Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEQLRAELSHLLGEKL-SRIECVNEKADTALWALYDSQGNPMPLMARSFSTP---GKARQLAWKTTMLARSGTVRMPTIYGVMTHEE--HPGPDVLLLERMRGVSVEAPARTPERWEQLKDQIVEALLAWHRQDSRGCVGAV--DNTQENFWPSWYRQHVEVLWTTLNQFNNTGLTMQDKRILFRTRECLPALFEGFNDNCVLIHGNFCLRSMLKDSRSDQLLAMVGPGLMLWAPREYELFRLMD---NSLAEDLLWSYLQRAPVAESFIWRRWLYVLWDEVAQLVNTGRFSRRNFDLASKSLLPWLA 5IGH Chain:A ((17-257)) ---------ARHGLKLHGPLTVNELGLDYRIVIATVDDGR--RWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMVIQPGSSTPDWV-VPQDSEVFAESFATALAALHAVPISAA-VDAGMLIRTPTQARQKVADDVDRVRRE--------FV-VNDKRLHRWQRWLDDDS-SWPDFSVVVHGDLYVGHVLIDN-TERVSGMIDWSEARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGR-------------------------------------------

General information: TITO was launched using: RESULT: Template: 5IGH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 901 1909 2.12 8.30 target 2D structure prediction score : 0.52 Monomeric hydrophicity matching model chain A : 0.60 3D Compatibility (PKB) : 2.12 2D Compatibility (Sec. Struct. Predict.) : 0.52 1D Compatibility (Hydrophobicity) : 0.60 QMean score : 0.226

(partial model without unconserved sides chains): PDB file : Tito_5IGH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5igh-query.scw PDB file : Tito_Scwrl_5IGH.pdb: