@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BCL2_HUMAN: (2020-01-31 )
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAHAGRTGYD
N
R
E
I
V
M
K
Y
I
H
Y
K
L
SQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVP
P
V
V
H
L
T
L
R
QAG
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
SSQLHLTPFTARG
R
F
A
T
V
V
E
E
L
F
RDGVNW
G
R
I
V
A
F
FEFGG
V
M
C
V
E
S
VNR
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
QDNG
G
W
D
A
F
V
E
LYGPSMRPLFD
F
S
W
L
S
L
K
T
L
L
S
L
A
L
V
G
A
C
I
T
L
G
A
Y
LGHK
2
PsiBlast_PDB
80.78
100%
-189
- C2 -
-
5JSN
-
BCL2_HUMAN
A:
[7-207]
------
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
------------------------------------------------------
S
P
V
P
P
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
17
PsiBlast_PDB
80.36
72%
-161
- C2 -
-
1G5M
-
BCL2_HUMAN
A:
[3-207]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
---------------
D
V
E
E
N
R
T
E
A
P
E
G
T
E
--------------------------
S
E
V
V
H
L
A
L
R
Q
A
G
D
D
F
S
R
R
Y
R
G
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
21
HHSearch
80.25
100%
-189
- C2 -
-
5JSN
-
BCL2_HUMAN
A:
[7-206]
------
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
------------------------------------------------------
S
P
V
P
P
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
5
PsiBlast_PDB
79.74
73%
-151
- C2 -
-
1GJH
-
?
A:
[3-207]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
---------------
D
V
E
E
N
R
T
E
A
P
E
G
T
E
--------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
13
PsiBlast_PDB
77.65
73%
-160
- C2 -
-
1YSW
1
BCL2_HUMAN
A:
[1-164]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
---------------
D
V
E
E
N
R
T
E
A
P
E
G
T
E
--------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
26
HHSearch
77.55
90%
-162
- C2 -
-
2O21
1
?
A:
[1-163]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
D
V
---------------------
E
E
N
R
T
E
----
A
----------------
P
E
G
T
E
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
15
PsiBlast_PDB
77.24
73%
-160
- C2 -
-
2O21
1
?
A:
[1-164]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
---------------
D
V
E
E
N
R
T
E
A
P
E
G
T
E
--------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
1
PsiBlast_PDB
76.67
100%
-193
- C2 -
-
2XA0
-
?
A:
[10-206]
---------
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
------------------------------------------------------------
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
14
PsiBlast_PDB
75.67
73%
-152
- C2 -
-
2O22
1
BCL2_HUMAN
A:
[1-164]
--
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
---------------
D
V
E
E
N
R
T
E
A
P
E
G
T
E
--------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
25
HHSearch
75.48
87%
-175
- C2 -
-
6GL8
1
BCL2_HUMAN
A:
[14-169]
------
G
S
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
A
D
-----------------------------------------------------
E
S
E
V
V
H
K
T
L
R
E
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
------------------------------------
3
PsiBlast_PDB
73.54
73%
-171
- C2 -
-
5VAU
-
?
A:
[3-167]
M
A
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
---------------------------------------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
16
PsiBlast_PDB
73.51
72%
-212
- C2 -
-
4AQ3
2
B2CL1_HUMAN (first)
A:
[12-165]
--------
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
------------------------------------------------------------
V
V
H
L
A
L
R
Q
A
G
D
D
F
S
R
R
Y
R
G
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
------------------------------------
12
PsiBlast_PDB
73.48
72%
-185
- C2 -
-
4LXD
1
?
A:
[6-163]
-----
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
--------------------------------------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
-----------------------------------
4
PsiBlast_PDB
73.17
73%
-166
- C2 -
-
5VAY
-
B2CL1_HUMAN
A:
[3-167]
M
A
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
---------------------------------------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
19
PsiBlast_PDB
72.58
71%
-177
- C2 -
-
6GL8
1
BCL2_HUMAN
A:
[14-169]
------
G
S
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
---------------------------------
A
D
------------
E
S
--------
E
V
V
H
K
T
L
R
E
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
------------------------------------
11
PsiBlast_PDB
72.22
72%
-201
- C2 -
-
4LVT
1
BCL2_HUMAN
A:
[9-163]
--------
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
A
---------------------------------------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
-----------------------------------
20
PsiBlast_PDB
72.15
69%
-202
- C2 -
-
2W3L
1
BCL2_HUMAN
A:
[1-144]
--------
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
---
D
A
---
S
E
---------------------------------------------------
V
V
H
K
T
L
R
E
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
G
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
---------------------------------
10
PsiBlast_PDB
72.11
72%
-189
- C2 -
-
5VAX
-
BCL2_HUMAN
A:
[11-168]
--------
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
------------------------------
T
E
--------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
S
M
R
--------------------------------
9
PsiBlast_PDB
71.90
73%
-185
- C2 -
-
4IEH
1
?
A:
[12-166]
--------
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
----------------------------------------------------------
S
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
-----------------------------------
6
PsiBlast_PDB
69.90
73%
-180
- C2 -
-
4MAN
1
BCL2_HUMAN
A:
[8-163]
-------
G
Y
D
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
-------------------------------------------------------------
E
V
V
H
L
T
L
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
E
F
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
W
I
Q
D
N
G
G
W
D
A
F
V
E
L
Y
G
P
-----------------------------------
27
HHSearch
65.65
53%
-163
- C2 -
-
3SP7
1
B2CL1_HUMAN
A:
[2-162]
----
E
F
M
S
Q
S
N
R
E
L
V
V
D
F
L
S
Y
K
L
S
Q
K
G
Y
S
W
S
Q
F
S
D
-----------------------------------------------------
E
S
E
A
V
K
Q
A
L
R
E
A
G
D
E
F
E
L
R
Y
R
R
A
F
S
D
L
T
S
Q
L
H
I
T
P
G
T
A
Y
Q
S
F
E
Q
V
V
N
E
L
F
R
D
G
V
N
W
G
R
I
V
A
F
F
S
F
G
G
A
L
C
V
E
S
V
D
K
E
M
Q
V
L
V
S
R
I
A
A
W
M
A
T
Y
L
N
D
H
L
E
P
W
I
Q
E
N
G
G
W
D
T
F
V
E
L
Y
G
N
N
A
---------------------------------