Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MINIIVEHHFA--ELPKKINRITIGICNEVYRIALDDHDVIIRLSTSD----KYLRGSEVHIPEFKQLGIKVPDILASDYSQTRIPLCYQIQSKIEGQ-DLGVVIESLNQTELMGLAREIATIFSKVKTLPVTTQFGVIWGGDNDVSDSWAERMKLWIQESIKHGRLTGIMNQQFEGIAKDLYRNYETYFDS-IKPTMYY-GDICSKNVMINQGVFNGLVDLDGLTQGDPLEALSRIKLSWYGTSHGEFYYNALIKELE--LTQSEQQLITVYALLNQLSWMCENGIQFNQNTKPIVNWEKAESDKNIYLQLASDLNNK 4R78 Chain:A ((26-279)) --KEKISSLLSQEEEVLSVEQL-GGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDI------EAGIKVNEYIESAITLDST-------SIKTKFDKIAPILQTIHTSAKEL-RGEFAP--FEEIKKYESLI----EEQIP---------YANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAAL---FLESEFTSQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKE------------------------------

General information: TITO was launched using: RESULT: Template: 4R78.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1076 -3049 -2.83 -12.55 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -2.83 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.336

(partial model without unconserved sides chains): PDB file : Tito_4R78.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4r78-query.scw PDB file : Tito_Scwrl_4R78.pdb: