Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVGETVDRIVAD-ALEAEVRSRYRPRSGSVAETVVCRLETGDGDGDEPPSRVVCKRGGASV-WTGDVIEPLVLEYMTAATDLPVPRVLASGSFADGSNDPLERWAIYEFREGANPGPRY-HKLEPTVRRRLVADAGELLGRLHGTSALAFDRVGGLARGADDRSLRLREPDGWHA-V-------DPGWPLTRV----PVP-L-AGDEDCRPVLTHGDYQPSNLLVDD---DGAVTAVLDWGNAHVTHAEYALARAEARFVDVYAGRLPRAERKQLQELFRRTYANCAPLETGFDRRAPVYKLLWVAQSGANYLRIAREPRGRRQLRTQVRRLVE 3TDW Chain:A ((4-275)) -NKLHYTTMIMTQFPDISIQSVESLGEGFRNYAILVN----------G--DWVFRFPKSQQGADELNKEIQLLPLLVGCVKVNIPQYVYIGKRS-----DGNPFVGYRKVQGQILGEDGMAVLPDDAKDRLALQLAEFMNELSAFP---VETAISAGVPVTNL---KNKILLLSEAVEDQVFPLLDESLRDYLTLRFQSYMTHPVYTRYTPRLIHGDLSPDHFLTNLNSRQTPLTGIIDFGDAAISDPDYDYVYLLEDCG------------ELF-TRQVMAYRGEVDLDT-HIRKVSLFVTFDQVSYLL------------------------

General information: TITO was launched using: RESULT: Template: 3TDW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1071 -11768 -10.99 -46.70 target 2D structure prediction score : 0.56 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -10.99 2D Compatibility (Sec. Struct. Predict.) : 0.56 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.252

(partial model without unconserved sides chains): PDB file : Tito_3TDW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3tdw-query.scw PDB file : Tito_Scwrl_3TDW.pdb: