@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DHX9_HUMAN: (2020-02-01 )
MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300-----.------.----......310-.-......320.......330.......340.......350.......360........-370....-...380...--....390.......400.......410.......420.......430.......440.......450.......460..--.--.--...470.......480.....-..490.......500.--........510.......520.......530.......540.......550.......560.......570.......580..-.....590.......-----600-----..-----------.-------.---.---.---...610...-----------....620...-.....630-........640.......650.......660.......670...-----.-----.----..680----.......690.......700.----.-------.....710.......720.......730.......740--.......750.......760.......770.......780.-......790.......800.......810.......820.......830.......840.......850.......860.......870.......880...-...-.890.---.---..--.---.--.900.......910.......920.......930.......940.......950.......960.......970.......--980-.--.......990.......1000....----..--1010----.---------.----------.----.-.-....1020......1030......1040......1050......1060......1070-....-.-.--.--.-1080......1090......1100......1110......1120..--....1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
D
V
K
N
F
L
Y
A
W
CGKRKMTPS
Y
E
I
R
AVGNKN
R
Q
K
F
M
C
E
V
Q
VEG
Y
N
YTGMGNSTNKKDA
Q
S
N
A
A
R
D
F
V
N
Y
L
V
R
I
N
E
IKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPP
H
L
A
L
K
AENNSEVGASGYGVPGPTWDRGA
N
L
K
D
Y
Y
S
R
K
E
E
Q
E
V
Q
A
T
LESE
E
V
D
LNAGLHG
N
W
T
L
E
N
A
K
A
R
L
N
Q
Y
F
Q
K
E
KIQGE
Y
K
YTQVGPDH
N
R
S
F
I
A
E
M
T
I
Y
I
K
Q
L
G
R
R
I
F
A
R
EHGSNK
K
L
A
A
Q
S
C
A
L
S
L
V
R
Q
L
Y
H
L
G
V
V
E
A
YSGLTKKKEGETVE
P
Y
KVNL
S
Q
D
L
E
H
Q
L
Q
N
I
I
Q
ELN
L
E
I
LPPP------E------D----PSV
P
V
A
L
NI-G-KLAQFEPSQRQNQV
G
V
V
PWSPPQSNWNPWTSSNIDEGPLAFA
T
P
E
Q
I
S
-
M
D
L
K
N
E
L
M
-
Y
Q
LEQDH-
D
L
Q
A
I
L
Q
ER--ELL
P
V
K
K
F
E
S
E
I
L
E
A
ISQN
S
V
V
I
I
RGATGCGKTTQ
V
P
Q
F
I
L
D
D
F
I
QNDRAAEC
N
I
V
V
TQPRR
I
S
A
V
S
V
A
E
R
V
A
F
ERGEE--P--G--KSCG
Y
S
V
R
F
E
S
ILPRPH
A
S
I
M
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
--
I
R
G
I
S
H
V
I
V
D
E
I
H
ERDI
N
T
D
F
L
L
V
V
L
R
D
V
V
Q
AYP
E
V
R
I
V
L
M
S
ATI
D
T
S
M
F
C
E
Y
F
FNCP
I
I
E
VYGRTY
P
V
Q
E
Y
F
L
E
D
C
I
Q
M
THF-VPPPKDKKKKDKDDD-----G-------GE-----------D-------D---D---A---N
C
N
L
I
CGDE-----------YGPETR-
L
S
M
-
S
QLNEKE--T
P
F
E
L
I
E
A
L
L
K
Y
I
E
TLNVP
G
A
V
L
V
F
LPG
W
N
L
I
Y
T
M
Q
K
H
LEMNPH-----F-----G----SH
R
Y
Q
----
I
L
P
L
H
SQIP
R
E
E
Q
R
KVFDPVP----V-------
G
V
T
K
V
I
L
STNIA
E
T
S
I
T
I
N
D
V
V
Y
V
I
D
S
C
K
Q
K
V
K
L
F
T
AH--NNMT
N
Y
A
T
V
WASKT
N
L
E
Q
RKGRAGRVR
P
G
F
C
F
H
L
C
S
R
A
R
F
E
-
R
L
E
T
HM
T
P
E
M
F
R
T
P
L
H
E
I
A
L
S
I
K
L
L
RLG
G
I
G
Q
F
L
A
K
AIEPPP
L
D
A
V
I
E
A
E
H
T
L
R
E
L
DALDANDEL
T
P
L
G
R
I
L
A
KLPIEPRF
G
K
M
M
I
M
G
C
I
F
Y
VG
D
A
I
C
T
I
A
A
-
A
TC-FPEPF---I---NE--G---
K
--
R
L
G
Y
I
HRNFAGNR
F
S
D
H
V
A
L
L
S
V
F
Q
A
W
D
D
ARMGGEE
A
E
I
R
F
C
EHKRL
N
M
A
T
L
R
M
T
W
E
A
K
V
Q
L
K
E
I
L
INSGF
P
E
D
C
L
L
T
Q
V
F--TN--T--GPD
N
N
L
D
V
V
I
S
L
L
A
F
GVYP
N
V
C
Y
H
K
----
E
K--
R
-------
K
---------
I
----------L----T-T-EGR
N
A
L
I
HKSSVNCPFSSQDMKYPS
P
F
F
V
F
G
E
K
I
R
T
R
AISAKGM
T
L
V
T
P
L
Q
L
L
L
F
A
---
S
K
KV-Q-S--D--G-
Q
I
V
L
VD
D
W
I
K
L
Q
IS
H
E
A
A
A
C
I
T
G
L
R
A
A
M
E
A
L
V
V
E
VTKQP
A
I
I
S
QLD--
P
V
N
E
R
M
L
N
M
I
R
Q
ISRPSAAG
I
N
L
M
I
GSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY
43
Fugue
86.23
55%
-8
- C2 -
-
5AOR
2
MLE_DROME
A:
[119-1158]
------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
A
Y
R
P
L
E
Q
R
D
M
N
---
E
A
E
A
F
D
V
N
A
A
I
H
G
N
W
T
I
E
N
A
K
E
R
L
N
I
Y
K
Q
T
N
N
I
R
D
D
Y
K
Y
T
P
V
G
P
E
H
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
L
N
R
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
H
L
N
V
I
E
P
F
S
G
T
L
K
K
--
D
E
Q
L
K
P
Y
P
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
P
V
V
N
P
R
------
N
IKIELD
G
----
P
P
I
P
L
I
V
N
L
-
S
-
R
I
E
S
----------
S
V
I
P
W
A
P
P
Q
A
N
W
N
T
W
H
A
C
N
I
D
E
G
E
L
A
T
T
S
I
D
D
L
S
-
M
D
Y
E
R
S
L
R
-
D
R
R
Q
N
D
N
-
E
Y
R
Q
F
L
E
F
R
--
E
K
L
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
I
R
G
N
T
G
C
G
K
T
T
Q
I
A
Q
Y
I
L
D
D
Y
I
C
S
G
Q
G
G
Y
A
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
E
Q
--
L
--
G
--
D
T
V
G
Y
S
V
R
F
E
S
V
F
P
R
P
Y
G
A
I
L
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
--
L
R
G
V
S
H
I
I
V
D
E
I
H
E
R
D
V
N
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
H
V
I
L
M
S
A
T
I
D
T
T
K
F
S
K
Y
F
G
I
C
P
V
L
E
V
P
G
R
A
F
P
V
Q
Q
F
F
L
E
D
I
I
Q
M
T
D
F
-
V
P
S
A
E
S
R
R
K
R
K
E
V
E
D
-----
E
-------
E
Q
-----------
L
LSEDKDE
A
---
E
---
I
---
N
Y
N
K
V
C
E
D
K
-----------
Y
S
Q
K
T
R
-
N
A
M
-
A
M
L
S
E
S
D
--
V
S
F
E
L
L
E
A
L
L
M
H
I
K
S
K
N
I
P
G
A
I
L
V
F
L
P
G
W
N
L
I
F
A
L
M
K
F
L
Q
N
T
N
I
-----
F
-----
G
D---
T
S
Q
Y
Q
----
I
L
P
C
H
S
Q
I
P
R
D
E
Q
R
K
V
F
E
P
V
P
----
E
-------
G
V
T
K
I
I
L
S
T
N
I
A
E
T
S
I
T
I
D
D
I
V
F
V
I
D
I
C
K
A
R
M
K
L
F
T
S
H
--
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
G
F
C
F
T
L
C
S
R
A
R
F
Q
-
A
L
E
D
N
L
T
P
E
M
F
R
T
P
L
H
E
M
A
L
T
I
K
L
L
R
L
G
S
I
H
H
F
L
S
K
A
L
E
P
P
P
V
D
A
V
I
E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
D
E
L
T
P
L
G
R
L
L
A
R
L
P
I
E
P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
A
D
L
M
A
I
M
A
S
Y
S
S
T
-
F
S
E
V
F
---
S
---
L
D
--
I
GQ-
R
--
R
L
A
N
H
Q
K
A
L
S
G
T
K
C
S
D
H
V
A
M
I
V
A
S
Q
M
W
R
R
E
K
Q
R
G
E
H
M
E
A
R
F
C
D
W
K
G
L
Q
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
A
G
F
P
E
E
C
M
I
S
H
E
V
--
D
E
--
R
ID
G
D
D
P
V
L
D
V
S
L
A
L
L
C
L
G
L
Y
P
N
I
C
V
H
K
----
E
K
--
R
-------
K
---------
V
----------
L
----
T
-
T
-
E
S
K
A
A
L
L
H
K
T
S
V
N
C
--
S
N
L
A
V
T
F
P
Y
P
F
F
V
F
G
E
K
I
R
T
R
A
V
S
C
K
Q
L
S
M
V
S
P
L
Q
V
I
L
F
G
---
S
R
K
I
-
D
L
A
--
A
--
N
-
N
I
V
R
V
D
N
W
L
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
K
P
A
L
E
D
L
I
T
V
A
C
D
N
P
S
D
I
L
R
L
E
--
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
K
S
A
-------------------------------------------------------------------------------------------------------------------
G
D
F
G
L
Q
R
-----
21
HHSearch
85.33
53%
-12
- C2 -
-
5AOR
2
MLE_DROME
A:
[119-1152]
-----------------------------------------------------------------------------------------------------------------------------------
L
G
E
A
Y
R
P
L
----------------
E
Q
R
D
M
N
E
A
E
A
F
D
V
N
A
A
I
H
G
N
W
T
I
E
N
A
K
E
R
L
N
I
Y
K
Q
T
N
N
I
R
D
D
Y
K
Y
T
P
V
G
P
E
H
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
L
N
R
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
H
L
N
V
I
E
P
F
S
G
T
L
--
K
K
D
E
Q
L
K
P
Y
P
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
P
V
V
N
P
R
------
N
------
I
KIEL
D
G
P
P
I
P
L
I
V
N
L
S
R
I
----------
E
S
S
V
I
P
W
A
P
P
Q
A
N
W
N
T
W
H
A
C
N
I
D
E
G
E
L
A
T
T
S
I
D
D
L
S
-
M
D
Y
E
R
S
L
R
-
D
R
R
Q
N
D
N
-
E
Y
R
Q
F
L
E
F
R
--
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L
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L
L
R
K
L
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-----
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EQLLSED
K
D
-----------
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-------
A
---
E
---
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---
N
Y
N
K
V
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K
-----------
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----
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----
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L
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---
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---
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D
IG
Q
---
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--
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R
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L
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L
A
L
L
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L
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L
Y
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N
I
C
V
H
K
----
E
K
--
R
-------
K
---------
V
----------
L
----
T
-
T
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S
K
A
A
L
L
H
K
T
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V
N
C
S
--
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L
A
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F
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Y
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A
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L
V
K
V
V
K
D
L
C
V
K
S
-
A
G
-----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.78
50%
-9
- C2 -
-
5AOR
2
MLE_DROME
A:
[119-1158]
-------------------------------------------------------------------------------------------------------------------------------
L
G
E
A
Y
R
P
L
------------------
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--
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A
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NIKIEL
D
------
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-
S
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----------
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K
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V
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-----
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S
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-----------
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-------
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---
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---
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N
Y
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-------
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----------
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A
G
D
F
G
L
Q
R
------------------------------------------------------------------------------------------------------------------------
22
HHSearch
64.98
38%
-26
- C2 -
-
5VHE
-
DHX36_BOVIN
A:
[109-905]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
L
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Y
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-------
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T
---------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
63.49
39%
-27
- C2 -
-
5VHA
-
DHX36_BOVIN
A:
[48-843]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
R
Y
I
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R
--
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K
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E
-------
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N
--
L
GKKRKMV
K
---------
V
----------
Y
----
T
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---
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--
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A
V
L
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A
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D
L
I
K
T
Q
--------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
62.77
35%
-15
- C2 -
-
5N9D
-
?
B:
[136-926]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
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Y
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--
L
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--
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-----------
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-------
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---
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---
P
Y
L
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-------
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T
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A
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---
G
Y
E
K
Q
L
I
K
A
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L
L
L
S
L
D
--------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
61.95
35%
-14
- C2 -
-
5N8R
-
?
B:
[136-926]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
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--
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L
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-----------
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-------
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---
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E
---
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----
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----
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R
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Y
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L
I
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A
I
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L
L
L
S
L
D
--------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.43
38%
-5
- C2 -
-
5VHC
1
DHX36_BOVIN
D:
[33-817]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
Q
L
L
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D
L
Q
K
K
K
T
D
L
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--
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E
Y
F
G
N
C
P
M
I
H
I
P
G
F
T
F
P
V
V
E
Y
L
L
E
D
I
I
E
K
I
R
Y
-
V
P
E
------------------------------------------------------
Y
---
Y
Y
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A
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Y
K
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R
WPGYLRELRQR
Y
S
A
S
T
V
-
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V
V
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M
M
D
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L
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L
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Y
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V
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L
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M
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F
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H
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V
IPL
G
K
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V
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Q
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L
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N
T
L
Q
M
L
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K
G
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L
L
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N
P
Q
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--
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--
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S
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-
K
I
I
K
A
V
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A
G
L
Y
P
K
V
A
K
I
R
LNL-------------
K
---------
M
----------
V
KVYT
K
-
T
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D
G
V
V
A
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I
H
P
K
S
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----
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L
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--
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K
E
L
R
K
E
L
D
I
L
L
Q
E
K
I
E
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.97
38%
-4
- C2 -
-
5VHD
1
DHX36_BOVIN
D:
[33-817]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
Q
L
L
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Q
K
K
K
T
D
L
R
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FR
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V
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V
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K
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G
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G
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A
C
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C
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Q
P
R
R
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S
A
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V
A
E
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V
A
A
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A
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CG
N
--
G
--
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S
T
G
Y
Q
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L
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L
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L
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L
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F
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V
V
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L
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K
I
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Y
-
V
P
E
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Y
---
Y
Y
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K
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WPGYLRELRQR
Y
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V
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L
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A
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N
T
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K
G
Q
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L
L
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R
N
P
Q
D
P
E
--
S
N
--
I
--
N
S
D
N
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-
K
I
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K
A
V
I
C
A
G
L
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P
K
V
A
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M
----------
V
KVYT
K
-
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V
A
-
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V
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V
----
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Q
T
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F
N
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N
W
L
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L
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L
L
Q
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K
I
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S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.89
38%
4
- C2 -
-
5VHA
-
DHX36_BOVIN
A:
[33-817]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
Q
L
L
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D
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Q
K
K
K
T
D
L
R
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FR
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N
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----------
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P
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.10
36%
-15
- C2 -
-
5N8Z
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
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K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
----
K
S
--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.82
36%
-13
- C2 -
-
5N94
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
N
I
L
D
K
P
K
T
-----
S
-----
K
----
G
Q
R
W
R
DHMA
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
-------
G
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
----
K
S
--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.57
36%
-11
- C2 -
-
5N8R
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
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Y
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Q
L
Y
N
I
L
D
K
P
K
T
-----
S
-----
K
----
G
Q
R
W
R
DHMA
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
-------
G
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
G
R
T
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A
T
N
Y
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--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
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M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
----
K
S
--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.50
36%
-10
- C2 -
-
5N9A
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
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Y
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Q
L
Y
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I
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D
K
P
K
T
-----
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-----
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----
G
Q
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W
R
DHMA
V
F
P
L
H
S
L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
-------
G
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
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D
D
V
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Y
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A
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--
T
N
I
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S
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W
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T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
P
I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
----
K
S
--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.50
36%
-10
- C2 -
-
5N90
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
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G
A
I
L
V
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L
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T
-----
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-----
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----
G
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DHMA
V
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L
M
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P
P
----
A
-------
G
Q
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A
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T
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V
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--
T
N
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L
D
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V
W
V
T
K
A
N
T
Q
Q
R
R
G
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A
G
R
V
R
P
G
I
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Y
N
L
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A
R
E
D
-
R
M
D
D
I
P
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P
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I
L
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K
L
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S
I
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L
K
L
L
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P
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A
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N
P
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A
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L
L
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R
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A
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G
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P
L
G
M
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L
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M
G
K
M
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M
S
A
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C
C
L
D
P
I
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A
A
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-
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-
F
K
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YSP
L
---
G
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--
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---
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--
R
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K
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A
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N
M
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L
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A
Y
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D
S
R
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--
H
A
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D
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N
F
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M
T
L
Q
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L
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R
M
K
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Q
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E
L
L
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Y
K
F
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A
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--
S
N
--
K
--
N
S
E
-
K
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L
L
R
A
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G
A
G
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Y
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M
A
H
L
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----
K
S
--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
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Y
F
Q
R
Q
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D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.50
36%
-10
- C2 -
-
5N8U
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
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A
I
A
I
A
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W
V
S
Y
E
R
C
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S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
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I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
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--
D
PL
M
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N
L
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L
I
L
D
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I
H
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R
S
V
E
T
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L
L
M
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L
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V
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L
P
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P
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L
K
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L
M
S
A
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V
R
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Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
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G
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M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
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P
Y
L
R
R
I
R
-----------
N
S
Y
D
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D
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-
L
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L
P
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S
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GC
E
D
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A
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-----
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-----
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----
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V
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----
A
-------
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--
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A
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R
R
G
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A
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R
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G
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Y
N
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A
R
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D
-
R
M
D
D
I
P
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I
L
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L
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S
I
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L
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L
L
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P
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N
P
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R
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G
M
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L
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M
G
K
M
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M
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A
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C
L
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P
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A
A
A
-
A
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-
F
K
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YSP
L
---
G
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--
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---
S
--
R
V
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I
K
R
R
M
A
R
N
M
R
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H
L
M
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I
I
A
Y
R
D
S
R
Y
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--
H
A
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R
D
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C
Y
K
N
F
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M
T
L
Q
Q
L
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R
M
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E
L
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Y
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Y
K
F
L
A
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C
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A
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--
S
N
--
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--
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S
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-
K
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L
L
R
A
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A
G
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M
A
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L
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----
K
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--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
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S
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D
S
A
Y
F
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Y
F
Q
R
Q
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D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.46
36%
-10
- C2 -
-
5N9E
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
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A
I
A
I
A
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W
V
S
Y
E
R
C
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S
--
L
--
G
--
N
S
V
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Y
Q
I
R
L
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R
K
A
R
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A
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-
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C
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V
L
L
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Q
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--
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M
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N
L
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L
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R
S
V
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L
L
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L
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P
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L
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M
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A
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D
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C
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Y
F
N
N
C
P
M
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F
P
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K
M
L
Y
L
E
D
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L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
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P
Y
L
R
R
I
R
-----------
N
S
Y
D
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-
L
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L
P
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E
D
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V
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----
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R
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A
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M
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L
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S
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L
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G
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A
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A
A
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L
---
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--
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---
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--
R
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I
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R
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M
A
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N
M
R
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H
L
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A
Y
R
D
S
R
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S
--
H
A
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R
D
F
C
Y
K
N
F
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M
T
L
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Q
L
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R
M
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L
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K
F
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A
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C
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--
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N
--
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--
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S
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-
K
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L
L
R
A
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A
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M
A
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----
K
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--
R
------------------RAIHTM----
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
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V
N
----
S
G
E
S
G
F
D
S
A
Y
F
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Y
F
Q
R
Q
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D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
56.30
36%
-11
- C2 -
-
5N96
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
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P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
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C
T
Q
P
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R
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A
I
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W
V
S
Y
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C
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S
--
L
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--
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S
V
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A
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V
L
L
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Q
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M
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N
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C
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F
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K
M
L
Y
L
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L
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K
T
N
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Q
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-----------------
R
-------
M
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-----------
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-------
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---
A
---
M
---
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P
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L
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R
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-----------
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-
L
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----
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------------------RAIHTM----
A
----
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----
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L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.28
36%
-10
- C2 -
-
5N9F
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
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D
F
C
D
Y
F
N
N
C
P
M
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M
F
P
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K
M
L
Y
L
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D
V
L
S
K
T
N
Y
E
F
Q
K
--------
P
P
E
R
-----
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
I
C
E
N
E
P
E
G
A
I
L
V
F
L
P
G
Y
D
K
I
S
Q
L
Y
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I
L
D
K
P
K
T
-----
S
-----
K
----
G
Q
R
W
R
DHMA
V
F
P
L
H
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L
M
Q
S
G
E
Q
Q
A
V
F
R
R
P
P
----
A
-------
G
Q
R
K
V
I
I
S
T
I
I
A
E
T
S
V
T
I
D
D
V
V
Y
V
I
N
S
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R
T
K
A
T
N
Y
D
I
E
--
T
N
I
Q
S
L
D
E
V
W
V
T
K
A
N
T
Q
Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
G
V
E
L
L
K
R
I
E
A
L
D
Q
T
G
T
L
T
P
L
G
M
H
L
A
K
L
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I
D
P
Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
R
D
F
C
Y
K
N
F
L
S
S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
I
G
A
G
L
Y
P
N
M
A
H
L
R
----
K
S
--
R
-------
Q
---------
I
KNRVRAIHTM
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.20
36%
-8
- C2 -
-
5N9D
-
?
A:
[136-852]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
L
E
E
-
N
A
K
K
R
L
E
A
R
--
K
K
L
P
T
M
K
Y
A
D
D
I
I
Q
A
V
R
E
N
Q
V
I
L
I
V
G
S
T
G
C
G
K
T
T
Q
V
P
Q
I
L
L
D
D
A
I
S
R
G
C
A
S
S
C
R
I
I
C
T
Q
P
R
R
I
S
A
I
A
I
A
E
W
V
S
Y
E
R
C
E
S
--
L
--
G
--
N
S
V
G
Y
Q
I
R
L
E
S
R
K
A
R
E
R
A
S
I
T
-
Y
C
T
T
G
V
L
L
Q
Q
L
Q
S
--
D
PL
M
H
N
L
S
V
L
I
L
D
E
I
H
E
R
S
V
E
T
D
L
L
M
G
L
L
K
V
I
L
P
H
R
P
D
L
K
V
I
L
M
S
A
T
V
R
E
Q
D
F
C
D
Y
F
N
N
C
P
M
F
R
I
E
G
V
M
F
P
V
K
M
L
Y
L
E
D
V
L
S
K
T
N
Y
E
F
Q
K
-----------------
R
-------
M
K
-----------
H
-------
E
---
A
---
M
---
I
E
P
Y
L
R
R
I
R
-----------
N
S
Y
D
S
R
V
L
D
K
-
L
R
L
P
E
S
E
GC
E
D
I
D
F
I
A
D
L
V
Y
Y
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C
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N
E
P
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G
A
I
L
V
F
L
P
G
Y
D
K
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Q
L
Y
N
I
L
D
K
P
K
T
-----
S
-----
K
----
G
Q
R
W
R
DHMA
V
F
P
L
H
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L
M
Q
S
G
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Q
Q
A
V
F
R
R
P
P
----
A
-------
G
Q
R
K
V
I
I
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I
I
A
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T
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T
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V
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Y
V
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A
T
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Y
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--
T
N
I
Q
S
L
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V
W
V
T
K
A
N
T
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Q
R
R
G
R
A
G
R
V
R
P
G
I
C
Y
N
L
F
S
R
A
R
E
D
-
R
M
D
D
I
P
T
P
E
I
L
R
S
K
L
E
S
I
I
L
S
L
K
L
L
H
I
D
D
P
Y
R
F
L
Q
T
L
I
N
A
P
N
P
E
A
I
K
M
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L
L
K
R
I
E
A
L
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Q
T
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T
L
T
P
L
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M
H
L
A
K
L
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I
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Q
M
G
K
M
I
L
M
S
A
L
F
C
C
L
D
P
I
T
S
A
A
A
-
A
L
S
-
F
K
S
P
F
YSP
L
---
G
K
--
E
---
S
--
R
V
D
E
I
K
R
R
M
A
R
N
M
R
S
D
H
L
M
V
H
N
T
I
I
A
Y
R
D
S
R
Y
S
--
H
A
E
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D
F
C
Y
K
N
F
L
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S
M
T
L
Q
Q
L
E
R
M
K
N
Q
F
S
E
L
L
Y
N
Y
K
F
L
A
S
S
N
C
K
D
A
A
--
S
N
--
K
--
N
S
E
-
K
I
P
L
L
R
A
I
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G
A
G
L
Y
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N
M
A
H
L
R
----
K
S
--
R
-------
Q
---------
I
KNRVRAIHTM
A
----
T
-
D
-
D
G
R
R
V
N
F
H
P
S
S
V
N
----
S
G
E
S
G
F
D
S
A
Y
F
V
Y
F
Q
R
Q
K
S
T
D
L
F
L
L
D
S
T
M
V
F
P
M
A
L
I
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
50.65
31%
-33
- C2 -
-
6FAA
6
?
A:
[24-655]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
E
V
R
--
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
Y
Q
V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
H
E
A
G
Y
T
K
---
G
N
R
K
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
A
R
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A
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M
G
V
R
--
L
--
G
--
H
E
V
G
Y
S
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F
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C
T
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-
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K
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K
-
Y
M
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M
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L
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SP
D
--
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A
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H
T
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I
L
L
A
L
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A
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R
L
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I
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S
A
T
L
N
A
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F
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A
Y
F
D
D
A
P
I
F
N
V
P
G
R
V
H
P
V
E
V
Y
Y
T
S
A
P
E
S
N
-------------------------------------------------------------------------------------
Y
L
--------------------
E
A
A
L
V
T
V
F
-
Q
I
H
A
T
Q
P
E
G
D
I
L
V
F
L
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G
Q
E
E
I
E
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A
C
E
R
V
E
E
I
R
R
-----
K
LGK--
R
----
V
P
E
I
I
----
A
L
P
I
Y
S
N
M
P
S
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M
Q
A
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F
E
P
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----
P
-------
G
A
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K
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V
F
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A
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L
T
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T
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T
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A
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A
A
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Q
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M
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R
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L
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A
L
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A
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A
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L
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V
G
R
Q
M
G
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F
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T
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M
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A
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A
L
I
A
A
T
Q
E
G
C
V
S
E
V
L
T
I
V
S
-
M
L
G
E
V
G
T
L
F
---
F
---
R
P
K-
D
---
K
KV
H
A
D
S
A
R
A
R
F
T
V
R
D
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G
D
H
L
T
L
L
N
I
Y
N
Q
W
V
E
A
E
Y
-----
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
E
A
----
S
C
------
G
---
G
V
N
N
P
T
P
I
L
R
A
L
T
A
A
F
F
L
N
A
A
R
L
N
----
R
A
G-
D
-------
G
---------
Y
----------
R
----
T
-
L
K
N
N
I
T
V
Y
V
H
P
S
S
V
V
R
G
M
-----
D
P
P
P
K
V
I
I
Y
H
E
L
V
V
T
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K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
---
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
50.34
31%
-32
- C2 -
-
6FAC
1
?
A:
[24-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
E
V
R
--
K
S
L
P
V
Y
A
Y
R
D
A
F
L
D
A
V
K
E
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V
L
I
L
V
G
E
T
G
S
G
K
T
T
Q
I
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Q
Y
L
H
E
A
G
Y
T
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---
G
N
R
K
I
A
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R
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A
A
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A
A
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--
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-
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Y
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M
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D
--
L
A
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I
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E
A
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E
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T
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H
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L
L
A
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L
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A
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R
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A
T
L
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F
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A
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F
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D
A
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I
F
N
V
P
G
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V
H
P
V
E
V
Y
Y
T
S
A
P
E
S
N
-------------------------------------------------------------------------------------
Y
L
--------------------
E
A
A
L
V
T
V
F
-
Q
I
H
A
T
Q
P
E
G
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L
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G
Q
E
E
I
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R
A
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R
V
E
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I
R
R
-----
K
LGK--
R
----
V
P
E
I
I
----
A
L
P
I
Y
S
N
M
P
S
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M
Q
A
K
I
F
E
P
T
P
----
P
-------
G
A
R
K
V
V
F
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T
N
I
A
E
T
S
L
T
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D
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Y
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T
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A
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L
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A
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A
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L
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I
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-
M
L
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G
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---
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---
R
P
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---
K
KV
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A
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A
R
A
R
F
T
V
R
D
G
G
D
H
L
T
L
L
N
I
Y
N
Q
W
V
E
A
E
Y
-----
S
P
I
W
A
R
E
N
F
L
A
Q
R
S
L
T
R
A
R
D
V
R
D
Q
L
A
K
L
C
D
R
I
L
D
G
S
E
A
----
S
C
------
G
---
G
V
N
N
P
T
P
I
L
R
A
L
T
A
A
F
F
L
N
A
A
R
L
N
----
R
A
G-
D
-------
G
---------
Y
----------
R
----
T
-
L
K
N
N
I
T
V
Y
V
H
P
S
S
V
V
R
G
M
-----
D
P
P
P
K
V
I
I
Y
H
E
L
V
V
T
S
K
E
Y
V
R
S
V
I
P
V
E
P
R
W
L
S
E
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
49.79
31%
-16
- C2 -
-
5LTJ
9
?
A:
[24-673]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
E
-
R
Y
F
K
I
L
K
A
R
--
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
Y
D
E
L
P
H
Q
--
T
G
K
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
--
L
--
G
--
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
-
S
K
T
L
L
K
-
Y
M
T
D
G
Q
L
L
R
E
A
M
H
DR
D
--
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
A
E
R
D
-------------------------------------------------------------------------------------
Y
V
E
--------------------
A
A
I
R
-
T
V
L
Q
I
H
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
EMIRE
S
-----
D
----
A
G
P
M
S
----
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
K
A
P
QPFR
P
GGR----
P
G
R
K
C
I
V
A
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
I
Y
N
P
R
--
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
K
E
L
I
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
--
D
L
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
D
G
E
L
T
P
L
G
N
L
A
S
E
F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
-
L
L
S
-
V
P
Q
I
W
---
V
---
R
P
A-
N
AR-
K
--
R
A
D
E
M
K
A
Q
F
A
-
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
K
G
A
E
A
R
G
-
E
D
M
K
K
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
E
L
V
S
T
P
---
F
--
H
-------
D
K
N
Y
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
----
S
S
NS
K
-------
V
---------
Y
----------
K
----
T
V
K
-
D
E
Q
L
V
L
I
H
P
S
T
T
V
T
T
--------
P
Y
E
W
V
V
Y
N
E
F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
---
P
V
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
48.82
31%
-17
- C2 -
-
6QIE
9
?
A:
[25-672]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
Y
F
K
I
L
K
A
R
--
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
Y
D
E
L
P
H
Q
--
T
G
K
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
--
L
--
G
--
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
-
S
K
T
L
L
K
-
Y
M
T
D
G
Q
L
L
R
E
A
M
H
DR
D
--
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
F
Y
T
P
E
A
E
R
D
-------------------------------------------------------------------------------------
Y
V
E
--------------------
A
A
I
R
-
T
V
L
Q
I
H
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
-----
E
MIRES
D
----
A
G
P
M
S
----
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
K
A
P
----
Q
PFRPGGR
P
G
R
K
C
I
V
A
T
N
I
A
E
T
G
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
I
Y
N
P
R
--
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
K
E
L
I
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
--
D
L
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
D
G
E
L
T
P
L
G
N
L
A
S
E
F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
-
L
L
S
-
V
P
Q
I
W
---
V
---
R
P
--
A
NAR
K
--
R
A
D
E
M
K
A
Q
F
A
-
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
K
G
A
E
A
R
G
-
E
D
M
K
K
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
E
L
V
S
T
P
---
F
--
H
-------
D
K
N
Y
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
----
S
S
NS
K
-------
V
---------
Y
----------
K
----
T
-
V
K
D
E
Q
L
V
L
I
H
P
S
T
T
V
T
T
--------
P
Y
E
W
V
V
Y
N
E
F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
---
P
V
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
42.74
97%
-134
- C2 -
-
3LLM
1
DHX9_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
W
S
P
P
Q
S
N
W
N
P
W
T
S
S
N
I
D
E
G
P
L
A
F
A
T
P
E
Q
I
S
-
M
D
L
K
N
E
L
M
-
Y
Q
L
E
Q
D
H
-
D
L
Q
A
I
L
Q
E
R
--
E
L
L
P
V
K
K
F
E
S
E
I
L
E
A
I
S
Q
N
S
V
V
I
I
R
G
A
T
G
C
G
K
T
T
Q
V
P
Q
F
I
L
D
D
F
I
Q
N
D
R
A
A
E
C
N
I
V
V
T
Q
P
R
R
I
S
A
V
S
V
A
E
R
V
A
F
E
R
G
E
E
--
P
--
G
--
K
S
C
G
Y
S
V
R
F
E
S
I
L
P
R
P
H
A
S
I
M
-
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
--
I
R
G
I
S
H
V
I
V
D
E
I
H
E
R
D
I
N
T
D
F
L
L
V
V
L
R
D
V
V
Q
A
Y
P
E
V
R
I
V
L
M
S
A
T
I
D
T
S
M
F
C
E
Y
F
F
N
C
P
I
I
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
30.71
96%
-28
- C2 -
-
3LLM
1
DHX9_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
W
S
P
P
Q
S
N
W
N
P
W
T
S
S
N
I
D
E
G
P
L
A
F
A
T
P
E
Q
I
S
M
D
--
L
K
N
E
L
M
Y
Q
L
E
Q
D
H
-
D
L
Q
A
I
L
Q
E
R
--
E
L
L
P
V
K
K
F
E
S
E
I
L
E
A
I
S
Q
N
S
V
V
I
I
R
G
A
T
G
C
G
K
T
T
Q
V
P
Q
F
I
L
D
D
F
I
Q
N
D
R
A
A
E
C
N
I
V
V
T
Q
P
R
R
I
S
A
V
S
V
A
E
R
V
A
F
E
R
G
E
E
--
P
--
G
--
K
S
C
G
Y
S
V
R
F
E
S
I
L
P
R
P
H
-
A
S
I
M
F
C
T
V
G
V
L
L
R
K
L
E
A
--
G
--
I
R
G
I
S
H
V
I
V
D
E
I
H
E
R
D
I
N
T
D
F
L
L
V
V
L
R
D
V
V
Q
A
Y
P
E
V
R
I
V
L
M
S
A
T
I
D
T
S
M
F
C
E
Y
F
F
N
C
P
I
I
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------