Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MADSARYTFNMAGIIMHPGEKRVLLRAVQGGWMLPQVEWQADEYSSWKEVARFNREMQG---LLDVCLSTVRCLGEDFERATMHFSRIYVMELHSSYDNLPADACWIDIEDLKEFMITPEEHLVWLEEWLAKRDEEERTPWYHPDWLAKAKVWIEQALAEPEAQPLVSIEQVGVAERGCLLRVQTKENAFYFKALPAFFRHELTLLQHLARYRVGCVPALVAVDEREHRLLMHDFGSKHLDQSLDLADWQEALRRYAILQIDHI---------QIDHIQIDHSAQVEQLEELGCPRLPL--ATLPDQLERLLTSEQSLLFDTPTALSLEQVRRLHDALPLIRSLCQELAGYGLPETLEHGDLHAQNIALSGGDYLYFDWTDSCIAHPFFSLYPFLLDIEARWPEARIRLREAYLQPWERYAARAQLVEAFELAQRLAPLHLAMLYATLIIPHMKARWEMQHGVPLNLKVLLDRLHDAG 1Z05 Chain:A ((34-429)) -------------DHIKQINAGRVYKLIDQKGPISRIDLSKESELAPASITKITRELIDAHLIHETTVQEAISRGRPAVGLQTNNLGWQFLSMRLGRGYLTIALHELGGEVLIDTKIDIHEI--------------------DQDDVLARLLFEIEEFFQTYAAQLDRVTSIAITLPG---LVNSEQGIVLQMPHYNV--KNLALGPEIYKAT--GLPVFVANDTRAWALAEKLFGHSQDVDNSVLISIHHGLG-AGIVLDGRVLQGRHGNIGELGHIQIDPQGKRCHCGNYGCLETVASSQAIRDQVTARIQAGEPSCLATVEEISIEDICAAAA----------------------DGDPLAVDVIQQLGRYLGAAIAIVINLFN-----PEKILIGGVINQAKSILYPSIEQCIREQSLPVYHQDLKLVESRFYKQATMPGAALIKQALYDG------------LLLMKVVEG--

General information: TITO was launched using: RESULT: Template: 1Z05.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1998 -40590 -20.32 -106.26 target 2D structure prediction score : 0.41 Monomeric hydrophicity matching model chain A : 0.62 3D Compatibility (PKB) : -20.32 2D Compatibility (Sec. Struct. Predict.) : 0.41 1D Compatibility (Hydrophobicity) : 0.62 QMean score : 0.211

(partial model without unconserved sides chains): PDB file : Tito_1Z05.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1z05-query.scw PDB file : Tito_Scwrl_1Z05.pdb: