@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CD4_HUMAN: (2020-01-31 )
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....----------------..230.......240.......250.......260.......270.......280.......--290.......300.......310.......320.......330.......340.......350...-....360.......370.......380.......390.......400.......410.......420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNRGV
P
F
R
H
L
L
L
V
L
Q
L
A
LLPAATQG
K
K
V
V
LGKKG
D
T
V
E
L
T
C
TASQK
K
S
I
Q
F
H
WKNS
N
Q
I
K
I
LGNQGSFLTKGPSK
L
N
D
R
A
D
S
R
R
SLWDQGN
F
P
L
I
I
K
N
L
K
IEDS
D
T
Y
I
C
EVEDQKE
E
V
Q
L
L
V
F
G
L
TANSD
T
H
L
LQG
Q
S
L
T
L
T
LESPPGSSPS
V
Q
CRSPRGKNIQGG
K
T
L
S
V
S
Q
L
E
LQDSG
T
W
T
C
T
V
LQNQ
K
K
V
E
F
K
I
D
I
V
V
L
A
FQK
A
S
S
I
V
YKKEG
E
Q
V
E
F
SFP
L
A
F
----------------
T
V
EKLTGSG
E
L
W
W
Q
AERASSSK
S
W
I
T
F
DLKNK
E
V
S
V
K
RVTQDPKLQMGKKL
P
L
H
L
T
L
P
Q
A
L
P
--
Q
YAGSG
N
L
T
L
A
L
EAKTGKL
H
Q
E
V
N
L
V
V
M
R
A
T
Q
LQKN
L
T
C
E
VWGPTS
P
K
L
M
L
S
L
K
LENKEAKVSKR
E
-
K
A
V
W
V
LNPEA
G
M
W
Q
C
LLSDS
G
Q
V
L
L
ESN
I
K
V
L
PTWSTPVQ
P
M
A
L
I
V
L
G
G
V
A
G
L
L
L
F
I
G
L
G
I
F
F
C
V
R
C
R
H
R
R
R
Q
A
E
R
M
S
Q
I
K
R
L
L
SEKKTCQC
P
H
R
F
Q
K
TCSPI
4
PsiBlast_PDB
99.79
100%
-86
- C2 -
-
5U1F
-
CD4_HUMAN
M:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
5
PsiBlast_PDB
98.39
100%
-79
- C2 -
-
6MET
-
CD4_HUMAN
A:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
1
PsiBlast_PDB
96.88
100%
-83
- C2 -
-
1WIO
-
CD4_HUMAN
A:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
2
PsiBlast_PDB
96.69
100%
-84
- C2 -
-
1WIP
-
CD4_HUMAN
A:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
3
PsiBlast_PDB
96.56
100%
-83
- C2 -
-
1WIQ
-
CD4_HUMAN
A:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
38
HHSearch
84.28
88%
-30
- C2 -
-
6MET
-
CD4_HUMAN
A:
[3-352]
---------------------------
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
TVEKLTGSGELWWQAE
R
A
S
S
--
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
--------------
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
QY
A
G
S
G
N
L
T
L
A
L
E
A
K
T
--
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
-
S
K
R
E
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
-
S
G
Q
--------------------------------------------------------------------------------
37
HHSearch
83.05
88%
-38
- C2 -
-
1WIO
-
CD4_HUMAN
B:
[3-352]
---------------------------
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
TVEKLTGSGELWWQAE
R
A
S
S
--
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
--------------
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
QY
A
G
S
G
N
L
T
L
A
L
E
A
K
T
--
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
-
S
K
R
E
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
-
S
G
Q
--------------------------------------------------------------------------------
16
PsiBlast_PDB
65.76
99%
-85
- C2 -
-
4RQS
-
CD4_HUMAN
B:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.77
99%
-
- C2 -
-
3T0E
-
CD4_HUMAN
E:
[1-363]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Y
G
S
F
L
W
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
A
S
S
I
V
Y
K
K
E
G
E
Q
V
E
F
S
F
P
L
A
F
----------------
T
V
E
K
L
T
G
S
G
E
L
W
W
Q
A
E
R
A
S
S
S
K
S
W
I
T
F
D
L
K
N
K
E
V
S
V
K
R
V
T
Q
D
P
K
L
Q
M
G
K
K
L
P
L
H
L
T
L
P
Q
A
L
P
--
Q
Y
A
G
S
G
N
L
T
L
A
L
E
A
K
T
G
K
L
H
Q
E
V
N
L
V
V
M
R
A
T
Q
L
Q
K
N
L
T
C
E
V
W
G
P
T
S
P
K
L
M
L
S
L
K
L
E
N
K
E
A
K
V
S
K
R
E
-
K
A
V
W
V
L
N
P
E
A
G
M
W
Q
C
L
L
S
D
S
G
Q
V
L
L
E
S
N
I
K
V
L
P
----------------------------------------------------------------------
9
PsiBlast_PDB
64.32
99%
-71
- C2 -
-
1GC1
-
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.27
99%
-77
- C2 -
-
1RZJ
-
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.23
99%
-76
- C2 -
-
1G9M
1
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.97
99%
-77
- C2 -
-
4H8W
1
CD4_HUMAN
C:
[1-176]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.91
99%
-79
- C2 -
-
3J70
-
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.58
99%
-73
- C2 -
-
4JM2
-
CD4_HUMAN
F:
[1-175]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.32
99%
-67
- C2 -
-
1G9N
-
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.09
99%
-66
- C2 -
-
5A8H
-
CD4_HUMAN (first)
B:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.25
99%
-65
- C2 -
-
5VN3
-
CD4_HUMAN
C:
[1-176]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.21
99%
-65
- C2 -
-
1RZK
-
CD4_HUMAN
C:
[1-181]
-------------------------
K
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
N
S
D
T
H
L
L
Q
G
Q
S
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
S
V
S
Q
L
E
L
Q
D
S
G
T
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
V
V
L
A
F
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.61
100%
-72
- C2 -
-
5CAY
3
CD4_HUMAN
B:
[3-175]
--------------------------
K
V
V
L
G
K
K
G
D
T
V
E
L
T
C
T
A
S
Q
K
K
S
I
Q
F
H
W
K
N
S
N
Q
I
K
I
L
G
N
Q
G
S
F
L
T
K
G
P
S
K
L
N
D
R
A
D
S
R
R
S
L
W
D
Q
G
N
F
P
L
I
I
K
N
L
K
I
E
D
S
D
T
Y
I
C
E
V
E
D
Q
K
E
E
V
Q
L
L
V
F
G
L
T
A
-----------
L
T
L
T
L
E
S
P
P
G
S
S
P
S
V
Q
C
R
S
P
R
G
K
N
I
Q
G
G
K
T
L
------------
W
T
C
T
V
L
Q
N
Q
K
K
V
E
F
K
I
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------