Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSVIDVGGEVREGEELDIGAVENWLKNQGVELVGPAVVTQYTGGASNWTYRLKYENTNLILRRPPKGTKAKSAHDMAREYMVQKNLAPYYPVLPKMVAL---CQDEAVIGCDFYVMERIEGIIPRAKLPPELSFNEE-----DVHELCVNVIDKLIE-----LHQVPYENTPLAELGKGTGYCRRQVEGWDKRYEKVHTINVPSFKYVRKWLNDNIPQDSTTCIIHNDWRFDNVILNPEHPTEVIGVLDWEMATLGDPLMDLGSALAYWV------EPTDNMIFRSTRRQPTHLKGMFSRKEVVDYYLQKTGLEPQNWTFYEVFGVFRLAVIAQQIYYRYYHKQTR-NPAFKDFWIVIHALHIRALKLIAQQKLQESEFAQQSLQKIQGILRR- 4OCV Chain:A ((24-378)) ------------TNEALFDVASHFALEGTVDSIEP-----YGDGHINTTYLVTTDGPRYILQRMNTGIFPDTVNLMRNVELVTSTLKAQGKETLDIVRTTSGDTWAEIDGGAWRVYKFIEHTMSYNLVPNPDVFREAGRAFGDFQNFLSGFDANQLTETIAHFHDTPHRFEDFKKALAADELGRAAGCGPEIEFYLSH---ADQYAVVMDGLRDGSIPLRVT---HNDTKLNNILMDAT-TGKARAIIDLDTIMPGSMLFDFGDSIRFGASTALEDERDLDKVHFSTELFRAYTEGFVGEL--------RDSITAREAELLPFSGNLLTMECGMRFLADYLEGDVYFATKYPEHNLVRSRTQIKLVREMEQR-------ADETRAIVADVMETT

General information: TITO was launched using: RESULT: Template: 4OCV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1730 1957 1.13 5.86 target 2D structure prediction score : 0.60 Monomeric hydrophicity matching model chain A : 0.66 3D Compatibility (PKB) : 1.13 2D Compatibility (Sec. Struct. Predict.) : 0.60 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.320

(partial model without unconserved sides chains): PDB file : Tito_4OCV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4ocv-query.scw PDB file : Tito_Scwrl_4OCV.pdb: