Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKRTEITFDFGTVPGAMRPYLEQATIYDSSCSEAAKTLFVEGA-EHAFLKICA---GGSLERECRMTRFMHGLGLA-PDVIAYESDGERDYLLTEAVEGQDGAEAVHLEQPDRLAAVFGESLRMLHSLPVDGCPYPH----RTAEMLEEAID----------K-----GI-DPGLVHRLENFTSDDVLIHGDYCLPNVILDRF--SFRSFIDVGNGGVGDRHFDLYWGLWTLRYN----LKTDRYHERFLDAYGRQ---DVDADRLADFTSFIEHSA 4H05 Chain:A ((17-266)) ------------------------WVVVEDGASGAGVYRLRGGGRELFVKVAALGAGVGLLGEAERLVWLAEVGIPVPRVVEGGGDERVAWLVTEAVPGRPASARWPREQRLDVAVALAGLARSLHALDWERCPFDRSLAVTVPQAARAVAEGSVDLEDLDEERKGWSGERLLAELERTRPADEDLAVCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFG-PECSAAFLREYGRGWDGAVSEEKLAFYRLLDEF--

General information: TITO was launched using: RESULT: Template: 4H05.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 950 -5487 -5.78 -25.40 target 2D structure prediction score : 0.67 Monomeric hydrophicity matching model chain A : 0.69 3D Compatibility (PKB) : -5.78 2D Compatibility (Sec. Struct. Predict.) : 0.67 1D Compatibility (Hydrophobicity) : 0.69 QMean score : 0.384

(partial model without unconserved sides chains): PDB file : Tito_4H05.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4h05-query.scw PDB file : Tito_Scwrl_4H05.pdb: