Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVSDETHAYWLEAAHALLGDASAEILAGDSEVATLLLTLTDRRQVVMKAVRAASEKRANLFFQWEALMLLSAEPDFPGPQPVSRHSLSDETEVFVLGY-VPGRHPAFESDEDFRVFGATLARFHKISKGKRLSGATNWD-----------------------LHRVARHYENPLLLQL-------LSDQ---ERTIVAAALDRFGPQFQAQIDEGVWTGLVHSDSHRHNVVI-DGARGS-LIDFGECGFGALFWDLG--VAVADSAVDAPERGEVCRQNL-VAGYCTVTPEAEPIVDKTLPV-------FEAMRSLEVITWPV---------------SDWSPERLAGDKEEAR------DNIEVSVRHLEALLDSP- 4QA5 Chain:A ((14-377)) ----LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHT-DAYLQHLQKVSQEGD---DDHPDSIEYG---LGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK---VAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDTFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGFNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV

General information: TITO was launched using: RESULT: Template: 4QA5.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1749 -65387 -37.39 -220.90 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.67 3D Compatibility (PKB) : -37.39 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.67 QMean score : 0.181

(partial model without unconserved sides chains): PDB file : Tito_4QA5.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4qa5-query.scw PDB file : Tito_Scwrl_4QA5.pdb: