@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K2BCP9_9BACT: (2019-01-30 )
MKKNELPIEQIEKINFAVRKGLGTNNWELMSLLSGGLTGIPVYRIIVENKSYAIKLEDVNDKDFDLQRSYKILETVSSQGIAPLVYFTDADQGIVLMKYIESKPRPEASPETIQKFSSLIRELHAKNSFPKWKSVIEILELVYQRLTLEYKKSKLIKESMHEINKMINVLFDQNDIRSCHCDLNPVNILFDGEKYFFVDWQAASPQSFYFDLAYCSNWFYFYNEDLCALFLKSYFGREVTEEENAKYYLMRIFTYIYLGIGFISLPFKENQNIPILSDENIEKLPSYLKFMQSLGSGVVDLENADVQQQFGFIFLKTAIKMMDQRYKHAYEFLLNKKTIN
Atome Classification :
(20 SA)
-------------------------------.......-------..10--...--.....20...-.------.--.-..30........40------......---------.---------.----------50.....--...60-........----------------70...-.....-80-..--..-------....--------90-------.-------..--......100-.---....-----.------.---110.......120-..--------.--..--..130-.-----------.--------------.-.----------.-....140.---...-------..---.150-------.---------.------------.-------.--.--------..----.----------.160...---..-.-----.----170..-----.-.--------....180.......190---.--.-.-....-.200.......210.....-----------------..220------.-----------------.------------------.......230....-.-.-----.-240-------...----......250.......260.......270.......280.......290.......300.......310.......320.......330.......340-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------MKKNEL
P
-------
I
E
Q
I
--
E
K
I
--
N
F
A
V
RKGLGT-N------
N
--
W
-
E
L
M
S
L
L
SGGLTG
I
P
------
V
Y
R
I
I
V---------E---------N----------K
S
Y
A
I
K
L
--EDVND-KD
F
D
L
Q
R
S
----------------
Y
K
I
L
E
-
T
V
SSQ-G
I
-
A
P
--
L
V
-------
Y
F
TD--------A--------D-------Q
G
--
I
V
L
M
K
Y
I
ES-K---PRPE-----A------
S
---
P
E
T
I
Q
K
F
S
S
L
I
R
E
-
L
H
--------A--KN--SFP---
K
-----------
W
--------------
K
-
S
----------
V
-
I
E
I
L
E
L
V
Y
---
Q
R
L
-------
T
L
---
E
Y
---------
K
---------
K
------------
S
-------
K
--
L
--------
I
K
----
E
----------
S
M
H
E
I
N
K
---
M
I
-
N
-----
V
----
L
F-DQ-----N-D--------
I
R
S
CHCDL
N
P
V
N
I
L
F-D---G--
E
-
K
-
Y
F
F
V
-
D
W
QAASP
Q
S
F
Y
F
D
L
A
Y
CS
N
-----------------
W
F
Y
--------
F
-----------------Y------------------NE
D
L
C
A
L
F
L
K
S
Y
FG-R-E-----V-T---------EEE----NAK
Y
Y
L
M
R
I
F
T
Y
I
Y
L
G
I
G
F
I
SLPFKENQNIPILSDE
N
I
E
K
L
P
S
Y
L
K
F
M
Q
S
LGS
G
V
V
DLEN
A
D
V
Q
Q
Q
F
G
F
I
F
L
K
T
A
I
K
M
M
D
Q
R
Y
K
H
A
Y
E
F
L
LNKKTIN---
26
Fugue
77.90
16%
-8
- C3 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNV
F
E
N
E
K
T
L
-------
Y
I
Y
C
--
K
Y
V
--
M
L
H
Y
G
K
D
L
V
N
-
P
------
N
EV
D
-
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
------
K
V
K
D
M
S
---------
K
---------
Q
----------
A
K
Y
L
I
R
L
--
Y
G
P
T
D
-
E
I
I
N
R
E
R
E
----------------
K
K
I
S
C
-
I
L
Y
N
K
-
N
I
-
A
K
--
K
I
-------
Y
V
F
F
-------------------------
T
N
--
G
R
I
E
E
F
M
D
G
-
Y
---
A
L
S
R
-----
E
------
D
I
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
-
L
H
D
IKLN
E
N
L
Y
--
K
E
--
L
Q
V
---
T
QKVPGTRPSF
L
W
--------------
N
-
T
----------
I
-
W
K
Y
F
H
L
L
N
---
E
E
R
K
KIC---
S
F
---
D
A
---------
K
---------
A
------------
N
-------
I
--
L
--------
K
L
----
I
----------
D
F
D
V
L
R
D
---
S
I
-
V
-----
E
----
V
E
-
S
L
-----
C
-
K
R
E
NSP---
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
-
T
VGE
G
--
D
-
S
-
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-----------------
E
Y
A
----------------------------------------------------------
G
-
F
-
N
-----
C
-
D
---------
W
D
L
----
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
---------------
D
E
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
-
L
Q
G
M
H
S
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
---------
49
HHSearch
73.33
16%
-37
- C3 -
-
3DXQ
-
?
B:
[6-264]
-----------------------------------------------------
A
--
R
A
K
L
A
A
I
P
M
L
-
A
------
G
--
Y
-
T
G
P
L
E
R
L
G
G
L
T
-
N
L
------
V
F
R
A
--------------------------------
G
D
L
C
L
R
I
--
P
--------
N
R
A
N
E
----------------
A
V
A
A
R
-
E
A
A
K
A
-
G
V
-
S
P
--
E
V
-------
L
H
V
D
--------
P
--------
A
-------
T
G
--
V
M
V
T
R
Y
I
A
G
-
A
Q
--
T
M
S
P
-----
E
K
F
K
T
--
R
---
P
G
S
P
A
R
A
G
E
A
F
R
K
-
L
H
--------
G
--
S
G
--
A
V
F
---
P
F
----------
R
--------------
F
-
E
----------
L
-
F
A
M
I
D
D
Y
L
---
K
V
L
-------
S
T
---
K
---------------------------------
N
-------
V
--
T
--------
L
P
----
A
----------
G
Y
H
D
V
V
R
E
A
G
G
V
R
S
-----
A
L
---
A
A
-
H
P
-----
L
-
P
--------
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
-
T
---
G
--
E
-
R
-
M
W
I
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
-----------------
E
G
---------
K
-----------------
F
------------------
N
A
N
Q
D
E
E
L
M
R
A
Y
F
G
-
G
-
E
-----
A
-
R
---------
P
A
E
----
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
--------------------------------------------------------------------------
47
HHSearch
73.27
17%
3
- C3 -
-
1NW1
-
CKA2_CAEEL
B:
[49-401]
-------------------------------------
I
-------
P
E
L
K
--
E
R
A
--
H
M
L
C
A
R
F
L
G
G
-
A
WKTVPL
E
--
H
-
L
R
I
S
R
I
K
G
G
M
S
-
N
M
------
L
F
L
C
R
L
---------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
--
Y
F
N
P
E
-
T
E
S
H
L
V
A
E
----------------
S
V
I
F
T
-
L
L
S
E
R
-
H
L
-
G
P
--
K
L
-------
Y
G
I
F
--------
S
-----------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
---
P
L
S
C
H
E
I
--
S
------
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--------
Q
--
L
E
--
V
P
I
---
W
-----------
K
E-------------
P
-
D
Y
---------
L
-
C
E
A
L
Q
R
W
L
---
K
Q
L
-------
T
G
---
T
V
---------
D
---------
A
------------
E
-------
H
R
F
D
--------
L
P
----
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
---
F
L
-
R
-----
A
H
I
--
S
L
-
S
K
-----
S
-
P
--------
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
---
K
----
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-----------------
E
W
T
--------
I
DYDIDEAPF
Y
K
I
Q
TENF
P
------------------
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
-
E
Q
G
-----
N
-
T
RENE
L
Y
K
K
S
E
D
L
----
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
-----------------------------------------------------------------------
46
HHSearch
72.87
17%
0
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[49-401]
-------------------------------------
I
-------
P
E
L
K
--
E
R
A
--
H
M
L
C
A
R
F
L
G
G
-
A
WKTVPL
E
--
H
-
L
R
I
S
R
I
K
G
G
M
S
-
N
M
------
L
F
L
C
R
L
---------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
--
Y
F
N
P
E
-
T
E
S
H
L
V
A
E
----------------
S
V
I
F
T
-
L
L
S
E
R
-
H
L
-
G
P
--
K
L
-------
Y
G
I
F
--------
S
-----------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
---
P
L
S
C
H
E
I
--
S
------
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--------
Q
--
L
E
--
V
P
I
---
W
-----------
K
E-------------
P
-
D
Y
---------
L
-
C
E
A
L
Q
R
W
L
---
K
Q
L
-------
T
G
---
T
V
---------
D
---------
A
------------
E
-------
H
R
F
D
--------
L
P
----
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
---
F
L
-
R
-----
A
H
I
--
S
L
-
S
K
-----
S
-
P
--------
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
---
K
----
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-----------------
E
W
T
--------
I
DYDIDEAPF
Y
K
I
Q
TENF
P
------------------
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
-
E
Q
G
-----
N
-
T
RENE
L
Y
K
K
S
E
D
L
----
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
-----------------------------------------------------------------------
52
HHSearch
71.23
19%
-4
* C3 *
-
4R7B
-
?
A:
[23-280]
---------------------------------------------------
K
I
I
--
K
E
K
I
S
S
L
L
S
Q
E
E
------
E
--
V
-
L
S
V
E
Q
L
-
G
G
M
T
-
N
Q
------
N
Y
L
A
K
T
---------
T
---------
N
----------
K
Q
Y
I
V
K
F
--
F
G
K
G
T
E
K
L
I
N
R
Q
D
E
----------------
K
Y
N
L
E
-
L
L
K
D
L
-
G
L
-
D
V
--
K
N
-------
Y
L
F
D
--------
I
--------
E
-------
A
G
--
I
K
V
N
E
Y
I
E
S
-
A
I
--
T
L
D
S
T
----
S
------
I
---
K
T
K
F
D
K
I
A
P
I
L
Q
T
-
I
H
--------
T
--
S
A
--
K
E
L
---
R
G----------
E
--------------
F
-
A
----------
P
-
F
E
E
I
K
K
Y
E
---
S
L
I
-------
E
E
---
Q
I
---------
P
---------
Y
AN----------
Y
-------
E
--
S
--------
V
R
----
N
----------
A
V
F
S
L
E
K
---
R
L
------------
A
D
-
L
G
-----
V
-
D
--------
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
-
S
---
P
Q-
G
-
R
-
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
-----------------
E
S
---------
E
-----------------
F
------------------
T
S
Q
E
E
E
T
F
L
S
H
Y
E
S
-
D
-
Q
-------
T
---------
P
V
S
----
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
----------------------------------------------------------------------------
25
Fugue
71.08
14%
-10
- C3 -
-
3I1A
2
?
A:
[3-330]
--------------------------------
K
Q
P
I
Q
A
-------------
Q
Q
L
--
I
E
L
L
K
V
H
Y
G
I
-
D
------
I
--
H
-
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
------
A
Y
Q
A
D
S
---------
E
---------
S
----------
K
S
Y
F
I
K
L
--
K
Y
-
G
Y
-
H
D
E
I
N
L
S
I
----------------
I
R
L
L
H
-
D
S
G
I
K
-
E
I
-
I
F
--
P
I
HTLEAKL
F
Q
Q
L
--------
K
--------
H
-------
F
K
--
I
I
A
Y
P
F
I
H
A
-
P
N
G-
F
T
Q
N
-----
L
------
T
---
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
-
I
H
--------
E
--
T
S
--
V
P
I
---
S
-----------
I
--------------
Q
-
Q
Q
LRKEIYSP
K
W
-
R
E
I
V
R
S
F
Y
---
N
Q
I
EFDNSDD
K
L
---
T
A
---------
A
---------
F
------------
K
-------
S
--
F
--------
F
N
----
Q
----------
N
S
A
A
I
H
R
---
L
V
-
D
-----
T
----
S
E
-
K
L
-----
S
-
K
K
IQPDLDK
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
---
E
--
E
-
S
-
I
Y
I
I
-
D
W
D
E
P
M
L
A
P
K
E
R
D
L
----------------------------------------------------------------------------
M
F
I
G
G
G
V
G
-
N
-
V
-----
W
-
N
---------
K
P
H
----
E
I
Q
Y
F
Y
E
G
Y
G
E
I
----------
N
V
D
K
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
S
--------------
R
N
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E
----
51
HHSearch
70.70
19%
-1
- C3 -
-
4R78
2
?
A:
[23-280]
---------------------------------------------------
K
I
I
--
K
E
K
I
S
S
L
L
S
Q
E
E
------
E
--
V
-
L
S
V
E
Q
L
-
G
G
M
T
-
N
Q
------
N
Y
L
A
K
T
---------
T
---------
N
----------
K
Q
Y
I
V
K
F
--
F
G
K
G
T
E
K
L
I
N
R
Q
D
E
----------------
K
Y
N
L
E
-
L
L
K
D
L
-
G
L
-
D
V
--
K
N
-------
Y
L
F
D
--------
I
--------
E
-------
A
G
--
I
K
V
N
E
Y
I
E
S
-
A
I
--
T
L
D
S
T
----
S
------
I
---
K
T
K
F
D
K
I
A
P
I
L
Q
T
-
I
H
--------
T
--
S
A
--
K
E
L
---
R
G
----------
E
--------------
F
-
A
----------
P
-
F
E
E
I
K
K
Y
E
---
S
L
I
-------
E
E
---
Q
I
---------
P
---------
Y
AN----------
Y
-------
E
--
S
--------
V
R
----
N
----------
A
V
F
S
L
E
K
---
R
L
------------
A
D
-
L
G
-----
V
-
D
--------
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
-
S
---
P
Q-
G
-
R
-
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
-----------------
E
S
---------
E
-----------------
F
------------------
T
S
Q
E
E
E
T
F
L
S
H
Y
E
S
-
D
-
Q
-------
T
---------
P
V
S
----
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
----------------------------------------------------------------------------
28
Fugue
70.32
18%
-16
- C3 -
-
4OCV
2
?
A:
[24-378]
------------------T
N
E
A
L
F
D
V
A
S
H
FA
L
E
G
T
V
D
S
-------
I
E
P
Y
G
D
G
H
I
--
N
T
T
Y
L
V
T
T
D
G
-
P
------
R
--
Y
-
I
L
Q
R
M
N
T
G
I
F
P
D
--------
T
V
N
L
M
R
---------
N
---------
V
----------
E
L
V
T
S
T
L
--
K
A
Q
G
K
-
E
T
L
D
I
V
R
T
TSGDTWAEIDG
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
Y
N
-
L
V
-
P
N
--
P
D
-------
V
F
R
E
--------
A
--------
G
-------
R
A
--
F
G
D
F
Q
N
F
L
S
-
G
---
F
D
A
N
-----
Q
------
L
---
T
E
T
I
A
H
F
H
D
---------------
T
--
P
H
--
R
F
E
---
D
-----------
F
--------------
K
-
K
----------
A
-
L
A
A
D
E
L
-----
G
R
A
-------
A
G
---
C
G
---------
P
---------
E
------------
I
-------
E
--
F
--------
Y
L
----
S
----------
H
A
D
Q
Y
A
V
---
V
M
-
D
-----
G
----
L
R
-
D
G
-----
S
I
P
--------
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
-
D
ATT
G
--
K
-
A
-
R
A
I
I
-
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
-----------------
F
G
A
--------
S
-----------------
T
------------------
A
L
E
D
E
R
D
L
D
K
V
H
F
S
-------------------------------
T
E
L
F
R
A
Y
T
E
G
F
V
G
E
L
R
D
S
I
T
A
R
E
A
E
L
L
P
F
S
G
--
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
G
D
V
Y
F
A
T
K
Y
--
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
48
HHSearch
70.05
16%
-32
- C- -
-
3DXQ
-
?
A:
[6-264]
-----------------------------------------------------
A
--
R
A
K
L
A
A
I
P
M
L
-
A
------
G
--
Y
-
T
G
P
L
E
R
L
G
G
L
T
-
N
L
------
V
F
R
A
--------------------------------
G
D
L
C
L
R
I
--
P
G
K
----
Y
I
N
R
A
N
E
----------------
A
V
A
A
R
-
E
A
A
K
A
-
G
V
-
S
P
--
E
V
-------
L
H
V
D
--------
P
--------
A
-------
T
G
--
V
M
V
T
R
Y
I
A
G
-
A
Q
--
T
M
S
P
-----
E
K
F
K
T
--
R
---
P
G
S
P
A
R
A
G
E
A
F
R
K
-
L
H
--------
G
--
S
G
--
A
V
F
---
P
F
----------
R
--------------
F
-
E
----------
L
-
F
A
M
I
D
D
Y
L
---
K
V
L
-------
S
--------------------------------------
N
-------
V
--
T
--------
L
P
----
A
----------
G
Y
H
D
V
V
R
E
A
G
G
V
R
S
-----
A
L
---
A
A
-
H
P
-----
L
-
P
--------
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
-
T
---
G
--
E
-
R
-
M
W
I
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
-----------------
E
G
---------
K
-----------------
F
------------------
N
A
N
Q
D
E
E
L
M
R
A
Y
F
G
-
G
-
E
-----
A
-
R
---------
P
A
E
----
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
--------------------------------------------------------------------------
22
Fugue
68.28
15%
7
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------------------------
G
M
K
E
L
L
S
T
MDLDTD
A
N
T
I
--
P
E
L
--
K
E
R
A
H
M
L
C
A
R
-
F
LGG---
A
--
W
-
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
MS
N
M
L
F
L
C
R
L
S
EVYPPIRN
E
---------
P
----------
N
K
V
L
L
R
V
--
Y
F
N
P
E
-
T
E
S
H
L
V
A
E
----------------
S
V
I
F
T
-
L
L
S
E
R
-
H
L
-
G
P
--
K
L
-------
Y
G
I
F
-------------------------
S
G
--
G
R
L
E
E
Y
I
P
S
-
R
P
L
S
C
H
E
I
-----
S
------
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--------
Q
--
L
E
VP
I
W
K
---
E
-----------
P
--------------
D
-
Y
----------
L
-
C
E
A
L
Q
R
W
L
---
K
Q
L
-------
T
G
---
T
V
DAE
H
R
F
D
L
P
E
---------
E
------------
C
-------
G
--
V
--------
S
S
----
V
----------
N
C
L
D
L
A
R
---
E
L
-
E
-----
F
----
L
R
-
A
H
I
S
L
SK
S
-
P
--------
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
------
K
-
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
-----------------
E
W
T
--------
I
-----------------
D
------------------
Y
D
I
------
D
E
A
P
F
-
Y
-
K
-----
I
-
Q
---------
T
E
N
----
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
-
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
-----
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------
50
HHSearch
67.88
13%
-58
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[6-289]
---------------------------------------------
D
I
T
E
--
D
E
L
--
R
N
F
L
T
-
Q
Y
D
V
-
G
------
S
--
L
-
T
S
Y
K
G
I
A
E
----
N
S
------
N
F
L
L
H
T
---------
T
---------
K
----------
D
P
L
I
L
T
L
--
Y
E
K
----
K
N
D
L
P
F
F
----------------
L
G
L
M
Q
-
H
L
A
A
K
-
G
L
S
C
P
--
L
P
-------
L
P
R
K
--------
D
GEL
L
G
E
L
S
G
-------
R
P
--
A
A
L
I
S
F
L
E
G
-
M
---
W
L
R
K
-----
P
------
E
---
A
K
H
C
R
E
V
G
K
A
L
A
A
-
M
H
--------
L
--
A
S
--
E
G
F
---
E
-----------
I
--------------
K
R
P
----------
N
-
A
L
S
V
D
G
W
K
V
L
W
D
K
S
-------
E
E
---
R
A
---------
D
---------
E
V-----------
E
-------
K
--
G
--------
L
R
----
E
----------
E
I
R
P
E
I
D
---
Y
L
-
A
-----
A
H
---
W
P
-
K
D
-----
L
-
P
--------
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
---
G
D-
E
-
L
-
S
G
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
-----------------
A
W
C
--------
F
EKDGA------------
Y
------------------
N
V
T
K
G
K
A
L
L
E
G
Y
Q
S
V
R
-
P
-----
L
-
S
---------
E
A
E
----
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
A
------------------------------------------------------------------------
36
SP3
65.05
15%
1
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------G
M
K
E
L
L
S
T
MDLDTDA
N
T
I
P
E
L
K
-------
E
R
A
H
--
M
L
C
--
A
R
F
L
G
G
A
W
K
T
-
V
------
P
--
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
------
L
F
L
C
R
L
---------
S
---------
E
VYPPIRNEP-
N
K
V
L
L
R
V
--
Y
F
N
P
E
-
T
E
S
H
L
V
A
E
----------------
S
V
I
F
T
-
L
L
S
E
R
-
H
L
-
G
P
--
K
L
-------
Y
G
I
F
--------
S
-----------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
---
P
L
S
C
-----
H
E
I
S
---
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--------
Q
--
L
E
--
V
-
P
---
I
-----------
W
--------------
K
-
E
----------
P
-
D
Y
L
C
E
A
L
Q
---
R
W
L
-------
K
Q
---
L
T
---------
G
---------
T
V
DAE
H
R
F
D
L
PEE
C
-------
G
--
V
--------
S
S
----
V
----------
N
C
L
D
L
A
R
---
E
L
-
E
-----
F
----
L
R
-
A
H
I
S
L
SK
S
-
P
--------
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
---
K
----
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
E
N
--------
F
-----------------
P
------------------
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
-
E
-
Q
-----
G
-
N
T--------
R
E
N
----
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
-------------------------
P
F
V
P
V
S
H
F
F
W
G
V
-
W
G
L
L
Q
V
E
L
S
P
V
----
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
-
Q
L
L
K
N
L
A
------
24
Fugue
63.71
12%
9
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
----------------------------------
T
D
I
T
-------
E
D
E
L
--
R
N
F
L
T
Q
Y
D
V
G
S
L
T
S
Y
-
K
------
G
--
I
-
A
E
N
S
N
F
L
L
H
T
T
K
D
P
------
L
I
L
T
L
Y
---------
E
---------
K
KN
D
-------
L
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
G
L
S
C
P
L
P
----------------
L
P
R
K
D
-
G
E
L
L
G
-
E
L
-
S
---------------------------------
G
-------
R
P
--
A
A
L
I
S
F
L
E
G
M
W
---
L
-
R
K
-----
P
------
E
---
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
--------
A
--
S
E
--
G
F
E
I
K
R
P
-----------
N
--------------
A
-
L
----------
S
-
V
D
G
W
K
V
L
W
---
D
K
S
-------
E
E
---
R
A
---------
D
EV-------
E
------------
K
-------
G
--
L
--------
R
E
----
E
----------
I
R
P
E
I
D
Y
---
L
A
-
A
-----
H
----
W
P
-
K
D
-----
L
-
P
--------
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
---
G
--
D
-
E
-
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
-----------------
A
W
C
--------
F
EKDGA------------
Y
------------------
N
V
T
K
G
K
A
L
L
E
G
Y
Q
S
V
R
-
P
-----
L
-
S
---------
E
A
E
----
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
A
G
-
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
-------------------------------------
V
A
E
Y
G
L
A
---
58
HHSearch
63.46
14%
-29
- C3 -
-
3C5I
3
?
D:
[14-332]
------------------------------------------------
P
--
L
Y
I
--
K
K
I
C
L
E
K
V
P
E
-
W
NHFTE-
D
--
N
-
L
R
V
K
Q
I
L
--
L
T
-
N
Q
------
L
F
E
V
G
L
---------
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
I
--
Y
G
K
H
V
D
E
L
Y
N
T
I
S
E
----------------
F
E
V
Y
K
-
T
M
S
K
Y
-
K
I
-
A
P
--
Q
L
-------
L
N
T
F
-------------------------
N
G
--
G
R
I
E
E
W
L
Y
G
-
D
---
P
L
R
I
D
D
L
--
K
------
N
---
P
T
I
L
I
G
I
A
N
V
L
G
K
-
F
H
--------
T
--
L
S
--
R
K
R
---
H
-----------
L
PEH-----------
W
-
D
RTP
C
------
I
-
F
K
M
M
E
K
W
K
---
N
Q
L
-------
F
K
---
Y
K
NI-------
E
---------
K
YNCD--------
I
-------
H
--
K
--------
Y
I
----
K
----------
E
S
D
K
F
I
K
---
F
M
-
K
-----
V
Y
S
KS
D
N
-
L
A
-----
N
-
T
--------
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
-
T
---
N
--
K
-
C
-
L
R
L
I
-
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
-----------------
E
T
---------
S
-----------------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
Y
E
N
R
K
L
F
I
T
A
Y
L
S
-
N
-
Y
L
DKVV
P
-
T
---------
P
K
L
I
D
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
---------------------------------------------------------------------------
59
HHSearch
60.53
15%
-19
- C3 -
-
2Q83
4
COTI_BACSU
A:
[19-311]
------------------------------------------------
L
--
T
E
L
--
A
E
N
V
L
Q
G
W
D
V
-
Q
---------
A
-
E
K
I
D
V
I
Q
-----
A
L
------
V
W
K
V
H
T
---------
D
---------
S
----------
G
A
V
C
L
K
R
--
I
H
R
P
E
---
K
K
A
L
F
S
----------------
I
F
A
Q
D
-
Y
L
A
K
K
-
G
M
N
V
P
--
G
I
-------
L
P
N
K
KGSL
Y
S
K
H
G
--------
S
-------
F
L
--
F
V
V
Y
D
W
I
E
G
-
R
---
P
F
E
L
-----
T
------
V
---
K
Q
D
L
E
F
I
M
K
G
L
A
D
-
F
H
--------
T
--
A
S
--
V
G
Y
---
Q
P
P
N--------
G
--------------
V
-
P
----------
I
-
F
T
K
L
G
R
W
P
---
N
H
Y
-------
T
K
R
C
K
Q
M
---------
E
T
W
K
L
M
A
E
A
E
K
------------
E
-------
D
--
P
F
S
Q
L
Y
L
Q
E
I
D
G
F
I
-
E
----------
D
G
L
R
I
K
D
---
R
L
-
L
Q
ST
Y
V
P
W
T
--
E
Q
-
L
K
-----
K
-
S
--------
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
---
E
N-
E
-
Q
-
I
W
V
I
-
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
-----------------
P
L
L
--------
D
TTGV-------------
W
------------------
D
D
E
T
F
N
V
M
L
N
A
Y
E
S
R
A
-
P
-----
L
-
T
---------
E
E
Q
----
K
Q
V
M
F
I
D
M
L
F
P
Y
E
L
Y
D
------------------------------------------------------------------------------------
64
HHSearch
58.74
17%
0
- C- -
-
2QG7
-
?
D:
[110-434]
-----------------------------------------------------------------------------
S
-
L
E
F
Q
I
I
N
G
G
-
T
-
N
I
------
L
I
K
V
K
D
---------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
--
Y
G
P
K
T
D---
N
R
E
R
E
----------------
K
K
I
S
C
-
I
L
Y
N
K
-
N
I
-
A
K
--
K
I
-------
Y
V
F
F
--------
T
--------
N
-----------
G
R
I
E
E
F
M
D
G
-
Y
---
A
L
S
R
EDI--
K
------
N
---
P
K
F
Q
K
L
I
A
K
N
L
K
L
-
L
H
--------
D
--
I
K
--
L
N
E
---
N
L----------
Y
KELQVTQKVPGTRP
S
-
F
----------
L
-
W
N
T
I
W
K
Y
F
---
H
L
L
-------
N
E
---
E
R
---------
K
---------
K
------------
I
CSFDAKA
N
--
I
--------
L
K
LIDF
D
----------
V
L
R
D
S
I
V
---
E
V
-
E
-----
S
LC--
K
R
-
E
N
-----
S
-
P
--------
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
-
T
---
V
G-
D
-
S
-
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-----------------
E
Y
A
GFNCDWDL
T
-----------------
P
------------------
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
-
T
D
D
-----
E
-
E
LI-------
N
Q
L
----
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
S
-------------------------------------------------------------------------
65
HHSearch
58.69
17%
0
- C- -
-
2QG7
-
?
E:
[110-434]
-----------------------------------------------------------------------------
S
-
L
E
F
Q
I
I
N
G
-
I
T
-
N
I
------
L
I
K
V
K
D
---------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
--
Y
G
P
K
T
D
E
I
I
N
R
E
R
E
----------------
K
K
I
S
C
-
I
L
Y
N
K
-
N
I
-
A
K
--
K
I
-------
Y
V
F
F
--------
T
--------
N
-----------
G
R
I
E
E
F
M
D
G
-
Y
---
A
L
S
R
EDI--
K
------
N
---
P
K
F
Q
K
L
I
A
K
N
L
K
L
-
L
H
--------
D
--
I
K
--
L
N
E
---
N
L----------
Y
KELQVTQKVPGTRP
S
-
F
----------
L
-
W
N
T
I
W
K
Y
F
---
H
L
L
-------
N
E
---
E
R
---------
K
---------
K
------------
I
CSFDAKA
N
--
I
--------
L
K
LIDF
D
----------
V
L
R
D
S
I
V
---
E
V
-
E
-----
S
LC--
K
R
-
E
N
-----
S
-
P
--------
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
-
T
---
V
GG
D
-
S
-
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
-----------------
E
Y
A
GFNCDWDL
T
-----------------
P
------------------
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
-
T
D
D
-----
E
-
E
LI-------
N
Q
L
----
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
S
-------------------------------------------------------------------------
37
SP3
58.45
11%
-26
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
----------------------------------------------------
G
S
--
P
A
A
W
V
E
R
L
F
G
-
Y
------
D
--
W
-
A
Q
---
Q
T
I
G
C
S
D
A
A
------
V
F
R
L
S
A
---------
Q
---------
G
----------
R
P
V
L
F
V
K
--
T
D
L
S
G
-
A
L
N
E
L
Q
D
E
----------------
A
A
R
L
S
-
W
L
A
T
T
-
G
V
P
C
A
--
A
V
-------
L
D
V
V
--------
T
--------
E
-------
A
G
R
D
W
L
L
L
G
E
V
P
G
-
Q
---
D
L
L
S
-----
S
------
H
LA
P
A
E
K
V
S
I
M
A
D
A
M
R
R
-
L
H
--------
T
--
L
D
--
P
A
----
T
-----------
C
--------------
P
-
F
----------
D
-
H
Q
A
K
H
R
I
E
---
R
A
R
-------
T
R
---
M
E
---------
A
---------
G
------------
L
-------
V
--
D
--------
Q
D
----
D
LDEEHQGL--
A
P
A
E
L
F
A
---
R
L
-
K
-----
A
----
R
M
P
D
G
-----
E
-
D
--------
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
-
E
---
N
--
G
-
R
F
S
G
F
I
-
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
-----------------
D
I
A
--------
E
E
----------------
L
------------------
G
G
E
W
A
D
R
F
L
V
L
Y
G
I
-
A
-
A
-----
P
-
D
---------
S
Q
R
----
I
A
F
Y
R
L
L
D
E
F
F
-----------------------------------------------------------------------------------------
62
HHSearch
57.57
14%
-30
- C3 -
-
5IGH
-
?
A:
[9-280]
------------------------------------------------
T
--
S
Q
L
--
Y
A
L
A
A
R
-
H
G
L
-
K
------
L
--
H
-
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
------
I
V
I
A
T
V
---------
D
D--------
G
----------
R
R
W
V
L
R
I
--
P
R
R
A
E
-
V
S
A
K
V
E
P
E
----------------
A
R
V
L
A
-
M
L
K
N
R
L
P
F
A
V
P
--
D
W
-------
R
V
A
N
--------
A
--------
E
L
V
A
Y
P
ML
E
D
--
S
T
A
M
V
I
Q
P
G
-
S
---
S
T
P
D
W
V
V
P
Q
D
------
S
---
E
V
F
A
E
S
F
A
T
A
L
A
A
-
L
H
--------
A
--
V
P
--
I
S
A
---
A
-----------
V
--------------
D
A
G
----------
M
L
I
R
T
P
T
Q
A
R
---
Q
K
V
-------
A
D
---
D
V
---------
D
---------
R
V
R
R
---------
E
F
------
V
--
V
--------
N
D
----
K
----------
R
L
H
R
W
Q
R
---
W
L
-
D
-----
D
D---
S
S
-
W
P
-----
D
-
F
--------
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
-
D
---
N
T-
E
R
V
-
S
G
M
I
-
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
-----------------
V
F
----------------------------------------------
G
E
E
G
L
A
K
L
L
L
T
Y
E
A
-
A
G
G
-----
R
V
W
---------
P
R
L
----
A
H
H
I
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
----------------------------------------------------------------------------------
23
Fugue
57.11
17%
18
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-----------------------------------------------
A
K
--
M
R
I
--
S
P
E
L
K
K
L
I
E
K
-
Y
------
R
--
C
-
V
K
D
T
---
E
G
M
S
P
A
K
------
V
Y
K
L
V
G
---------
E
---------
N
----------
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
-
T
T
Y
D
V
E
R
E
----------------
K
D
M
M
L
-
W
L
E
G
K
-
L
P
-
V
P
KV
L
H
-------
F
E
R
H
--------
D
--------
G
-------
W
S
--
N
L
L
M
S
E
A
D
G
-
V
---
L
C
S
E
-----
E
Y
EDEQS
P
---
E
K
I
I
E
L
Y
A
E
C
I
R
L
-
F
H
--------
S
ID
I
S
--
D
C
P
---
Y
-----------
T
--------------
N
-
S
----------
L
-
D
S
R
L
A
E
L
D
---
Y
L
L
N
N
DLADV
D
C
---
E
N
---------
W
---------
E
------------
E
-------
D
--
T
--------
P
F
----
K
----------
D
P
R
E
L
Y
D
---
F
L
-
K
-----
T
----
E
K
-
P
E
-----
E
-
E
--------
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
-
K
---
D
--
G
-
K
-
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
-----------------
S
I
R
--------
E
-----------------
D
IG----------------
E
E
Q
Y
V
E
L
F
F
D
L
L
-
G
-
I
-
K
-----
P
-
D
---------
W
E
K
----
I
K
Y
Y
I
L
L
D
E
L
F
-----------------------------------------------------------------------------------------