@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BDH2_HUMAN: (2020-01-31 )
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDGGWSL
Atome Classification :
(20 SA)
.........10........20........30........40....-.------..-------.------50...---.--..----..60-...----..----.-..70----.----.----.---.....80......---..90........100.......110.......120.......130.......140.......150.......160.......--170.......180.......---190.-----......200-----........210.......220.......230.......240...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGRLD
G
K
V
I
I
L
T
A
A
AQGI
G
Q
A
A
A
L
A
F
A
REG
A
K
V
I
A
TDI
N
E
S
K
L
Q
E
-
L
------
E
K-------Y------PGI
Q
T
---
R
--
V
L
----
D
V
T
K
-
K
K
Q
----
I
D
----
Q
-
F
A
N
E
----
V
----
E
----
R
---
L
D
V
L
F
N
V
A
G
F
VHH---G
T
V
LDCEEKDW
D
F
S
M
N
L
N
V
R
S
M
Y
L
M
I
K
A
F
L
P
K
M
L
A
Q
KSG
N
I
I
N
M
S
S
V
A
S
S
V
K
G
V
V
N
R
C
V
YSTTK
A
A
VIG
L
T
K
S
V
A
A
D
F
I
QQG--I
R
C
N
CVCPGTVD
T
P
S
L
Q
E
R
I
---
Q
ARG-----
N
P
E
E
A
R
N
D
------
F
L
K
R
QKTGRFA
T
A
E
E
I
A
M
L
C
V
Y
LASDE
S
A
Y
VTGN
P
V
I
IDGGWSL
1
PsiBlast_PDB
98.19
100%
-121
- C4 -
-
2AG5
1
BDH2_HUMAN
A:
[1-245]
M
G
R
L
D
G
K
V
I
I
L
T
A
A
A
Q
G
I
G
Q
A
A
A
L
A
F
A
R
E
G
A
K
V
I
A
T
D
I
N
E
S
K
L
Q
E
-
L
------
E
K
-------
Y
------
P
G
I
Q
T
---
R
--
V
L
----
D
V
T
K
-
K
K
Q
----
I
D
----
Q
-
F
A
N
E
----
V
----
E
----
R
---
L
D
V
L
F
N
V
A
G
F
V
H
H
---
G
T
V
L
D
C
E
E
K
D
W
D
F
S
M
N
L
N
V
R
S
M
Y
L
M
I
K
A
F
L
P
K
M
L
A
Q
K
S
G
N
I
I
N
M
S
S
V
A
S
S
V
K
G
V
V
N
R
C
V
Y
S
T
T
K
A
A
V
I
G
L
T
K
S
V
A
A
D
F
I
Q
Q
G
--
I
R
C
N
C
V
C
P
G
T
V
D
T
P
S
L
Q
E
R
I
---
Q
A
R
G
-----
N
P
E
E
A
R
N
D
------
F
L
K
R
Q
K
T
G
R
F
A
T
A
E
E
I
A
M
L
C
V
Y
L
A
S
D
E
S
A
Y
V
T
G
N
P
V
I
I
D
G
G
W
S
L
41
HHSearch
97.48
100%
-121
- C4 -
-
2AG5
1
BDH2_HUMAN
A:
[2-245]
-
G
R
L
D
G
K
V
I
I
L
T
A
A
A
Q
G
I
G
Q
A
A
A
L
A
F
A
R
E
G
A
K
V
I
A
T
D
I
N
E
S
K
L
Q
E
-
L
------
E
K
-------
Y
------
P
G
I
Q
T
---
R
--
V
L
----
D
V
T
K
-
K
K
Q
----
I
D
----
Q
-
F
A
N
E
----
V
----
E
----
R
---
L
D
V
L
F
N
V
A
G
F
V
H
H
---
G
T
V
L
D
C
E
E
K
D
W
D
F
S
M
N
L
N
V
R
S
M
Y
L
M
I
K
A
F
L
P
K
M
L
A
Q
K
S
G
N
I
I
N
M
S
S
V
A
S
S
V
K
G
V
V
N
R
C
V
Y
S
T
T
K
A
A
V
I
G
L
T
K
S
V
A
A
D
F
I
Q
Q
G
--
I
R
C
N
C
V
C
P
G
T
V
D
T
P
S
L
Q
E
R
I
---
Q
A
R
G
-----
N
P
E
E
A
R
N
D
------
F
L
K
R
Q
K
T
G
R
F
A
T
A
E
E
I
A
M
L
C
V
Y
L
A
S
D
E
S
A
Y
V
T
G
N
P
V
I
I
D
G
G
W
S
L
2
PsiBlast_PDB
73.82
43%
-126
- C4 -
-
4YQZ
-
?
A:
[32-257]
---------
L
V
I
A
A
G
Q
G
I
G
R
A
I
A
E
A
F
Q
R
E
G
A
E
V
L
G
A
T
L
H
P
E
K
L
Q
G
-
V
---------------
V
------
P
A
V
R
--------
L
----
D
A
R
D
-
K
E
A
----
V
F
----
R
-
L
I
Q
G
----
L
----
D
----
R
---
L
D
V
L
V
N
A
Q
G
V
V
P
V
---
G
G
L
L
E
A
T
D
Q
D
W
E
E
A
F
L
L
N
A
K
S
V
F
W
A
M
Q
A
A
L
P
K
M
A
A
Q
G
G
G
S
V
I
N
I
A
S
V
A
A
-
F
K
T
V
P
G
R
F
I
Y
S
A
T
K
A
A
L
V
A
M
T
K
A
A
A
L
E
F
A
P
K
G
--
V
R
V
N
A
I
C
P
G
T
V
D
T
P
S
L
R
E
-------
R
A
-----
G
G
E
E
G
L
R
A
------
F
A
E
R
Q
L
L
K
R
L
G
R
P
E
E
I
A
A
L
A
V
Y
L
A
S
D
E
G
A
F
A
T
G
S
A
F
V
V
D
G
G
M
S
L
5
PsiBlast_PDB
71.60
33%
-74
- C4 -
-
4NBT
1
?
A:
[2-240]
-
K
K
L
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
I
A
G
D
L
G
D
L
T
Y
S
------------------
H
------
P
N
V
E
G
---
M
--
Y
L
----
N
V
T
D
-
V
T
G
----
V
E
----
K
-
F
Y
Q
S
----
V
IDKY
G
----
K
---
I
D
I
L
V
N
N
A
G
I
T
K
D
---
A
M
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
P
Q
M
Q
T
N
G
Y
G
S
I
I
N
I
S
S
V
V
-
G
V
F
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
L
K
T
V
--------------
P
Q
D
L
L
D
K
------
F
A
A
L
T
M
L
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
R
L
10
PsiBlast_PDB
67.88
34%
-44
- C4 -
-
5ITW
-
BACC_BACSU
A:
[4-253]
--
N
L
T
D
K
T
V
L
I
T
G
G
A
S
G
I
G
Y
A
A
V
Q
A
F
L
G
Q
Q
A
N
V
V
V
A
D
I
D
E
A
Q
G
E
A
-
M
VRKENN
D
R
-------
L
------
H
F
V
Q
T
---
D
--
I
T
----
D
E
A
A
C
Q
H
A
----
V
E
----
S
-
A
V
H
T
----
F
----
G
----
G
---
L
D
V
L
I
N
N
A
G
I
E
I
V
---
A
P
I
H
E
M
E
L
S
D
W
N
K
V
L
Q
V
N
L
T
G
M
F
L
M
S
K
H
A
L
K
H
M
L
A
A
G
K
G
N
I
I
N
T
C
S
V
G
G
L
V
-
A
W
P
D
I
P
A
Y
N
A
S
K
G
G
V
L
Q
L
T
K
S
M
A
V
D
Y
A
K
H
Q
--
I
R
V
N
C
V
C
P
G
I
I
D
T
P
-
L
N
E
K
S
FLE
N
N
E
G
-----
T
L
E
E
I
K
K
E
------
K
A
K
V
N
P
L
L
R
L
G
K
P
E
E
I
A
N
V
M
L
F
L
A
S
D
L
S
S
Y
M
T
G
S
A
I
T
A
D
G
G
Y
T
-
9
PsiBlast_PDB
67.64
34%
-47
- C4 -
-
5ITV
1
