Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEQVQADRMILEDLLVSIQRDLGLVV-HEAISIRRGWLNLKWKLETDQGTYLLKQYNRERFKLYDEEVLLMAFSQQIRLRR-RGVKCPKLLTNEGRYFLKS-----DQGERFMVMEFCEGQLVAPGGTNADQMRALGREVALMHRVLNDGSLGVKDKP-QFVPPSRMERLDYWKRVMEQAAESEIPEVLTALETQYTATE-RFRDE-LNPMQPGWAHRDVWVDNLLFRPA---GVAAILDFDRLNYDYPQLDIARAVLSCALHSELDVVLVSAFMEGYREEREVPKGYLVQGIRWLWYMESVWWVNANILEHQGPPARFAWEMDWLAKHLDMLPELLEQV 6EF6 Chain:A ((27-302)) ----------DVTIAQQALTHYDVSDNASLRLL-NLSENATYLVEDGEHQSILRVHRQDYH---QPHEIESELDWLAALRTDSDVTVPTVVPARDGRRVVTVDPAD-VPRHVVHFEMVGGAEPDEESLTLDDFQTLGRITASLHEHSQRWTRPAGFGRFSWDWEHCLGDTPRWGRWQDAEG--VGASETALLTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANLLVDSSTPQRTITVIDFDDCGFGWYFYDFGTAVSFIEHD-PRLGEWQESWVAGYRSRRELPAADEAM-------------------------------------------------

General information: TITO was launched using: RESULT: Template: 6EF6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1167 -616 -0.53 -2.37 target 2D structure prediction score : 0.60 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -0.53 2D Compatibility (Sec. Struct. Predict.) : 0.60 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.277

(partial model without unconserved sides chains): PDB file : Tito_6EF6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6ef6-query.scw PDB file : Tito_Scwrl_6EF6.pdb: