Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MMIWGDGTFVMASGQLLCFARLFLLVPQLSSDAPDTILPDILEAFERHQDLHRVCGSPLSARPQPGLTNRVFRLEAEKGTFFLRLPRLEAAGNIDRKAEARNLMLAAATGIAVPPVFCDAEAGILVTRAVKVSGSPAALSEQPSYS----LARALGEALGQLHGSGVTFEGLLDPDSVLQAQ-----WQGLRDAVRCREEMTGLEIVLQPIGAATADGAGPALVPSHGDPSPGNCLMSCD-QLWLIDWEFSGMSDPAWDLAYAVLEHEMSADEEQVFLQAYAATGAAVPEADRLCVMKAKCDAVSALWALEQVAAGRDEDVFLPFARQRRGRALRQLARLS 4R78 Chain:A ((40-301)) ----------------------------------------------------------LSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFS------LEKRLADLGVDRK--------SCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSH-EKIAIYKILQDTIWSLWTVYKEEQGED---FGDYGVNRYQRAVKGLA---

General information: TITO was launched using: RESULT: Template: 4R78.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1154 -7497 -6.50 -29.75 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.70 3D Compatibility (PKB) : -6.50 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.70 QMean score : 0.238

(partial model without unconserved sides chains): PDB file : Tito_4R78.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4r78-query.scw PDB file : Tito_Scwrl_4R78.pdb: