Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPARKRRQGGLSLEEEEEEDANSESEGSSSEEED-DAAEQE----KGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGLKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP 6I26 Chain:A ((753-3804)) --EEDAGETETALDEEE----GAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGG----EQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGAGADATDTQEQD--------DVGGSG----TTQNTYEEDQEDVTKNN--------EESREEATAALKQLGDSMKEYHRRRQDI----KEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGS------ATQDQLQTID----------------EDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDI--

General information: TITO was launched using: RESULT: Template: 6I26.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 731 176818 241.88 733.68 target 2D structure prediction score : 0.45 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : 241.88 2D Compatibility (Sec. Struct. Predict.) : 0.45 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.102

(partial model without unconserved sides chains): PDB file : Tito_6I26.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6i26-query.scw PDB file : Tito_Scwrl_6I26.pdb: