V
A
L
Q
A
Y
A
E
G
G
G
---------------------------------------------------------------------------------------------------------------------------------
45
SP3
62.52
15%
-27
- C4 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
--------------------------------------------
G
S
P
A
A
W
V
E
R
L
F
----
G
-
Y
---------
D
W
A
Q
Q
T
-
I
G
C
S
D
A
A
V
F
R
L
S
A
-
Q
---------
G
----------
R
P
V
--------
L
F
V
K
T
D
--
L
S
G
-
A
L
--
N
--
E
L
-
Q
--
D
E
A
A
R
L
S
W
L
A
T
-
T
---
G
V
-
P
C
A
A
V
L
D
V
V
T
E
-------
A
G
R
D
----
W
L
L
L
G
E
V
P
G
Q
-
D
L
-
L
S
S
H--------
L
----
A
-----------
P
--
A
E
K
V
S
---
I
M
A
D
A
M
R
R
L
H
T
--
L
-----
D
P
A
T
-
C
P
F
D
H--------------
Q
---------------
A
K
H
R
I
E
R
A
R
T
R
M
E
------------
A
G
L
-----------
V
D
Q
--
D
D
------
L
------------
D
E
E
-----
H
Q
G
L
A
P
A
E
L
F
A
R
L
------
K
--
A
R
MPD
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
---
N
-------
G
R
F
S
G
F
---
I
-
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
-
D
I
A
E
E
-------
L
------------------
G
------------------
G
E
W
A
D
R
F
L
V
L
Y
G
I
A
A
P
--------------
D
----------
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
------------------------------------------------------------------------------------------
34
Fugue
61.91
15%
-13
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-----------------------------------------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
----
K
-
Y
------
R
C
V
K
D
T
----
E
G
M
S
P
A
K
V
Y
K
L
V
G
-
E
---------
N
----------
E
N
---------
L
Y
L
K
M
T
D
S
R
Y
K
-
G
T
--
T
--
Y
D
-
V
--
E
R
E
K
D
M
M
L
W
L
E
-
G
---
K
L
-
P
-
V
P
K
V
L
H
F
E
R
H
DG----
W
S
------
N
L
L
M
S
E
A
D
G
V
-
L
C
-
S
E
E
---------
Y
EDEQ
S
-----------
P
--
E
K
I
I
E
---
L
Y
A
E
C
I
R
L
F
H
S
--
I
DISDC
P
Y
-
T
-
N
S
L
D
---------------
S
---------------
R
L
A
E
L
D
Y
L
L
N
N
D
L
------------
A
D
V
-----------
D
C
E
--
N
W
------
E
------------
E
D
T
-----
P
F
-
K
D
P
R
E
L
Y
D
F
L
------
K
T
E
K
P
---
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
---
D
-------
G
-
K
V
S
G
---
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
-
S
I
R
---------
E
------------------
D
------------------
I
G
---------------------------------------------------------------------------
E
E
Q
Y
V
E
L
F
F
D
L
L
G
-----
I
K
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------