Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKHEKLKQLSPLLKQAISFQPMTSGFSGDRTFLVTTPSEKLVLKLSDIQKYASLKKKTSILQNLKKRGVLCSEVMEVGVSAEQNCTFRIFPFIEGE-NARASIRLLTEEEQYKIGRRAGRDLRIMHTCDAPTYVAPWDDRVLAKHERYVYAYQSSGV-AFSHDQFVLDFIQSHADVV--KERPNQFQHDDFHVGNIIIQRHQYAGVIDFDQSDWGDPIHDFYKLSLFSRESSIPFSAGQLDAYLSTQTTHDFWLLFSIYTAMSCFSSIVWTLSYDPGHVKDMVNRVERMLTDHKRFTQLTPVWYTDWLDSCV 3DXQ Chain:A ((8-260)) ----AKLAAIPMLAGYTGPLERLGGLTN-LVFRA----GDLCLRIPGK--YINRANEAVAAREAAKAGVS-PEVLHVDP----ATGVMVTRYIAGAQTMSPEKFK----TRPGSPARAGEAFRKLHGSGAVFPFRFE---LFAMIDDYLKVLS--NVTLPAGYHDVVREAGGVRSALAAHPLPLAACHCDPLCENFLDTG-ERMWIVDWEYSGMNDPLWDLGDLS-VEGKFNANQDEELMRAYFGGEARPAERGRVVIYKAMCDLLWTLWGLIQ--------------------------------------

General information: TITO was launched using: RESULT: Template: 3DXQ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1138 -21097 -18.54 -86.82 target 2D structure prediction score : 0.55 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -18.54 2D Compatibility (Sec. Struct. Predict.) : 0.55 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.193

(partial model without unconserved sides chains): PDB file : Tito_3DXQ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3dxq-query.scw PDB file : Tito_Scwrl_3DXQ.pdb: