Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSRPVPADLLEITDALLPGAPLDSARLAEHGNMHHVVLLPGIAAVRVSKRAGAAAELPRRVGILHAVAAAG-MPFAVPEPMTAVTTFGERAAVAVSWIDGASLPEG----------TGDPTVFGPLLDALREVRISPELEAALHRPRRRADDGSGWADILNNQVIPRLPARWRDRVRQRSDELLAI--EEVPASLVHGDLGGGNVHFGADGTLTGVLDWDMAILSDPAIDAALVATWH----GWHMLRAAT-------DEQIYRRAGAWDAAVGAGHLHAI--LRGRPLSNVDGFVRSVIAWLEDPGRCRDR 5IQC Chain:A ((10-289)) ---TNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYIS-DELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTID--NKQNV-LEEYILLRET-IYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQE------------------------

General information: TITO was launched using: RESULT: Template: 5IQC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1093 -37922 -34.69 -149.30 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -34.69 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.370

(partial model without unconserved sides chains): PDB file : Tito_5IQC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5iqc-query.scw PDB file : Tito_Scwrl_5IQC.pdb: