Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -------------MKKNELPIEQI--EKINFAVRKGLGTNNWELMSLLSGGLTGIPVYRIIVENKSYAIKLEDVNDKDFDLQRS----------------YKILE-TVSSQGIAPLVYFTDADQGIVLMKYIESKPRPEASPETIQKFSSLIRELHAKNSFPKWKSVIEILELVYQRLTLEYKKSKLIKESMHEINKMINVLFDQN-DIRSCHCDLNPVNILFD---GEKYFFVDWQAASPQSFYFDLAYCSNWFYFYNEDLCALFLKSYFGREVTEEENAKYYLMRIFTYIYLGIGFISLPFKENQNIPILSDENIEKLPSYLKFMQSLGSGVVDLENADVQQQFGFIFLKTAIKMMDQRYKHAYEFLLNKKTIN--- 4OCV Chain:A ((24-378)) TNEALFDVASHFALEGTVDSIEPYGDGHINTTYLVTTDGPRYILQRMNTGIFPD--TVNLMRNVELVTSTLKAQGKETLDIVRTTSGDTWAEIDGGAWRVYKFIEHTMSYNLVPNPDVFREAGRAFGDFQNFLSGFDANQLTETIAHFHD------TPHRFEDFKKALAADEL--GRAAGCGPEIEFYLSHADQYAVVMDGLRDGSIPLRVTHNDTKLNNILMDATTGKARAIIDLDTIMPGSMLFDFGDSIRFGASTALEDERDLDKVHFS----------TELFRAYTEGFVGELRDSITAREAELLPFSG--NLLTMECGMRFLADYLEGDVYFATKY--PEHNLVRSRTQIKLVREMEQRADETRAIVADVMETT

General information: TITO was launched using: RESULT: Template: 4OCV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1532 -23799 -15.53 -75.31 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -15.53 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.164

(partial model without unconserved sides chains): PDB file : Tito_4OCV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4ocv-query.scw PDB file : Tito_Scwrl_4OCV.pdb: