@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CA123_HUMAN: (2020-01-31 )
MGKIALQLKATLENITNLRPVGEDFRWYLKMKCGNCGEISDKWQYIRLMDSVALKGGRGSASMVQKCKLCARENSIEILSSTIKPYNAEDNENFKTIVEFECRGLEPVDFQPQAGFAAEGVESGTAFSDINLQEKDWTDYDEKAQESVGIYEVTHQFVKC
Atome Classification :
(20 SA)
---------------------------------------------------------------------------....-.....10........20--------........30........40.......-------.50.....-...60...--.....70.-------.......------80---...--.-.....90........100---------------------....----.--....110.......120.-.----.---------....130...--....140.....---.----.150.......160
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------MG
K
I
-
A
L
Q
L
K
A
T
L
E
N
ITNLRPV--------GED
F
R
W
Y
L
K
MKCGNCGEIS
D
K
W
Q
Y
I
R
L
-------
M
D
S
V
ALKG-GRG
S
A
S
M
V
--
Q
K
C
K
L
C
AR-------EN
S
I
E
I
L
------
S
----
S
TI--K-PYNAEDNEN
F
K
T
I
V
E
F
-----------------------ECRG----L--EPVDFQPQAGFAAEGVES-G----T---------AFSDINLQEK--DWTD
Y
D
E
K
A
Q
E
S---V----
G
I
Y
E
V
T
H
Q
F
VKC
6
HHSearch
92.96
100%
-64
- C7 -
-
5ZRT
5
CZIB_HUMAN
A:
[21-180]
---------------------------------------------------------------------------
M
G
K
I
-
A
L
Q
L
K
A
T
L
E
N
I
T
N
L
R
P
V
--------
G
E
D
F
R
W
Y
L
K
M
K
C
G
N
C
G
E
I
S
D
K
W
Q
Y
I
R
L
-------
M
D
S
V
A
L
K
G
-
G
R
G
S
A
S
M
V
--
Q
K
C
K
L
C
A
R
-------
E
N
S
I
E
I
L
------
S
----
S
T
I
--
K
-
P
Y
N
A
E
D
N
E
N
F
K
T
I
V
E
F
-----------------------
E
C
R
G
----
L
--
E
P
V
D
F
Q
P
Q
A
G
F
A
A
E
G
V
E
S
-
G
----
T
---------
A
F
S
D
I
N
L
Q
E
K
--
D
W
T
D
Y
D
E
K
A
Q
E
S
---
V
----
G
I
Y
E
V
T
H
Q
F
V
K
C
1
PsiBlast_PDB
92.96
100%
-64
- C7 -
-
5ZRT
5
CZIB_HUMAN
A:
[21-180]
---------------------------------------------------------------------------
M
G
K
I
-
A
L
Q
L
K
A
T
L
E
N
I
T
N
L
R
P
V
--------
G
E
D
F
R
W
Y
L
K
M
K
C
G
N
C
G
E
I
S
D
K
W
Q
Y
I
R
L
-------
M
D
S
V
A
L
K
G
-
G
R
G
S
A
S
M
V
--
Q
K
C
K
L
C
A
R
-------
E
N
S
I
E
I
L
------
S
----
S
T
I
--
K
-
P
Y
N
A
E
D
N
E
N
F
K
T
I
V
E
F
-----------------------
E
C
R
G
----
L
--
E
P
V
D
F
Q
P
Q
A
G
F
A
A
E
G
V
E
S
-
G
----
T
---------
A
F
S
D
I
N
L
Q
E
K
--
D
W
T
D
Y
D
E
K
A
Q
E
S
---
V
----
G
I
Y
E
V
T
H
Q
F
V
K
C
5
HHSearch
90.91
100%
-66
- C7 -
-
5ZLQ
-
CZIB_HUMAN
A:
[4-162]
----------------------------------------------------------------------------
G
K
I
-
A
L
Q
L
K
A
T
L
E
N
I
T
N
L
R
P
V
--------
G
E
D
F
R
W
Y
L
K
M
K
C
G
N
C
G
E
I
S
D
K
W
Q
Y
I
R
L
-------
M
D
S
V
A
L
K
G
-
G
R
G
S
A
S
M
V
--
Q
K
C
K
L
C
A
R
-------
E
N
S
I
E
I
L
------
S
----
S
T
I
--
K
-
P
Y
N
A
E
D
N
E
N
F
K
T
I
V
E
F
-----------------------
E
C
R
G
----
L
--
E
P
V
D
F
Q
P
Q
A
G
F
A
A
E
G
V
E
S
-
G
----
T
---------
A
F
S
D
I
N
L
Q
E
K
--
D
W
T
D
Y
D
E
K
A
Q
E
S
---
V
----
G
I
Y
E
V
T
H
Q
F
V
K
C
2
PsiBlast_PDB
90.91
100%
-66
- C7 -
-
5ZLQ
-
CZIB_HUMAN
A:
[4-162]
----------------------------------------------------------------------------
G
K
I
-
A
L
Q
L
K
A
T
L
E
N
I
T
N
L
R
P
V
--------
G
E
D
F
R
W
Y
L
K
M
K
C
G
N
C
G
E
I
S
D
K
W
Q
Y
I
R
L
-------
M
D
S
V
A
L
K
G
-
G
R
G
S
A
S
M
V
--
Q
K
C
K
L
C
A
R
-------
E
N
S
I
E
I
L
------
S
----
S
T
I
--
K
-
P
Y
N
A
E
D
N
E
N
F
K
T
I
V
E
F
-----------------------
E
C
R
G
----
L
--
E
P
V
D
F
Q
P
Q
A
G
F
A
A
E
G
V
E
S
-
G
----
T
---------
A
F
S
D
I
N
L
Q
E
K
--
D
W
T
D
Y
D
E
K
A
Q
E
S
---
V
----
G
I
Y
E
V
T
H
Q
F
V
K
C
3
PsiBlast_PDB
59.35
26%
12
- C7 -
-
1ZSO
-
?
A:
[5-154]
--------------------------------------------------------------------------------
V
V
R
I
K
A
E
L
E
N
V
K
R
L
F
-
C
--------
D
D
E
Y
L
W
I
F
N
I
R
D
S
T
S
S
L
T
R
D
N
I
Q
F
-
R
K
-------
T
D
I
L
E
I
P
N
-
S
R
G
T
A
N
F
M
--
I
K
W
T
E
Y
P
K
-------
Y
S
T
I
N
F
V
------
N
----
T
K
N
--
S
C
S
Y
E
E
V
N
N
N
E
W
R
D
F
A
S
F
-----------------------
E
C
R
G
----
I
--
E
L
I
D
F
F
P
S
N
N
F
I
V
E
D
T
K
--
G
----
K
---------
L
Y
Y
D
V
N
L
S
D
Q
--
N
W
C
D
Y
N
E
E
H
E
M
C
---
V
----
G
I
Y
N
L
E
Y
E
----
34
Fugue
43.32
15%
-78
- C2 -
-
1I1G
-
REG7_PYRFU
A:
[2-141]
---------------------------------------------------------------------------
I
D
E
R
-
D
K
I
I
L
E
I
L
E
K
D
A
R
T
P
--------------------------------------------
F
T
E
I
A
K
K
L
-
G
I
S
E
T
A
V
R
--
K
R
V
K
A
L
E
E
-------
K
G
I
I
E
G
Y
------
T
----
I
K
I
--
N
-
P
K
K
L
G
Y
S
L
V
T
I
T
G
V
D
T
-----------------------
K
P
E
K
----
L
--
F
E
V
A
E
K
L
K
E
Y
D
F
V
K
E
L
Y
L
-
S
----
S
---------
G
D
H
M
I
M
A
V
I
W
AK
D
G
E
D
L
A
E
I
I
S
N
K
---
I
GKIE
G
V
T
K
V
C
P
A
I
I
L
E
30
Fugue
41.78
25%
23
- C7 -
-
1ZSO
-
?
A:
[2-156]
----------------------------------------------------------------------------
K
N
T
-
V
V
R
I
K
A
E
L
E
N
V
K
R
L
F
C
---------
D
D
E
Y
L
W
I
F
N
I
R
D
S
T
S
S
L
T
R
D
N
I
Q
F
-
R
K
-------
T
D
I
L
E
I
P
N
-
S
R
G
T
A
N
F
I
--
K
W
T
E
Y
P
K
Y
-------
S
T
I
N
F
V
N
------
T
----
K
N
S
--
C
-
S
Y
E
E
V
N
N
N
E
W
R
D
F
A
S
F
-----------------------
E
C
R
G
----
I
--
E
L
I
D
F
F
P
S
N
N
F
I
V
E
D
-
T
K
-
G
----
K
---------
L
Y
Y
D
V
N
L
S
D
Q
--
N
W
C
D
Y
N
E
E
H
E
C
M
---
V
----
G
I
Y
N
L
E
Y
E
V
N
--
32
Fugue
37.87
23%
-82
- C6 -
-
2X5C
-
?
A:
[30-128]
----------------------------------------------------------------------------------------------------------------------------
Y
K
Q
E
Y
D
M
A
-------
A
D
L
V
R
M
L
R
-
G
L
G
V
F
-
M
H
--
A
K
C
P
R
C
G
A
-------
E
G
S
V
S
I
V
------
E
----
T
------------
K
N
G
Y
K
Y
L
V
I
R
-----------------------
H
P
D
G
--------
G
T
H
T
V
P
K
T
D
I
S
A
I
L
K
E
L
-
C
----
E
---------
V
K
K
D
L
E
Y
V
L
K
--
R
Y
K
E
Y
E
E
E
G
G
V
K
---
F
----
C
A
E
---------
7
HHSearch
37.80
26%
-5
- C7 -
-
1ZSO
-
?
A:
[1-156]
---------------------------------------------------------------------------
M
K
N
T
-
V
V
R
I
K
A
E
L
E
N
V
K
R
L
F
C
---------
D
D
E
Y
L
W
I
F
N
I
R
D
S
T
S
S
L
T
-
R
D
N
I
Q
F
R
K
-------
T
D
I
L
E
I
P
N
-
S
R
G
T
A
N
F
M
--
I
K
W
T
E
Y
P
K
-------
Y
S
T
I
N
F
V
------
N
----
T
K
N
S-
C
-
S
Y
E
E
V
N
N
N
E
W
R
D
F
A
S
F
-----------------------
E
C
R
G
----
I
--
E
L
I
D
F
F
P
S
N
N
F
I
V
E
D
-
T
K
-
G
----
K
---------
L
Y
Y
D
V
N
L
S
D
Q
--
N
W
C
D
Y
N
E
E
H
E
M
C
---
V
----
G
I
Y
N
L
E
Y
E
V
N
--
8
HHSearch
36.89
26%
19
- C7 -
-
1ZSO
-
?
B:
[-3-156]
---------------------------------------------------------------------------
M
K
N
T
-
V
V
R
I
K
A
E
L
E
N
V
K
R
L
F
C
---------
D
D
E
Y
L
W
I
F
N
I
R
D
S
T
S
S
L
T
-
R
D
N
I
Q
F
R
K
-------
T
D
I
L
E
I
P
N
-
S
R
G
T
A
N
F
M
--
I
K
W
T
E
Y
P
K
-------
Y
S
T
I
N
F
V
------
N
----
T
K
N
S-
C
-
S
Y
E
E
V
N
N
N
E
W
R
D
F
A
S
F
-----------------------
E
C
R
G
----
I
--
E
L
I
D
F
F
P
S
N
N
F
I
V
E
D
-
T
K
-
G
----
K
---------
L
Y
Y
D
V
N
L
S
D
Q
--
N
W
C
D
Y
N
E
E
H
E
M
C
---
V
----
G
I
Y
N
L
E
Y
E
V
N
--
41
Fugue
33.20
16%
-59
- C1 -
-
1E7P
-
FRDB_WOLSU
K:
[1-239]
---------------------------------------------------------------------------
M
G
R
----
M
L
T
I
R
V
F
K
Y
D
P
Q
S
A
V
--------
S
K
P
H
F
Q
E
Y
K
I
E
E
A
P
S
M
T
I
F
I
V
L
N
M
I
R
E
TYDPDLN
F
D
F
V
C
R
A
G
-
I
C
G
S
C
G
M
M
IN
G
R
P
S
L
A
C
R
TLTKDFE
D
G
V
I
T
L
L
------
P
LPAF
K
L
I
--
K
-
D
L
S
V
D
T
G
N
W
F
N
G
M
S
Q
R
VESWIHAQKEHDISKLEERIEPE
V
A
Q
E
----
V
--
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-
K
----
I
MREDFVGAA
G
L
N
R
V
V
R
F
M
I
--
D
P
H
D
-
E
R
T
D
E
D
Y
---
Y
----
E
L
I
G
D
D
D
G
V
F
G
C
38
Fugue
32.57
20%
68
- C6 -
-
3OG9
-
?
A:
[4-209]
------------------------------------------------------MTDYVFKAGRKDLAPLLLLHS
T
G
G
D
-
E
H
Q
L
V
E
I
A
E
M
I
A
P
S
H
P
I
LSIRGRIN
E
Q
G
V
N
R
Y
F
K
L
R
-
G
L
G
G
F
T
K
E
N
F
D
-
L
E
S
-------
L
D
E
E
T
D
W
L
-
T
D
E
V
S
L
L
A
--
E
K
H
D
L
-
D
V
-------
H
K
M
I
A
I
G
YSNG--
A
----
N
V
A
--
L
-
N
M
F
L
R
G
K
I
N
F
D
K
I
I
A
F
-------------------------
H
G
----
M
--
Q
L
E
D
F
E
Q
T
V
Q
L
D
D
K
H
V
F
L
-
S
----
Y
---------
A
P
N
D
M
I
V
P
Q
K
--
N
F
G
D
L
K
G
D
L
E
D
S
GCQ
L
----
E
I
Y
E
S
S
L
G
H
Q
L
T
44
Fugue
32.24
12%
-38
- C6 -
-
1GSA
-
?
?:
[1-122]
---------------------------------------------------------------------------
M
I
K
L
-
G
I
V
M
----
D
P
I
A
N
I
N
I
K
--------
K
D
--------------------
S
S
F
A
M
-------
L
L
E
A
Q
R
R
G
-
Y
--
E
L
H
Y
M
--
E
M
G
D
L
Y
L
I
-------
N
G
E
A
R
A
H
------
T
----
R
T
L
--
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
-----------------------
P
L
A
D
----
L
--
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
-
T
----
Y
---------
I
L
E
R
A
E
E
K
---------------
G
---
T
----
L
I
V
N
K
P
Q
S
L
R
D
C
29
HHSearch
30.29
21%
-131
- C7 -
-
5Y06
-
?
A:
[223-256]
-------------------------------------------------------------------------------------------------------------------
R
C
G
A
C
R
------
I
E
I
D
R
-------
G
E
I
A
R
I
T
A
-
A
--
A
D
D
D
V
--
V
R
C
P
E
C
G
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
29.73
17%
60
- C6 -
-
1R5E
-
?
A:
[29-133]
--------------------------------------------------------------------------------------------------------------------------------------------------
D
-
N
V
T
S
S
Q
L
L
--
S
V
R
H
Q
L
A
E
-------
S
A
G
L
P
R
D
------
Q
----
H
E
F
VS
S
-
Q
A
P
Q
S
L
R
N
R
Y
N
N
L
Y
S
H
-----------------------
T
Q
R
T
----
L
--
D
M
A
D
M
Q
H
R
Y
M
T
G
A
S
G
I
N
P
-
G
MLPH
E
---------
N
V
D
D
M
R
S
A
I
T
--
D
W
S
D
M
R
E
A
L
Q
H
A
---
M
----
G
I
H
A
D
I
------
27
HHSearch
29.34
17%
-120
- C7 -
-
3NA7
-
?
A:
[199-234]
------------------------------------------------------------------------------------------------------------------
Q
A
C
G
G
C
F
------
I
R
L
N
D
-------
K
I
Y
T
E
V
L
T
---
S
--
G
D
M
--
I
T
C
P
Y
C
G
R
-------
I
L
Y
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
25.92
22%
-7
* C8 *
-
5L9W
2
APCB_AROAE
C:
[1-127]
--------------------------------------------------------------------------------------
M
Y
E
R
I
R
F
T
E
Y
L
--------
D
L
D
L
N
D
E
-
H
W
Y
C
H
D
C
G
T
--------
K
L
-------
I
S
A
---------
R
E
S
Y
K
--
K
G
C
-
L
V
A
E
-------
R
R
P
H
E
I
H
------
N
----
P
V
I
--
E
G
E
Y
S
F
A
P
D
E
N
W
V
R
I
L
E
F
-----------------------
Y
C
P
G
CTRQ
I
--
E
T
E
Y
L
P
P
G
H
P
I
T
---
V
D
I
-
E
----
V
---------
D
I
D
S
L
K
A
R
L
K
--
K
G
V
I
V
I
K
D
G
K
L
T
---
K
----
P
E
A
E
V
-------
24
HHSearch
25.74
21%
-94
- C7 -
-
5JB3
-
RS27_PYRFU
W:
[10-43]
------------------------------------------------------------------------------------------------------------
R
S
R
F
L
R
V
K
C
I
D
C
G
N
E
Q
--
I
V
F
-
S
--------------------
H
P
A
T
K
--
V
R
C
L
I
C
G
A
-------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
25.62
21%
65
- C- -
-
2PN0
-
?
A:
[4-127]
---------------------------------------------------------------------------
K
P
K
I
M
I
----------------------------------------
S
S
L
D
A
E
R
L
E
I
L
-------
L
E
T
L
S
Q
N
A
-
F
P
G
R
D
D
L
E
--
A
E
L
A
R
A
E
V
-------
V
D
P
E
E
I
P
PTVVTM
N
----
S
T
V
--
R
-
F
R
V
E
S
S
A
E
E
F
L
T
L
V
Y
P
-----------------------
K
D
V
D
----
T
SG
E
K
I
S
I
L
A
P
V
G
S
A
L
L
G
L
A
Q
-
G
---------------------
D
E
I
--
E
W
P
K
P
G
G
G
-
V
L
R
---
V
----
R
I
V
E
V
T
Y
-----
39
Fugue
25.05
18%
51
- C6 -
-
4RHJ
1
?
A:
[19-318]
SHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETV
M
F
M
P
-
V
L
N
C
G
Q
M
L
D
E
A
A
G
T
E
T
P
--------
T
S
D
E
W
Y
L
G
S
L
E
A
S
T
--
E
L
L
E
K
G
------------
Y
V
P
V
S
V
G
G
D
G
S
A
T
L
S
M
V
--
E
A
Y
K
R
L
F
P
-------
S
D
D
I
V
I
V
------
H
----
F
S
A
--
R
-
P
S
V
S
D
P
R
S
P
L
R
V
L
L
D
--------------------------
K
G
----
L
--------------
L
K
G
V
V
S
V
G
----
N
------------------
R
--
Q
V
S
S
E
D
R
K
V
R
K
L
---
H
----
K
M
F
Y
M
D
M
R
D
I
R
N