@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CPSF5_HUMAN: (2020-01-31 )
MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
Atome Classification :
(20 SA)
-.........10........20.....---...30........40--------.........-----------------50........60........70..-......80........--90........--100.......110...-....120.......130...--....140.......150.......160.......170...--....180.......190......-.200-........210..---.....220.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MSVVPPNRSQTGWPR
G
V
T
Q
F
G
N
K
Y
I
Q
---QTKP
L
T
L
E
R
T
I
N
L
Y
---------PLTNYTFGT-----------------KEPLYEK
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-IG
M
R
RTV
E
G
V
L
I
V
HEH--RLP
H
V
L
L
L
QL--GT
T
F
F
KLPGGELNPG
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
LGRQDG
V
--
L
Q
D
W
V
I
D
D
C
IGNWWRPNFEPPQYPYIPAHITK
P
K
EH
K
K
L
F
--
L
V
Q
LQE
K
A
L
F
AVPKN
Y
K
L
V
A
A
P
L
-
F
E
L
--YDNAPGYG
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
IYN
38
HHSearch
98.48
100%
-117
- C- -
-
3Q2S
-
CPSF5_HUMAN
A:
[21-227]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
7
PsiBlast_PDB
98.48
100%
-117
- C- -
-
3Q2S
-
CPSF5_HUMAN
A:
[21-227]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
37
HHSearch
98.38
100%
-124
- C4 -
-
3BHO
1
CPSF5_HUMAN
A:
[1-208]
--------------------
F
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
-------
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
4
PsiBlast_PDB
98.27
100%
-124
- C4 -
-
3BHO
1
CPSF5_HUMAN
A:
[1-208]
--------------------
F
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
-------
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
6
PsiBlast_PDB
98.18
99%
-125
- C4 -
-
3N9U
2
CPSF5_HUMAN
A:
[25-230]
----------------------
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
3
PsiBlast_PDB
97.55
98%
-129
- C4 -
-
3BAP
1
CPSF5_HUMAN
A:
[21-227]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
------
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
1
PsiBlast_PDB
96.48
100%
-125
- C4 -
-
3MDG
2
CPSF5_HUMAN
A:
[28-227]
-------------------------------
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
8
PsiBlast_PDB
96.10
100%
-119
- C4 -
-
3Q2T
-
CPSF5_HUMAN
A:
[1-207]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
----
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
21
Fugue
95.86
100%
-126
- C4 -
-
2CL3
-
CPSF5_HUMAN
A:
[21-227]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
-------
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
5
PsiBlast_PDB
95.84
99%
-126
- C4 -
-
2CL3
-
CPSF5_HUMAN
A:
[21-227]
---------------------
G
N
K
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
-------
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
9
PsiBlast_PDB
95.22
98%
-111
- C4 -
-
2J8Q
-
CPSF5_HUMAN
A:
[22-227]
----------------------
S
M
Y
I
Q
---
Q
T
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
-----
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
10
PsiBlast_PDB
95.15
100%
-121
- C4 -
-
3P5T
-
CPSF5_HUMAN
A:
[34-227]
-------------------------------------
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
2
PsiBlast_PDB
95.00
100%
-116
- C4 -
-
3MDI
1
CPSF5_HUMAN
A:
[29-227]
--------------------------------
K
P
L
T
L
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
11
PsiBlast_PDB
93.02
100%
-114
- C4 -
-
3P6Y
-
CPSF5_HUMAN
A:
[1-194]
-------------------------------------
E
R
T
I
N
L
Y
---------
P
L
T
N
Y
T
F
G
T
-----------------
K
E
P
L
Y
E
K
D
S
S
V
A
A
R
F
Q
R
M
R
E
E
F
D
K
-
I
G
M
R
R
T
V
E
G
V
L
I
V
H
E
H
--
R
L
P
H
V
L
L
L
Q
L
--
G
T
T
F
F
K
L
P
G
G
E
L
N
P
G
E
-
D
E
V
E
G
L
K
R
L
M
T
E
I
L
G
R
Q
D
G
V
--
L
Q
D
W
V
I
D
D
C
I
G
N
W
W
R
P
N
F
E
P
P
Q
Y
P
Y
I
P
A
H
I
T
K
P
K
E
H
K
K
L
F
--
L
V
Q
L
Q
E
K
A
L
F
A
V
P
K
N
Y
K
L
V
A
A
P
L
-
F
E
L
--
Y
D
N
A
P
G
Y
G
P
I
I
S
S
---
L
P
Q
L
L
S
R
F
N
F
I
Y
N
35
Fugue
48.71
10%
9
- C4 -
-
2A6T
-
DCP2_SCHPO
A:
[1-245]
------
M
S
F
T
N
A
T
F
S
Q
V
L
D
D
L
S
A
R
F
I
L
NLP
A
E
E
Q
S
S
V
E
R
L
C
F
Q
I
---------
E
Q
A
H
W
F
Y
E
D
FIRAQNDQLPSLGLRVF
S
A
K
L
F
A
H
C
P
L
L
W
K
W
H
E
E
A
F
D
D
F
L
R
-
Y
K
T
R
I
P
V
R
G
A
I
M
L
D
M
---
S
M
Q
Q
C
V
L
V
K
G
WK
A
S
S
G
W
G
F
P
K
G
K
I
D
K
D
E
-
S
D
V
D
C
A
I
R
E
V
Y
E
E
T
G
----------------------
F
D
C
S
S
R
I
N
P
N
E
F
I
D
M
T
I
R
G
Q
N
V
R
L
Y
--
I
I
P
G
I
S
L
D
T
R
F
E
I
S
K
I
E
W
H
N
L
M
D
-
L
P
T
--
F
K
M
K
N
K
F
Y
M
V
I
P
F
---
L
A
P
L
K
K
W
I
K
K
R
N
I
24
Fugue
41.71
10%
-57
- C4 -
-
1VHZ
1
NUDE_ECOLI
A:
[2-187]
---------
S
L
S
K
S
L
Q
K
P
T
I
L
N
V
E
T
V
A
---
R
S
R
L
F
T
V
E
S
V
D
L
E
F
---------
S
N
G
V
R
R
V
Y
E
-----------------
R
M
R
P
T
N
R
E
A
V
M
I
V
P
I
V
D
---------------
D
H
L
I
L
I
R
E
Y
--
A
V
G
------
T
--
E
S
Y
E
L
G
F
S
K
G
L
I
D
P
G
E
-
S
V
Y
E
A
A
N
R
E
L
K
E
E
V
G
F
G
A
N
D
--
L
T
F
L
K
K
L
S
M
A
P
S
Y
F
S
S
K
M
N
I
V
V
A
Q
D
L
Y
P
E
S
L
E
G
D
E
P
E
P
L
P
--
Q
V
R
W
P
L
A
H
M
M
D
L
L
E
D
P
D
F
N
----------------
E
A
R
N
V
S
A
---
L
F
L
V
R
E
W
L
K
G
Q
G
R
32
Fugue
40.09
20%
-56
- C4 -
-
5M1P
-
?
A:
[3-189]
-----
A
M
N
S
V
F
S
G
L
D
M
L
I
L
L
---
P
Y
E
R
---
R
G
T
R
L
V
V
E
---
D
Y
R
---------
P
D
H
I
Y
C
I
G
A
-----------------
D
F
G
-
K
N
Q
D
Y
S
V
F
S
V
L
D
L
--------------
D
T
G
A
I
A
C
L
E
R
--
M
N
G
---------------------
A
T
W
S
-
D
Q
V
A
R
L
K
A
L
S
E
D
Y
-
G
H
A
Y
V
V
--
A
D
T
W
----
G
V
G
D
A
I
A
E
E
L
D
A
Q
G
I
N
Y
T
P
L
P
V
K
S
S
S
V
K
E
Q
L
I
SN
L
A
L
L
M
E
K
G
Q
V
A
V
P
N
D
K
T
I
L
D
E
L
R
N
F
R
Y
--
Y
R
T
A
S
G
N
Q
V
M
R
A
Y
GRG
H
D
D
I
V
M
S
L
A
L
A
Y
S
34
Fugue
37.87
11%
-5
- C3 -
-
1QWT
-
IRF3_HUMAN
A:
[17-255]
E
N
P
L
K
R
L
L
V
P
G
E
E
W
E
F
E
V
T
A
F
Y
R
G
R
Q
V
---
F
Q
Q
T
I
S
C
P
E
G
L
R
L
V
GSEVGDRTL
P
G
W
P
V
T
L
P
D
-----------------
P
G
M
S
L
-
T
D
R
G
V
M
S
Y
V
R
H
V
L
S
C
L
G
G
G
L
A
L
W
R
A
G
Q
W
L
W
A
Q
R
L
G
HC
H
T
Y
W
A
V
S
E
E
L
--
L
P
N
S
G
H
G
P
D
G
E
V
P
K
D
K
E
G
G
V
F
D
L
G
P
F
I
V
D
L
I
T
F
T
E
G
S
GR
S
P
R
Y
A
L
W
F
C
V
G
E
S
W
-
P
Q
D
Q
P
W
T
K
R
L
V
M
V
K
V
V
P
--
T
C
L
R
A
L
--
V
E
M
A
R
V
G
G
A
S
S
L
E
N
T
V
D
L
H
I
S
N
S
-
H
P
L
--
S
L
T
S
D
Q
Y
K
A
Y
L
Q
D
---
L
V
E
G
M
D
F
Q
G
P
G
E
S
22
Fugue
36.32
9%
-61
- C4 -
-
1G0S
-
ADPP_ECOLI
A:
[1-209]
--
M
L
K
P
D
N
L
P
V
T
F
G
K
N
D
V
E
I
I
A
R
E
T
L
Y
---
R
G
F
----------
F
---------
S
L
D
L
Y
R
F
R
H
-----------------
R
L
F
N
G
Q
M
S
H
E
V
R
R
E
I
F
E
R
G
H
A
A
V
L
-
L
P
F
D
P
V
R
D
E
V
V
L
I
E
Q
I
--
R
I
A
A
Y
D
T
S
E
---
T
P
W
L
L
E
M
V
A
G
M
I
E
E
G
E
-
S
V
E
D
V
A
R
R
E
A
I
E
E
A
G
L
I
V
K
R
-------
T
K
P
V
L
S
F
L
A
S
P
G
G
T
S
E
R
S
S
I
M
V
G
E
V
D
A
T
T
A
S
N
E
D
-------
I
R
V
H
V
V
S
R
E
Q
A
Y
Q
W
V
E
E
G
K
-
I
D
N
--
A
A
S
V
I
A
L
Q
W
L
Q
L
H
---
H
Q
A
L
K
N
E
W
A
----
29
Fugue
31.36
14%
-67
- C- -
-
3F13
-
?
A:
[11-156]
---------------------------------------------------------------------------------------------------------
R
L
P
S
D
L
A
R
R
A
T
A
I
I
E
--
M
P
D
G
V
L
V
T
A
-----
S
R
Y
N
L
P
G
G
K
A
N
R
G
E
-
L
R
S
Q
A
L
I
R
E
I
R
E
E
T
G
L
R
I
N
S
--
M
L
Y
L
F
D
H
I
------
T
P
F
N
A
H
K
V
Y
L
C
I
A
G
Q
P
K
P
Q
N
E
I
E
R
I
A
--
L
V
S
S
P
D
T
D
M
D
L
F
V
E
G
R
A
I
L
R
R
Y
A
-
R
L
R
NE
E
T
A
K
G
E
A
L
R
A
L
L
G
---
L
A
R
Y
I
A
K
V
D
----