@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DP13A_HUMAN: (2020-02-01 )
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA
Atome Classification :
(20 SA)
.........10........20........30.....-...40...-.....50........60........70........80.-.......90........100.......110-.......120.......130.......140.......150.......160.......170.......180........190.......200....-...210..-.....220........230----.......240......-..250.......260.......270.......280.......290.......300.......310...-.....-320.......330.-......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPGIDKLP
I
E
E
T
LEDSP
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
YDA
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
QRFPLGG
D
D
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
ASND
H
D
A
A
I
N
R
Y
S
R
L
S
KKREND
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
KMG-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
MD-S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
EVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWD
R
Q
F
Y
F
TQGG
N
L
M
S
-
Q
AR-GDVAG-G
L
A
M
DIDN
C
S
V
M
A
V
-DCED
R
R
Y
C
F
Q
ITSFDGKK
S
S
I
L
QAESKK
D
H
E
E
W
I
C
T
INNI
S
K
Q
I
Y
LSENP
E
E
T
A
A
R
V
N
Q
S
A
L
E
AVTPS
P
S
F
Q
Q
R
H
E
SLRPAAGQSRPPTARTSSSGSLGSEST
N
L
A
A
L
S
L
D
S
LVAPDT
P
I
Q
F
D
IISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKS
E
T
E
D
S
I
L
H
Q
L
F
I
V
R
F
L
GSMEVKSDDH
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
ES
H
L
L
V
T
C
D
C
L
K
LIDPQT
Q
V
T
R
L
TFPL
P
C
V
V
L
Y
A
THQEN
K
R
L
F
G
F
V
L
RTSSGRSESNL
S
S
V
C
Y
I
F
ESNN
E
G
E
K
I
C
D
S
VG
L
A
K
Q
I
A
L
H
A
E
L
D
R
R
A
S
E
K
Q
K
E
I
E
R
V
K
E
K
Q
Q
K
E
L
N
K
Q
K
Q
I
E
K
D
L
E
E
Q
S
R
L
I
AASSRPNQASSEG
Q
F
V
V
L
SSSQSEESDLGEGGKKRESEA
1
PsiBlast_PDB
92.93
99%
-70
- C1 -
-
2Q13
-
DP13A_HUMAN
A:
[4-378]
---
M
D
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
R
F
P
L
---
D
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
K
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
--------
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
M
S
-
Q
A
R
-
G
D
V
A
G
-
G
L
A
M
D
I
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
I
S
K
Q
I
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
89.95
100%
-73
- C1 -
-
5C5B
-
DP13A_HUMAN
C:
[4-374]
---
M
D
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
--------
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
K
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
N
------
S
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
M
S
-
Q
A
R
-
G
D
V
A
G
-
G
L
A
M
D
I
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.66
99%
-68
- C1 -
-
5C5B
1
DP13A_HUMAN
A:
[4-375]
---
M
D
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
---------
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
K
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
N
K
-----
S
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
M
S
-
Q
A
R
-
G
D
V
A
G
-
G
L
A
M
D
I
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
I
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.59
96%
-74
- C1 -
-
2Z0O
-
DP13A_HUMAN
A:
[2-372]
-
P
G
I
D
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
R
F
P
L
---
D
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
K
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
----------
D
R
Q
F
Y
F
T
Q
G
G
N
L
M
S
-
Q
A
R
-
G
D
V
A
G
-
G
L
A
M
D
I
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
S
-----
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.91
96%
-54
- C1 -
-
2ELB
-
DP13A_HUMAN
A:
[6-374]
-----
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
R
F
P
-----
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
-----
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
D
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
N
K
T
G
----
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
M
S
-
Q
A
R
-
G
D
V
-----
A
M
D
I
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
80.47
56%
-38
- C1 -
-
5C5B
1
DP13B_HUMAN
D:
[5-374]
----
D
K
L
L
L
E
E
A
L
Q
D
S
P
Q
T
R
S
L
L
S
V
F
E
E
D
A
G
T
L
T
D
Y
-
T
N
Q
L
L
Q
A
M
-
Q
R
V
Y
G
A
Q
N
E
M
C
L
A
T
Q
Q
L
S
K
Q
L
L
A
Y
E
K
Q
N
F
A
L
G
K
G
D
E
E
V
-
I
S
T
L
H
Y
F
S
K
V
V
D
E
L
N
L
L
H
T
E
L
A
K
Q
L
A
D
T
M
V
-
L
P
I
I
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
L
F
G
L
A
S
N
E
H
D
L
S
M
A
K
Y
S
R
L
P
K
K
K
E
N
E
K
V
K
T
E
V
G
K
E
V
A
A
A
R
R
K
Q
H
L
S
S
L
Q
-
Y
Y
C
A
L
N
A
L
Q
Y
R
K
Q
M
A
M
M
E
P
M
I
G
F
A
H
G
-
Q
I
N
F
F
K
K
G
-
A
E
M
F
-
S
K
R
M
D
S
F
L
S
S
V
A
D
M
----
V
Q
S
I
Q
V
E
L
E
-
A
E
A
E
K
M
-
R
V
S
Q
Q
E
L
L
S
V
D
E
S
V
Y
T
P
D
S
D
V
A
A
P
Q
I
N
R
N
L
I
Q
K
A
G
Y
L
N
L
R
N
K
T
G
L
V
T
T
T
W
E
R
L
Y
F
F
T
Q
G
G
N
L
M
C
-
Q
P
R
-
G
A
V
A
G
-
G
L
I
Q
D
L
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
T
P
N
G
K
S
G
I
I
L
Q
A
E
S
R
K
E
N
E
E
W
I
C
A
I
N
N
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
79.24
56%
-36
- C1 -
-
5C5B
1
DP13B_HUMAN
B:
[5-374]
----
D
K
L
L
L
E
E
A
L
Q
D
S
P
Q
T
R
S
L
L
S
V
F
E
E
D
A
G
T
L
T
D
Y
-
T
N
Q
L
L
Q
A
M
-
Q
R
V
Y
G
A
Q
N
E
M
C
L
A
T
Q
Q
L
S
K
Q
L
L
A
Y
E
K
Q
N
F
A
L
G
K
G
D
E
E
V
-
I
S
T
L
H
Y
F
S
K
V
V
D
E
L
N
L
L
H
T
E
L
A
K
Q
L
A
D
T
M
V
-
L
P
I
I
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
L
F
G
L
A
S
N
E
H
D
L
S
M
A
K
Y
S
R
L
P
K
K
K
E
N
E
K
V
K
T
E
V
G
K
E
V
A
A
A
R
R
K
Q
H
L
S
S
L
Q
-
Y
Y
C
A
L
N
A
L
Q
Y
R
K
Q
M
A
M
M
E
P
M
I
G
F
A
H
G
-
Q
I
N
F
F
K
K
G
-
A
E
M
F
-
S
K
R
M
D
S
F
L
S
S
V
A
D
M
----
V
Q
S
I
Q
V
E
L
E
-
A
E
A
E
K
M
-
R
V
S
Q
Q
E
L
L
S
V
D
E
S
V
Y
T
P
D
S
D
V
A
A
P
Q
I
N
R
N
L
I
Q
K
A
G
Y
L
N
L
R
N
K
T
G
L
V
T
T
T
W
E
R
L
Y
F
F
T
Q
G
G
N
L
M
C
-
Q
P
R
-
G
A
V
A
G
-
G
L
I
Q
D
L
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
T
P
N
G
K
S
G
I
I
L
Q
A
E
S
R
K
E
N
E
E
W
I
C
A
I
N
N
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
65.86
99%
-93
- C- -
-
2Q12
-
DP13A_HUMAN
A:
[13-259]
------------
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
R
F
P
-----
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.26
95%
-93
- C- -
-
2Q12
-
DP13A_HUMAN
A:
[13-259]
------------
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
R
F
P
-----
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
V
A
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.33
95%
-87
- C1 -
-
2Z0N
-
DP13A_HUMAN
A:
[13-255]
------------
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
-
M
N
Q
L
Y
Q
A
M
-
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
--------
E
V
M
-
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
A
M
M
-
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
T
M
M
H
-
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
M
Q
A
-
Q
I
S
F
F
K
M
G
-
S
E
N
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
M
D
-
S
D
I
E
T
M
-
Q
Q
T
I
E
D
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.89
20%
-2
- C1 -
-
5H3D
-
?
A:
[9-362]
-----
K
L
D
F
E
E
C
L
K
D
S
P
R
F
R
A
S
I
E
L
V
E
A
E
V
S
E
L
E
T
R
-
L
E
K
L
L
K
L
G
-
T
G
L
L
E
S
G
R
H
Y
L
A
A
S
R
A
F
V
V
G
I
C
D
L
A
R
----
L
G
P
P
E
P
M
M
-
A
E
C
L
E
K
F
T
V
S
L
N
H
K
L
D
S
H
A
E
L
L
D
A
T
Q
H
T
L
Q
-
Q
Q
I
Q
T
L
V
K
E
G
L
R
G
F
R
E
A
R
R
D
F
W
R
G
A
E
S
L
E
A
A
L
T
H
N
A
E
V
P
R
R
R
A
Q
E
A
E
E
A
G
A
A
--
L
R
T
A
R
A
G
Y
R
G
R
A
L
D
-
Y
A
L
Q
I
N
V
I
E
D
K
R
K
F
D
I
M
E
F
V
L
R
L
V
E
A
-
Q
A
T
H
F
Q
Q
G
-
H
E
E
L
S
--
R
L
S
Q
Y
R
K
E
L
G
A
Q
LHQL
V
L
N
S
A
R
E
-
K
-
R
D
M
E
Q
R
-
H
V
L
L
K
Q
K
E
L
G
G
E
E
---
P
E
P
S
L
R
E
G
P
G
G
L
V
M
E
---
G
H
L
F
K
R
A
S
N
A
F
--
K
T
W
S
R
R
W
F
T
I
Q
S
N
Q
L
V
Y
-
Q
K
K
Y
K
D
P
V
T
-
V
V
V
D
D
L
R
L
C
T
V
K
L
C
-
P
D
S
E
R
R
F
C
F
E
V
V
S
--
T
S
K
S
C
L
L
Q
A
D
S
E
R
L
L
Q
L
W
V
S
A
V
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.24
20%
4
- C1 -
-
4CKH
-
ACAP1_HUMAN
A:
[4-357]
-----
K
L
D
F
E
E
C
L
K
D
S
P
R
F
R
A
S
I
E
L
V
E
A
E
V
S
E
L
E
T
R
-
L
E
K
L
L
K
L
G
-
T
G
L
L
E
S
G
R
H
Y
L
A
A
S
R
A
F
V
V
G
I
C
D
L
A
R
----
L
G
P
P
E
P
M
M
-
A
E
C
L
E
K
F
T
V
S
L
N
H
K
L
D
S
H
A
E
L
L
D
A
T
Q
H
T
L
Q
-
Q
Q
I
Q
T
L
V
K
E
G
L
R
G
F
R
E
A
R
R
D
F
W
R
G
A
E
S
L
E
A
A
L
T
H
N
A
E
V
P
R
R
R
A
Q
E
A
E
E
A
G
A
A
--
L
R
T
A
R
A
G
Y
R
G
R
A
L
D
-
Y
A
L
Q
I
N
V
I
E
D
K
R
K
F
D
I
M
E
F
V
L
R
L
V
E
A
-
Q
A
T
H
F
Q
Q
G
-
H
E
E
L
S
--
R
L
S
Q
Y
R
K
E
L
G
A
Q
LHQL
V
L
N
S
A
R
E
-
K
-
R
D
M
E
Q
R
-
H
V
L
L
K
Q
K
E
L
G
G
E
E
---
P
E
P
S
L
R
E
G
P
G
G
L
V
M
E
---
G
H
L
F
K
R
A
S
N
A
F
--
K
T
W
S
R
R
W
F
T
I
Q
S
N
Q
L
V
Y
-
Q
K
K
Y
K
D
P
V
T
-
V
V
V
D
D
L
R
L
C
T
V
K
L
C
-
P
D
S
E
R
R
F
C
F
E
V
V
S
--
T
S
K
S
C
L
L
Q
A
D
S
E
R
L
L
Q
L
W
V
S
A
V
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.27
20%
4
- C1 -
-
4CKG
-
ACAP1_HUMAN
A:
[4-357]
-----
K
L
D
F
E
E
C
L
K
D
S
P
R
F
R
A
S
I
E
L
V
E
A
E
V
S
E
L
E
T
R
-
L
E
K
L
L
K
L
G
-
T
G
L
L
E
S
G
R
H
Y
L
A
A
S
R
A
F
V
V
G
I
C
D
L
A
R
----
L
G
P
P
E
P
M
M
-
A
E
C
L
E
K
F
T
V
S
L
N
H
K
L
D
S
H
A
E
L
L
D
A
T
Q
H
T
L
Q
-
Q
Q
I
Q
T
L
V
K
E
G
L
R
G
F
R
E
A
R
R
D
F
W
R
G
A
E
S
L
E
A
A
L
T
H
N
A
E
V
P
R
R
R
A
Q
E
A
E
E
A
G
A
A
--
L
R
T
A
R
A
G
Y
R
G
R
A
L
D
-
Y
A
L
Q
I
N
V
I
E
D
K
R
K
F
D
I
M
E
F
V
L
R
L
V
E
A
-
Q
A
T
H
F
Q
Q
G
-
H
E
E
L
S
--
R
L
S
Q
Y
R
K
E
L
G
A
Q
LHQL
V
L
N
S
A
R
E
-
K
-
R
D
M
E
Q
R
-
H
V
L
L
K
Q
K
E
L
G
G
E
E
---
P
E
P
S
L
R
E
G
P
G
G
L
V
M
E
---
G
H
L
F
K
R
A
S
N
A
F
--
K
T
W
S
R
R
W
F
T
I
Q
S
N
Q
L
V
Y
-
Q
K
K
Y
K
D
P
V
T
-
V
V
V
D
D
L
R
L
C
T
V
K
L
C
-
P
D
S
E
R
R
F
C
F
E
V
V
S
--
T
S
K
S
C
L
L
Q
A
D
S
E
R
L
L
Q
L
W
V
S
A
V
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
55.85
78%
40
- C1 -
-
2ELB
-
DP13A_HUMAN
A:
[6-374]
-----
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
D
A
T
A
I
S
N
Y
M
N
--
Q
L
Y
Q
A
M
H
R
I
Y
D
A
Q
N
E
L
S
A
A
T
H
L
T
S
K
L
L
K
E
Y
E
K
Q
------
R
F
P
E
V
M
S
S
T
L
Q
Q
F
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Q
L
A
D
--
A
M
F
P
I
T
Q
F
K
E
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
A
S
N
D
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
V
K
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
-------
T
H
M
Y
F
C
A
L
N
T
L
Q
Y
K
K
K
I
A
L
L
E
P
L
L
G
Y
-
Q
A
M
Q
I
S
F
F
K
G
S
M
E
N
-
L
N
E
-
Q
L
E
E
F
L
A
N
I
G
T
S
----
V
Q
N
V
R
R
E
D
S
M
D
I
E
T
Q
Q
M
T
I
E
D
L
E
V
A
S
D
P
L
Y
V
--
P
D
P
D
P
T
D
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
A
R
N
K
----
T
G
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
S
Q
M
A
R
G
-
D
V
A
D
I
M
D
N
C
-------
S
V
A
V
M
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
K
D
H
E
E
W
I
C
T
I
N
N
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
51.83
99%
-175
* C1 *
-
2ELA
-
DP13A_HUMAN
B:
[499-640]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
L
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
R
L
F
G
F
V
L
R
T
S
S
------
L
S
S
V
C
Y
I
F
E
S
N
N
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
A
L
H
A
E
L
D
R
R
A
S
E
K
Q
K
---------------------------------------------------------------------
7
PsiBlast_PDB
51.32
56%
-
- C1 -
-
4H8S
-
DP13B_HUMAN
A:
[2-377]
-
P
A
V
D
K
L
L
L
E
E
A
L
Q
D
S
P
Q
T
R
S
L
L
S
V
F
E
E
D
A
G
T
L
T
D
Y
-
T
N
Q
L
L
Q
A
M
-
Q
R
V
Y
G
A
Q
N
E
M
C
L
A
T
Q
Q
L
S
K
Q
L
L
A
Y
E
K
Q
N
F
A
----
D
E
E
V
-
I
S
T
L
H
Y
F
S
K
V
V
D
E
L
N
L
L
H
T
E
L
A
K
Q
L
A
D
T
M
V
-
L
P
I
I
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
L
F
G
L
A
S
N
E
H
D
L
S
M
A
K
Y
S
R
L
P
K
K
K
E
N
E
K
V
K
T
E
V
G
K
E
V
A
A
A
R
R
K
Q
H
L
S
S
L
Q
-
Y
Y
C
A
L
N
A
L
Q
Y
R
K
Q
M
A
M
M
E
P
M
I
G
F
A
H
G
-
Q
I
N
F
F
K
K
G
-
A
E
M
F
S
K
-
R
M
D
S
F
L
S
S
V
A
D
M
----
V
Q
S
I
Q
V
E
L
E
-
A
E
A
E
K
M
-
R
V
S
Q
Q
E
L
L
S
V
D
E
S
V
Y
T
P
D
S
D
V
A
A
P
Q
I
N
R
N
L
I
Q
K
A
G
Y
L
N
L
R
N
K
T
G
L
V
T
T
T
W
E
R
L
Y
F
F
T
Q
G
G
N
L
M
C
-
Q
P
R
-
G
A
V
A
G
-
G
L
I
Q
D
L
D
N
C
S
V
M
A
V
-
D
C
E
D
R
R
Y
C
F
Q
I
T
T
P
N
G
K
S
G
I
I
L
Q
A
E
S
R
K
E
N
E
E
W
I
C
A
I
N
N
I
S
R
Q
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
51.16
100%
-188
- C1 -
-
2EJ8
-
B:
[11-148]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
I
L
H
Q
L
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
R
L
F
G
F
V
L
R
T
S
-------
L
S
S
V
C
Y
I
F
E
S
N
N
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
A
L
H
A
E
L
D
-----------------------------------------------------------------------------
43
Fugue
50.99
99%
-180
- C1 -
-
2ELA
-
DP13A_HUMAN
A:
[496-633]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
H
Q
L
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
R
L
F
G
F
V
L
R
T
S
L
-------
S
S
V
C
Y
I
F
E
S
N
N
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
A
L
H
A
E
L
D
R
----------------------------------------------------------------------------
9
PsiBlast_PDB
50.47
100%
-180
- C1 -
-
2ELA
-
DP13A_HUMAN
A:
[496-633]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
H
Q
L
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
R
L
F
G
F
V
L
R
T
S
-------
L
S
S
V
C
Y
I
F
E
S
N
N
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
A
L
H
A
E
L
D
R
----------------------------------------------------------------------------
27
HHSearch
50.40
99%
-180
- C1 -
-
2ELA
-
DP13A_HUMAN
A:
[496-633]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
H
Q
L
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
R
L
F
G
F
V
L
R
T
S
-------
L
S
S
V
C
Y
I
F
E
S
N
N
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
A
L
H
A
E
L
D
R
----------------------------------------------------------------------------