Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence AKCLVQLKNAQDTVVSSFEALAGVRKVVQAKGFKWMCKTAIEDCHPYGCIIPKGLTPVGTV---- 1QME Chain:A ((645-702)) AEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDV-----RANTAI-KDIKKI-TLTLGD

General information: TITO was launched using: RESULT: Template: 1QME.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 174 -28204 -162.09 -522.29 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.67 3D Compatibility (PKB) : -162.09 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.67 QMean score : 0.296

(partial model without unconserved sides chains): PDB file : Tito_1QME.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1qme-query.scw PDB file : Tito_Scwrl_1QME.pdb: