Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MWQAVNRLLSECLGPAEIRERTELPGGDIHEAWRLSYGEKEVFVKCNTREM-LPIFTAESDQLSLLARS--KTVQVPEVYGVGSDRDYSFLLLEYIPLKPLDA------------HNAYCLGQQLAHLHQWSEQLQFGLDFDNDLATTPQPNSWQRRWAQFFAEKRIGWQLQLAAEKGMSFGDIDDITNAVQERLQSHQPQPSLLHGDLWPANCAASS-NGP-VIFDPA-CYWGDRECDLSMLPLY------PTLPAQIYDGYQSVWPLPIGFIERQSIYQLYYLLNRSNLF----GGKHLINAQKAVDNLLHPEQFSL 5IQC Chain:A ((13-302)) --KAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVN---NEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTID------N-KQNVLEEYILLRETI-----YNDLT--DIEKDYIESFMERLNATT-VFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNI--DIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRT-------

General information: TITO was launched using: RESULT: Template: 5IQC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1168 -28271 -24.20 -107.90 target 2D structure prediction score : 0.62 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -24.20 2D Compatibility (Sec. Struct. Predict.) : 0.62 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.333

(partial model without unconserved sides chains): PDB file : Tito_5IQC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5iqc-query.scw PDB file : Tito_Scwrl_5IQC.pdb: