@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DESP_HUMAN: (2020-01-31 )
MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240---------..---------.....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......-690.......700.......710...----....720.......730...----....740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020-......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSCNGGSHP
R
I
N
T
L
G
R
M
I
RAESGP
D
L
R
Y
E
V
TSGGGGTS
R
M
Y
Y
SRRGVITDQNSDGYCQTGTMSRHQ
N
Q
N
T
I
Q
E
L
L
Q
N
C
S
D
C
L
M
R
A
E
L
I
VQPELKYGDG
I
Q
LTRSR
E
L
D
E
C
F
A
QAN
D
Q
M
E
I
L
D
S
L
I
R
E
M
R
QMGQ
P
C
D
A
Y
Q
K
R
L
L
Q
L
Q
E
Q
M
R
A
L
Y
K
A
ISV
P
R
V
RRASSKGGG
G
Y
TCQSGS
G
W
D
E
F
T
K
H
V
T
S
E
C
L
G
W
M
R
Q
Q
R
AEM
D
M
V
A
WG
V
D
L
A
S
V
E
Q
H
I
N
SHRGIHNSIG
D
Y
R
W
Q
L
D
K
I
K
A
D
L
---------
R
E
---------
K
S
A
I
Y
Q
L
E
E
E
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
L
R
Q
L
Q
N
I
I
Q
ATSR
E
I
M
W
INDCEEE
E
L
L
Y
DWSDKNT
N
I
A
Q
K
Q
E
A
F
S
I
R
M
S
Q
L
E
V
K
E
K
E
L
N
K
L
K
QESD
Q
L
V
LNQHPA
S
D
K
I
E
A
Y
M
D
T
L
Q
T
Q
W
S
W
I
L
Q
I
T
K
C
I
D
V
H
LKEN
A
A
Y
F
Q
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
L
Q
D
S
I
R
KKYPCDKNM
P
L
Q
H
L
L
E
Q
I
K
E
L
E
K
E
R
E
K
I
L
E
Y
K
R
Q
V
Q
N
L
V
NKSK
K
I
V
Q
LKPRNPDYRSNK
P
I
I
L
R
A
LCD
Y
K
Q
D
Q
K
I
V
HKGD
E
C
I
LKDNNE
R
S
K
W
Y
V
TGPGG
V
D
M
L
VPSV
G
L
I
IPPPN
P
L
A
V
D
L
S
C
K
I
E
Q
Y
Y
E
A
I
L
A
L
W
N
Q
L
Y
I
N
M
K
S
L
V
S
W
H
Y
C
M
I
D
I
E
K
I
R
A
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
E
L
H
Y
Q
E
F
I
RNSQGSEMFGD
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
T
L
V
I
QLPGYPQH
Q
T
V
T
T
T
E
I
THHGTCQDVNHN
K
V
I
ETNREN
D
K
Q
E
T
W
M
L
M
E
L
Q
K
I
R
R
Q
I
E
HCEG
R
M
T
LK-NLPLADQGSS
H
H
I
T
V
K
I
N
E
L
K
S
VQN
D
----
S
Q
A
I
A
E
V
L
N
Q
L
K
D
M
L
A
NFRG----SE
K
Y
C
Y
L
Q
N
E
V
F
G
L
F
Q
K
L
E
NINGV
T
D
G
Y
L
N
S
L
C
T
V
R
A
L
L
Q
A
I
L
Q
T
E
D
M
L
K
V
Y
E
A
RLTEEE
T
V
C
L
D
L
D
K
V
E
A
Y
R
C
G
L
K
K
I
K
N
D
L
N
L
K
K
S
L
L
A
T
M
K
T
E
L
Q
K
A
Q
Q
I
H
S
Q
TSQQYP
L
Y
DL
D
L
G
K
F
G
E
K
V
T
Q
L
T
D
R
W
Q
R
I
D
K
Q
I
D
F
R
LW
D
L
E
K
Q
I
K
Q
L
R
N
Y
R
D
N
Y
Q
A
F
C
K
W
L
Y
D
A
K
R
R
Q
D
S
L
E
SMKFG
D
S
N
T
V
M
R
F
L
N
E
Q
K
N
L
H
S
E
ISGKRD
K
S
E
E
V
Q
K
I
A
E
L
C
A
N
S
I
K
D
Y
E
L
Q
L
A
S
Y
T
S
G
L
E
T
L
L
NIP
I
K
R
T
MIQSPS
G
V
I
L
Q
E
A
A
D
V
H
A
R
Y
I
E
L
L
TRSG
D
Y
Y
R
F
L
S
E
M
L
K
S
L
E
D
LKLKN
T
K
I
E
V
L
E
E
E
L
R
L
ARDANSENCNKN
K
F
L
D
Q
N
L
Q
K
Y
Q
A
E
C
S
Q
F
K
A
K
L
A
S
L
E
E
L
K
R
Q
AELDG
K
S
A
K
Q
N
L
D
K
C
Y
G
Q
I
K
E
L
N
E
K
I
T
R
L
T
Y
EI
E
D
E
K
R
R
R
K
S
V
E
D
R
F
D
QQKN
D
Y
D
Q
L
Q
K
A
R
Q
C
E
K
ENL
G
W
Q
K
L
E
S
E
KA
I
K
E
K
E
Y
E
I
E
R
L
R
V
L
L
Q
EEGTR
K
R
E
Y
E
N
E
L
A
K
V
R
N
H
Y
N
E
E
M
S
N
L
R
N
K
Y
ET
E
I
N
I
T
K
T
T
I
K
E
I
SMQKEDD
S
K
N
L
R
N
Q
L
D
R
L
S
RENR
D
L
K
D
E
I
V
R
L
N
D
S
I
L
Q
A
T
E
Q
R
R
R
A
E
E
N
A
L
Q
Q
K
AC
G
S
E
I
M
Q
K
K
Q
H
L
E
I
E
L
K
Q
V
M
Q
QRSED
N
A
R
H
K
Q
S
L
E
E
A
A
K
T
I
Q
D
K
N
K
E
I
E
R
L
K
A
E
F
Q
E
E
A
K
R
R
W
E
Y
E
N
E
L
S
K
V
R
NNY
D
E
E
I
I
S
L
K
N
Q
FET
E
I
N
I
T
K
T
T
I
H
Q
L
T
MQKEEDTSG
Y
R
A
Q
I
D
N
L
T
REN
R
S
L
S
E
E
I
K
R
L
K
N
T
L
T
Q
T
T
E
N
L
R
R
V
E
E
D
I
Q
Q
QKAT
G
S
E
V
S
Q
R
K
Q
Q
L
E
V
E
L
R
Q
V
T
Q
M
R
T
E
E
S
V
R
Y
K
Q
S
L
D
D
A
A
K
T
I
Q
D
K
N
K
E
I
E
R
L
K
Q
L
I
DKETNDRKCLEDEN
A
R
L
Q
R
V
Q
Y
D
L
Q
KANS
S
A
T
E
T
I
N
K
L
K
V
Q
E
Q
E
L
T
R
L
R
I
D
Y
E
RVSQERTV
K
D
Q
D
I
T
R
F
Q
N
S
L
K
E
L
Q
L
Q
K
Q
K
V
E
E
E
L
N
R
L
K
RTAS
E
D
S
C
K
R
K
K
L
E
E
E
L
E
G
M
R
R
S
L
K
E
Q
A
I
K
I
T
N
L
T
Q
Q
L
E
Q
A
S
I
V
K
KR
S
E
D
D
L
R
Q
Q
R
D
V
L
D
G
H
L
R
E
K
Q
R
T
Q
E
E
L
R
R
L
S
S
E
V
E
A
L
R
R
Q
L
L
Q
E
Q
E
S
V
K
Q
A
H
L
R
N
E
H
F
Q
K
A
I
E
D
K
SRSLNE
S
K
I
E
I
E
R
L
Q
S
L
T
E
N
L
T
K
E
H
L
M
L
E
E
E
L
R
N
LRL
E
Y
D
D
L
RRGRSEADSDKN
A
T
I
L
E
L
R
S
Q
LQISNN
R
T
L
E
L
Q
G
L
I
N
D
L
Q
R
E
R
E
N
L
R
Q
E
I
E
K
F
Q
K
Q
A
L
E
A
S
N
R
I
Q
E
S
K
N
Q
C
T
Q
V
V
Q
E
R
E
S
L
L
V
K
I
K
V
L
E
Q
D
K
A
R
L
Q
R
L
E
D
E
L
N
R
A
K
S
T
L
E
A
E
T
R
V
K
Q
R
L
E
C
E
K
Q
Q
I
Q
N
D
L
N
Q
W
K
T
Q
YS
R
K
E
E
A
I
R
K
I
E
S
E
R
E
K
S
E
R
E
K
N
S
L
R
S
E
I
E
R
L
Q
A
E
I
K
R
I
E
E
R
C
R
R
K
L
E
D
S
T
R
E
T
Q
S
Q
L
E
T
E
R
S
R
Y
Q
R
E
I
D
K
L
R
QRPYGSHRETQT
E
C
E
W
T
V
D
T
S
K
L
V
F
D
G
L
R
K
K
V
T
A
M
Q
L
Y
E
C
Q
LI
D
K
T
T
L
D
K
L
L
KG
K
K
S
V
E
E
V
A
S
E
I
Q
P
F
L
R
GAGSIAGASA-S
P
K
E
K
Y
S
L
V
E
A
K
R
K
KLISPE
S
T
V
M
L
L
E
AQAATGGIIDPHRNE
K
L
T
V
D
S
A
I
A
R
D
L
IDFD
D
R
Q
Q
I
Y
A
A
E
KAITGFDDPFSG
K
T
V
S
V
S
E
A
I
K
K
N
LI
D
R
E
T
G
M
R
L
L
E
A
Q
IASGGVVDPVNSVFLP
K
D
V
A
L
A
R
G
L
I
D
R
D
L
Y
R
SLNDPRDSQKNFVDPVTKK
K
V
S
Y
V
Q
L
K
E
R
CRIEPHT
G
L
L
L
L
S
V
Q
K
RS
M
S
F
QGIRQP
V
T
V
T
E
L
V
DSGILRPS
T
V
N
E
L
ESGQI
S
Y
D
E
V
G
E
R
I
K
D
F
LQGS
S
C
I
A
G
I
YNE
T
T
K
Q
K
L
G
I
Y
E
A
M
KIGLVRPG
T
A
L
E
L
L
E
AQAAT
G
F
I
VDPVSNLRL
P
V
E
E
A
Y
KRGLV
G
I
E
F
K
E
K
L
L
S
A
E
R
AVTGYNDPET
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
EKGH
G
I
R
L
L
E
A
QIATGGIIDPKESHRLP
V
D
I
A
Y
KRGY
F
N
E
E
L
S
E
I
LSDPSDDTKGFFDPNTEEN
L
T
Y
L
Q
L
K
E
R
CIKDEET
G
L
C
L
LP
L
K
E
K
K
K
Q
V
QT
S
Q
K
NTLRK
R
R
V
V
I
VDPETNKE
M
S
V
Q
E
A
Y
K
KGLI
D
Y
E
T
F
K
E
L
C
E
QECEW
E
E
I
T
I
TGSDG
S
T
R
V
V
L
V
DRKTGSQYD
I
Q
D
A
I
D
K
G
L
V
D
R
K
F
F
D
Q
YRSGS
L
S
L
T
Q
F
A
D
M
I
S
LKNGVGTSSSMGSGVS
D
D
V
FSS
S
R
H
E
S
V
S
K
I
S
T
I
S
S
V
R
N
L
T
I
RSSSFSDTLEESS
P
I
A
A
I
FDTEN
L
E
K
I
S
I
T
E
G
I
E
RG
I
V
D
S
IT
G
Q
R
L
L
E
AQACTGGIIHPTTG
Q
K
L
S
L
Q
D
A
V
SQGVI
D
Q
D
M
A
T
RLK
P
A
Q
K
A
F
I
GFEGVKGKKK
M
S
A
A
E
A
V
K
E
KWL
P
Y
E
A
GQ
R
F
L
E
F
Q
Y
L
TGGLVDPEVHGRI
S
T
E
E
A
I
R
K
GFID
G
R
A
A
Q
R
L
Q
D
T
S
S
Y
A
K
I
L
TCPK
T
K
L
K
I
S
Y
K
D
AI
N
R
S
M
V
E
D
I
TG
L
R
L
L
E
AASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNS
S
Y
S
Y
S
Y
S
FSSSSIGH
22
Fugue
92.30
100%
-119
- C1 -
-
3R6N
2
DESP_HUMAN
A:
[1-450]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
W
D
E
F
T
K
H
V
T
S
E
C
L
G
W
M
R
Q
Q
R
A
E
M
D
M
V
A
W
G
V
D
L
A
S
V
E
Q
H
I
N
S
H
R
G
I
H
N
S
I
G
D
Y
R
W
Q
L
D
K
I
K
A
D
L
---------
R
E
---------
K
S
A
I
Y
Q
L
E
E
E
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
L
R
Q
L
Q
N
I
I
Q
A
T
S
R
E
I
M
W
I
N
D
C
E
E
E
E
L
L
Y
D
W
S
D
K
N
T
N
I
A
Q
K
Q
E
A
F
S
I
R
M
S
Q
L
E
V
K
E
K
E
L
N
K
L
K
Q
E
S
D
Q
L
V
L
N
Q
H
P
A
S
D
K
I
E
A
Y
M
D
T
L
Q
T
Q
W
S
W
I
L
Q
I
T
K
C
I
D
V
H
L
K
E
N
A
A
Y
F
Q
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
L
Q
D
S
I
R
K
K
Y
P
C
D
K
N
M
P
L
Q
H
L
L
E
Q
I
K
E
L
E
K
E
R
E
K
I
L
E
Y
K
R
Q
V
Q
N
L
V
N
K
S
K
K
I
V
Q
L
K
P
R
N
P
D
Y
R
S
N
K
P
I
I
L
R
A
L
C
D
Y
K
Q
D
Q
K
I
V
H
K
G
D
E
C
I
L
K
D
N
N
E
R
S
K
W
Y
V
T
G
P
G
G
V
D
M
L
V
P
S
V
G
L
I
I
P
P
P
N
P
L
A
V
D
L
S
C
K
I
E
Q
Y
Y
E
A
I
L
A
L
W
N
Q
L
Y
I
N
M
K
S
L
V
S
W
H
Y
C
M
I
D
I
E
K
I
R
A
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
E
L
H
Y
Q
E
F
I
R
N
S
Q
G
S
E
M
F
G
D
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
T
L
V
I
Q
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.30
100%
-119
- C1 -
-
3R6N
2
DESP_HUMAN
A:
[1-450]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
W
D
E
F
T
K
H
V
T
S
E
C
L
G
W
M
R
Q
Q
R
A
E
M
D
M
V
A
W
G
V
D
L
A
S
V
E
Q
H
I
N
S
H
R
G
I
H
N
S
I
G
D
Y
R
W
Q
L
D
K
I
K
A
D
L
---------
R
E
---------
K
S
A
I
Y
Q
L
E
E
E
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
L
R
Q
L
Q
N
I
I
Q
A
T
S
R
E
I
M
W
I
N
D
C
E
E
E
E
L
L
Y
D
W
S
D
K
N
T
N
I
A
Q
K
Q
E
A
F
S
I
R
M
S
Q
L
E
V
K
E
K
E
L
N
K
L
K
Q
E
S
D
Q
L
V
L
N
Q
H
P
A
S
D
K
I
E
A
Y
M
D
T
L
Q
T
Q
W
S
W
I
L
Q
I
T
K
C
I
D
V
H
L
K
E
N
A
A
Y
F
Q
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
L
Q
D
S
I
R
K
K
Y
P
C
D
K
N
M
P
L
Q
H
L
L
E
Q
I
K
E
L
E
K
E
R
E
K
I
L
E
Y
K
R
Q
V
Q
N
L
V
N
K
S
K
K
I
V
Q
L
K
P
R
N
P
D
Y
R
S
N
K
P
I
I
L
R
A
L
C
D
Y
K
Q
D
Q
K
I
V
H
K
G
D
E
C
I
L
K
D
N
N
E
R
S
K
W
Y
V
T
G
P
G
G
V
D
M
L
V
P
S
V
G
L
I
I
P
P
P
N
P
L
A
V
D
L
S
C
K
I
E
Q
Y
Y
E
A
I
L
A
L
W
N
Q
L
Y
I
N
M
K
S
L
V
S
W
H
Y
C
M
I
D
I
E
K
I
R
A
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
E
L
H
Y
Q
E
F
I
R
N
S
Q
G
S
E
M
F
G
D
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
T
L
V
I
Q
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
92.20
100%
-121
- C1 -
-
3R6N
2
DESP_HUMAN
A:
[3-449]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
E
F
T
K
H
V
T
S
E
C
L
G
W
M
R
Q
Q
R
A
E
M
D
M
V
A
W
G
V
D
L
A
S
V
E
Q
H
I
N
S
H
R
G
I
H
N
S
I
G
D
Y
R
W
Q
L
D
K
I
K
A
D
L
---------
R
E
---------
K
S
A
I
Y
Q
L
E
E
E
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
L
R
Q
L
Q
N
I
I
Q
A
T
S
R
E
I
M
W
I
N
D
C
E
E
E
E
L
L
Y
D
W
S
D
K
N
T
N
I
A
Q
K
Q
E
A
F
S
I
R
M
S
Q
L
E
V
K
E
K
E
L
N
K
L
K
Q
E
S
D
Q
L
V
L
N
Q
H
P
A
S
D
K
I
E
A
Y
M
D
T
L
Q
T
Q
W
S
W
I
L
Q
I
T
K
C
I
D
V
H
L
K
E
N
A
A
Y
F
Q
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
L
Q
D
S
I
R
K
K
Y
P
C
D
K
N
M
P
L
Q
H
L
L
E
Q
I
K
E
L
E
K
E
R
E
K
I
L
E
Y
K
R
Q
V
Q
N
L
V
N
K
S
K
K
I
V
Q
L
K
P
R
N
P
D
Y
R
S
N
K
P
I
I
L
R
A
L
C
D
Y
K
Q
D
Q
K
I
V
H
K
G
D
E
C
I
L
K
D
N
N
E
R
S
K
W
Y
V
T
G
P
G
G
V
D
M
L
V
P
S
V
G
L
I
I
P
P
P
N
P
L
A
V
D
L
S
C
K
I
E
Q
Y
Y
E
A
I
L
A
L
W
N
Q
L
Y
I
N
M
K
S
L
V
S
W
H
Y
C
M
I
D
I
E
K
I
R
A
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
E
L
H
Y
Q
E
F
I
R
N
S
Q
G
S
E
M
F
G
D
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
T
L
V
I
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
61.23
100%
-
- C3 -
-
5DZZ
-
DESP_HUMAN
A:
[1961-2448]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
T
S
K
L
V
F
D
G
L
R
K
K
V
T
A
M
Q
L
Y
E
C
Q
L
I
D
K
T
T
L
D
K
L
L
K
G
K
K
S
V
E
E
V
A
S
E
I
Q
P
F
L
R
G
A
G
S
I
A
G
A
S
A
-
S
P
K
E
K
Y
S
L
V
E
A
K
R
K
K
L
I
S
P
E
S
T
V
M
L
L
E
A
Q
A
A
T
G
G
I
I
D
P
H
R
N
E
K
L
T
V
D
S
A
I
A
R
D
L
I
D
F
D
D
R
Q
Q
I
Y
A
A
E
K
A
I
T
G
F
D
D
P
F
S
G
K
T
V
S
V
S
E
A
I
K
K
N
L
I
D
R
E
T
G
M
R
L
L
E
A
Q
I
A
S
G
G
V
V
D
P
V
N
S
V
F
L
P
K
D
V
A
L
A
R
G
L
I
D
R
D
L
Y
R
S
L
N
D
P
R
D
S
Q
K
N
F
V
D
P
V
T
K
K
K
V
S
Y
V
Q
L
K
E
R
C
R
I
E
P
H
T
G
L
L
L
L
S
V
Q
K
R
S
M
S
F
Q
G
I
R
Q
P
V
T
V
T
E
L
V
D
S
G
I
L
R
P
S
T
V
N
E
L
E
S
G
Q
I
S
Y
D
E
V
G
E
R
I
K
D
F
L
Q
G
S
S
C
I
A
G
I
Y
N
E
T
T
K
Q
K
L
G
I
Y
E
A
M
K
I
G
L
V
R
P
G
T
A
L
E
L
L
E
A
Q
A
A
T
G
F
I
V
D
P
V
S
N
L
R
L
P
V
E
E
A
Y
K
R
G
L
V
G
I
E
F
K
E
K
L
L
S
A
E
R
A
V
T
G
Y
N
D
P
E
T
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
E
K
G
H
G
I
R
L
L
E
A
Q
I
A
T
G
G
I
I
D
P
K
E
S
H
R
L
P
V
D
I
A
Y
K
R
G
Y
F
N
E
E
L
S
E
I
L
S
D
P
S
D
D
T
K
G
F
F
D
P
N
T
E
E
N
L
T
Y
L
Q
L
K
E
R
C
I
K
D
E
E
T
G
L
C
L
L
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.09
100%
-
- C3 -
-
5DZZ
-
DESP_HUMAN
A:
[1960-2448]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
D
T
S
K
L
V
F
D
G
L
R
K
K
V
T
A
M
Q
L
Y
E
C
Q
L
I
D
K
T
T
L
D
K
L
L
K
G
K
K
S
V
E
E
V
A
S
E
I
Q
P
F
L
R
G
A
G
S
I
A
G
A
S
A
-
S
P
K
E
K
Y
S
L
V
E
A
K
R
K
K
L
I
S
P
E
S
T
V
M
L
L
E
A
Q
A
A
T
G
G
I
I
D
P
H
R
N
E
K
L
T
V
D
S
A
I
A
R
D
L
I
D
F
D
D
R
Q
Q
I
Y
A
A
E
K
A
I
T
G
F
D
D
P
F
S
G
K
T
V
S
V
S
E
A
I
K
K
N
L
I
D
R
E
T
G
M
R
L
L
E
A
Q
I
A
S
G
G
V
V
D
P
V
N
S
V
F
L
P
K
D
V
A
L
A
R
G
L
I
D
R
D
L
Y
R
S
L
N
D
P
R
D
S
Q
K
N
F
V
D
P
V
T
K
K
K
V
S
Y
V
Q
L
K
E
R
C
R
I
E
P
H
T
G
L
L
L
L
S
V
Q
K
R
S
M
S
F
Q
G
I
R
Q
P
V
T
V
T
E
L
V
D
S
G
I
L
R
P
S
T
V
N
E
L
E
S
G
Q
I
S
Y
D
E
V
G
E
R
I
K
D
F
L
Q
G
S
S
C
I
A
G
I
Y
N
E
T
T
K
Q
K
L
G
I
Y
E
A
M
K
I
G
L
V
R
P
G
T
A
L
E
L
L
E
A
Q
A
A
T
G
F
I
V
D
P
V
S
N
L
R
L
P
V
E
E
A
Y
K
R
G
L
V
G
I
E
F
K
E
K
L
L
S
A
E
R
A
V
T
G
Y
N
D
P
E
T
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
E
K
G
H
G
I
R
L
L
E
A
Q
I
A
T
G
G
I
I
D
P
K
E
S
H
R
L
P
V
D
I
A
Y
K
R
G
Y
F
N
E
E
L
S
E
I
L
S
D
P
S
D
D
T
K
G
F
F
D
P
N
T
E
E
N
L
T
Y
L
Q
L
K
E
R
C
I
K
D
E
E
T
G
L
C
L
L
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.24
100%
-112
- C3 -
-
1LM7
-
DESP_HUMAN
A:
[2209-2448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
Q
G
I
R
Q
P
V
T
V
T
E
L
V
D
S
G
I
L
R
P
S
T
V
N
E
L
E
S
G
--
S
Y
D
E
V
G
E
R
I
K
D
F
L
Q
G
S
S
C
I
A
G
I
Y
N
E
T
T
K
Q
K
L
G
I
Y
E
A
M
K
I
G
L
V
R
P
G
T
A
L
E
L
L
E
A
Q
A
A
T
G
F
I
V
D
P
V
S
N
L
R
L
P
V
E
E
A
Y
K
R
G
L
V
G
I
E
F
K
E
K
L
L
S
A
E
R
A
V
T
G
Y
N
D
P
E
T
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
E
K
G
H
G
I
R
L
L
E
A
Q
I
A
T
G
G
I
I
D
P
K
E
S
H
R
L
P
V
D
I
A
Y
K
R
G
Y
F
N
E
E
L
S
E
I
L
S
D
P
S
D
D
T
K
G
F
F
D
P
N
T
E
E
N
L
T
Y
L
Q
L
K
E
R
C
I
K
D
E
E
T
G
L
C
L
L
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
52.16
100%
-112
- C3 -
-
1LM7
-
DESP_HUMAN
A:
[2209-2448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
Q
G
I
R
Q
P
V
T
V
T
E
L
V
D
S
G
I
L
R
P
S
T
V
N
E
L
E
S
G
--
S
Y
D
E
V
G
E
R
I
K
D
F
L
Q
G
S
S
C
I
A
G
I
Y
N
E
T
T
K
Q
K
L
G
I
Y
E
A
M
K
I
G
L
V
R
P
G
T
A
L
E
L
L
E
A
Q
A
A
T
G
F
I
V
D
P
V
S
N
L
R
L
P
V
E
E
A
Y
K
R
G
L
V
G
I
E
F
K
E
K
L
L
S
A
E
R
A
V
T
G
Y
N
D
P
E
T
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
E
K
G
H
G
I
R
L
L
E
A
Q
I
A
T
G
G
I
I
D
P
K
E
S
H
R
L
P
V
D
I
A
Y
K
R
G
Y
F
N
E
E
L
S
E
I
L
S
D
P
S
D
D
T
K
G
F
F
D
P
N
T
E
E
N
L
T
Y
L
Q
L
K
E
R
C
I
K
D
E
E
T
G
L
C
L
L
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
51.84
42%
-90
- C1 -
-
3PE0
-
B:
[7-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
S
L
H
S
F
V
A
A
A
T
K
E
L
M
W
L
N
E
K
E
E
E
E
V
G
F
D
W
S
D
R
N
T
N
M
T
A
K
K
E
S
Y
S
A
L
M
R
E
L
E
L
K
E
K
K
I
K
E
L
Q
N
A
G
D
R
L
L
R
E
D
H
P
A
R
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
W
S
W
M
L
Q
L
C
C
C
I
E
A
H
L
K
E
N
A
A
Y
F
Q
F
F
S
D
V
R
E
A
E
G
Q
L
Q
K
L
Q
E
A
L
R
R
K
Y
S
C
D
R
S
A
T
V
T
R
L
E
D
L
L
Q
D
A
Q
D
E
K
E
Q
L
N
E
Y
K
G
H
L
S
G
L
A
K
R
A
K
A
V
V
Q
L
K
P
R
H
P
A
H
P
---
R
L
P
L
L
A
V
C
D
Y
K
Q
V
E
V
T
V
H
K
G
D
E
C
Q
L
V
G
P
A
Q
P
S
H
W
K
V
L
S
S
S
G
S
E
A
A
V
P
S
V
C
F
L
V
P
P
P
N
Q
E
A
Q
E
A
V
T
R
L
E
A
Q
H
Q
A
L
V
T
L
W
H
Q
L
H
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.52
41%
-95
- C1 -
-
3PE0
-
PLEC_HUMAN
A:
[7-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
S
L
H
S
F
V
A
A
A
T
K
E
L
M
W
L
N
E
K
E
E
E
E
V
G
F
D
W
S
D
R
N
T
N
M
T
A
K
K
E
S
Y
S
A
L
M
R
E
L
E
L
K
E
K
K
I
K
E
L
Q
N
A
G
D
R
L
L
R
E
D
H
P
A
R
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
W
S
W
M
L
Q
L
C
C
C
I
E
A
H
L
K
E
N
A
A
Y
F
Q
F
F
S
D
V
R
E
A
E
G
Q
L
Q
K
L
Q
E
A
L
R
R
K
Y
S
C
D
R
S
A
T
V
T
R
L
E
D
L
L
Q
D
A
Q
D
E
K
E
Q
L
N
E
Y
K
G
H
L
S
G
L
A
K
R
A
K
A
V
V
Q
L
K
P
R
H
P
A
H
P
M
R
G
R
L
P
L
L
A
V
C
D
Y
K
Q
V
E
V
T
V
H
K
G
D
E
C
Q
L
V
G
P
A
Q
P
S
H
W
K
V
L
S
---
S
E
A
A
V
P
S
V
C
F
L
V
P
P
P
N
Q
E
A
Q
E
A
V
T
R
L
E
A
Q
H
Q
A
L
V
T
L
W
H
Q
L
H
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
45.90
34%
-
- C3 -
-
5DZZ
-
DESP_HUMAN
A:
[1965-2447]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
F
D
G
L
R
K
K
V
T
A
M
Q
L
Y
E
C
Q
L
I
D
K
T
T
L
D
K
L
L
K
G
K
K
S
V
E
E
V
A
S
E
I
Q
P
F
L
R
G
A
G
S
I
A
G
A
S
A
-
S
P
K
E
K
Y
S
L
V
E
A
K
R
K
K
L
I
S
P
E
S
T
V
M
L
L
E
A
Q
A
A
T
G
G
I
I
D
P
H
R
N
E
K
L
T
V
D
S
A
I
A
R
D
L
I
D
F
D
D
R
Q
Q
I
Y
A
A
E
K
A
I
T
G
F
D
D
P
F
S
G
K
T
V
S
V
S
E
A
I
K
K
N
L
I
D
R
E
T
G
M
R
L
L
E
A
Q
I
A
S
G
G
V
V
D
P
V
N
S
V
F
L
P
K
D
V
A
L
A
R
G
L
I
D
R
D
L
Y
R
S
L
N
D
P
R
D
S
Q
K
N
F
V
D
P
V
T
K
K
K
V
S
Y
V
Q
L
K
E
R
C
R
I
E
P
H
T
G
L
L
L
L
S
V
Q
K
R
S
--------------------------
M
S
F
------------------------------------------
Q
G
I
R
Q
P
V
T
V
T
E
L
V
D
S
G
I
L
R
P
S
T
V
N
E
L
E
S
G
Q
I
S
Y
D
E
V
G
E
R
I
------------------------------------------------
K
D
F
L
Q
G
S
S
C
I
A
G
I
Y
N
E
T
T
K
Q
K
L
G
I
Y
E
A
M
K
I
G
L
V
R
P
G
T
A
L
E
L
L
E
A
Q
A
A
T
G
F
I
V
D
P
V
S
N
L
R
L
P
V
E
E
A
Y
K
R
G
L
V
G
I
E
F
K
E
K
L
L
S
A
E
R
A
V
T
G
Y
N
D
P
E
T
G
N
I
I
S
L
F
Q
A
M
N
K
E
L
I
E
K
G
H
G
I
R
L
L
E
A
Q
I
A
T
G
G
I
I
D
P
K
E
S
H
R
L
P
V
D
I
A
Y
K
R
G
Y
F
N
E
E
L
S
E
I
L
S
D
P
S
D
D
T
K
G
F
F
D
P
N
T
E
E
N
L
T
Y
L
Q
L
K
E
R
C
I
K
D
E
E
T
G
L
C
L
L
P
L
K
-----------------------------------------------------------------
39
HHSearch
44.58
100%
-69
- C3 -
-
1LM5
-
DESP_HUMAN
B:
[2613-2808]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
S
S
P
I
A
A
I
F
D
T
E
N
L
E
K
I
S
I
T
E
G
I
E
R
G
I
V
D
S
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
H
P
T
T
G
Q
K
L
S
L
Q
D
A
V
S
Q
G
V
I
D
Q
D
M
A
T
R
L
K
P
A
Q
K
A
F
I
G
F
E
G
V
---
K
K
M
S
A
A
E
A
V
K
E
K
W
L
P
Y
E
A
G
Q
R
F
L
E
F
Q
Y
L
T
G
G
L
V
D
P
E
V
H
G
R
I
S
T
E
E
A
I
R
K
G
F
I
D
G
R
A
A
Q
R
L
Q
D
T
S
S
Y
A
K
I
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
I
N
R
S
M
V
E
D
I
T
G
L
R
L
L
E
A
A
S
V
---------------------------------------------------------------
4
PsiBlast_PDB
44.02
100%
-68
- C3 -
-
1LM5
-
DESP_HUMAN
A:
[2616-2811]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
I
A
A
I
F
D
T
E
N
L
E
K
I
S
I
T
E
G
I
E
R
G
I
V
D
S
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
H
P
T
T
G
Q
K
L
S
L
Q
D
A
V
S
Q
G
V
I
D
Q
D
M
A
T
R
L
K
P
A
Q
K
A
F
I
G
F
-------
K
M
S
A
A
E
A
V
K
E
K
W
L
P
Y
E
A
G
Q
R
F
L
E
F
Q
Y
L
T
G
G
L
V
D
P
E
V
H
G
R
I
S
T
E
E
A
I
R
K
G
F
I
D
G
R
A
A
Q
R
L
Q
D
T
S
S
Y
A
K
I
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
I
N
R
S
M
V
E
D
I
T
G
L
R
L
L
E
A
A
S
V
S
S
K
------------------------------------------------------------
24
Fugue
43.89
100%
-68
- C3 -
-
1LM5
-
DESP_HUMAN
A:
[2616-2811]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
I
A
A
I
F
D
T
E
N
L
E
K
I
S
I
T
E
G
I
E
R
G
I
V
D
S
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
H
P
T
T
G
Q
K
L
S
L
Q
D
A
V
S
Q
G
V
I
D
Q
D
M
A
T
R
L
K
P
A
Q
K
A
F
I
G
F
-------
K
M
S
A
A
E
A
V
K
E
K
W
L
P
Y
E
A
G
Q
R
F
L
E
F
Q
Y
L
T
G
G
L
V
D
P
E
V
H
G
R
I
S
T
E
E
A
I
R
K
G
F
I
D
G
R
A
A
Q
R
L
Q
D
T
S
S
Y
A
K
I
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
I
N
R
S
M
V
E
D
I
T
G
L
R
L
L
E
A
A
S
V
S
S
K
------------------------------------------------------------
7
PsiBlast_PDB
40.65
31%
119
- C1 -
-
5J1I
-
PLEC_HUMAN
A:
[14-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
L
K
D
I
R
L
Q
L
E
A
C
E
T
R
T
V
H
R
L
R
L
P
L
-
D
K
E
P
A
R
E
C
A
Q
R
I
A
E
Q
Q
K
A
Q
A
E
VEGL
G
K
G
V
A
R
L
S
A
E
A
E
K
V
L
A
L
-------
S
P
A
A
P
T
L
R
S
E
L
E
L
T
L
G
K
L
E
Q
V
R
S
L
S
A
I
Y
L
E
K
L
K
T
I
S
L
V
I
R
G
T
Q
G
A
E
E
V
L
R
A
H
E
E
Q
L
K
E
A
Q
A
V
P
A
T
L
P
E
L
E
A
T
K
A
S
L
K
K
L
R
A
Q
A
E
A
Q
Q
P
T
F
D
A
L
R
D
E
L
R
G
A
Q
E
V
G
E
R
L
Q
Q
R
H
G
E
R
D
V
E
V
E
R
W
R
E
R
V
A
Q
L
L
E
R
W
Q
A
V
L
A
Q
T
D
V
R
Q
R
E
L
E
Q
L
G
R
Q
L
R
Y
Y
R
E
S
A
D
P
L
G
A
W
L
Q
D
A
R
R
R
Q
E
Q
I
Q
A
M
---
D
S
Q
A
V
R
E
Q
L
R
Q
E
Q
A
L
L
E
E
I
E
R
H
G
E
K
V
E
E
C
Q
R
F
A
K
Q
Y
I
N
A
I
K
D
Y
E
L
Q
L
V
T
Y
K
A
Q
L
E
----------
K
V
Q
S
G
S
E
S
V
I
Q
E
Y
V
D
L
R
T
H
Y
S
E
L
T
T
L
T
S
Q
Y
I
K
F
I
S
E
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.75
62%
-70
- C3 -
-
2N03
-
PLEC_HUMAN
A:
[4405-4605]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
W
S
D
P
T
E
E
T
G
P
V
A
G
I
L
D
T
E
T
L
E
K
V
S
I
T
E
A
M
H
R
N
L
V
D
N
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
D
P
S
T
G
E
R
F
P
V
T
D
A
V
N
K
G
L
V
D
K
I
M
V
D
R
I
N
L
A
Q
K
A
F
C
G
F
E
D
P
R
T
K
T
K
M
S
A
A
Q
A
L
K
K
G
W
L
Y
Y
E
A
G
Q
R
F
L
E
V
Q
Y
L
T
G
G
L
I
E
P
D
T
P
G
R
V
P
L
D
E
A
L
Q
R
G
T
V
D
A
R
T
A
Q
K
L
R
D
V
G
A
Y
S
K
Y
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
L
D
R
S
M
V
E
E
G
T
G
L
R
L
L
E
A
A
A
----------------------------------------------------------------
42
HHSearch
39.24
63%
-76
- C3 -
-
2N03
-
PLEC_HUMAN
A:
[4409-4604]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
E
E
T
G
P
V
A
G
I
L
D
T
E
T
L
E
K
V
S
I
T
E
A
M
H
R
N
L
V
D
N
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
D
P
S
T
G
E
R
F
P
V
T
D
A
V
N
K
G
L
V
D
K
I
M
V
D
R
I
N
L
A
Q
K
A
F
C
G
F
E
D
P
R
T
K
T
K
M
S
A
A
Q
A
L
K
K
G
W
L
Y
Y
E
A
G
Q
R
F
L
E
V
Q
Y
L
T
G
G
L
I
E
P
D
T
P
G
R
V
P
L
D
E
A
L
Q
R
G
T
V
D
A
R
T
A
Q
K
L
R
D
V
G
A
Y
S
K
Y
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
L
D
R
S
M
V
E
E
G
T
G
L
R
L
L
E
A
A
-----------------------------------------------------------------
56
HHSearch
36.39
40%
39
- C1 -
-
3PDY
-
B:
[9-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
R
Y
L
Q
D
L
L
A
W
V
E
E
N
Q
H
R
V
D
G
A
E
W
G
V
D
L
P
S
V
E
A
Q
L
G
S
H
R
G
L
H
Q
S
I
E
E
F
R
A
K
I
E
R
A
R
S
D
E
GQLSPATRG
A
Y
---------
R
D
C
L
G
R
L
D
L
Q
Y
A
K
L
L
N
S
S
K
A
R
L
R
S
L
E
S
L
H
S
F
V
A
A
A
T
K
E
L
M
W
L
N
E
K
E
E
E
E
V
G
F
D
W
S
D
R
N
T
N
M
T
A
K
K
E
S
Y
S
A
L
M
R
E
L
E
L
K
E
K
K
I
K
E
L
Q
N
A
G
D
R
L
L
R
E
D
H
P
A
R
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
W
S
W
M
L
Q
L
C
C
C
I
E
A
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
36.08
33%
28
- C3 -
-
1LM5
-
DESP_HUMAN
B:
[2613-2808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
S
S
P
I
A
A
I
F
D
T
E
N
L
E
K
I
S
I
T
E
G
I
E
R
G
I
V
D
S
I
T
G
Q
R
L
L
E
A
Q
A
C
T
G
G
I
I
H
P
T
T
G
Q
K
L
S
L
Q
D
A
V
S
Q
G
V
I
D
Q
D
M
A
T
R
L
K
P
A
Q
K
A
F
I
G
F
E
G
V
---
K
K
M
S
A
A
E
A
V
K
E
K
W
L
P
Y
E
A
G
Q
R
F
L
E
F
Q
Y
L
T
G
G
L
V
D
P
E
V
H
G
R
I
S
T
E
E
A
I
R
K
G
F
I
D
G
R
A
A
Q
R
L
Q
D
T
S
S
Y
A
K
I
L
T
C
P
K
T
K
L
K
I
S
Y
K
D
A
I
N
R
S
M
V
E
D
I
T
G
L
R
L
L
E
A
A
S
--
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
35.99
38%
48
- C1 -
-
3PDY
2
PLEC_HUMAN
A:
[7-208]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
T
L
R
Y
L
Q
D
L
L
A
W
V
E
E
N
Q
H
R
V
D
G
A
E
W
G
V
D
L
P
S
V
E
A
Q
L
G
S
H
R
G
L
H
Q
S
I
E
E
F
R
A
K
I
E
R
A
R
S
D
E
---------
G
Q
LSPATRGAY
R
D
C
L
G
R
L
D
L
Q
Y
A
K
L
L
N
S
S
K
A
R
L
R
S
L
E
S
L
H
S
F
V
A
A
A
T
K
E
L
M
W
L
N
E
K
E
E
E
E
V
G
F
D
W
S
D
R
N
T
N
M
T
A
K
K
E
S
Y
S
A
L
M
R
E
L
E
L
K
E
K
K
I
K
E
L
Q
N
A
G
D
R
L
L
R
E
D
H
P
A
R
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
W
S
W
M
L
Q
L
C
C
C
I
E
A
H
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
34.57
24%
-36
- C1 -
-
5J1G
1
?
A:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
E
S
R
C
Q
R
C
I
S
E
L
K
D
I
R
L
Q
L
E
A
C
E
T
R
T
V
H
R
-
L
R
L
P
L
D
K
E
P
A
R
E
C
A
Q
R
I
A
E
Q
Q
K
A
Q
A
E
----
V
E
G
L
G
K
G
V
A
R
L
S
A
E
A
E
K
V
L
A
LPEP
S
P
A
A
P
T
L
R
S
E
L
E
L
T
L
G
K
L
E
Q
V
R
S
L
S
A
I
Y
L
E
K
L
K
T
I
S
L
V
I
R
G
T
Q
G
A
E
E
V
L
R
A
H
E
E
Q
L
K
E
A
Q
A
V
P
A
T
L
P
E
L
E
A
T
K
A
S
L
K
K
L
R
A
Q
A
E
A
Q
Q
P
T
F
D
A
L
R
D
E
L
R
G
A
Q
E
V
G
E
R
L
Q
Q
R
H
G
E
R
D
V
E
V
E
R
W
R
E
R
V
A
Q
L
L
E
R
W
Q
A
V
L
A
Q
T
D
V
R
Q
R
E
L
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------