Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MHSEHPFSQLIPDVIIDAVESSSDQYTNYQIYPLNSYENRVYQVGMEDGPALIAKFYRPDRWSNKQILEEHTALSLLEKKG-VPVAAPLAFNGQTLFEHANFRLSLTNKVIGNAPEAEDLDDLFQIG-ELIGETHSVLTKLPLIGRQSP-----SLIESIESQIKW-LLASP-SDVSK--TQTSTLPHALQKEFITLFDSLMQMSKDVMSQSGSIQRQT---IHGDCHASNLLKSITG-MVLLDFDDIQTGYPCQDIWL-HLTA---KEHHQQQLSEL-IEGYESHHPFDRRSLAL-IDA----FKLERTVRYAAWLSQRWNDPAFPKAFPWFGTQDYWLGLRKELIDLKAQWRNDTE 2Q83 Chain:A ((11-346)) ------LSAEDAKKLTELAENVLQGW-DVQAEKIDVIQALVWKVHTDSGAVCLKRIHRP----EKKALFSIFAQDYLAKKGMNVPGILPNKKGSLYSKHGSFLFVVYDWIEGRPFELTV-KQDLEFIMKGLADFHTASVGYQPPNGVPIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLLQSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIPLLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSALPKEELESAFEYERIKANALRQLI--------------

General information: TITO was launched using: RESULT: Template: 2Q83.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1290 -12066 -9.35 -39.30 target 2D structure prediction score : 0.48 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -9.35 2D Compatibility (Sec. Struct. Predict.) : 0.48 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.313

(partial model without unconserved sides chains): PDB file : Tito_2Q83.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2q83-query.scw PDB file : Tito_Scwrl_2Q83.pdb: