@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ASNS_HUMAN: (2020-01-31 )
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
Atome Classification :
(20 SA)
--------------------.........10...----.....20.-.-......30-----------........40........50........60....-.------.---------..70------.--......-------------..80.......--.---90--.----........100.-----.....----------------.110.....------------------..120.......130.......140.....----..150---....----....160......--------.170--.-----.----------------......---.180..---.....190..---------.-.--...-200.....----..210.......220--..-...------...230-.......240.......250.......260....-------..-----.270.......280-.......290.......300.......310....---...320......-----------------------.330.......340.......350--........------.360-........--370...--....380-........390.......400..-------.....410.......420-.......-430----.......440-.----......450...--...----------.460.....-..470....--...--------480.....----..490...-.....500.......510.......520...--------..----------..530.----.......540.......550.......560
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------M
C
G
I
W
A
L
FGSDDC
L
----
S
V
Q
C
L
S
A
M
-
K
-
I
A
HRGPD
A
-----------
F
R
F
ENVNGY
T
N
C
C
F
G
F
H
R
L
A
VVDPLFGMQP
I
R
V
K-K------Y---------
P
Y
L
-------
W
--
L
C
YN
G
E
-------------IY
N
H
K
K
M
Q
Q
HF--
E
---
F
---
E
----
Y
Q
TKVD
G
E
I
I
L
H
-----
L
YDKG----------------G
I
E
Q
T
I
C
M
L
------------------
D
G
V
F
A
F
V
LLDTAN
K
K
V
F
LGRDTYG
V
R
P
L
F
K
----
A
MTE----D
G
F
L
----
A
V
C
SEAK
G
L
V
T
L
K--------HS----A-----T----------------
P
F
L
K
VE---PFLPGH---
Y
E
V
L
D
LKPNG---------
K
-
V
--
A
S
V
-
E
M
V
K
Y
HHC----RDV
P
L
H
A
L
Y
D
N
V
E
K
---LF-PG
F
------
E
I
E
T
V
K-N
N
L
R
I
L
F
N
N
A
V
K
K
R
L
M
TDRR
I
G
C
L
LSGGL
D
S
S
L
V
-------
A
A
-----
T
L
L
K
Q
L
K
E
A
Q
V
QYP-
L
Q
T
FAIGMED
S
P
D
L
L
A
A
R
K
V
A
D
H
IGSE
H
Y
E
V
L
FN---S
E
E
G
I
Q
A
L
D
E
V
I
-----------------------
F
SLET
Y
D
I
T
T
V
R
A
S
V
G
M
Y
L
I
S
K
----
Y
I
RKNTD
S
------
V
V
I
--
F
SGEGSDE--LTQ
G
Y
I
--
Y
F
HKAP--SP
E
K
A
E
E
E
S
E
R
L
L
R
E
L
Y
L
F
D
V
L
R-------ADRTTAAH
G
L
E
L
RV
P
F
L
D-HRFS
S
Y
Y
-LSL----PPEMRI
P
K
N
G
-
I
----
E
K
H
L
L
R
E
T
FEDS--NL
I
----------
P
K
E
I
LWR
P
K
-
E
A
F
S
D
G
I
T
S
--
V
K
N
--------
S
W
F
K
I
L
Q
E
----
Y
V
E
-
H
QV
D
-
D
A
M
M
A
N
A
A
Q
KFPFNTPKTKE
G
Y
Y
Y
R
Q
V
F
E
R
H--------YP----------G
R
A
D
-
W
----
L
S
HYWMPKWINATDPS
A
R
T
L
T
H
Y
K
S
A
VKA
20
Fugue
100.00
39%
0
- C- -
-
1CT9
2
ASNB_ECOLI
A:
[1-516]
------------------AS
I
F
G
V
F
D
I
K
T
D
A
V
E
L
----
R
K
K
A
L
E
L
S
R
L
-
M
R
H
R
G
P
D
W
-----------
S
G
I
Y
A
S
--
D
N
-
A
I
L
A
H
E
R
L
S
I
V
D
V
N
A
G
A
Q
P
L
Y
N
Q
-
Q
------
K
----------
T
H
-------
V
--
L
A
V
N
G
E
-------------
I
Y
N
H
Q
A
L
R
A
E
Y
--
G
DR-
Y
---
Q
----
F
Q
T
G
S
D
C
E
V
I
L
A
-----
L
Y
Q
E
K
----------------
G
-
P
E
F
L
D
D
L
------------------
Q
G
M
F
A
F
A
L
Y
D
S
E
K
D
A
Y
L
I
G
R
D
H
L
G
I
I
P
L
Y
M
----
G
Y
D
E
----
H
G
Q
L
----
Y
V
A
S
E
M
K
A
L
V
P
V
C
R---------------------------------------
T
I
K
---
E
F
P
A
G
S
---
Y
L
W
--
S
Q
D
G
-------------------
E
I
R
S
Y
Y
H
R
----
D
W
F
D
Y
D
A
V
K
D
N
V
T
----------------
D
----
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
-------
S
A
-----
I
T
K
K
Y
A
---------
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
K
A
M
G
I
K
------
M
V
L
---
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
C
-
K
--
M
----
E
K
H
I
L
R
E
C
F
E
A
Y
----
L
----------
P
A
S
V
A
W
R
Q
K
-
E
Q
F
S
---
D
G
--
V
G
Y
--------
S
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
-------------------------------
L
P
S
A
A
E
C
V
P
G
--------
21
Fugue
98.65
38%
0
- C- -
-
1CT9
2
ASNB_ECOLI
A:
[1-516]
------------------AS
I
F
G
V
F
D
I
K
T
D
A
V
E
L
----
R
K
K
A
L
E
L
S
-
R
L
M
R
H
R
G
P
D
W
-----------
S
G
I
Y
A
---
S
D
N
A
I
L
A
H
E
R
L
S
I
V
D
V
N
A
G
A
Q
P
L
Y
N
Q
-
Q
------
K
---------
T
-
H
-------
V
--
L
A
V
N
G
E
-------------
I
Y
N
H
Q
A
L
R
A
E
Y
--
G
DR-
Y
---
Q
----
F
Q
T
G
S
D
C
E
V
I
L
A
-----
L
Y
Q
E
K
----------------
G
-
P
E
F
L
D
D
L
------------------
Q
G
M
F
A
F
A
L
Y
D
S
E
K
D
A
Y
L
I
G
R
D
H
L
G
I
I
P
L
Y
M
----
G
Y
D
E
----
H
G
Q
L
----
Y
V
A
S
E
M
K
A
L
V
P
V
C
--------
R
-------------------------------
T
I
K
---
E
F
P
A
G
S
---
Y
L
W
S
Q
D
G
E
I
R
---------
S
-
Y
--
Y
H
R
-
D
W
F
D
Y
D
A
V
----
K
D
N
V
----------------------------
T
D
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
-------
S
A
-----
I
T
K
K
Y
--------
A
-
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
K
A
M
G
I
K
------
M
V
L
---
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
--
C
K
-
M
----
E
K
H
I
L
R
E
C
F
E
A
Y
----
L
----------
P
A
S
V
A
W
R
Q
K
-
E
Q
F
S
---
D
G
--
V
G
Y
--------
S
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
----------
L
-----------------------------
P
S
A
A
E
C
V
P
G
37
HHSearch
94.76
37%
0
- C- -
-
1CT9
6
ASNB_ECOLI
D:
[1-516]
---------------------
A
S
I
F
G
V
F
D
I
K
T
D
A
VELR
K
K
A
L
E
L
S
R
-
L
-
M
R
H
R
G
P
D
W
-----------
S
G
I
Y
A
S
D
---
N
A
I
L
A
H
E
R
L
S
I
V
D
V
N
A
G
A
Q
P
L
Y
N
--
Q
------
Q
---------
K
T
H
-------
V
--
L
A
V
N
G
E
-------------
I
Y
N
H
Q
A
L
R
A
E
Y
--
G
---
D
RY-
Q
----
F
Q
T
G
S
D
C
E
V
I
L
A
-----
L
Y
Q
E
K
----------------
G
-
P
E
F
L
D
D
L
------------------
Q
G
M
F
A
F
A
L
Y
D
S
E
K
D
A
Y
L
I
G
R
D
H
L
G
I
I
P
L
Y
M
----
G
Y
D
E
----
H
G
Q
L
----
Y
V
A
S
E
M
K
A
L
V
P
V
C
--------
R
-------------------------------
T
I
K
---
E
F
P
A
G
S
---
Y
L
W
S
Q
--
D
-
G
---------
E
-
I
--
R
S
Y
Y
H
R
D
W
F
D
--------
Y
D
----------------
A
V
K
------
D
N
V
T
D
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
-------
S
A
-----
I
T
K
K
Y
A
A
------
Q
-
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
K
A
-
M
G
I
------
K
M
V
--
L
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
C
-
G
K
-
M
----
E
K
H
I
L
R
E
C
F
E
A
----
Y
L
----------
P
A
S
V
A
W
R
Q
------
D
G
V
G
Y
--
S
-----------
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
----------
L
P
S
A
A
E
CVPG-----------------------------
36
HHSearch
94.44
37%
0
- C- -
-
1CT9
2
ASNB_ECOLI
A:
[1-516]
---------------------
A
S
I
F
G
V
F
D
I
K
T
D
A
VELR
K
K
A
L
E
L
S
R
-
L
-
M
R
H
R
G
P
D
W
-----------
S
G
I
Y
A
S
D
---
N
A
I
L
A
H
E
R
L
S
I
V
D
V
N
A
G
A
Q
P
L
Y
N
--
Q
------
Q
---------
K
T
H
-------
V
--
L
A
V
N
G
E
-------------
I
Y
N
H
Q
A
L
R
A
E
Y
--
G
---
D
RY-
Q
----
F
Q
T
G
S
D
C
E
V
I
L
A
-----
L
Y
Q
E
K
----------------
G
-
P
E
F
L
D
D
L
------------------
Q
G
M
F
A
F
A
L
Y
D
S
E
K
D
A
Y
L
I
G
R
D
H
L
G
I
I
P
L
Y
M
----
G
Y
D
E
----
H
G
Q
L
----
Y
V
A
S
E
M
K
A
L
V
P
V
C
--------
R
-------------------------------
T
I
K
---
E
F
P
A
G
S
---
Y
L
W
S
Q
--
D
-
G
---------
E
-
I
--
R
S
Y
Y
H
R
D
W
F
D
--------
Y
D
-
A
---------------
V
K
------
D
N
V
T
D
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
-------
S
A
-----
I
T
K
K
Y
A
---------
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
K
A
-
M
G
I
------
K
M
V
--
L
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
C
--
K
-
M
----
E
K
H
I
L
R
E
C
F
E
A
----
Y
L
----------
P
A
S
V
A
W
R
Q
K
-
E
Q
F
S
D
G
V
G
Y
--
S
-----------
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
----------
L
P
S
A
A
E
CVPG-----------------------------
1
PsiBlast_PDB
94.36
37%
0
- C- -
-
1CT9
2
ASNB_ECOLI
A:
[29-516]
---------------------------------------------------
H
R
G
P
D
--------------
W
S
G
I
Y
A
S
D
N
A
I
L
A
H
E
R
L
S
I
V
D
V
N
A
G
A
Q
P
L
Y
N
Q
-
Q
------
K
---------
T
H
V
----------
L
A
V
N
G
E
-------------
I
Y
N
H
Q
A
L
R
A
E
Y
GD
R
---
Y
---
Q
----
F
Q
T
G
S
D
C
E
V
I
L
A
-----
L
Y
Q
E
K
----------------
G
P
E
-
F
L
D
D
L
------------------
Q
G
M
F
A
F
A
L
Y
D
S
E
K
D
A
Y
L
I
G
R
D
H
L
G
I
I
P
L
Y
M
----
G
Y
D
E
----
H
G
Q
L
----
Y
V
A
S
E
M
K
A
L
V
P
V
C
--------
R
T
-------------------------------
I
K
---
E
F
P
A
G
S
---
Y
L
---
W
S
Q
D
G
---------
E
-
I
--
R
S
------
Y
Y
H
R
----
D
W
F
D
Y
D
A
V
K
D
N
V
--------------------
T
D
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
SAITKKY
A
---------------------
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
-
K
A
M
G
I
------
K
M
V
--
L
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
C
---K
M
----
E
K
H
I
L
R
E
C
F
E
----
A
Y
L
----------
P
A
S
V
A
W
R
Q
K
-
E
Q
F
S
D
G
-----
V
G
Y
--------
S
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
LPSAAECVPG---------------------------------------
23
Fugue
70.63
19%
-2
- C3 -
-
1JGT
3
BLS_STRCL
A:
[4-508]
------------------PV
L
P
A
A
F
G
F
L
A
S
A
R
T
G
----
G
G
P
V
F
A
T
--
R
-
G
S
H
T
D
I
D
T
--------------
P
Q
G
E
R
S
L
A
A
T
L
V
H
A
P
S
V
A
P
D
R
A
-
V
A
R
S
L
T
G
A
-
P
------------------
T
-------
T
--
A
V
L
A
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
-
L
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
R
T
--
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
-----
P
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
H
P
KGFPLADA
R
R
----
V
-----
A
----------------
G
L
T
G
V
Y
---
Q
V
P
A
G
A
---
V
M
D
I
D
L
-
G
S
G
---------
T
-
A
--
V
T
H
-
R
T
W
T
P
G
L
S
----
R
R
I
L
-------------------------
P
E
G
E
A
V
-
A
A
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
------
E
-
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
L
P
L
T
A
L
Y
R
----
A
L
D
G
P
E
R
--------
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
L
A
H
D
M
A
T
F
D
G
L
N
E
----
M
-------
S
P
V
L
S
T
L
A
G
H
W
T
T
H
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
R
-
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
----
A
L
----------
P
A
E
T
V
N
R
P
K
L
S
S
F
S
R
L
L
L
D
HG
V
A
E
--------
D
R
V
H
E
A
K
R
----
Q
V
V
-
R
E
L
F
-
D
L
T
V
G
G
G
R
H
----------------------------------------------------------
P
S
E
V
D
T
D
D
V
V
R
S
V
A
D
R
T
------
22
Fugue
70.33
19%
-17
- C3 -
-
1Q19
2
CARA_PECCC
A:
[2-501]
--------------------
S
N
S
F
C
V
V
Y
K
G
--------
S
D
T
D
I
N
N
I
-
Q
-
R
D
F
D
G
------------------------
K
G
E
A
L
S
N
G
Y
L
F
I
E
Q
N
G
H
Y
Q
K
C
E
M
E
-
R
------
G
-------------------
T
--
A
Y
L
I
G
S
-------------
L
Y
N
R
T
F
L
I
G
L
A
--
G
VWE
G
---
E
----
A
Y
L
A
N
D
A
E
L
L
A
L
-----
L
F
T
R
L
----------------
G
-
A
N
A
L
A
L
A
------------------
E
G
D
F
C
F
F
I
D
E
P
-
N
G
E
L
T
V
I
T
E
S
R
G
F
S
P
V
H
V
----
V
Q
G
K
----
K
A
W
M
TNSL
K
L
V
T
A
A
E
G
E
G
A
L
W
--------
F
E
----
E
-----
E
----------------
A
L
V
C
Q
S
---
L
M
R
A
D
T
YTP
V
K
N
A
Q
R
L
K
P
G
---------
A
-
V
--
H
V
L
-
T
H
D
S
E
G
Y
-----
S
F
V
E
S
R
T
L
T
T
P
A
S
N
---
Q
L
-
L
A
L
------
P
R
E
P
L
L
-
A
L
I
D
R
Y
L
N
A
P
L
E
D
L
A
P
R
F
D
T
V
G
I
P
L
S
G
G
L
D
S
S
L
V
-------
T
A
-----
L
A
S
R
H
F
K
------
K
-
L
N
T
Y
S
I
G
T
E
L
S
N
E
F
E
F
S
Q
Q
V
A
D
A
L
G
T
H
H
Q
M
K
I
L
S
---
E
T
E
V
I
N
G
I
I
E
S
I
-----------------------
Y
Y
N
E
I
F
D
G
L
S
A
E
I
Q
S
G
L
F
N
V
Y
R
----
Q
A
Q
G
Q
V
S
--------
C
M
--
L
T
G
Y
G
S
D
L
--
L
F
G
G
I
L
--
K
P
G
A
Q
Y
--
D
N
P
N
Q
L
L
A
E
Q
V
Y
R
T
R
W
T
G
---
E
F
-------
A
T
H
G
A
S
C
Y
G
I
D
I
R
H
P
F
W
S
-
H
S
L
I
S
L
C
-
H
A
L
----
H
P
D
Y
K
I
F
-
D
N
-
E
----
V
K
N
I
L
R
E
Y
A
D
S
L
--
Q
L
L
----------
P
K
D
I
V
W
R
K
K
-
I
G
I
H
E
G
-
S
S
--
V
N
Q
--------
A
F
A
N
V
L
G
S
----
T
V
D
N
Y
Q
T
K
-
S
R
F
T
Y
R
V
Y
Q
A
F
L
R
G
R
L
-------------------------------------------------------
S
I
T
D
V
T
P
S
Q
L
K
D
L
I
K
----
38
HHSearch
67.27
20%
-20
- C3 -
-
1JGT
7
BLS_STRCL
B:
[26-491]
---------------------------------------------
P
-
V
-
F
A
T
R
G
S
H
T
-----------
D
I
D
T
P
Q
G
-
E
R
S
L
A
A
T
L
V
H
A
P
S
---
V
A
P
D
R
A
V
A
R
S
L
T
------
G
---------
A
P
T
-------
T
--
A
V
L
A
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
-
L
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
R
T
G
--
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
H
R
--------
D
P
----
K
GFPLA
D
ARRVA-----------
G
L
T
G
V
Y
---
Q
V
P
A
G
A
---
V
M
D
I
D
--
L
G
S
---------
G
-
T
--
A
V
T
-
H
R
T
W
T
P
G
L
------
S
R
----------------
R
I
L
------
P
E
G
E
A
V
-
A
A
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
------
G
E
-
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
L
P
L
T
A
L
Y
R
----
A
L
D
--
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
---
L
D
T
V
L
A
H
D
M
A
T
F
D
-
G
L
N
E
M
-------
S
P
V
L
S
T
L
A
G
H
W
T
T
H
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
R
-
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
----
A
L
----------
P
A
E
T
V
N
R
P
K
-
L
G
V
H
E
G
S
G
T
--
T
-------------------------------------------------------------------------------------------------------------------------
40
HHSearch
66.96
22%
-17
- C3 -
-
1Q15
-
CARA_PECCC
B:
[41-465]
---------------------------------------------------------------------------------------------
G
H
Y
Q
K
C
E
M
E
-------------------
R
G
-------
T
--
A
Y
L
I
G
S
-------------
L
Y
N
R
T
F
L
I
G
L
A
--
G
---
V
WEG
E
----
A
Y
L
A
N
D
A
E
L
L
A
L
-----
L
F
T
R
L
----------------
G
-
A
N
A
L
A
L
A
------------------
E
G
D
F
C
F
F
I
D
E
P
-
N
G
E
L
T
V
I
T
E
S
R
G
F
S
P
V
H
V
----
V
Q
G
K
------
K
A
----
W
M
T
N
S
L
K
L
V
T
A
A
E
--------
G
E
GALW
F
-----
E
EEALVCQSLMRADTYT
P
V
K
N
A
Q
---
R
L
K
P
G
A
---
V
H
V
L
T
--
H
D
S
---------
E
G
Y
SF
V
E
S
-
R
T
L
T
T
P
A
S
-------
N
Q
L
--------------
L
A
L
------
P
R
E
P
L
L
-
A
L
I
D
R
Y
L
N
A
P
L
E
D
L
A
P
R
F
D
T
V
G
I
P
L
S
G
G
L
D
S
S
L
V
-------
T
A
-----
L
A
S
R
H
F
K
------
K
-
L
N
T
Y
S
I
G
T
E
L
S
N
E
F
E
F
S
Q
Q
V
A
D
A
L
G
T
H
H
Q
M
K
I
L
S
---
E
T
E
V
I
N
G
I
I
E
S
I
-----------------------
Y
Y
N
E
I
F
D
G
L
S
A
E
I
Q
S
G
L
F
N
V
Y
R
----
Q
A
Q
--
G
Q
V
------
S
C
M
--
L
T
G
Y
G
S
D
L
--
L
F
G
G
I
L
--
K
P
G
A
Q
Y
D-
N
P
N
Q
L
---
L
A
E
Q
V
Y
R
-
T
R
W
T
G
E
F
-------
A
T
H
G
A
S
C
Y
G
I
D
I
R
H
P
F
W
S
-
H
S
L
I
S
L
C
-
H
A
L
----
H
P
D
Y
K
I
F
-
D
N
-
E
----
V
K
N
I
L
R
E
Y
A
D
S
L
--
Q
L
L
----------
P
K
D
I
V
W
R
K
K
-
I
G
I
H
E
G
S
S
V
--
N
-------------------------------------------------------------------------------------------------------------------------
39
HHSearch
66.41
22%
-16
* C3 *
-
1Q19
2
CARA_PECCC
A:
[41-453]
---------------------------------------------------------------------------------------------
G
H
Y
Q
K
C
E
M
E
-------------------
R
G
-------
T
--
A
Y
L
I
G
S
-------------
L
Y
N
R
T
F
L
I
G
L
A
--
G
---
V
WEG
E
----
A
Y
L
A
N
D
A
E
L
L
A
L
-----
L
F
T
R
L
----------------
G
-
A
N
A
L
A
L
A
------------------
E
G
D
F
C
F
F
I
D
E
P
-
N
G
E
L
T
V
I
T
E
S
R
G
F
S
P
V
H
V
----
V
Q
G
K
------
K
A
----
W
M
T
N
S
L
K
L
V
T
A
A
E
--------
G
E
GALW
F
-----
E
EEALVCQSLMRADTYT
P
V
K
N
A
Q
---
R
L
K
P
G
A
---
V
H
V
L
T
--
H
D
S
---------
E
G
Y
SF
V
E
S
-
R
T
L
T
T
P
A
S
-------
N
Q
L
--------------
L
A
L
------
P
R
E
P
L
L
-
A
L
I
D
R
Y
L
N
A
P
L
E
D
L
A
P
R
F
D
T
V
G
I
P
L
S
G
G
L
D
S
S
L
V
-------
T
A
-----
L
A
S
R
H
F
K
------
K
-
L
N
T
Y
S
I
G
T
E
L
S
N
E
F
E
F
S
Q
Q
V
A
D
A
L
G
T
H
H
Q
M
K
I
L
S
---
E
T
E
V
I
N
G
I
I
E
S
I
-----------------------
Y
Y
N
E
I
F
D
G
L
S
A
E
I
Q
S
G
L
F
N
V
Y
R
----
Q
A
Q
--
G
Q
V
------
S
C
M
--
L
T
G
Y
G
S
D
L
--
L
F
G
G
I
L
--
K
P
G
A
Q
Y
D-
N
P
N
Q
L
---
L
A
E
Q
V
Y
R
-
T
R
W
T
G
E
F
-------
A
T
H
G
A
S
C
Y
G
I
D
I
R
H
P
F
W
S
-
H
S
L
I
S
L
C
-
H
A
L
----
H
P
D
Y
K
I
F
-
D
N
-
E
----
V
K
N
I
L
R
E
Y
A
D
S
L
--
Q
L
L
----------
P
K
D
I
V
W
R
K
K
-
I
G
I
H
E
G
S
S
V
--
N
-------------------------------------------------------------------------------------------------------------------------
24
Fugue
64.96
43%
0
- C- -
-
1CT9
2
ASNB_ECOLI
A:
[193-516]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
W
F
D
Y
D
A
V
------
K
D
N
------
V
--
T
D
K
-
N
E
L
R
Q
A
L
E
D
S
V
K
S
H
L
M
S
D
V
P
Y
G
V
L
L
S
G
G
L
D
S
S
I
I
-------
S
A
-----
I
T
K
K
Y
A
---------
L
H
S
F
A
V
G
L
P
G
S
P
D
L
K
A
A
Q
E
V
A
N
H
L
G
T
V
H
H
E
I
H
F
T
---
V
Q
E
G
L
D
A
I
R
D
V
I
-----------------------
Y
H
I
E
T
Y
D
V
T
T
I
R
A
S
T
P
M
Y
L
M
S
R
----
K
I
K
A
M
G
I
K
------
M
V
L
---
S
G
E
G
S
D
E
--
V
F
G
G
Y
L
--
Y
F
H
K
A
P
--
N
A
K
E
L
H
E
E
T
V
R
K
L
L
A
L
H
M
Y
D
C
A
R
-------
A
N
K
A
M
S
A
W
G
V
E
A
R
V
P
F
L
D
-
K
K
F
L
D
V
A
-
M
R
I
----
N
P
Q
D
K
M
C
-
K
--
M
----
E
K
H
I
L
R
E
C
F
E
A
Y
----
L
----------
P
A
S
V
A
W
R
Q
K
-
E
Q
F
S
D
G
-----
V
G
Y
--------
S
W
I
D
T
L
K
E
----
V
A
A
-
Q
Q
V
S
-
D
Q
Q
L
E
T
A
R
F
R
F
P
Y
N
T
P
T
S
K
E
A
Y
L
Y
R
E
I
F
E
E
L
--------
F
P
------------------------
L
P
S
A
A
E
C
V
P
G
---------------
7
PsiBlast_PDB
64.17
22%
-20
- C3 -
-
1MBZ
3
BLS_STRCL
A:
[77-463]
-----------------------------------------------------------------------------------------------------------------------------------------
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
L
-
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
--
R
T
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
H
----------------------------------------------------
G
---
F
P
L
A
D
A
R
R
V
A
---------
G
-
L
--
T
G
V
-
Y
Q
V
P
A
G
A
V
----
M
D
I
D
L
G
S
G
T
A
V
T
H
R
---
T
W
T
P
G
L
SRRILP
E
G
E
A
V
A
-
A
-
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
E
-------
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
--
L
P
L
T
A
L
----
Y
R
A
L
D
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
------
L
A
H
D
M
A
T
F
D
G
L
N
EMSP---
V
L
S
T
L
A
G
H
W
T
T
H
--
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
-
R
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
A
----
L
----------
P
A
E
T
V
N
R
P
K
-
L
G
V
H
E
G
-
S
G
--
T
T
S
--------
S
F
S
R
L
L
L
D
----
H
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.46
22%
-19
- C3 -
-
1MC1
3
BLS_STRCL
A:
[77-463]
-----------------------------------------------------------------------------------------------------------------------------------------
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
L
-
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
--
R
T
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
-----------------------------------------------------
G
---
F
P
L
A
D
A
R
R
V
A
---------
G
-
L
--
T
G
V
-
Y
Q
V
P
A
G
A
V
----
M
D
I
D
L
G
S
G
T
A
V
T
H
R
---
T
W
T
P
G
L
SRRILP
E
G
E
A
V
A
-
A
-
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
E
-------
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
--
L
P
L
T
A
L
----
Y
R
A
L
D
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
------
L
A
H
D
M
A
T
F
D
G
L
N
EMSP---
V
L
S
T
L
A
G
H
W
T
T
H
--
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
-
R
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
A
----
L
----------
P
A
E
T
V
N
R
P
K
-
L
G
V
H
E
G
-
S
G
--
T
T
S
--------
S
F
S
R
L
L
L
D
----
H
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.32
22%
-22
- C3 -
-
1JGT
3
BLS_STRCL
A:
[77-463]
-----------------------------------------------------------------------------------------------------------------------------------------
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
L
-
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
--
R
T
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
H
--------------------------------------------------
P
K
G
---
F
P
L
A
D
A
R
R
V
A
---------
G
-
L
--
T
G
V
-
Y
Q
V
P
A
G
A
V
----
M
D
I
D
L
G
S
G
T
A
V
T
H
R
---
T
W
T
P
G
L
SRRILP
E
G
E
A
V
A
-
A
-
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
E
-------
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
--
L
P
L
T
A
L
----
Y
R
A
L
D
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
------
L
A
H
D
M
A
T
F
D
G
L
N
EMSP---
V
L
S
T
L
A
G
H
W
T
T
H
--
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
-
R
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
A
----
L
----------
P
A
E
T
V
N
R
P
K
-
L
------------
S
--------
S
F
S
R
L
L
L
D
----
H
--------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.74
22%
-25
- C3 -
-
1MB9
1
BLS_STRCL
A:
[77-463]
-----------------------------------------------------------------------------------------------------------------------------------------
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
L
-
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
--
R
T
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
---------------------------------------------------------
F
P
L
A
D
A
R
R
V
A
---------
G
-
L
--
T
G
V
-
Y
Q
V
P
A
G
A
V
----
M
D
I
D
L
G
S
G
T
A
V
T
H
R
---
T
W
T
P
G
L
SRRILP
E
G
E
A
V
A
-
A
-
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
E
-------
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
--
L
P
L
T
A
L
----
Y
R
A
L
D
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
------
L
A
H
D
M
A
T
F
D
G
L
N
EMSP---
V
L
S
T
L
A
G
H
W
T
T
H
--
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
-
R
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
A
----
L
----------
P
A
E
T
V
N
R
P
K
--------------
S
--------
S
F
S
R
L
L
L
D
----
H
--------------------------------------------------------------------------------------------------
25
Fugue
61.83
18%
-4
- C3 -
-
1ECF
3
PUR1_ECOLI
A:
[1-492]
---------------------
C
G
I
V
G
I
A
G
V
M
P
V
N
----
Q
S
I
Y
D
A
L
T
-
V
-
L
Q
H
R
G
Q
D
A
AGIITIDANNC
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
-
T
------
A
GSSSASEAQ
P
F
Y
VNSPYGI
T
--
L
A
H
N
G
N
-------------
L
T
N
A
H
E
L
R
K
K
L
--
F
---
E
---
E
KRRH
I
N
T
T
S
D
S
E
I
L
L
N
-----
I
F
A
S
E
LDNFRHYPLEADNIFA
A
I
A
A
T
N
R
L
I
------------------
R
G
A
Y
A
C
V
A
M
I
I
G
H
-
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
----
G
K
R
D
IDEN
R
T
E
Y
----
M
V
A
S
E
S
V
A
L
D
T
L
G
--------
F
D
----
F
-----
L
----------------
R
D
V
A
--------
P
G
-----
E
A
I
Y
I
T
E
E
G
---------
Q
-
L
--
F
T
R
-
Q
C
A
D
--------
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
---
A
R
-
P
D
S
------
F
I
D
K
---------------------------
I
S
V
Y
S
A
R
V
N
M
-------
G
T
-----
K
L
G
E
K
I
A
R
E
W
E
D
L
D
-
I
-
D
V
V
I
P
I
P
E
T
S
-
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
---
N
R
Y
V
G
R
T
F
I
M
P
G
-----------------------
Q
Q
L
R
R
K
S
V
R
-------
R
K
L
N
A
N
----
R
A
E
F
R
D
K
N
------
V
L
L
--
V
D
----
D
S
--
I
V
R
G
------------------
T
T
S
E
Q
I
I
E
M
A
R
E
----------------
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
-
I
R
F
P
N
V
Y
G
I
D
M
----
P
S
A
T
E
L
I
A
H
G
-
R
----
E
V
D
E
I
R
Q
I
I
G
-----------------
A
D
G
L
I
F
Q
D
L
-
N
D
L
I
D
A
V
R
A
--
E
N
P
---------------------------
D
-
I
Q
Q
F
E
C
S
V
F
N
G
V
Y
V
T
K
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
--------
D
D
----------
A
K
A
V
-
Q
----
R
Q
---------------------------
34
Fugue
55.77
19%
-
- C- -
-
3WAI
-
AGLB3_ARCFU (first)
A:
[-1-868]
MKIEEGKLVIWINGDKGYNG
L
A
E
V
G
K
K
F
E
K
D
T
G
I
----
K
V
T
V
E
H
P
D
-
K
-
L
E
E
K
F
P
Q
V
-----------
A
A
T
G
D
--
G
P
D
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
T
P
D
-
K
AFQDKL
Y
---------
P
F
T
-------
W
DA
V
R
Y
N
G
K
LIAYPIAVEALSL
I
Y
N
K
D
L
L
P
N
P
P
--
K
T--
W
---
E
----
E
I
P
A
L
D
K
E
L
K
A
K
GKSAL
M
F
N
L
Q
----------------
E
P
Y
F
T
W
P
L
I
AADGGYAFKDVGVDNAGA
K
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
N
A
D
T
D
Y
S
I
A
E
A
A
F
N
KGET
A
M
T
I
----
N
G
P
W
----
A
W
S
N
I
D
T
S
K
V
N
Y
G
--------
V
T
----
V
-----
L
----------------
P
T
F
K
G
Q
PSK
P
F
V
G
V
L
---
S
A
G
I
N
A
A
S
P
N
---------
K
-
E
--
L
A
K
-
E
F
L
E
N
Y
L
L
----
T
D
E
G
L
E
A
V
N
K
D
K
P
L
GAV
A
L
-
K
S
Y
------
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
-------
N
A
ASGRQ
T
V
D
E
A
L
K
D
A
Q
T
N
K
Q
W
Y
D
A
L
T
W
M
R
E
N
T
P
D
---
G
E
K
Y
D
E
Y
-
P
F
E
T
Y
G
V
I
-
S
---
W
W
D
Y
G
H
W
I
E
A
V
A
HRMPIANPFQAGIGNKYNNVPGA
S
S
F
F
T
A
E
N
E
S
Y
A
E
F
V
A
E
K
L
N
V
K
----
Y
V
V
S
D
I
E
M
ETGKYY
A
M
A
--
V
W
A
E
G
D
L
P
--
L
A
E
K
Y
Y
GG
Y
F
Y
Y
S
P
--
T
G
T
F
G
Y
A
N
S
Q
W
D
I
P
L
N
S
I
I
I
P
L
R
-------
I
P
S
E
L
Y
Y
S
T
M
E
A
K
L
H
L
F
D
G
S
G
L
S
H
Y
R
-
M
I
Y
ESDY
P
A
E
W
K
S
Y
S
S
Q
-
V
NLNN
E
S
Q
V
L
Q
T
A
L
Y
E
A
--
V
M
R
ARYGVSPTMG
T
Q
E
V
L
Y
--
K
-
Y
A
Y
T
Q
L
Y
E
K
--
K
M
G
IPVKIAPS
G
Y
V
K
I
F
E
R
VKGA
V
V
T
-
G
K
V
S
--
A
N
V
T
E
V
S
V
N
A
T
I
K
T
N
Q
N
R
T
F
E
Y
W
Q
T
V
E
V
K
N
GTYTVVLP
Y
S
----------
H
N
S
D
-
Y
----
P
V
K
P
I
T
P
Y
H
I
K
A
-
G
N
V
V
K
E
I
T
I
Y
E
S
Q
V
Q
N
5
PsiBlast_PDB
50.56
22%
0
- C- -
-
1M1Z
-
BLS_STRCL
A:
[77-468]
-----------------------------------------------------------------------------------------------------------------------------------------
G
E
-------------
I
Y
N
R
D
E
L
L
S
V
L
--
P
---
A
---
G
----
P
A
P
E
G
D
A
E
L
V
L
R
-----
L
L
E
R
Y
----------------
D
L
-
H
A
F
R
L
V
------------------
N
G
R
F
A
T
V
V
--
R
T
G
D
R
V
L
L
A
T
D
H
A
G
S
V
P
L
Y
T
----
C
V
A
P
-----
G
E
V
----
R
A
S
T
E
A
K
A
L
A
A
H
--------------------------------------------------------
F
P
L
A
D
A
R
R
V
A
---------
G
-
L
--
T
G
V
-
Y
Q
V
P
A
G
A
V
----
M
D
I
D
L
G
S
G
T
A
V
T
H
R
---
T
W
T
P
G
L
SRRILP
E
G
E
A
V
A
-
A
-
V
R
A
A
L
E
K
A
V
A
Q
R
V
T
P
G
D
T
P
L
V
V
L
S
G
G
I
D
S
S
G
V
-------
A
A
-----
C
A
H
R
A
A
G
E
-------
L
D
T
V
S
M
G
T
D
T
S
N
E
F
R
E
A
R
A
V
V
D
H
L
R
T
R
H
R
E
I
T
I
P
---
T
T
E
L
L
A
Q
L
P
Y
A
V
-----------------------
W
A
S
E
S
V
D
P
D
I
I
E
Y
L
--
L
P
L
T
A
L
----
Y
R
A
L
D
G
P
E
------
R
R
I
--
L
T
G
Y
G
A
D
I
--
P
L
G
G
M
H
--
R
E
D
R
L
P
--
A
L
D
T
V
------
L
A
H
D
M
A
T
F
D
G
L
N
EMSP---
V
L
S
T
L
A
G
H
W
T
T
H
--
P
Y
W
D
-
R
E
V
L
D
L
L
-
V
S
L
----
E
A
G
L
K
R
-
R
H
G
-
R
----
D
K
W
V
L
R
A
A
M
A
D
A
----
L
----------
P
A
E
T
V
N
R
P
K
--------------
S
--------
S
F
S
R
L
L
L
D
----
H
--------------------------------------------------------------------------------------------------
27
Fugue
49.36
16%
-33
- C1 -
-
5SVD
-
NOP9_YEAST
A:
[5-589]
--------------------
Q
M
F
F
G
V
L
D
R
E
E
L
E
Y
----
F
K
Q
A
E
S
T
L
-
Q
-
L
D
A
F
E
A
P
E
-----------
E
K
F
Q
F
V
T
S
I
I
E
E
A
K
G
K
E
L
K
L
V
T
S
Q
I
-----------------------------
T
-------
S
--
K
L
M
E
R
V
-------------
I
L
E
C
D
E
T
Q
L
K
D
--
I
---
F
---
Q
----
S
F
N
G
V
F
F
G
L
S
C
H
-----
K
Y
A
S
H
----------------
V
L
E
T
L
F
V
R
S
------------------
A
A
L
V
E
R
E
L
L
T
Y
V
T
M
E
N
M
F
L
F
M
L
N
E
L
K
P
H
L
K
----
T
M
M
N
----
H
Q
Y
A
----
S
H
V
L
R
L
L
I
L
I
L
S
S
--------
K
T
----
L
-----
P
----------------
V
Y
Q
T
P
E
---
S
F
K
S
E
L
---
R
D
I
I
T
T
L
Y
K
G
FTNGAESRS
D
-
I
--
S
Q
S
-
T
I
T
K
F
R
E
Y
SVDK
V
A
S
P
V
I
Q
L
I
I
Q
V
E
G
---
I
F
------------
D
R
D
R
-
S
F
W
R
L
V
F
N
T
A
D
E
K
D
P
K
E
E
S
F
L
E
Y
L
L
S
D
P
V
G
S
H
F
L
-------
E
N
-----
V
I
----
G
S
A
R
L
K
Y
V
-
E
R
L
Y
R
L
Y
M
K
D
R
I
V
K
L
A
K
R
---
D
T
T
G
A
F
V
V
R
A
L
L
E
HLK
E
K
D
V
K
Q
I
L
D
A
V
V
-----------------------
P
E
L
S
M
L
L
N
S
N
M
D
F
G
T
A
I
I
N
T
S
N
KQGG
Y
L
R
D
D
V
I
A
------
Q
L
I
QK
Y
Y
P
E
K
S
D
A
KN
I
L
E
S
C
L
--
L
L
S
A
S
T
LG
N
T
R
D
D
W
P
T
A
E
E
R
R
R
S
V
F
L
E
Q
L
I
D
-------
Y
D
D
K
F
L
N
I
T
I
D
S
M
L
A
L
P
E
-
E
R
L
I
Q
M
C
---------------
Y
H
G
-
V
----
F
S
H
V
V
E
H
V
L
Q
T
T
RV
D
I
I
----------
K
R
K
M
L
L
N
I
L
-
S
K
E
S
V
N
L
A
---
C
N
V
--------
Y
G
S
H
I
M
D
K
----
L
W
E
-
F
T
A
K
L
T
L
Y
K
E
R
I
A
R
A
L
V
L
E
T
E
K
V
K
N
S
I
Y
G
R
Q
V
W
K
N
--------------------------
W
K---
L
E
L
Y
V
R
K
M
W
D
W
K
K
L
I
K
E
Q
E
F
E
I
F
P
-----
2
PsiBlast_PDB
47.49
28%
-52
- C3 -
-
1Q15
-
CARA_PECCC
A:
[241-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
P
L
S
G
G
L
D
S
S
L
V
-------
T
A
-----
L
A
S
R
H
F
K
K
-------
L
N
T
Y
S
I
G
T
E
L
S
N
E
F
E
F
S
Q
Q
V
A
D
A
L
G
T
H
H
Q
M
K
I
L
S
---
E
T
E
V
I
N
G
I
I
E
S
I
-----------------------
Y
Y
N
E
I
F
D
G
L
S
A
E
I
Q
S
G
L
F
N
V
------
Y
R
Q
A
Q
G
Q
V
------
S
C
M
--
L
T
G
Y
G
S
D
L
--
L
F
G
G
I
L
----------
K
P
G
A
Q
Y
D
N
P
N
Q
L
L
A
E
----
Q
V
Y
R
TRWTGEF
A
T
H
G
A
S
C
Y
G
I
D
I
R
H
P
F
W
S
-
H
S
L
I
S
L
C
-
H
A
L
----
H
P
D
Y
K
I
F
D
N
E
-
V
-----
K
N
I
L
R
E
Y
A
D
S
L
--
Q
L
L
----------
P
K
D
I
V
W
R
-----------
S
--
V
N
Q
--------
A
F
A
N
V
L
G
S
----
T
V
D
-
N
----------------------------------------------------------------------------------------------