@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ELMO1_HUMAN: (2020-02-01 )
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
Atome Classification :
(20 SA)
.........10.....-------------...20........30........40....--.-...50....--....60-..-----------...----...--------70........80........90...----.----....100......-.110........120.--......130.......140.--.-...-..150-.........160.......170......--.180.......190....---...200.......210.--------......220----------.-----------.-------------.....230..---.--....240.......250...---.-.-..260......----.270.......280.......290-----.......300.....--.---.310---.---.---.-......320.......330.......340...-.....350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.-......640.......650........660.......670......-.680.......690.-......700.......710.......720.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPP
P
A
D
I
V
K
V
A
I
EWPG-------------AY
P
K
L
M
EIDQKK
P
L
S
A
I
I
K
E
VCDGWSLAN--H-
E
Y
F
A
L
Q
HAD--SS
N
F
Y
I
-TE-----------KNR----NEI--------KNG
T
I
L
R
L
TTSPA
Q
N
A
Q
Q
L
H
E
R
I
Q
S----S----SM
D
A
K
L
E
A
L
K
D
L
A
-
S
L
S
-
R
D
V
T
F
A
Q
E
F
INL--D
G
I
S
L
L
T
Q
M
V
E
S
G
T
E
R
Y
Q
K
L
--
Q
-
K
I
M
-
K
P
C
---
F
G
D
M
L
S
F
T
L
T
A
F
V
E
L
M
D
HGIVSW
D
T
F
S
V
--
A
F
I
K
K
I
A
S
F
V
NKSA
I
D
I
S
---
I
L
Q
R
S
L
A
I
L
E
S
M
VLN
S
H
--------
D
L
Y
Q
K
V
A
Q
E
----------
I
-----------
T
-------------
I
G
Q
L
I
PHLQG---S--DQE
I
Q
T
Y
T
I
A
V
I
N
A
L
FLKA
P
---
D
-
E
-
R
R
Q
E
M
A
N
I
L
A
Q
----
K
Q
L
R
S
I
I
L
T
H
V
I
R
A
Q
R
A
I
N
N
E
M
A
H
-----
Q
L
Y
V
L
Q
V
L
T
F
N
L
L
E
D
--
R
---
M
M-----T---K---M-D
P
Q
D
Q
A
Q
R
D
I
I
F
E
L
R
R
I
AFDAESEPNN-SSG
S
-
M
E
K
R
K
S
M
Y
T
R
D
Y
K
KLGFINHVNPAMDFTQTPP
G
M
L
A
L
D
N
M
L
Y
F
A
K
HHQ
D
A
Y
I
R
I
V
LENSSREDKHECPFGR
S
S
I
E
L
T
K
M
L
C
E
I
L
K
VGEL
P
S
E
T
C
NDFH
P
M
F
F
THDR
S
F
E
E
F
F
C
I
C
I
Q
L
L
N
K
T
W
K
E
M
RA
T
S
E
D
F
N
K
V
M
Q
V
V
K
E
Q
V
M
R
A
LTTKPS
S
L
D
Q
F
K
S
K
L
QNL
S
Y
T
E
I
L
K
I
R
Q
S
ERM
N
Q
E
D
FQSR
P
I
L
E
L
K
E
KI
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
RRQD
K
F
W
Y
C
R
LSPN
H
K
V
L
H
YGDLEESPQGEVP
H
D
S
L
Q
DKLPV
A
D
I
K
A
V
VTGKDCPH
M
K
E
KGALKQ-
N
K
E
V
L
E
L
A
F
S
I
LYDSN
C
-
Q
L
N
F
IAPDKH
E
Y
C
I
WTD
G
L
N
A
L
L
G
K
D
M
M
-
S
D
L
T
R
N
D
L
D
T
L
L
S
M
E
-
I
K
L
R
L
L
D
LENIQIPDAPPPIPKEPSNY
D
F
V
Y
DCN
8
HHSearch
97.77
75%
-144
- C6 -
-
6IDX
-
?
A:
[9-519]
----
S
D
I
V
K
V
A
I
E
W
P
G
-------------
A
N
A
Q
L
L
E
I
D
Q
K
R
P
L
A
S
I
I
K
E
V
C
D
G
W
S
L
P
N
--
P
-
E
Y
Y
T
L
R
Y
A
D
--
G
P
Q
L
Y
I
-
T
E
-----------
Q
T
R
----
S
D
I
--------
K
N
G
T
I
L
Q
L
A
I
S
P
S
R
A
A
R
Q
L
M
E
R
T
Q
S
----
S
----
N
M
E
T
R
L
D
A
M
K
E
L
A
-
K
L
S
-
A
D
V
T
F
A
T
E
F
I
N
M
--
D
G
I
I
V
L
T
R
L
V
E
S
G
T
K
L
L
------------
S
H
---
Y
S
E
M
L
A
F
T
L
T
A
F
L
E
L
M
D
H
G
I
V
S
W
D
M
V
S
I
--
T
F
I
K
Q
I
A
G
Y
V
S
Q
P
M
V
D
V
S
---
I
L
Q
R
S
L
A
I
L
E
S
M
V
L
N
S
Q
--------
S
L
Y
Q
K
I
A
E
E
----------
I
-----------
T
-------------
V
G
Q
L
I
S
H
L
Q
V
---
S
--
N
Q
E
I
Q
T
Y
A
I
A
L
I
N
A
L
F
L
K
A
P
---
E
-
D
-
K
R
Q
D
M
A
N
A
F
A
Q
----
K
H
L
R
S
I
I
L
N
H
V
I
R
G
N
R
P
I
K
T
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M
A
H
-----
Q
L
Y
V
L
Q
V
L
T
F
N
L
L
E
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--
R
---
M
M
-----
T
---
K
---
M
-
D
P
N
D
Q
A
Q
R
D
I
I
F
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L
R
R
I
A
F
D
A
E
-----------
T
E
K
R
K
A
M
Y
T
K
D
Y
K
M
L
G
F
T
N
H
I
N
P
A
M
D
F
T
Q
T
P
P
G
M
L
A
L
D
N
M
L
Y
L
A
K
V
H
Q
D
T
Y
I
R
I
V
L
E
N
S
S
R
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D
K
H
E
C
P
F
G
R
S
A
I
E
L
T
K
M
L
C
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I
L
Q
V
G
E
L
P
N
E
G
R
N
D
Y
H
P
M
F
F
T
H
D
R
A
F
E
E
L
F
G
I
C
I
Q
L
L
N
K
T
W
K
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M
R
A
T
A
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D
F
N
K
V
M
Q
V
V
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Q
I
T
R
A
L
P
S
K
P
N
S
L
D
Q
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K
S
K
L
R
S
L
S
Y
S
E
I
L
R
L
R
Q
S
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.33
73%
-144
- C6 -
-
6IDX
-
?
A:
[9-519]
----
S
D
I
V
K
V
A
I
E
W
P
G
-------------
A
N
A
Q
L
L
E
I
D
Q
K
R
P
L
A
S
I
I
K
E
V
C
D
G
W
S
L
P
N
--
P
-
E
Y
Y
T
L
R
Y
A
D
--
G
P
Q
L
Y
I
-
T
E
-----------
Q
T
R
----
S
D
I
--------
K
N
G
T
I
L
Q
L
A
I
S
P
S
R
A
A
R
Q
L
M
E
R
T
Q
S
----
S
----
N
M
E
T
R
L
D
A
M
K
E
L
A
-
K
L
S
-
A
D
V
T
F
A
T
E
F
I
N
M
--
D
G
I
I
V
L
T
R
L
V
E
S
G
T
K
-----------
L
-
L
S
H
---
Y
S
E
M
L
A
F
T
L
T
A
F
L
E
L
M
D
H
G
I
V
S
W
D
M
V
S
I
--
T
F
I
K
Q
I
A
G
Y
V
S
Q
P
M
V
D
V
S
---
I
L
Q
R
S
L
A
I
L
E
S
M
V
L
N
S
Q
--------
S
L
Y
Q
K
I
A
E
E
----------
I
-----------
T
-------------
V
G
Q
L
I
S
H
L
Q
V
---
S
--
N
Q
E
I
Q
T
Y
A
I
A
L
I
N
A
L
F
L
K
A
P
---
E
-
D
-
K
R
Q
D
M
A
N
A
F
A
Q
----
K
H
L
R
S
I
I
L
N
H
V
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R
G
N
R
P
I
K
T
E
M
A
H
-----
Q
L
Y
V
L
Q
V
L
T
F
N
L
L
E
E
--
R
---
M
M
-----
T
---
K
---
M
-
D
P
N
D
Q
A
Q
R
D
I
I
F
E
L
R
R
I
A
F
D
A
E
-----------
T
E
K
R
K
A
M
Y
T
K
D
Y
K
M
L
G
F
T
N
H
I
N
P
A
M
D
F
T
Q
T
P
P
G
M
L
A
L
D
N
M
L
Y
L
A
K
V
H
Q
D
T
Y
I
R
I
V
L
E
N
S
S
R
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D
K
H
E
C
P
F
G
R
S
A
I
E
L
T
K
M
L
C
E
I
L
Q
V
G
E
L
P
N
E
G
R
N
D
Y
H
P
M
F
F
T
H
D
R
A
F
E
E
L
F
G
I
C
I
Q
L
L
N
K
T
W
K
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M
R
A
T
A
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D
F
N
K
V
M
Q
V
V
R
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L
P
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P
N
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S
K
L
R
S
L
S
Y
S
E
I
L
R
L
R
Q
S
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
94.84
75%
-103
- C6 -
-
6IE1
2
?
A:
[10-517]
-----
D
I
V
K
V
A
I
E
W
P
G
-------------
A
N
A
Q
L
L
E
I
D
Q
K
R
P
L
A
S
I
I
K
E
V
C
D
G
W
S
L
P
N
--
P
-
E
Y
Y
T
L
R
Y
A
D
--
G
P
Q
L
Y
I
-
T
E
-----------
Q
T
R
----
S
D
I
--------
K
N
G
T
I
L
Q
L
A
I
S
P
S
R
A
A
R
Q
L
M
E
R
T
Q
S
----
S
----
N
M
E
T
R
L
D
A
M
K
E
L
A
-
K
L
S
-
A
D
V
T
F
A
T
E
F
I
N
M
--
D
G
I
I
V
L
T
R
L
V
E
S
G
T
K
L
L
------------
S
H
---
Y
S
E
M
L
A
F
T
L
T
A
F
L
E
L
M
D
H
G
I
V
S
W
D
M
V
S
I
--
T
F
I
K
Q
I
A
G
Y
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P
M
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V
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---
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L
Q
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L
A
I
L
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M
V
L
N
S
Q
--------
S
L
Y
Q
K
I
A
E
E
----------
I
-----------
T
-------------
V
G
Q
L
I
S
H
L
Q
V
---
S
--
N
Q
E
I
Q
T
Y
A
I
A
L
I
N
A
L
F
L
K
A
P
---
E
-
D
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K
R
Q
D
M
A
N
A
F
A
Q
----
K
H
L
R
S
I
I
L
N
H
V
I
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G
N
R
P
I
K
T
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M
A
H
-----
Q
L
Y
V
L
Q
V
L
T
F
N
L
L
E
E
--
R
---
M
M
-----
T
---
K
---
M
-
D
P
N
D
Q
A
Q
R
D
I
I
F
E
L
R
R
I
A
F
D
A
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S
D
P
S
N
A
P
G
S
G
-
T
E
K
R
K
A
M
Y
T
K
D
Y
K
M
L
G
F
T
N
H
I
N
P
A
M
D
F
T
Q
T
P
P
G
M
L
A
L
D
N
M
L
Y
L
A
K
V
H
Q
D
T
Y
I
R
I
V
L
E
N
S
S
R
E
D
K
H
E
C
P
F
G
R
S
A
I
E
L
T
K
M
L
C
E
I
L
Q
V
G
E
L
P
N
E
G
R
N
D
Y
H
P
M
F
F
T
H
D
R
A
F
E
E
L
F
G
I
C
I
Q
L
L
N
K
T
W
K
E
M
R
A
T
A
E
D
F
N
K
V
M
Q
V
V
R
E
Q
I
T
R
A
L
P
S
K
P
N
S
L
D
Q
F
K
S
K
L
R
S
L
S
Y
S
E
I
L
R
L
R
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.14
73%
-102
- C6 -
-
6IE1
2
?
A:
[10-517]
-----
D
I
V
K
V
A
I
E
W
P
G
-------------
A
N
A
Q
L
L
E
I
D
Q
K
R
P
L
A
S
I
I
K
E
V
C
D
G
W
S
L
P
N
--
P
-
E
Y
Y
T
L
R
Y
A
D
--
G
P
Q
L
Y
I
-
T
E
-----------
Q
T
R
----
S
D
I
--------
K
N
G
T
I
L
Q
L
A
I
S
P
S
R
A
A
R
Q
L
M
E
R
T
Q
S
----
S
----
N
M
E
T
R
L
D
A
M
K
E
L
A
-
K
L
S
-
A
D
V
T
F
A
T
E
F
I
N
M
--
D
G
I
I
V
L
T
R
L
V
E
S
G
T
K
-----------
L
-
L
S
H
---
Y
S
E
M
L
A
F
T
L
T
A
F
L
E
L
M
D
H
G
I
V
S
W
D
M
V
S
I
--
T
F
I
K
Q
I
A
G
Y
V
S
Q
P
M
V
D
V
S
---
I
L
Q
R
S
L
A
I
L
E
S
M
V
L
N
S
Q
--------
S
L
Y
Q
K
I
A
E
E
----------
I
-----------
T
-------------
V
G
Q
L
I
S
H
L
Q
V
---
S
--
N
Q
E
I
Q
T
Y
A
I
A
L
I
N
A
L
F
L
K
A
P
---
E
-
D
-
K
R
Q
D
M
A
N
A
F
A
Q
----
K
H
L
R
S
I
I
L
N
H
V
I
R
G
N
R
P
I
K
T
E
M
A
H
-----
Q
L
Y
V
L
Q
V
L
T
F
N
L
L
E
E
--
R
---
M
M
-----
T
---
K
---
M
-
D
P
N
D
Q
A
Q
R
D
I
I
F
E
L
R
R
I
A
F
D
A
E
S
D
P
S
N
-
A
P
G
S
G
T
E
K
R
K
A
M
Y
T
K
D
Y
K
M
L
G
F
T
N
H
I
N
P
A
M
D
F
T
Q
T
P
P
G
M
L
A
L
D
N
M
L
Y
L
A
K
V
H
Q
D
T
Y
I
R
I
V
L
E
N
S
S
R
E
D
K
H
E
C
P
F
G
R
S
A
I
E
L
T
K
M
L
C
E
I
L
Q
V
G
E
L
P
N
E
G
R
N
D
Y
H
P
M
F
F
T
H
D
R
A
F
E
E
L
F
G
I
C
I
Q
L
L
N
K
T
W
K
E
M
R
A
T
A
E
D
F
N
K
V
M
Q
V
V
R
E
Q
I
T
R
A
L
P
S
K
P
N
S
L
D
Q
F
K
S
K
L
R
S
L
S
Y
S
E
I
L
R
L
R
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
49.97
97%
-134
- C8 -
-
3A98
-
ELMO1_HUMAN
B:
[530-727]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
M
---------
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
S
N
C
-
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
G
K
D
M
M
-
S
D
L
T
R
N
D
L
D
T
L
L
S
M
E
-
I
K
L
R
L
L
D
L
E
N
I
Q
I
P
D
A
P
P
P
I
P
K
E
P
S
N
Y
D
F
V
Y
D
C
N
10
HHSearch
44.92
97%
-88
- C8 -
-
3A98
-
ELMO1_HUMAN
B:
[530-727]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
M
---------
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
-
S
N
C
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
G
K
D
M
M
-
S
D
L
T
R
N
D
L
D
T
L
L
S
M
E
-
I
K
L
R
L
L
D
L
E
N
I
Q
I
P
D
A
P
P
P
I
P
K
E
P
S
N
Y
D
F
V
Y
D
C
N
29
Fugue
44.65
95%
-148
- C8 -
-
2VSZ
-
ELMO1_HUMAN
A:
[527-673]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
G
S
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
M
K
------
E
-
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
S
N
C
-
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
--------------------------------------------------------
4
PsiBlast_PDB
44.65
100%
-149
- C8 -
-
2VSZ
-
ELMO1_HUMAN
A:
[532-673]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
M
K
E
-------
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
S
N
C
-
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
--------------------------------------------------------
28
Fugue
41.67
99%
-61
- C8 -
-
3A98
-
ELMO1_HUMAN
B:
[530-727]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
---------M
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
S
N
C
-
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
G
K
D
--M
S
D
L
T
R
N
D
L
D
T
L
L
S
-
E
M
I
K
L
R
L
L
D
L
E
N
I
Q
I
P
D
A
P
P
P
I
P
K
E
P
S
N
Y
D
F
V
Y
D
C
N
17
HHSearch
41.06
97%
-105
- C8 -
-
2VSZ
-
ELMO1_HUMAN
B:
[529-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
P
I
L
E
L
K
E
K
I
Q
P
E
I
L
E
L
I
K
Q
Q
R
L
N
R
L
V
E
G
T
C
F
R
K
L
N
A
R
R
R
Q
D
K
F
W
Y
C
R
L
S
P
N
H
K
V
L
H
Y
G
D
L
E
E
S
P
Q
G
E
V
P
H
D
S
L
Q
D
K
L
P
V
A
D
I
K
A
V
V
T
G
K
D
C
P
H
M
K
E
K
G
A
L
K
Q
-
N
K
E
V
L
E
L
A
F
S
I
L
Y
D
S
-
N
C
Q
L
N
F
I
A
P
D
K
H
E
Y
C
I
W
T
D
G
L
N
A
L
L
G
K
------------------------------------------------------
38
Fugue
39.37
11%
-60
- C6 -
-
1IAL
-
IMA1_MOUSE
A:
[70-496]
---
N
Q
G
T
V
N
W
S
V
E
D
I
V
-------------
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
--------------------------
Q
-----------
P
P
I
----
D
N
I
--------
I
R
A
G
L
I
P
K
F
V
S
F
------
L
G
K
T
D
C
S
----
P
----
I
Q
F
E
S
A
W
A
L
T
N
I
A
-
S
---
G
T
S
E
Q
T
K
A
V
V
D
G
--
G
A
I
P
A
F
I
S
L
L
A
S
P
H
---
A
H
I
--
S
-
E
Q
A
-
V
W
A
---
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
-------
A
I
--
D
P
L
L
A
L
L
A
V
P
D
L
S
T
L
A
C
G
---
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
--------
P
A
P
P
L
D
A
V
E
----------
Q
-----------
I
-------------
L
P
T
L
V
R
L
L
H
H
---
N
--
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
-
T
D
G
P
---
N
-
E
-
R
I
E
M
V
V
K
K
G
V
V
----
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
IVTGT
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
FP
S
---
L
L
-----
T
---
N
---
P
---
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
----------
A
G
R
---
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
S
-
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
--
T
V
E
Q
I
V
Y
L
V
H
C
G
-----------------
I
I
E
P
L
M
N
L
L
S
A
K
-----------------
D
T
K
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
L
G
-------------
E
T
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
----------
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
34.86
10%
-96
- C6 -
-
3QML
-
SIL1_YEAST
C:
[16-300]
----------------------------------------------------------------------------------------------------------------
G
D
Y
E
F
S
S
D
F
K
E
M
R
N
I
I
D
S
N
P
T
L
S
S
----
Q
----
D
I
A
R
L
E
D
S
F
D
R
I
M
-
E
F
A
-
H
D
Y
K
H
G
Y
K
I
I
T
H
--
E
F
A
L
L
A
N
L
S
L
N
E
N
L
P
---------
L
T
L
-
R
E
L
---
S
T
R
V
I
T
S
C
L
R
N
N
P
P
V
V
E
F
I
N
E
S
F
P
N
F
K
S
--
K
I
M
A
A
L
S
N
L
N
D
S
R
S
-
S
N
I
---
L
I
K
R
Y
L
S
I
L
N
E
L
P
V
T
S
E
--------
D
L
Y
S
T
V
V
L
Q
----------
N
-----------
V
-------------
Y
E
R
N
N
K
----------
D
K
Q
L
Q
I
K
V
L
E
L
I
S
K
I
L
K
A
D
M
YEL
Q
-
E
-
W
A
N
E
F
Q
E
M
V
Q
N
KSID
E
L
H
T
R
T
F
F
D
T
L
Y
N
L
K
K
I
F
K
S
D
I
T
I
-----
N
K
G
F
L
N
W
L
A
Q
Q
C
K
A
R
--
Q
---
S
N
LDNGL
Q
---
E
---
R
-
D
T
E
Q
D
S
F
D
K
K
L
I
D
S
R
H
L
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
34.62
18%
-12
- C6 -
-
3DAD
-
FHOD1_HUMAN
A:
[14-339]
-----
S
V
V
T
V
R
V
Q
Y
L
E
DTDPFASANFPEP
R
R
A
P
T
C
S
L
D
G
A
L
P
L
G
A
Q
I
P
A
V
H
R
L
L
G
A
P
L
--
K
L
E
D
S
A
L
Q
V
S
P
--
S
G
Y
Y
L
D
-
T
E
LSLEEQREMGF
Y
E
E
----
I
S
K
--------
G
R
K
P
T
L
I
L
R
T
Q
L
S
V
R
V
N
A
I
L
E
K
L
Y
S
----
S
----
S
G
P
E
L
R
R
S
L
F
S
L
K
Q
I
F
Q
-
E
D
K
D
L
V
P
E
F
V
H
S
--
E
G
L
S
C
L
I
R
V
G
A
A
A
D
---
H
N
Y
--
Q
-
S
Y
I
-
L
R
A
---
L
G
Q
L
M
L
-
F
V
D
G
M
L
G
V
V
A
H
---------
S
--
D
T
I
Q
W
L
Y
T
L
C
A
S
L
--
S
R
L
---
V
V
K
T
A
L
K
L
L
L
V
F
V
E
Y
S
E
--------
N
N
A
P
L
F
I
R
A
----------
V
-----------
N
SVASTTGAPPWAN
L
V
S
I
L
E
E
K
N
G
---
A
--
D
P
E
L
L
V
Y
T
V
T
L
I
N
K
T
L
A
A
L
P
---
D
Q
D
-
S
F
Y
D
V
T
D
A
L
E
Q
----
Q
G
M
E
A
L
V
Q
R
H
L
G
T
A
G
T
--
D
V
D
L
R
T
-----
Q
L
V
L
Y
E
N
A
L
K
L
E
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
33.66
15%
-58
- C6 -
-
3OBV
2
DIAP1_MOUSE
D:
[4-261]
------------------------------------------------------------------------------------------------------------------------
R
S
A
M
M
Y
I
Q
E
L
R
S
G
L
R
D
MHLL
S
----
C
L
E
S
L
R
V
S
L
N
N
-------
N
P
V
S
W
V
Q
T
F
G
A
---
E
G
L
A
S
L
L
D
I
L
K
R
L
H
D
E
--
K
E
--
E
T
S
G
---
N
Y
---
D
S
R
N
Q
H
E
I
I
R
C
L
K
A
F
M
N
N
-
K
F
G
I
K
T
M
L
E
TE
E
G
I
L
L
L
V
R
A
M
D
P
A
--
V
P
N
---
M
M
I
D
A
A
K
L
L
S
A
L
C
I
L
P
Q
PE------
D
M
N
E
R
V
L
E
A
----------
M
TERAEMDEVE-
R
-------------
F
Q
P
L
L
D
G
L
K
S
---
G
T-
S
I
A
L
K
V
G
C
L
Q
L
I
N
A
L
I
T
P
A
E
---
E
-
L
D
F
R
V
H
I
R
S
E
L
M
R
----
L
G
L
H
Q
V
L
Q
E
L
R
E
I
----
E
N
E
D
M
K
V
-----
Q
L
C
V
F
D
E
Q
G
D
E
D
F
F
D
--
L
---
K
G
RLDD-
I
---
R
---
M
-
E
M
D
D
F
--
G
E
V
F
Q
I
I
L
N
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
32.93
19%
-15
- C6 -
-
3DAD
-
FHOD1_HUMAN
A:
[37-336]
---------------
P
-------------
R
R
A
P
T
C
S
L
D
G
A
L
P
L
G
A
Q
I
P
A
V
H
R
L
L
G
A
P
L
KL
E
-
D
S
A
-
L
Q
V
S
P
---
S
G
Y
Y
L
D
T
E
-----------
L
S
L
EEQR
E
M
-GFYEEISK
G
R
K
P
T
L
I
L
R
T
Q
L
S
V
R
V
N
A
I
L
E
K
L
Y
S
----
S
----
S
G
P
E
L
R
R
S
L
F
S
L
K
-
Q
I
F
Q
E
D
K
D
L
V
P
E
F
V
H
S
--
E
G
L
S
C
L
I
R
V
G
A
A
A
----------------
D
-----
H
N
Y
Q
S
Y
I
L
R
A
L
G
Q
L
M
L
F
-
V
D
G
M
L
G
V
V
A
HS
D
T
I
Q
W
L
Y
T
L
C
A
S
L
--
S
R
L
---
V
V
K
T
A
L
K
L
L
L
V
F
V
E
Y
S
E
--------
N
N
A
P
L
F
I
R
A
VNSVASTTGA
P
-----------
P
-------------
W
A
N
L
V
S
I
L
E
E
KNG
A
--
D
P
E
L
L
V
Y
T
V
T
L
I
N
K
T
L
A
A
L
P
---
D
-
Q
D
S
F
Y
D
V
T
D
A
L
E
Q
----
Q
G
M
E
A
L
V
Q
R
H
L
G
T
--
A
G
T
D
V
D
L
R
T
-----
Q
L
V
L
Y
E
N
A
L
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
31.99
15%
-49
- C6 -
-
4UWX
2
DIAP1_MOUSE
A:
[4-235]
------------------------------------------------------------------------------------------------------------------------
F
S
A
M
M
Y
I
Q
E
L
R
S
G
L
R
D
----
M
HLLS
C
L
E
S
L
R
V
S
L
N
N
-------
N
P
V
S
W
V
Q
T
F
G
A
---
E
G
L
A
S
L
L
D
I
L
K
R
L
H
D
E
--
K
------
G
---
N
Y
---
D
S
R
N
Q
H
E
I
I
R
C
L
K
A
F
M
N
N
-
K
F
G
I
K
T
M
L
E
TE
E
G
I
L
L
L
V
R
A
M
D
P
A
--
V
P
N
---
M
M
I
D
A
A
K
L
L
S
A
L
C
I
L
P
Q
PE------
D
M
N
E
R
V
L
E
A
----------
M
TERAEMDEVE-
R
-------------
F
Q
P
L
L
D
G
L
K
S
---
G
T-
S
I
A
L
K
V
G
C
L
Q
L
I
N
A
L
I
T
P
A
E
---
E
-
L
D
F
R
V
H
I
R
S
E
L
M
R
----
L
G
L
H
Q
V
L
Q
E
L
R
E
I
----
E
N
E
D
M
K
V
-----
Q
L
C
V
F
D
E
Q
G
D
E
D
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
31.34
12%
-52
- C6 -
-
4DVG
-
?
B:
[64-312]
----------------------------------------------------------------------------------------------------------------------
A
I
T
D
P
K
Y
L
A
D
L
L
K
T
R
D
D
M
----
D
----
L
L
N
E
M
V
V
V
F
R
S
-------
S
S
V
S
F
I
K
T
F
V
S
V
--
G
G
L
A
N
L
M
A
I
Y
K
K
K
I
E
A
---
E
--
N
-
S
N
---
T
A
----
I
D
E
E
R
K
C
C
E
V
L
R
Y
V
F
A
E
-
E
D
A
T
V
A
L
I
E
ID
G
G
V
E
L
L
L
K
G
M
N
S
K
--
R
I
T
PDN
Q
L
D
I
L
L
E
I
T
L
T
S
S
M
V
E
H
PSQEGLYL
G
G
D
V
C
V
M
N
A
----------
F
SNLVSEGVDMK
K
-------------
F
L
S
F
F
S
L
F
S
K
---
S
K-
S
E
K
F
K
H
A
S
L
V
L
I
N
N
L
I
D
Q
-
P
---
E
-
L
E
H
R
M
D
V
R
N
S
F
I
E
----
I
G
L
V
N
E
L
E
N
M
K
N
T
E
-
W
M
K
I
D
K
I
K
D
-----
S
I
N
D
F
F
D
S
W
E
E
D
K
K
E
--
V
ESR
F
D
DL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
30.67
13%
-8
- C6 -
-
3EG5
-
?
D:
[15-324]
------------------------------------------
V
L
V
L
F
E
Q
M
L
V
D
M
N
L
N
E
--
E
-
K
Q
Q
P
L
R
E
K
D
IV
I
K
R
E
M
V
-
S
Q
-----------
Y
L
H
----
T
-----------------
S
S
R
S
A
M
M
Y
I
Q
E
L
R
S
G
L
R
D
MHLL
S
----
C
L
E
S
L
R
V
S
L
T
S
-------
H
P
V
S
W
V
Q
T
F
G
A
---
E
G
L
A
S
L
L
D
I
L
K
R
L
H
D
E
--
K
---------------
D
S
R
N
Q
H
E
I
I
R
C
L
K
A
F
M
N
N
-
K
F
G
I
K
T
M
L
E
TE
E
G
I
L
L
L
V
R
A
M
D
P
A
--
V
P
N
---
M
M
I
D
A
A
K
L
L
S
A
L
C
I
L
P
Q
PE------
D
M
N
E
R
V
L
E
A
----------
M
TERAEMDEVE-
R
-------------
F
Q
P
L
L
D
G
L
K
S
---
G
T-
S
I
A
L
K
V
G
C
L
Q
L
I
N
A
L
I
T
P
A
E
---
E
-
L
D
F
R
V
H
I
R
S
E
L
M
R
----
L
G
L
H
Q
V
L
Q
E
L
R
E
I
----
E
N
E
D
M
K
V
-----
Q
L
C
V
F
D
E
Q
G
D
E
D
F
F
D
--
L
---
K
G
RLDD-
I
---
R
---
M
-
E
M
D
D
F
--
G
E
V
F
Q
I
I
L
N
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
29.83
14%
-52
- C6 -
-
4YDH
-
FMNL1_HUMAN
A:
[123-397]
--------------------------------------------------------------------------------------------------------------------------------------------------
L
R
E
L
E
T
S
L
R
T
-------
N
H
I
G
W
V
Q
E
F
L
N
E
EN
R
G
L
D
V
L
L
E
Y
L
A
F
A
Q
C
S
V
T
Y
D
MS
R
-
K
A
L
R
N
S
R
IVS
Q
K
D
D
V
H
V
C
I
M
C
L
R
A
I
M
N
Y
-
Q
S
G
F
S
L
V
M
N
HP
A
C
V
N
E
I
A
L
S
L
N
N
K
--
N
P
R
---
T
K
A
L
V
L
E
L
L
A
A
V
C
L
V
R
---------
G
G
H
D
I
I
L
A
A
----------
F
DNFKEVCGEQH
R
-------------
F
E
K
L
M
E
Y
F
R
N
---
E
DS
N
I
D
F
M
V
A
C
M
Q
F
I
N
I
V
V
H
S
V
E
---
N
-
M
N
F
R
V
F
L
Q
Y
E
F
T
H
----
L
G
L
D
L
Y
L
E
R
L
R
L
T
----
E
S
D
K
L
Q
V
-----
Q
I
Q
A
Y
L
D
N
I
F
D
-
V
G
A
--
L
---
L
E
DTE--
T
---
K
NAV
L
E
H
M
E
E
L
--
Q
E
Q
V
A
L
L
T
E
R
L
R
D
A
E
N
E
------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
29.50
13%
-49
- C6 -
-
4YDH
-
FMNL1_HUMAN
C:
[123-397]
--------------------------------------------------------------------------------------------------------------------------------------------------
L
R
E
L
E
T
S
L
R
T
-------
N
H
I
G
W
V
Q
E
F
L
N
E
EN
R
G
L
D
V
L
L
E
Y
L
A
F
A
Q
C
S
V
T
Y
D
M---
K
A
L
R
N
S
R
IVS
Q
K
D
D
V
H
V
C
I
M
C
L
R
A
I
M
N
Y
-
Q
S
G
F
S
L
V
M
N
HP
A
C
V
N
E
I
A
L
S
L
N
N
K
--
N
P
R
---
T
K
A
L
V
L
E
L
L
A
A
V
C
L
V
R
---------
G
G
H
D
I
I
L
A
A
----------
F
DNFKEVCGEQH
R
-------------
F
E
K
L
M
E
Y
F
R
N
---
E
DS
N
I
D
F
M
V
A
C
M
Q
F
I
N
I
V
V
H
S
V
E
---
N
-
M
N
F
R
V
F
L
Q
Y
E
F
T
H
----
L
G
L
D
L
Y
L
E
R
L
R
L
T
----
E
S
D
K
L
Q
V
-----
Q
I
Q
A
Y
L
D
N
I
F
D
-
V
G
A
--
L
---
L
E
DTE--
T
KNA
V
---
L
E
H
M
E
E
L
--
Q
E
Q
V
A
L
L
T
E
R
L
R
D
A
E
N
E
------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------