@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DHX30_HUMAN: (2020-01-31 )
MFSLDSFRKDRAQHRQRQCKLPPPRLPPMCVNPTPGGTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPESIRPGGPGGLSRSLGREEEEDEEEELEEGTIDVTDFLSMTQQDSHAPLRDSRGSSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWIAPELRLQSDDILPLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLKELRRALGRMVERSLRSELAALPPSVQEEHGQLLALLAELLRGPCGSFDVRKTADD
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270---.......280....---...290.......300.......310.......320.......330.......340.......350.......360.......370-..----......---380.......390.......400-.....-----------------.-.410.......420...-------....430.......440.......450.......460.......470.......-480.......490.......500.......510-..--......520.......530.-......540.......550.......560.......570.......580.......590.......600.......610.......620......------------------------------------.630----------..-.-----.....640------------------------------------.-----------------..---------.---------------------------------....650----------------------------------.........660.......670.......680.......690-.-...-----.----....----700.......710.......720---..---......730.......740.......750.......--760.........770.......780.......790.....-..800........810.......820..-.....830.......840.......850.......860.......870.......880.......890...--....900..-...-.--.-910.......920.......930.......940....-...950.......960.......970.......980.......990.--......1000.........1010......1020--........1030......1040...-...1050-......1060...--...1070......1080-.......1090......1100......1110......1120......1130......1140......1150......1160-----------------......1170......1180......1190.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MF
S
L
D
S
F
R
K
D
R
A
Q
H
R
Q
R
QCKLPPPRLP
P
M
CVNPTPGG
T
I
S
R
A
S
R
D
L
L
K
EFP
Q
P
K
N
L
L
N
S
V
I
G
R
A
LGISHAK
D
K
L
V
Y
V
HTNGPK
K
K
K
V
T
L
H
I
KWP
K
S
V
E
V
EGYGSKKI
D
A
E
R
Q
A
A
A
A
A
C
Q
L
F
K
G
WGLLG
P
R
N
E
L
F
D
A
A
K
Y
R
V
L
A
D
RFGSPADSWWRPEPTMPPTSWRQL
N
P
E
SIRPGGPG
G
L
S
R
SLGREEEE
D
E
E
E
E
L
E
EG
T
I
D
V
T
D
F
L
S
M
TQQDSHAPLRDSRGS
S
F
EMTD
D
D
S
A
I
R
A
L
T
QFPL
P
K
N
L
L
A
K
V
I
Q
IATSS
S
T
A
K
N
L
M
Q
F
HTVG---TK
T
K
L
S
T
L
T
L
LWPC---
P
M
T
F
V
AKGRRKAEAEN
K
A
A
A
L
A
C
K
K
L
K
SLGLVDRNNE
P
L
T
H
A
M
Y
N
L
A
S
L
R
E
L
G
E
T
QRR
P
C
T
I
QV
P
E
P
I
L
R
K
I
E
T
F
L
NHYPVESSW--IA----P
E
L
R
LQ---SDD
I
L
PLGKDSGPLSDPITGKPY-VPLL
E
-----------------
A
-
E
E
V
R
L
S
Q
S
L
L
E
L
W
R
RRG-------P
V
W
QEAPQLPVDP
H
R
D
T
I
L
N
A
I
E
QH
P
V
V
V
I
SGDTGCGKTTR
I
P
Q
L
L
L
E
R
Y
V
TEG-RG
A
R
C
N
V
I
I
TQPRR
I
S
A
V
S
V
A
Q
R
V
S
H
EL
G
P
S
L
--
R
R--NV
G
F
Q
V
R
LESKPPSRG
G
A
L
L
-
F
C
T
V
G
I
L
L
R
K
L
QSNPSLE
G
V
S
H
V
I
V
D
E
V
H
ERDV
N
T
D
F
L
L
I
L
L
K
G
L
Q
RL
N
P
A
L
R
L
V
L
M
SATGD
N
E
R
F
S
R
Y
FGGCPVIKVPGFMY
P
V
K
E
H
Y
L
E
D
I
L
A
------------------------------------
K
L
G
-----------
K
H
-
Q
-----
Y
L
H
R
HRH-------------------------------------H-----------------ES---------E---------------------------------DE
C
A
L
------------------------------------
D
L
D
L
V
T
D
L
V
L
H
I
DARGEPG
G
I
L
C
FLP
G
W
Q
E
I
K
G
V
Q
Q
R
L
Q
E
---
A
-LGM-----H----ES
K
Y
----
L
I
L
PVHSNIPMM
D
Q
K
A
IFQQPP----VG---
V
R
K
I
V
L
A
TNIAE
T
S
I
T
I
N
D
I
V
H
V
V
D
SGLH
K
E
E
R
Y
D
L
--
K
--
T
K
V
S
C
L
E
T
V
W
V
S
R
A
N
V
I
Q
RRGRAGRCQSG
F
A
Y
HLF
P
R
-
S
R
L
E
-KMVPFQ
V
P
E
I
L
R
T
P
L
E
N
L
V
L
Q
A
K
-IHMP
E
K
T
A
V
E
F
L
S
K
AVDSPN
I
K
A
V
D
E
A
V
I
L
L
Q
E
IGVL
D
Q
R
E
Y
L
T
T
L
G
Q
R
L
A
HIST
D
P
R
L
A
K
A
I
V
L
A
A
I
F
R
C
--
L
H
P
L
L
V
V
V
S
-
C
LT-R--D-P
F
S
S
S
L
Q
N
R
A
E
V
D
K
V
K
A
L
L
SHDSGS
D
H
L
A
F
V
R
A
VA
G
W
-
E
E
V
L
R
WQDR
S
S
R
E
N
Y
L
E
E
NLLYA
P
S
L
R
F
I
H
G
L
I
K
Q
F
S
E
N
I
Y
E
A
F
LVG--KPSD
C
T
L
---
A
S
A
QCNEYS
E
E
E
E
L
V
K
G
V
L
M
A
----GLY
P
N
L
I
Q
VRQGKVTRQGKFKPN
S
V
-
T
Y
R
TKSG-
N
I
L
L
H
KSTI
N
R
E
A
--
T
R
L
R
S
R
W
L
T
Y
F
M
A
VK-S-N
G
S
V
F
V
RDSSQV
H
P
L
A
V
L
L
L
TDG
D
V
H
I
RDDG
R
R
A
T
I
SLSDS
D
L
L
R
LEGD
S
R
T
V
R
L
L
K
E
L
R
R
A
L
G
R
M
V
E
R
S
L
R
S
E
L
A
ALPP
S
-----------------
V
Q
E
E
H
G
Q
L
L
A
L
L
A
E
L
L
RGPCGSFDVRKTADD
21
Fugue
90.55
31%
-34
- C2 -
-
5AOR
2
MLE_DROME
A:
[119-1158]
---
L
G
E
A
Y
R
P
L
E
Q
R
D
M
N
E
A
E
A
F
D
V
N
A
A
I
H
------
G
N
W
T
I
E
N
A
K
E
R
L
N
I
Y
K
Q
T
N
N
I
R
D
D
Y
K
Y
T
P
V
G
P
E
H
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
L
N
---------
R
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
H
L
N
V
I
E
P
F
S
G
T
L
K
K
D
E
----------------------------
Q
L
K
P
Y
P
V
K
L
-------------------------
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
P
V
V
N
P
R
N
I
K
I
E
L
D
G
P
P
--------
I
P
L
I
V
N
L
-----------------------------
S
R
I
E
S
S
V
I
P
W
A
P
---
P
Q
A
------------------
N
W
N
T
W
H
A
C
N
I
D
E
G
E
L
A
T
T
S
I
D
D
L
S
M
D
Y
E
R
S
L
R
D
R
R
Q
N
D
---------------------------------------------------------------
N
E
Y
-
R
Q
F
L
E
-----------------
F
-
R
E
-----------------------------
K
L
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
I
R
G
N
T
G
C
G
K
T
T
Q
I
A
Q
Y
I
L
D
D
Y
I
C
S
G
-
Q
G
G
Y
A
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
E
Q
L
--
G
D
--
T
V
G
Y
S
V
R
F
E
S
V
F
P
R
P
Y
G
A
I
L
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
L
R
G
V
S
H
I
I
V
D
E
I
H
E
R
D
V
N
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
H
V
I
L
M
S
A
T
I
D
T
T
K
F
S
K
Y
F
G
I
C
P
V
L
E
V
P
G
R
A
F
P
V
Q
Q
F
F
L
E
D
I
I
Q
------------------------------------
M
T
D
-----------
F
V
P
S
-----
A
E
S
R
R
K
R
-------------------------------------
K
-----------------
E
V
---------
E
---------------------------------
D
E
E
Q
L
LSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDV
S
F
E
L
L
E
A
L
L
M
H
I
K
S
K
N
I
P
G
A
I
L
V
F
L
P
G
W
N
L
I
F
A
L
M
K
F
L
Q
N
---
T
-
N
I
F
G----
D
----
T
S
Q
Y
----
Q
I
L
P
C
H
S
Q
I
P
R
D
E
Q
R
K
V
F
E
P
V
P
----
E
G
---
V
T
K
I
I
L
S
T
N
I
A
E
T
S
I
T
I
D
D
I
V
F
V
I
D
I
C
K
A
R
M
K
L
F
T
S
--
H
--
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
G
F
C
F
T
L
C
S
R
-
A
R
F
Q
-
A
L
E
D
N
L
T
P
E
M
F
R
T
P
L
H
E
M
A
L
T
I
K
-
L
-
L
R
L
G
S
I
H
H
F
L
S
K
A
L
E
P
P
P
V
D
A
V
I
E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
D
E
L
T
P
L
G
R
L
L
A
R
L
P
I
E
P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
--
A
D
L
M
A
I
M
A
S
Y
S
S
T
-
F
--
S
-
E
V
F
S
L
D
I
G
Q
R
R
L
A
N
H
Q
K
A
L
S
G
T
K
C
S
D
H
V
A
M
I
V
A
S
Q
M
W
-
R
R
E
K
Q
-
R
G
E
H
M
E
A
R
F
C
D
W
K
G
L
Q
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
A
---
G
--
F
P
E
E
C
M
I
SHE
V
D
E
R
I
D
G
D
D
P
V
L
D
V
S
L
A
L
L
C
L
----
G
L
Y
P
N
I
C
V
H
K
E
K
R
K
V
L
T
------------
T
E
S
K
-
A
A
L
L
H
K
T
S
V
N
C
S
N
--
L
A
V
T
F
P
Y
P
F
F
V
F
G
E
K
-
I
R
T
R
A
V
S
C
K
Q
L
S
M
V
S
P
L
Q
V
I
L
F
G
S
R
K
I
D
L
A
A
N
N
I
-----
V
R
V
D
N
W
L
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
K
P
A
L
E
D
L
I
T
V
A
C
D
N
P
S
D
I
L
R
L
-------------------
E
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
K
S
A
G
D
F
G
L
Q
R
----
37
HHSearch
83.30
29%
-4
- C2 -
-
5AOR
2
MLE_DROME
A:
[119-1155]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
A
Y
R
P
L
---------------------------------------
E
Q
R
-
D
M
N
----
E
A
E
A
F
-
D
V
N
A
A
I
H
G
N
W
T
I
E
N
A
K
E
R
L
N
I
Y
K
Q
T
----
N
N
I
R
D
D
Y
K
Y
T
P
V
G
PEH
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
LNR
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
H
L
N
V
I
E
P
F
S
G
T
----------
L
--
K
K
D
E
Q
L
K
P
Y
P
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
P
V
V
N
PR
N
I
KIEL
D
G
P
P
I
P
LIV
N
L
S
R
I
-----------
E
S
S
V
I
P
W
-
A
P
P
Q
A
NWNTWHACNIDEGELAT
T
-
S
I
D
D
L
S
M
D
Y
E
R
S
L
R
D
R
R
QNDNEYR
Q
F
L
E
F
R
E
K
L
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
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R
G
N
T
G
C
G
K
T
T
Q
I
A
Q
Y
I
L
D
D
Y
I
C
S
G
-
Q
G
G
Y
A
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
E
Q
L
--
G
D
--
T
V
G
Y
S
V
R
F
E
S
V
F
P
R
P
Y
G
A
I
L
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
L
R
G
V
S
H
I
I
V
D
E
I
H
E
R
D
V
N
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
H
V
I
L
M
S
A
T
I
D
T
T
K
F
S
K
Y
F
G
I
C
P
V
L
E
V
P
G
R
A
F
P
V
Q
Q
F
F
L
E
D
I
I
Q
------------------------------------
M
T
D
-----------
F
V
-
P
-----
S
A
E
S
R
R
K
RKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNA
M
-----------------
A
M
---------
L
---------------------------------
S
E
S
D
V
------------------------------------
S
F
E
L
L
E
A
L
L
M
H
I
K
S
K
N
I
P
G
A
I
L
V
F
L
P
G
W
N
L
I
F
A
L
M
K
F
L
Q
N
---
T
-
N
I
F
G----
D
----
T
S
Q
Y
----
Q
I
L
P
C
H
S
Q
I
P
R
D
E
Q
R
K
V
F
E
P
V
P
----
E
G
---
V
T
K
I
I
L
S
T
N
I
A
E
T
S
I
T
I
D
D
I
V
F
V
I
D
I
C
K
A
R
M
K
L
F
T
S
--
H
--
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
G
F
C
F
T
L
C
S
R
-
A
R
F
Q
-
A
L
E
D
N
L
T
P
E
M
F
R
T
P
L
H
E
M
A
L
T
I
K
-
L
L
R
L
-
G
S
I
H
H
F
L
S
K
A
L
E
P
P
P
V
D
A
V
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E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
D
E
L
T
P
L
G
R
L
L
A
R
L
P
I
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P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
--
A
D
L
M
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M
A
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-
Y
S
S
-
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FS
E
-
V
F
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R
R
L
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-
N
H
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K
A
L
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T
K
C
S
D
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A
M
I
V
A
S
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M
W
-
R
R
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Q
R
-
G
E
H
M
E
A
R
F
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D
W
K
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L
Q
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
A
G
F
P
E
--
E
C
M
I
S
H
E
---
V
D
E
R
I
D
G
D
D
P
V
L
D
V
S
L
A
L
L
C
L
----
G
L
Y
P
N
I
C
V
H
K
E
K
R
---------
K
---
V
L
T
T
E
S
K
-
A
A
L
L
H
K
T
S
V
N
C
S
N
LA
V
T
F
P
Y
P
F
F
V
F
G
E
K
I
R
-
T
-
R
-
A
V
S
C
K
Q
L
S
M
V
S
P
L
Q
V
I
L
F
G
S
R
K
I
D
L
A
A
---
N
N
I
V
R
V
D
N
--
W
L
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
K
P
A
L
E
D
L
I
T
V
A
C
D
N
P
S
D
I
L
--
R
-----------------
L
E
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
K
S
A
G
D
F
G
-------
39
HHSearch
79.22
34%
-22
- C2 -
-
5N9D
-
?
B:
[146-928]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
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L
L
D
D
A
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S
R
G
-
C
A
S
S
C
R
I
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C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
-----------
Y
E
-
F
-----
Q
K
F
R
D
R
R
PKRDPPERRMKHEAMIEP-------------------
Y
LRRIRNSYDSRVLDKLR
L
P
---------
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
GQRW
R
D
H
M
----
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
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G
R
T
K
A
T
N
Y
D
I
--
E
--
T
N
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Q
S
L
D
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V
W
V
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K
A
N
T
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Q
R
R
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R
A
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R
V
R
P
G
I
C
Y
N
L
F
S
R
-
A
R
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-
R
M
D
D
I
P
T
P
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L
R
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K
L
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S
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I
L
S
L
K
-
L
L
H
I
-
D
D
P
Y
R
F
L
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N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
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A
L
D
Q
T
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T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K-
S
-
P
F
Y
S
P
L
G
K
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
R
Y
S
---
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
S
N
-
C
K
-----
D
A
A
S
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
S
R
Q
I
K
-
N
R
V
R
A
I
H
T
-
M
A
T
D
D
G
R
-
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
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G
D
G
V
E
A
G
V
-
T
Q
N
T
P
Y
L
C
V
A
K
--
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------
G
Y
E
K
Q
L
I
K
A
I
E
L
L
L
S
L
D
E
R
----------
40
HHSearch
78.79
34%
-24
- C2 -
-
5N8R
-
?
B:
[146-928]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
A
R
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
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V
P
Q
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L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
-----------
Y
E
-
F
-----
Q
------PPERRMKHEAMIEP-----------------------
Y
LRRIRNSYDSRVLDKLR
L
P
---------
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
GQRW
R
D
H
M
----
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
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--
E
--
T
N
I
Q
S
L
D
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V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
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R
-
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
-
L
L
H
I
-
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K-
S
-
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
R
Y
S
---
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
S
N
-
C
K
-----
D
A
A
S
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
S
R
Q
------
R
A
I
H
T
-
M
A
T
D
D
G
R
-
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
V
E
A
G
V
-
T
Q
N
T
P
Y
L
C
V
A
--
K
T
Y
Y
F
K
C
N
R
E
T
A
D
V
V
I
Q
L
R
S
N
L
E
K
L
L
L
K
K
A
L
Y
P
A
P
I
E
E
N
--------------------
G
Y
E
K
Q
L
I
K
A
I
E
L
L
L
S
L
D
E
R
----------
17
PsiBlast_PDB
78.69
34%
-40
- C2 -
-
5AOR
2
MLE_DROME
A:
[383-1158]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
I
R
G
N
T
G
C
G
K
T
T
Q
I
A
Q
Y
I
L
D
D
Y
I
C
S
G
-
Q
G
G
Y
A
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
E
Q
L
--
G
D
--
T
V
G
Y
S
V
R
F
E
S
V
F
P
R
P
Y
G
A
I
L
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
L
R
G
V
S
H
I
I
V
D
E
I
H
E
R
D
V
N
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
H
V
I
L
M
S
A
T
I
D
T
T
K
F
S
K
Y
F
G
I
C
P
V
L
E
V
P
G
R
A
F
P
V
Q
Q
F
F
L
E
D
I
I
Q
MTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYN
K
V
C
-----------
E
D
-
K
-----
Y
S
Q
K
T
R
N
-------------------------------------
A
-----------------
M
A
---------
M
L--------------------------------
S
E
S
D
V
------------------------------------
S
F
E
L
L
E
A
L
L
M
H
I
K
S
K
N
I
P
G
A
I
L
V
F
L
P
G
W
N
L
I
F
A
L
M
K
F
L
Q
N
---
T
N
I
F
G
-----
D
----
T
S
Q
Y
----
Q
I
L
P
C
H
S
Q
I
P
R
D
E
Q
R
K
V
F
E
P
V
P
----
E
G
---
V
T
K
I
I
L
S
T
N
I
A
E
T
S
I
T
I
D
D
I
V
F
V
I
D
I
C
K
A
R
M
K
L
F
T
S
--
H
--
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
G
F
C
F
T
L
C
S
R
-
A
R
F
Q
-
A
L
E
D
N
L
T
P
E
M
F
R
T
P
L
H
E
M
A
L
T
I
K
-
L
-
L
R
L
G
S
I
H
H
F
L
S
K
A
L
E
P
P
P
V
D
A
V
I
E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
D
E
L
T
P
L
G
R
L
L
A
R
L
P
I
E
P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
AD
L
M
A
I
M
A
S
Y
S
-
S
T
F
-
S
--
E
-
V
F
S
L
D
I
G
Q
R
R
L
A
N
H
Q
K
A
-
L
S
G
T
K
C
S
D
H
V
A
M
I
V
A
S
Q
M
W
R
R
E
K
Q
R
G
E
H
M
E
A
R
--
F
C
D
W
K
G
L
Q
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
A
---
G
--
F
P
E
E
C
M
I
----
S
H
E
V
D
E
R
I
D
G
D
D
P
V
L
D
V
S
L
A
LLCL
G
L
Y
P
N
I
C
V
H
K
E
K
R
-----------
K
-
V
L
T
T
E
S
K
-
A
A
L
L
H
K
T
S
V
N
C
S
N
--
L
A
V
T
F
P
Y
P
F
F
V
F
G
E
K
I
R
-
T
R
A
V
S
C
K
Q
L
S
M
V
S
P
L
Q
V
I
L
F
----------
G
S
R
-
K
I
D
L
A
A
N
N
I
V
R
V
D
N
-------------
W
L
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
K
P
A
LEDLITVACDNPSDILR
L
E
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
K
S
A
G
D
F
G
L
Q
R
----
38
HHSearch
77.68
37%
-9
- C2 -
-
5VHE
-
DHX36_BOVIN
A:
[116-905]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
I
S
G
E
T
G
C
G
K
T
T
Q
V
T
Q
F
I
L
D
N
Y
I
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R
G
-
K
G
S
A
C
R
I
V
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
A
E
R
A
E
S
C
GN
G
N
--
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
S
I
L
-
Y
C
T
T
G
I
I
L
Q
W
L
Q
S
D
P
H
L
S
S
V
S
H
I
V
L
D
E
I
H
E
R
N
L
Q
S
D
V
L
M
T
V
V
K
D
L
L
S
Y
R
P
D
L
K
V
V
L
M
S
A
T
L
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
------------------------------------
K
I
R
-----------
Y
V
-
P
-----
E
Q
K
----GHVNRQEKYYYEAIYKERWPGYLRELRQRYSASTVDV
V
-----------------
E
M
---------
M
---------------------------------
D
D
E
K
V
------------------------------------
D
L
N
L
I
A
A
L
I
R
Y
I
V
L
E
E
E
D
G
A
I
L
V
F
L
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
---
Q
-
V
M
F
-----
K
----
S
D
K
F
----
I
I
I
P
L
H
S
L
M
P
T
V
N
Q
T
Q
V
F
K
R
T
P
----
P
G
---
V
R
K
I
V
I
A
T
N
I
A
E
T
S
I
T
I
D
D
V
V
Y
V
I
D
G
G
K
I
K
E
T
H
F
D
T
--
Q
--
N
N
I
S
T
M
S
A
E
W
V
S
K
A
N
A
K
Q
R
K
G
R
A
G
R
V
Q
P
G
H
C
Y
H
L
Y
N
S
-
L
R
A
S
-
L
L
D
D
Y
Q
L
P
E
I
L
R
T
P
L
E
E
L
C
L
Q
I
K
-
I
L
R
L
G
-
G
I
A
H
F
L
S
R
L
M
D
P
P
S
N
E
A
V
L
L
S
I
K
H
L
M
E
L
N
A
L
D
K
Q
E
E
L
T
P
L
G
V
H
L
A
R
L
P
V
E
P
H
I
G
K
M
I
L
F
G
A
L
F
C
C
--
L
D
P
V
L
T
I
A
A
-
S
L
S
-
F
K-
D
-
P
F
V
I
P
L
G
K
E
K
V
A
D
A
R
R
K
E
L
A
A
A
T
A
S
D
H
L
T
V
V
N
A
F
K
G
W
-
E
K
A
K
Q
R
-
G
F
R
Y
E
K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Q
M
L
H
N
M
K
G
Q
F
A
E
H
L
L
G
A
G
F
V
S
--
S
R
N
P
------
Q
D
P
E
S
N
I
N
S
D
N
E
K
I
I
K
A
V
I
C
A
----
G
L
Y
P
K
V
A
K
I
R
L
N
L
G
K
K
-----
R
K
M
V
K
V
Y
T
K
T
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
Q
--
T
E
F
N
Y
N
W
L
I
Y
H
L
K
M
R
-
T
-
S
-
S
I
Y
L
Y
D
C
T
E
V
S
P
Y
C
L
L
F
F
G
G
D
-
I
S
I
Q
K
D
N
D
Q
E
T
I
A
V
D
E
--
W
I
I
F
Q
S
P
A
R
I
A
H
L
V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
K
D
-----------------
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
-------------
6
PsiBlast_PDB
75.17
35%
-44
- C2 -
-
5N8S
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRRM---
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
----
G
Q
R
W
RDHM
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
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D
D
V
V
Y
V
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N
S
G
R
T
K
A
T
N
Y
D
I
--
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
-
A
R
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D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
--
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
T
S
A
A
A
-
A
L
S
F
K
--
S
-
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
T
D
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.07
35%
-32
- C2 -
-
5N96
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
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R
A
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T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
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P
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M
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N
L
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V
L
I
L
D
E
I
H
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R
S
V
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D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
----
G
Q
R
W
RDHM
A
V
F
P
L
H
S
L
M
Q
S
G
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Q
Q
A
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F
R
R
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P
----
A
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---
Q
R
K
V
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I
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V
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L
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P
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M
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A
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A
A
A
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A
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--
S
-
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F
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S
M
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Q
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L
L
Y
N
Y
K
F
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--
S
-
S
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C
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---
A
A
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--
N
K
N
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K
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L
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R
A
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A
----
G
L
Y
P
N
M
A
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K
---
S
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------
R
A
I
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A
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D
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D
G
----------------------------------------------------------------------------------------------------------
41
HHSearch
75.04
37%
1
- C2 -
-
5VHA
-
DHX36_BOVIN
A:
[53-845]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
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V
I
S
G
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T
G
C
G
K
T
T
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V
T
Q
F
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L
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N
Y
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G
-
K
G
S
A
C
R
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V
C
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P
R
R
I
S
A
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S
V
A
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R
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A
A
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R
A
E
S
C
GN
G
N
--
S
T
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
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G
S
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L
-
Y
C
T
T
G
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W
L
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P
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L
S
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L
M
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V
V
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V
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A
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M
I
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P
G
F
T
F
P
V
V
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Y
L
L
E
D
I
I
E
------------------------------------
K
I
R
-----------
Y
V
-
P
-----
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Q
-----QEKYYYEAIYKERWPGYLRELRQRYSASTVDV-----
V
-----------------
E
M
---------
M
---------------------------------
D
D
E
K
V
------------------------------------
D
L
N
L
I
A
A
L
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Y
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A
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L
P
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T
L
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D
L
L
M
S
---
Q
-
V
M
F
-----
K
----
S
D
K
F
----
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I
I
P
L
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S
L
M
P
T
V
N
Q
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Q
V
F
K
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----
P
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---
V
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K
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Q
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S
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L
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L
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Y
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L
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T
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L
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L
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K
-
I
L
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-
G
I
A
H
F
L
S
R
L
M
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P
S
N
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A
V
L
L
S
I
K
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L
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L
N
A
L
D
K
Q
E
E
L
T
P
L
G
V
H
L
A
R
L
P
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E
P
H
I
G
K
M
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L
F
G
A
L
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C
--
L
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L
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S
L
S
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P
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A
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K
G
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L
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S
--
S
R
N
P
------
Q
D
P
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S
N
I
N
S
D
N
E
K
I
I
K
A
V
I
C
A
----
G
L
Y
P
K
V
A
K
I
R
L
N
L
G
K
K
----
R
K
M
V
K
-
V
Y
T
K
T
D
G
-
V
V
A
I
H
P
K
S
V
N
V
E
Q
--
T
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F
N
Y
N
W
L
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Y
H
L
K
M
R
-
T
-
S
-
S
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Y
L
Y
D
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V
S
P
Y
C
L
L
F
F
G
G
D
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-
S
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K
D
N
D
Q
E
T
I
A
V
D
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--
W
I
I
F
Q
S
P
A
R
I
A
H
L
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K
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L
R
K
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D
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L
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K
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S
P
H
P
V
D
W
K
D
-----------------
T
K
S
R
D
C
A
V
L
S
A
I
I
D
L
I
K
T
Q
E
K
----------
14
PsiBlast_PDB
74.76
35%
-27
- C2 -
-
5N9D
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
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S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
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S
A
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A
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A
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W
V
S
Y
E
R
C
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S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
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S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
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L
M
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L
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V
L
I
L
D
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D
L
L
M
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L
L
K
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P
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R
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L
K
V
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L
M
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A
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V
R
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Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
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Y
Y
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P
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A
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Y
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K
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Q
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---
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-
K
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-----
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----
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A
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---
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N
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Q
Q
R
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A
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R
P
G
I
C
Y
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L
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S
R
-
A
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D
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R
M
D
D
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P
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P
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I
L
R
S
K
L
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L
S
L
K
L
L
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I
D
D
--
P
Y
R
F
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L
I
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A
P
N
P
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A
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K
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G
V
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R
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E
A
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T
L
T
P
L
G
M
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L
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K
L
P
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G
K
M
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M
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A
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--
L
D
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A
-
A
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--
S
-
P
F
Y
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K
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S
R
V
D
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R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
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R
M
K
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Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
Q
I
K
N
R
V
R
A
I
H
T
M
A
T
D
D
G
R
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V
N
F
H
P
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S
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--
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V
Y
F
Q
R
Q
K
-
S
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D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.62
35%
-27
- C2 -
-
5N8U
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
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Q
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L
L
D
D
A
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G
-
C
A
S
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C
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R
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A
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A
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A
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W
V
S
Y
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R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
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R
K
A
R
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A
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-
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Q
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L
L
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L
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R
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K
V
I
L
M
S
A
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V
R
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Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
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C
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N
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P
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G
A
I
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Y
D
K
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Q
L
Y
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---
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-
K
T
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-----
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----
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A
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----
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---
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A
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L
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T
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M
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A
A
A
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A
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S
P
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G
K
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K
R
R
M
A
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N
M
R
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D
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L
M
V
H
N
T
I
I
A
Y
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R
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S
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R
Y
S
--
H
A
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D
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Y
K
N
F
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S
M
T
L
Q
Q
L
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R
M
K
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Q
F
S
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L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
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--
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K
N
S
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K
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P
L
L
R
A
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G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
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D
D
G
R
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F
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Y
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F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.40
35%
-34
- C2 -
-
5N9F
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
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L
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D
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A
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G
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C
A
S
S
C
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C
T
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R
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A
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A
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A
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W
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R
C
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S
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--
G
N
--
S
V
G
Y
Q
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R
L
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R
K
A
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A
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C
T
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L
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C
D
Y
F
N
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P
M
F
R
I
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G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKPPERRM
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
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A
D
L
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Y
Y
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C
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Q
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K
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A
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---
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L
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D
D
--
P
Y
R
F
L
Q
T
L
I
N
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N
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K
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A
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C
--
L
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K
--
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F
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--
H
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M
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L
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Q
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L
L
Y
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Y
K
F
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S
-
S
N
C
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D
---
A
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S
--
N
K
N
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K
I
P
L
L
R
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A
----
G
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Y
P
N
M
A
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L
R
K
---
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K
N
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V
R
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M
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N
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S
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-
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L
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L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.04
36%
-14
- C2 -
-
5VHD
1
DHX36_BOVIN
D:
[59-816]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
V
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G
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C
G
K
T
T
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V
T
Q
F
I
L
D
N
Y
I
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G
-
K
G
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A
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R
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C
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P
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R
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A
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R
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A
A
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A
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--
G
N
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K
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M
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F
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V
V
E
Y
L
L
E
D
I
I
E
------------------------------------
K
I
---------------
R
-----
Y
V
P
E
----------------------------------------------------------------------YYYEAIYKERWPGYLRELRQRYSASTVDVVEMM
D
D
E
K
V
------------------------------------
D
L
N
L
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A
A
L
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Y
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V
L
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Q
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P
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L
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A
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D
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L
L
S
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L
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Q
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L
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L
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S
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L
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K
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H
L
L
G
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G
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V
S
SR
N
P
Q
D
--------
P
E
S
N
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E
K
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K
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V
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----
G
L
Y
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K
V
A
K
I
R
----
L
N
------
M
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K
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V
Y
T
K
T
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V
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P
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S
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--
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W
L
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H
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S
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S
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L
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F
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P
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V
K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
--------------------------------------------------------
5
PsiBlast_PDB
73.95
35%
-28
- C2 -
-
5N8R
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
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V
G
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L
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D
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G
-
C
A
S
S
C
R
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C
T
Q
P
R
R
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S
A
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A
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A
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W
V
S
Y
E
R
C
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S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
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R
K
A
R
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S
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T
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Y
C
T
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G
V
L
L
Q
Q
L
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L
I
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L
L
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L
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K
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P
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K
V
I
L
M
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V
R
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Q
D
F
C
D
Y
F
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C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
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YEFQKRM----
K
H
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E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
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A
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Y
Y
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P
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----
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A
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P
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M
D
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P
T
P
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K
L
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L
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P
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R
F
L
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N
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L
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M
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A
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A
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M
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H
N
T
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Y
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R
D
S
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R
Y
S
--
H
A
E
R
D
F
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Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
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K
I
P
L
L
R
A
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----
G
L
Y
P
N
M
A
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K
---
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R
------
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A
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H
T
M
A
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D
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G
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N
F
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P
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--
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L
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D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.95
36%
-5
- C2 -
-
5VHC
1
DHX36_BOVIN
D:
[59-816]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
S
Y
G
M
Q
K
E
L
V
N
M
I
D
N
H
Q
V
T
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G
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G
C
G
K
T
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Q
F
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D
N
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G
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K
G
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A
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C
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A
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A
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A
A
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G
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S
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M
I
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P
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F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
------------------------------------
K
I
---------------
R
-----
Y
V
P
E
----------------------------------------------------------------------YYYEAIYKERWPGYLRELRQRYSASTVDVVEMM
D
D
E
K
V
------------------------------------
D
L
N
L
I
A
A
L
I
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Y
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V
L
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---
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-----
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----
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---
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P
H
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L
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A
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K
A
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Q
R
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F
L
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S
N
T
L
Q
M
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N
M
K
G
Q
F
A
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H
L
L
G
A
G
F
V
S
SR
N
P
Q
D
--------
P
E
S
N
I
N
S
D
N
E
K
I
I
K
A
V
I
C
A
----
G
L
Y
P
K
V
A
K
I
R
----
L
N
L
----
K
M
V
K
-
V
Y
T
K
T
D
G
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V
V
A
I
H
P
K
S
V
N
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--
T
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F
N
Y
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W
L
I
Y
H
L
K
M
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-
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S
I
Y
L
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D
C
T
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V
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D
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W
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P
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K
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R
K
E
L
D
I
L
L
Q
E
K
I
E
S
--------------------------------------------------------
15
PsiBlast_PDB
73.90
35%
-31
- C2 -
-
5N9E
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
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A
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A
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A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
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S
R
K
A
R
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A
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T
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C
T
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G
V
L
L
Q
Q
L
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L
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L
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A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
----
G
Q
R
W
RDHM
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
--
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
-
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
--
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
T
S
A
A
A
-
A
L
S
F
K
--
S
-
P
F
Y
S
P
L
G
K
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
T
D
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.89
35%
-26
- C2 -
-
5N90
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
----
G
Q
R
W
RDHM
A
V
F
P
L
H
S
L
M
Q
S
G
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Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
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T
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T
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K
A
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--
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Q
S
L
D
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V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
-
A
R
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D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
--
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
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M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
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S
A
A
A
-
A
L
S
F
K
--
S
-
P
F
Y
S
P
L
G
K
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S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
T
D
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.74
35%
-25
- C2 -
-
5N8Z
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
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D
K
---
P
-
K
T
S
-----
K
----
G
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R
W
RDHM
A
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F
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L
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S
L
M
Q
S
G
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Q
Q
A
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F
R
R
P
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----
A
G
---
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K
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I
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T
I
I
A
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T
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--
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R
F
L
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I
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A
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N
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A
I
K
M
G
V
E
L
L
K
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A
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T
L
T
P
L
G
M
H
L
A
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L
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I
D
P
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K
M
I
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M
S
A
L
F
C
C
--
L
D
P
I
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A
A
A
-
A
L
S
F
K
--
S
-
P
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Y
S
P
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S
R
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D
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I
K
R
R
M
A
R
N
M
R
S
D
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L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
T
D
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.51
35%
-26
- C2 -
-
5N98
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
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R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
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V
L
I
L
D
E
I
H
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R
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V
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D
L
L
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G
L
L
K
V
I
L
P
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R
P
D
L
K
V
I
L
M
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A
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V
R
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Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
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C
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N
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P
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G
A
I
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Y
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K
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Q
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N
I
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---
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K
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-----
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A
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----
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---
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---
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K
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A
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A
----
G
L
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P
N
M
A
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L
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---
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------
R
A
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D
G
----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.44
35%
-29
- C2 -
-
5N9A
-
?
A:
[152-855]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
-
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
L
--
G
N
--
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
D
P
L
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
------------------------------------
K
T
N
YEFQKRM----
K
H
-
E
AMIEP
Y
L
R
R
I
R
N
S------------------------------------
Y
-----------------
D
S
RVLDKLRLP
E
---------------------------------
S
E
G
C
E
------------------------------------
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
---
P
-
K
T
S
-----
K
----
G
Q
R
W
RDHM
A
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
G
---
Q
R
K
V
I
I
S
T
I
I
A
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T
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V
T
I
D
D
V
V
Y
V
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N
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G
R
T
K
A
T
N
Y
D
I
--
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
-
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
--
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
--
L
D
P
I
T
S
A
A
A
-
A
L
S
F
K
--
S
-
P
F
Y
S
P
L
G
K
E
S
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
-
R
D
S
-
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
--
S
-
S
N
C
K
D
---
A
A
S
--
N
K
N
S
E
K
I
P
L
L
R
A
I
I
G
A
----
G
L
Y
P
N
M
A
H
L
R
K
---
S
R
------
R
A
I
H
T
M
A
T
D
D
G
R
R
V
N
F
H
P
S
S
V
N
S
G
E
--
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
-
S
-
T
-
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
G
D
G
----------------------------------------------------------------------------------------------------------
56
HHSearch
67.61
32%
-53
- C2 -
-
6FAC
1
?
A:
[24-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
E
V
R
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
----
G
N
R
K
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
V
A
D
E
M
G
V
R
L
--
G
H
--
E
V
G
Y
S
I
R
F
E
D
C
T
S
-
E
K
T
I
L
K
-
Y
M
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D
G
M
L
L
R
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M
V
T
S
P
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L
A
D
Y
S
C
I
M
I
D
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A
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R
T
V
H
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D
I
L
L
A
L
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K
D
L
T
R
A
R
P
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L
R
L
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I
S
S
A
T
L
N
A
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K
F
S
A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
S
A
P
E
S
------------------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
E
A
A
L
V
T
V
F
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
T
G
Q
E
E
I
E
R
A
C
E
R
V
E
E
---
I
-
R
R
K
LGK--
R
----
V
P
E
I
----
I
A
L
P
I
Y
S
N
M
P
S
E
M
Q
A
K
I
F
E
P
T
P
----
P
G
---
A
R
K
V
V
F
S
T
N
I
A
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T
S
L
T
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G
I
V
Y
V
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G
Y
V
K
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N
T
F
S
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--
V
GT
T
G
Q
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L
A
V
V
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C
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R
A
A
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N
Q
R
M
G
R
A
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R
V
K
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G
K
C
F
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L
Y
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-
Y
A
Y
L
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D
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L
S
S
V
V
L
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L
K
-
A
L
G
I
D
-
D
L
L
G
F
--
D
F
L
D
P
P
P
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L
L
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K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
E
F
P
T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
--
V
S
E
V
L
T
I
V
S
-
M
L
G
-
E
V-
G
T
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
-
V
E
A
E
------
Y
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
--
E
-----------
A
S
C
G
G
-
V
N
N
P
T
P
I
L
R
A
L
T
A
----
A
F
F
L
N
A
A
R
L
N
R
A
G
----
D
-----
G
Y
-
R
T
L
K
N
N
I
-
T
V
Y
V
H
P
S
S
V
V
R
G
M
---
D
P
P
P
K
V
I
I
Y
H
E
L
V
V
-
T
-
S
-
K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
------------------------------------------------------------------------------------------------------------
57
HHSearch
65.72
32%
-48
- C2 -
-
6FAA
6
?
A:
[24-655]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
E
V
R
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
----
G
N
R
K
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
V
A
D
E
M
G
V
R
L
--
G
H
--
E
V
G
Y
S
I
R
F
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D
C
T
S
-
E
K
T
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L
K
-
Y
M
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D
G
M
L
L
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M
V
T
S
P
D
L
A
D
Y
S
C
I
M
I
D
E
A
H
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R
T
V
H
T
D
I
L
L
A
L
I
K
D
L
T
R
A
R
P
E
L
R
L
I
I
S
S
A
T
L
N
A
E
K
F
S
A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
S
A
P
E
S
------------------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
E
A
A
L
V
T
V
F
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
T
G
Q
E
E
I
E
R
A
C
E
R
V
E
E
---
I
-
R
R
K
LGK--
R
----
V
P
E
I
----
I
A
L
P
I
Y
S
N
M
P
S
E
M
Q
A
K
I
F
E
P
T
P
----
P
G
---
A
R
K
V
V
F
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
I
D
S
G
Y
V
K
E
N
T
F
S
P
--
V
--
T
G
Q
S
T
L
A
V
V
P
C
S
R
A
A
A
N
Q
R
M
G
R
A
G
R
V
K
P
G
K
C
F
R
L
Y
T
K
-
Y
A
Y
L
S
E
M
D
E
S
P
T
P
E
I
Q
R
T
S
L
S
S
V
V
L
Q
L
K
-
A
L
G
I
D
-
D
L
L
G
F
--
D
F
L
D
P
P
P
T
E
L
L
I
K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
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T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
--
V
S
E
V
L
T
I
V
S
-
M
L
G
-
E
V-
G
T
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
-
V
E
A
E
------
Y
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
--
E
-----------
A
S
C
G
G
-
V
N
N
P
T
P
I
L
R
A
L
T
A
----
A
F
F
L
N
A
A
R
L
N
R
A
G
----
D
-----
G
Y
-
R
T
L
K
N
N
I
-
T
V
Y
V
H
P
S
S
V
V
R
G
M
---
D
P
P
P
K
V
I
I
Y
H
E
L
V
V
-
T
-
S
-
K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
A
-----------------------------------------------------------------------------------------------------------
53
HHSearch
64.69
30%
-39
- C2 -
-
5LTJ
9
?
A:
[32-673]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
R
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
Y
D
E
L
P
H
Q
---
T
G
K
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
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R
V
A
D
E
L
D
V
K
L
--
G
E
--
E
V
G
Y
S
I
R
F
E
N
K
T
S
S
-
K
T
L
L
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-
Y
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Q
L
L
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A
M
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R
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C
I
I
L
D
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A
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R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
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R
R
K
D
L
K
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I
V
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A
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L
D
A
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K
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Q
S
Y
F
F
N
A
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L
L
A
V
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
A
E
R
------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
E
A
A
I
R
T
V
L
Q
I
H
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
---
E
-
V
D
E
MIRES
D
----
A
G
P
M
----
S
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
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R
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A
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P
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GRP
G
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A
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A
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V
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Q
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N
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--
R
--
T
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L
V
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A
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A
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Q
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A
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C
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Y
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-
E
A
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S
N
L
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V
L
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L
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K
L
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L
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D
L
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D
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L
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G
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I
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--
V
S
T
----------
P
F
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-
D
K
N
Y
Y
T
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I
R
R
A
L
L
A
----
G
F
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A
M
R
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S
S
N
-
S
-------
K
V
Y
-
K
T
V
K
D
E
Q
-
L
V
L
I
H
P
S
T
T
V
T
T
------
P
Y
E
W
V
V
Y
N
E
F
V
L
-
T
-
T
-
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
Y
---------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.63
35%
-34
- C2 -
-
6FAC
1
?
A:
[6-543]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
R
L
L
K
Q
K
I
E
E
A
E
R
A
Q
R
-------
T
I
Q
E
V
R
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
G
N
R
K
I
A
C
----
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
V
A
D
E
M
G
V
R
L
--
G
H
--
E
V
G
Y
S
I
R
F
E
D
C
T
-
S
E
K
T
I
L
K
-
Y
M
T
D
G
M
L
L
R
E
M
V
T
S
P
D
L
A
D
Y
S
C
I
M
I
D
E
A
H
E
R
T
V
H
T
D
I
L
L
A
L
I
K
D
L
T
R
A
R
P
E
L
R
L
I
I
S
S
A
T
L
N
A
E
K
F
S
A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
------------------------------------------------------------------------------------------------------------------------------
S
A
---------
P
---------------------------------
E
S
N
Y
L
------------------------------------
E
A
A
L
V
T
--
V
F
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
T
G
Q
E
E
I
E
R
A
C
E
R
V
E
E
IRR
K
-
L
G
K
-----
R
----
V
P
E
I
----
I
A
L
P
I
Y
S
N
M
P
S
E
M
Q
A
K
I
F
E
P
T
P
----
P
G
---
A
R
K
V
V
F
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
I
D
S
G
Y
V
K
E
N
T
F
S
P
VG
T
--
T
G
Q
S
T
L
A
V
V
P
C
S
R
A
A
A
N
Q
R
M
G
R
A
G
R
V
K
P
G
K
C
F
R
L
Y
T
K
Y
A
Y
L
S
-
E
M
D
E
S
P
T
P
E
I
Q
R
T
S
L
S
S
V
V
L
Q
L
K
A
L
G
I
D
D
L
L
G
F
D
F
L
----
D
P
P
P
T
E
L
L
I
K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
E
F
P
T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
--
V
S
E
V
L
T
I
V
S
-
M
L
G
-
E
VG
T
-
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
-
V
E
A
-
E
Y
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.69
35%
-25
- C2 -
-
6FAA
6
?
A:
[17-543]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
A
Q
R
-------
T
I
Q
E
V
R
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
G
N
R
K
I
A
C
----
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
V
A
D
E
M
G
V
R
L
--
G
H
--
E
V
G
Y
S
I
R
F
E
D
C
T
-
S
E
K
T
I
L
K
-
Y
M
T
D
G
M
L
L
R
E
M
V
T
S
P
D
L
A
D
Y
S
C
I
M
I
D
E
A
H
E
R
T
V
H
T
D
I
L
L
A
L
I
K
D
L
T
R
A
R
P
E
L
R
L
I
I
S
S
A
T
L
N
A
E
K
F
S
A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
------------------------------------------------------------------------------------------------------------------------------
S
A
---------
P
---------------------------------
E
S
N
Y
L
------------------------------------
E
A
A
L
V
T
--
V
F
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
T
G
Q
E
E
I
E
R
A
C
E
R
V
E
E
IRR
K
-
L
G
K
-----
R
----
V
P
E
I
----
I
A
L
P
I
Y
S
N
M
P
S
E
M
Q
A
K
I
F
E
P
T
P
----
P
G
---
A
R
K
V
V
F
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
I
D
S
G
Y
V
K
E
N
T
F
S
P
V----
T
G
Q
S
T
L
A
V
V
P
C
S
R
A
A
A
N
Q
R
M
G
R
A
G
R
V
K
P
G
K
C
F
R
L
Y
T
K
Y
A
Y
L
S
-
E
M
D
E
S
P
T
P
E
I
Q
R
T
S
L
S
S
V
V
L
Q
L
K
A
L
G
I
D
D
L
L
G
F
D
F
L
----
D
P
P
P
T
E
L
L
I
K
S
L
N
M
L
Y
A
L
G
A
L
N
S
A
G
Q
L
T
R
V
G
R
Q
M
G
E
F
P
T
E
P
M
L
A
K
A
L
I
A
A
T
Q
E
G
C
--
V
S
E
V
L
T
I
V
S
-
M
L
G
-
E
VG
T
-
L
F
F
R
P
K
D
K
K
V
H
A
D
S
A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
-
V
E
A
-
E
Y
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
31.26
42%
-20
- C2 -
-
3LLM
1
DHX9_HUMAN
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
W
--
S
P
----
P
Q
S
N
W
N
---
P
W
T
S
S
N
I
--
D
E
G
P
L
A
F
A
T
P
E
Q
I
S
M
D
L
K
N
E
-----------------
L
M
Y
Q
L
E
Q
D
H
D
L
Q
A
I
L
Q
E
R
E
--------------
L
L
P
V
K
K
F
E
S
E
I
L
E
A
I
S
Q
N
S
V
V
I
I
R
G
A
T
G
C
G
K
T
T
Q
V
P
Q
F
I
L
D
D
F
I
Q
N
D
-
R
A
A
E
C
N
I
V
V
T
Q
P
R
R
I
S
A
V
S
V
A
E
R
V
A
F
E
R
G
E
E
P
--
G
K
--
S
C
G
Y
S
V
R
F
E
S
I
L
P
R
P
H
A
-
S
I
M
F
C
T
V
G
V
L
L
R
K
L
E
A
G
--
I
R
G
I
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H
V
I
V
D
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I
H
E
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D
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N
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D
F
L
L
V
V
L
R
D
V
V
Q
A
Y
P
E
V
R
I
V
L
M
-
S
A
T
I
D
T
S
F
C
E
Y
F
F
N
C
P
I
I
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------