Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRTYTFDQVEKAIEQLYPDFTINTIEISGEGNDCIAYEINRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLP--LPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQSQNQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLMED-DEEYGMEFVSKILNHYKHKDIPTVLEKYRMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSIKIK 6CAV Chain:D ((19-298)) ------------IEHYFDNFKVDSIEIIGS---SVAYLVNNEYIFKTKF-------YAKEKAIYNFLNTNLETNVKIPNIEYSYISDE---LSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDI-SECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESF-MERLNATTVFEGKKCLCHNDFSCNHLLLDG-NNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEI------

General information: TITO was launched using: RESULT: Template: 6CAV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain D - contact count / total energy / energy per contact / energy per residue : 1191 22758 19.11 85.24 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain D : 0.77 3D Compatibility (PKB) : 19.11 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.481

(partial model without unconserved sides chains): PDB file : Tito_6CAV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6cav-query.scw PDB file : Tito_Scwrl_6CAV.pdb: