Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MQLDSPGTLKQCLISQRPLQGGLTHDNTLLICADGSQWVCKRSLGRH--QSGLATEANVYSLLVNTRFALPIKLVHLDIASQMLLRPYIEGT-TTTSW-AQLSIEQAILLLKAIHQITATHHGKVSSPTSLTLNPANQLRVIWRYFRSRTSQRAKMMDIYGKLSTILQNRQSLFN-TLSTFTLNHGDFHPGNLIATPAQQLVPIDWERAHFGDPAFDLALINWHGQDPIVNSALQARAIALYTQCPAEQVALQKRVVCWSLVRLFNDYLYLTSNGLKVDKLAHFEETTAMLLNAAS 4R78 Chain:A ((38-280)) -----------EVLSVEQL-GGMTNQNYLAKTT-NKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLF--DIEAGIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFA--------PFEEIKKYESLIEEQIP-YA----NYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEF---TSQEEETFLSHYESDQT--PVSHEKIAIYKILQDTIWSLWTVYKEE--------------------

General information: TITO was launched using: RESULT: Template: 4R78.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1067 -3720 -3.49 -15.63 target 2D structure prediction score : 0.51 Monomeric hydrophicity matching model chain A : 0.66 3D Compatibility (PKB) : -3.49 2D Compatibility (Sec. Struct. Predict.) : 0.51 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.239

(partial model without unconserved sides chains): PDB file : Tito_4R78.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4r78-query.scw PDB file : Tito_Scwrl_4R78.pdb: