@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHP3_HUMAN: (2020-01-31 )
MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
Atome Classification :
(20 SA)
......---.---..10........20........30....-...-.40.-........50........60........70........80........90.......---.100.-----.-......-----110.......120.......130.......140-.......150.......160.......170.......180........190.......200.......210..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGAAH
S
---
A
---
S
E
E
V
R
E
L
EGKTGF
S
S
D
Q
I
E
Q
L
H
R
R
F
K
Q
L-SGD-QP-T-IRKENFNNVPDLEL
N
P
I
R
S
K
I
V
R
A
F
FDNRNLRKGPSGLADEI
N
F
E
D
F
L
T
I
M
S
Y
FRPI---DT-TM-----
D
-
E
E
Q
V
E
L
-----
S
R
K
E
K
L
R
F
L
F
H
M
YDSDSD
G
R
I
T
L
E
E
Y
R
N
V
V
E
E
L
-LSGNPHI
E
K
E
S
A
R
SIAD
G
A
M
M
E
A
A
S
V
C
MGQM
E
P
D
Q
V
YE-GI
T
F
E
D
F
L
K
I
W
QGID
I
E
T
K
M
H
V
R
F
LN
M
E
T
M
ALCH
1
PsiBlast_PDB
78.78
33%
30
- C3 -
-
2CT9
-
CHP1_RAT
A:
[8-201]
----------LLR
D
E
E
L
E
E
I
K
K
E
T
G
F
S
H
S
Q
I
T
R
L
Y
S
R
F
T
S
L
D
K
G
E
-
N
G
-
T
-
L
S
R
E
D
F
Q
R
I
P
E
L
A
I
N
P
L
G
D
R
I
I
N
A
F
F
---------
S
E
G
E
D
Q
V
N
F
R
G
F
M
R
T
L
A
H
F
R
P
I
---
E
-----------------EPLN-
S
R
S
N
K
L
H
F
A
F
R
L
Y
D
L
D
K
D
D
K
I
S
R
D
E
L
L
Q
V
L
R
M
M
-
V
G
V
N
--
I
S
D
E
Q
L
G
S
I
A
D
R
T
I
Q
E
A
----------
D
Q
D
G
D
S
A
I
S
F
T
E
F
V
K
V
L
E
K
V
D
V
E
Q
K
M
S
I
R
F
L
H
K
L
A
A
A
L
--
3
PsiBlast_PDB
78.30
29%
-9
- C3 -
-
2BEC
-
CHP2_HUMAN
A:
[20-196]
----------------------
E
T
G
F
S
Q
A
S
L
L
R
L
H
H
R
F
R
A
L
-
D
R
N
-
K
K
-
G
Y
L
S
R
M
D
L
Q
Q
I
G
A
L
A
V
N
P
L
G
D
R
I
I
E
S
F
F
--------
P
D
G
-
S
Q
R
V
D
F
P
G
F
V
R
V
L
A
H
F
R
P
V
EDE
D
T
E-----------
K
P
E
P
LN---
S
R
R
N
K
L
H
Y
A
F
Q
L
Y
D
L
D
R
D
G
K
I
S
R
H
E
M
L
Q
V
L
-
R
L
-
M
V
G
-
V
Q
V
T
E
E
Q
L
E
N
I
A
D
R
T
V
Q
E
A
D
E
D
G
D
G
----------
A
V
S
F
V
E
F
T
K
S
L
E
K
M
D
V
E
Q
K
M
S
I
R
I
L
K
--------
37
HHSearch
77.41
34%
49
- C3 -
-
2CT9
-
CHP1_RAT
A:
[8-201]
------LL-
R
---
D
E
E
L
E
E
I
K
K
E
T
G
F
S
H
S
Q
I
T
R
L
Y
S
R
F
T
S
L
-
D
K
G
E
N
G
-
T
-
L
S
R
E
D
F
Q
R
I
P
E
L
A
I
N
P
L
----
G
D
R
I
I
N
A
--
F
F
S
E
G
E
D
---
Q
V
N
F
R
G
F
M
R
T
L
A
H
F
R
P
I
---
E
-------------
E
P
L
N
-----
S
R
S
N
K
L
H
F
A
F
R
L
Y
D
L
D
K
D
D
K
I
S
R
D
E
L
L
Q
V
L
R
M
M
V
G
V
---
N
I
S
D
E
Q
L
G
S
I
A
D
R
T
I
Q
E
A
D
Q
D
G
D
S
----------
A
I
S
F
T
E
F
V
K
V
L
E
K
V
D
V
E
Q
K
M
S
I
R
F
L
H
K
L
A
A
A
L
--
38
HHSearch
75.56
26%
19
- C3 -
-
2BEC
-
CHP2_HUMAN
A:
[11-189]
-------------
I
P
D
G
D
S
I
R
R
E
T
G
F
S
Q
A
S
L
L
R
L
H
H
R
F
R
A
L
-
D
R
N
K
K
G
-
Y
-
L
S
R
M
D
L
Q
Q
I
G
A
L
A
V
N
P
L
G
----
D
R
I
I
E
S
--
F
F
P
D
G
S
Q
---
R
V
D
F
P
G
F
V
R
V
L
A
H
F
R
P
V
---
E
D
-
E
D
-----
T
E
K
P
E
P
L
N
-----
S
R
R
N
K
L
H
Y
A
F
Q
L
Y
D
L
D
R
D
G
K
I
S
R
H
E
M
L
Q
V
L
R
L
M
V
G
V
---
Q
V
T
E
E
Q
L
E
N
I
A
D
R
T
V
Q
E
A
D
E
D
G
D
G
----------
A
V
S
F
V
E
F
T
K
S
L
E
K
M
D
V
E
Q
K
---------------
2
PsiBlast_PDB
73.65
34%
79
- C3 -
-
2E30
-
CHP1_HUMAN
A:
[1-195]
M
G
S
R
A
S
---
T
LLR
D
E
E
L
E
E
I
K
K
E
T
G
F
S
H
S
Q
I
T
R
L
Y
S
R
F
T
S
L
D
K
G
E
-
N
G
-
T
-
L
S
R
E
D
F
Q
R
I
P
E
L
A
I
N
P
L
G
D
R
I
I
N
A
F
F
--------
P
E
G
-
E
D
Q
V
N
F
R
G
F
M
R
T
L
A
H
F
R
P
I
---
E
D
-
N
E
-----
K
-
S
K
D
V
N
G
PEPLN
S
R
S
N
K
L
H
F
A
F
R
L
Y
D
L
D
K
D
E
K
I
S
R
D
E
L
L
Q
V
L
R
M
M
-
V
G
V
N
--
I
S
D
E
Q
L
G
S
I
A
D
R
T
I
Q
E
A
----------
D
Q
D
G
D
S
A
I
S
F
T
E
F
V
K
V
L
E
K
V
D
V
E
Q
K
M
S
I
R
F
L
H
--------
5
PsiBlast_PDB
73.45
27%
14
- C3 -
-
1TCO
2
CANB1_BOVIN
B:
[1-167]
---------
G
---
N
E
A
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
11
PsiBlast_PDB
72.94
27%
11
- C3 -
-
4ORA
-
CANB1_HUMAN
B:
[5-168]
---------------
A
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
10
PsiBlast_PDB
72.79
27%
5
- C3 -
-
4OR9
-
CANB1_HUMAN
B:
[5-168]
---------------
A
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
6
PsiBlast_PDB
72.58
27%
4
- C3 -
-
1AUI
-
CANB1_HUMAN
B:
[5-167]
----------------
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
14
PsiBlast_PDB
72.02
27%
6
- C3 -
-
5SVE
-
CANB1_HUMAN
B:
[6-168]
----------------
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
13
PsiBlast_PDB
71.52
27%
13
- C3 -
-
4ORC
-
CANB1_HUMAN
B:
[5-168]
---------------
A
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
8
PsiBlast_PDB
71.08
27%
14
- C3 -
-
1MF8
-
CANB1_HUMAN
B:
[6-168]
----------------
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
4
PsiBlast_PDB
70.65
27%
14
- C3 -
-
4IL1
-
CALM1_RAT (first)
A:
[166-507]
-------------------
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
12
PsiBlast_PDB
70.60
27%
16
- C3 -
-
4ORB
-
CANB1_MOUSE
B:
[6-168]
----------------
S
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
7
PsiBlast_PDB
70.54
27%
-0
- C3 -
-
1M63
-
CANB1_HUMAN
B:
[12-167]
-----------------------
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
I
H
K
K
M
V
V
------------
17
PsiBlast_PDB
69.57
23%
10
- C3 -
-
5B8I
3
?
B:
[2-168]
---------
S
---
S
Q
V
L
N
D
I
V
S
G
S
N
F
D
H
E
E
V
D
R
L
W
K
R
F
M
K
L
-
D
R
D
-
K
S
G
T
-
I
E
R
D
E
F
L
S
L
P
Q
V
S
S
N
P
L
S
T
R
M
I
-
A
I
F
D
E
D
G
--------
G
G
D
V
D
F
Q
E
F
V
S
G
L
S
A
F
S
S
--------------------
K
G
-----
N
K
E
E
K
L
R
F
A
F
K
V
Y
D
I
D
R
D
G
F
I
S
N
G
E
L
F
I
V
L
K
M
M
-
V
G
S
N
--
L
K
D
M
Q
L
Q
Q
I
V
D
K
T
I
M
E
A
D
L
D
G
D
G
R
----------
I
S
F
E
E
F
T
R
M
V
E
N
T
D
V
S
M
S
M
T
L
------------
39
HHSearch
68.94
34%
86
- C3 -
-
2E30
-
CHP1_HUMAN
A:
[1-194]
M
G
S
R
A
S
TLL
R
---
D
E
E
L
E
E
I
K
K
E
T
G
F
S
H
S
Q
I
T
R
L
Y
S
R
F
T
S
L
-
D
K
G
E
N
G
-
T
-
L
S
R
E
D
F
Q
R
I
P
E
L
A
I
N
P
L
----
G
D
R
I
I
N
A
--
F
F
P
E
G
E
D
---
Q
V
N
F
R
G
F
M
R
T
L
A
H
F
R
P
I
---
E
D
-
N
E
KSKDV
N
-
G
P
E
P
L
N
-----
S
R
S
N
K
L
H
F
A
F
R
L
Y
D
L
D
K
D
E
K
I
S
R
D
E
L
L
Q
V
L
R
M
M
V
G
V
---
N
I
S
D
E
Q
L
G
S
I
A
D
R
T
I
Q
E
A
D
Q
D
G
D
S
----------
A
I
S
F
T
E
F
V
K
V
L
E
K
V
D
V
E
Q
K
M
S
I
R
F
L
---------
40
HHSearch
68.30
33%
21
- C3 -
-
4F0Z
3
CANB1_HUMAN
B:
[7-161]
---------
Y
---
P
-----
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
N
S
G
-
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
----
Q
R
V
I
D
I
--
F
D
T
D
G
N
G
---
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
S
V
K
--------------------
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
V
G
N
---
N
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
----------
R
I
S
F
E
E
F
C
A
V
V
G
G
L
D
-------------------
41
HHSearch
68.15
27%
27
- C3 -
-
5B8I
3
?
B:
[2-168]
---------
S
---
S
Q
V
L
N
D
I
V
S
G
S
N
F
D
H
E
E
V
D
R
L
W
K
R
F
M
K
L
-
D
R
D
K
S
G
-
T
-
I
E
R
D
E
F
L
S
L
P
Q
V
S
S
N
P
L
S
----
T
R
M
I
A
I
--
F
D
E
D
G
G
G
---
D
V
D
F
Q
E
F
V
S
G
L
S
A
F
S
S
K
--------------------
G
-----
N
K
E
E
K
L
R
F
A
F
K
V
Y
D
I
D
R
D
G
F
I
S
N
G
E
L
F
I
V
L
K
M
M
V
G
S
---
N
L
K
D
M
Q
L
Q
Q
I
V
D
K
T
I
M
E
A
D
L
D
G
D
G
----------
R
I
S
F
E
E
F
T
R
M
V
E
N
T
D
V
S
M
S
M
T
L
------------
9
PsiBlast_PDB
66.96
27%
7
- C3 -
-
4F0Z
3
CANB1_HUMAN
B:
[7-161]
-----------------
Y
P
L
E
M
C
S
H
F
D
A
D
E
I
K
R
L
G
K
R
F
K
K
L
-
D
L
D
-
N
S
G
S
-
L
S
V
E
E
F
M
S
L
P
E
L
Q
Q
N
P
L
V
Q
R
V
I
D
I
F
D
T
D
G
N
---------
G
E
V
D
F
K
E
F
I
E
G
V
S
Q
F
--------------------
S
V
K
G
-----
D
K
E
Q
K
L
R
F
A
F
R
I
Y
D
M
D
K
D
G
Y
I
S
N
G
E
L
F
Q
V
L
K
M
M
-
V
G
N
N
--
L
K
D
T
Q
L
Q
Q
I
V
D
K
T
I
I
N
A
D
K
D
G
D
G
R
----------
I
S
F
E
E
F
C
A
V
V
G
G
L
D
-------------------