BACC_BACSU
A:
[4-253]
--
N
L
T
D
K
T
V
L
I
T
G
G
A
S
G
I
G
Y
A
A
V
Q
A
F
L
G
Q
Q
A
N
V
V
V
A
D
I
D
E
A
Q
G
E
A
-
M
VRKENN
D
R
-------
L
------
H
F
V
Q
T
---
D
--
I
T
----
D
E
A
A
C
Q
H
A
----
V
E
----
S
-
A
V
H
T
----
F
----
G
----
G
---
L
D
V
L
I
N
N
A
G
I
E
I
V
---
A
P
I
H
E
M
E
L
S
D
W
N
K
V
L
Q
V
N
L
T
G
M
F
L
M
S
K
H
A
L
K
H
M
L
A
A
G
K
G
N
I
I
N
T
C
S
V
G
G
L
V
-
A
W
P
D
I
P
A
Y
N
A
S
K
G
G
V
L
Q
L
T
K
S
M
A
V
D
Y
A
K
H
Q
--
I
R
V
N
C
V
C
P
G
I
I
D
T
P
-
L
N
E
K
S
FLE
N
N
E
G
-----
T
L
E
E
I
K
K
E
------
K
A
K
V
N
P
L
L
R
L
G
K
P
E
E
I
A
N
V
M
L
F
L
A
S
D
L
S
S
Y
M
T
G
S
A
I
T
A
D
G
G
Y
T
-
17
PsiBlast_PDB
65.92
35%
-20
- C4 -
-
2CFC
2
HCDR_XANP2
A:
[3-248]
------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
-
T
------
A
R
TH-----
W
------
H
A
Y
A
D
---
K
--
V
L
RVRA
D
V
A
D
-
E
G
D
----
V
N
----
A
A
I
A
A
T
----
M
----
E
----
Q
FGA
I
D
V
L
V
N
N
A
G
I
T
G
N
SEA
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
-
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
--
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
T
Q
W
R
L
------------
D
Q
P
E
L
R
D
Q
------
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
-
4
PsiBlast_PDB
65.90
34%
-32
- C4 -
-
4DQX
-
?
A:
[25-271]
---
L
N
Q
R
V
C
I
V
T
G
G
G
S
G
I
G
R
A
T
A
E
L
F
A
K
N
G
A
Y
V
V
V
A
D
V
N
E
D
A
A
V
R
-
V
------
A
N
-------
E
------
I
G
S
K
A
FGV
R
--
V
-----
D
V
S
S
-
A
K
D
AESM
V
E
----
K
-
T
T
A
K
----
W
----
G
----
R
---
V
D
V
L
V
N
N
A
G
F
G
T
T
---
G
N
V
V
T
I
P
E
E
T
W
D
R
I
M
S
V
N
V
K
G
I
F
L
C
S
K
Y
V
I
P
V
M
R
R
N
G
G
G
S
I
I
N
T
T
S
Y
-
T
A
T
S
A
I
A
D
R
T
A
Y
V
A
S
K
G
A
I
S
S
L
T
R
A
M
A
M
D
H
A
K
E
G
--
I
R
V
N
A
V
A
P
G
T
I
D
S
P
Y
F
T
K
I
F
---
A
E
A
K
-----
D
P
A
K
L
R
S
D
------
F
N
A
R
A
V
M
D
R
M
G
T
A
E
E
I
A
E
A
M
L
F
L
A
S
D
R
S
R
F
A
T
G
S
I
L
T
V
D
G
G
S
S
I
18
PsiBlast_PDB
65.10
34%
-35
- C4 -
-
4NBU
1
?
A:
[9-247]
-
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
A
G
K
E
A
V
------
E
A
-------
N
------
P
G
V
V
F
---
I
--
R
V
----
D
V
S
D
-
R
E
S
----
V
H
----
R
-
L
V
E
N
----
V
----
A
ERFG
K
---
I
D
I
L
I
N
N
A
G
I
T
R
D
---
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
-
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
--------------
P
E
K
V
I
E
K
------
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
---
42
HHSearch
63.84
24%
-20
- C4 -
-
5VPS
2
?
A:
[13-263]
---
I
A
G
K
T
A
L
V
C
A
A
S
K
G
L
G
R
G
C
A
E
A
L
A
A
E
G
V
N
L
V
I
V
A
R
T
R
D
T
L
E
E
-
T
------
A
E
-------
E
IRAASN
V
S
V
T
A
---
V
--
A
C
----
D
I
T
T
-
P
D
G
----
R
A
----
A
-
A
L
A
A
----
C
----
P
----
Q
---
P
D
I
L
V
N
N
A
G
G
P
P
P
---
G
D
F
R
D
F
S
H
D
D
W
I
R
A
L
E
A
N
M
L
T
P
I
E
L
I
R
A
T
V
D
G
M
I
G
R
G
F
G
R
I
V
N
I
T
S
S
A
V
K
-
A
P
I
D
V
L
A
L
S
N
G
A
R
S
G
L
T
G
F
V
A
G
L
S
R
K
V
A
G
Q
G
--
V
T
I
N
N
L
L
P
G
L
F
D
T
D
R
I
A
T
T
L
---
A
A
S
A
KAQGV
T
V
D
E
L
R
A
R
------
R
A
K
E
I
P
A
G
R
L
G
T
R
A
E
F
G
A
A
C
A
F
L
C
S
V
H
A
G
Y
I
T
G
Q
N
W
L
L
D
G
G
A
Y
-
15
PsiBlast_PDB
63.69
33%
-13
- C4 -
-
3RRO
5
FABG_VIBCH
A:
[10-250]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
-
I
------
S
D
-------
Y
------
L
G
D
N
G
---
K
GM
A
L
----
N
V
T
N
-
P
E
S
----
I
E
AVLK
A
-
I
T
D
E
----
F
----
G
----
G
---
V
D
I
L
V
N
N
A
G
I
T
R
D
---
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
-
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
---------
M
T
K
A
-----
L
N
D
E
Q
R
T
A
------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
39
HHSearch
62.86
24%
-23
- C4 -
-
5IDY
2
?
B:
[11-264]
-
L
G
I
A
G
K
T
A
L
V
C
A
A
S
K
G
L
G
R
G
C
A
E
A
L
A
A
E
G
V
N
L
V
I
V
A
R
T
R
D
T
L
E
R
-
T
------
A
D
EIRAAS-
N
------
V
S
V
A
T
---
V
--
A
C
----
D
I
T
T
-
P
D
G
----
R
A
----
A
-
A
L
A
A
----
C
----
P
----
Q
---
P
D
I
L
V
N
N
A
G
G
P
P
P
---
G
D
F
R
D
F
S
H
D
D
W
I
R
A
L
E
S
N
M
L
T
P
I
E
L
I
R
A
T
V
D
G
M
I
A
R
G
F
G
R
I
V
N
I
T
S
S
A
V
K
-
A
P
I
D
V
L
A
L
S
N
G
A
R
S
G
L
T
G
F
V
A
G
L
A
R
K
V
V
G
Q
G
--
V
T
I
N
N
L
L
P
G
L
F
D
T
D
R
I
A
T
T
L
---
A
A
A
A
NAQGV
T
V
D
E
L
R
A
R
------
R
T
R
D
I
P
A
G
R
L
G
T
R
A
E
F
G
A
A
C
A
F
L
C
S
V
H
A
G
Y
I
T
G
Q
N
W
L
L
D
G
G
A
Y
P
11
PsiBlast_PDB
62.38
33%
-10
- C4 -
-
3TZH
1
?
A:
[10-247]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
-
I
------
S
D
-------
Y
------
L
G
D
N
G
---
K
GM
A
L
----
N
V
T
N
-
P
E
S
----
I
E
AVLK
A
-
I
T
D
E
----
F
----
G
----
G
---
V
D
I
L
V
N
N
A
G
I
T
R
D
---
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
-
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
A
I
E
T
D
---------
M
T
K
A
-----
L
N
D
E
Q
R
T
A
------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
---
16
PsiBlast_PDB
62.09
33%
-14
- C4 -
-
4I08
2
FABG_VIBCH
A:
[10-250]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
-
I
------
S
D
-------
Y
------
L
G
D
N
G
---
K
GM
A
L
----
N
V
T
N
-
P
E
S
----
I
E
AVLK
A
-
I
T
D
E
----
F
----
G
----
G
---
V
D
I
L
V
N
N
A
G
I
T
R
D
---
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
-
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
---------
M
---------
N
D
E
Q
R
T
A
------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
14
PsiBlast_PDB
61.52
33%
-11
- C4 -
-
3RSH
2
FABG_VIBCH
A:
[10-250]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
-
I
------
S
D
-------
Y
------
L
G
D
N
G
---
K
GM
A
L
----
N
V
T
N
-
P
E
S
----
I
E
AVLK
A
-
I
T
D
E
----
F
----
G
----
G
---
V
D
I
L
V
N
N
A
G
I
T
R
D
---
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
-
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
---------
M
T
K
--------
D
E
Q
R
T
A
------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
38
HHSearch
60.63
28%
-60
- C4 -
-
4O6V
3
?
C:
[9-239]
--
M
T
I
Q
K
V
A
I
I
T
A
G
G
S
G
M
G
A
A
S
A
R
R
L
A
Q
D
G
F
A
V
A
I
L
S
S
S
G
K
-
G
E
A
-
L
------
A
K
-------
E
------
L
G
G
I
G
---
V
--
T
G
----
S
N
Q
S
-
N
D
D
----
L
Q
----
K
-
L
V
D
Q
TLEK
W
----
G
----
R
---
I
D
V
L
V
N
S
A
G
H
G
P
R
---
A
P
I
L
E
I
T
D
E
D
W
H
K
G
M
D
T
Y
F
L
N
A
V
R
P
A
R
L
V
V
P
A
M
Q
K
Q
K
S
G
V
I
I
N
I
S
T
A
W
A
F
-
E
P
S
A
M
F
P
T
S
A
V
F
R
A
G
L
A
S
F
T
K
I
F
A
D
T
Y
A
A
E
N
--
I
R
M
N
N
V
L
P
G
W
I
D
S
L
P
T
T
E
E
R
---
R
------------------------
E
S
V
P
M
Q
R
Y
G
K
S
E
E
I
A
A
T
V
S
F
L
A
S
D
G
A
A
Y
I
T
G
Q
N
L
R
V
D
G
G
L
T
-
37
HHSearch
60.58
28%
-57
- C4 -
-
4O6V
4
?
D:
[11-239]
----
I
Q
K
V
A
I
I
T
A
G
G
S
G
M
G
A
A
S
A
R
R
L
A
Q
D
G
F
A
V
A
I
L
S
S
S
G
K
-
G
E
A
-
L
------
A
K
-------
E
------
L
G
G
I
G
---
V
--
T
G
----
S
N
Q
S
-
N
D
D
----
L
Q
----
K
-
L
V
D
Q
TLEK
W
----
G
----
R
---
I
D
V
L
V
N
S
A
G
H
G
P
R
---
A
P
I
L
E
I
T
D
E
D
W
H
K
G
M
D
T
Y
F
L
N
A
V
R
P
A
R
L
V
V
P
A
M
Q
K
Q
K
S
G
V
I
I
N
I
S
T
A
W
A
F
-
E
P
S
A
M
F
P
T
S
A
V
F
R
A
G
L
A
S
F
T
K
I
F
A
D
T
Y
A
A
E
N
--
I
R
M
N
N
V
L
P
G
W
I
D
S
L
P
T
T
E
E
R
---
R
------------------------
E
S
V
P
M
Q
R
Y
G
K
S
E
E
I
A
A
T
V
S
F
L
A
S
D
G
A
A
Y
I
T
G
Q
N
L
R
V
D
G
G
L
T
-
13
PsiBlast_PDB
60.56
33%
-11
- C4 -
-
4WK6
1
?
A:
[10-249]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
-
I
------
S
D
-------
Y
------
L
G
D
N
G
---
K
GM
A
L
----
N
V
T
N
-
P
E
S
----
I
E
AVLK
A
-
I
T
D
E
----
F
----
G
----
G
---
V
D
I
L
V
N
N
A
G
I
T
R
D
---
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
V
V
G
T
M
-
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
---------
M
T
K
A
-----
L
N
D
E
Q
R
T
A
------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
-
44
HHSearch
60.39
27%
-19
- C4 -
-
3LF2
1
?
C:
[5-262]
--
D
L
S
E
A
V
A
V
V
T
G
G
S
S
G
I
G
L
A
T
V
E
L
L
L
E
A
G
A
A
V
A
F
C
A
R
D
G
E
R
L
R
A
-
A
------
E
S
ALRQRFP
G
------
A
R
L
F
A
---
S
--
V
C
----
D
V
L
D
-
A
L
Q
----
V
R
----
A
-
F
A
E
A
CERT
L
----
G
----
C
---
A
S
I
L
V
N
N
A
G
Q
G
R
V
---
S
T
F
A
E
T
T
D
E
A
W
S
E
E
L
Q
L
K
F
F
S
V
I
H
P
V
R
A
F
L
P
Q
L
E
S
R
A
D
A
A
I
V
C
V
N
S
L
L
A
S
-
Q
P
E
P
H
M
V
A
T
S
A
A
R
A
G
V
K
N
L
V
R
S
M
A
F
E
F
A
P
K
G
--
V
R
V
N
G
I
L
I
G
L
V
E
S
G
Q
W
R
R
R
F
---
E
A
R
E
-----
E
R
E
L
D
W
A
Q
WTAQLA
R
N
K
Q
I
P
L
G
R
L
G
K
P
I
E
A
A
R
A
I
L
F
L
A
S
P
L
S
A
Y
T
T
G
S
H
I
D
V
S
G
G
L
S
-
54
HHSearch
60.31
25%
-13
* C4 *
-
2Z1N
-
?
B:
[3-260]
-
L
G
I
Q
G
K
L
A
V
V
T
A
G
S
S
G
L
G
F
A
S
A
L
E
L
A
R
N
G
A
R
L
L
L
F
S
R
N
R
E
K
L
E
A
-
A
------
A
S
RIASLVS
G
------
A
Q
V
D
I
---
V
--
A
G
----
D
I
R
E
-
P
G
D
----
I
D
----
R
-
L
F
E
K
ARD-
L
----
G
----
G
---
A
D
I
L
V
Y
S
T
G
G
P
R
P
---
G
R
F
M
E
L
G
V
E
D
W
D
E
S
Y
R
L
L
A
R
S
A
V
W
V
G
R
R
A
A
E
Q
M
V
E
K
G
W
G
R
M
V
Y
I
G
S
V
T
L
L
-
R
P
W
Q
D
L
A
L
S
N
I
M
R
L
P
V
I
G
V
V
R
T
L
A
L
E
L
A
P
H
G
--
V
T
V
N
A
V
L
P
S
L
I
L
T
D
R
V
R
S
L
--------------------
S
------
M
A
S
R
I
P
M
G
R
V
G
K
P
E
E
L
A
S
V
V
A
F
L
A
S
E
K
A
S
F
I
T
G
A
V
I
P
V
D
G
G
A
H
I