Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDDATDELATLIARGLGV---LRPKRLHAGAEAVAYELDD---ARVLKVYHAGGS-AERFATIASFYARLNS-DRAGFAVPRILTHGVE----------GGRAYSVEKRLLGEPLSTRAHFLTDTDLIDAYLAAALRVGRIQVEPEWNSWTMFGEQRHGDW--HQHVRGQIESQSRALARM--LQPAYWERLANATADVRQHFDRP--FLGKVCLIHGDFHPGNVLVGATG--RVLSLVDFGAFTTFGDAAFDVATACGYFSMY--EPDQATTRRSLVARLLRMEGSPPGALVAMYLKLAAFLTCTAYPDDRVAVQDTGHFQWAMSVLFDPMLDELVDRVPH 6EF6 Chain:A ((29-320)) ------TIAQQALTHYDVSDNASLRLL-NLSENATYLVEDGEHQSILRVHRQDYHQPHEIESELDWLAALRTDS--DVTVPTVVPARDGRRVVTVDPADVPRHVVHFEMVGGAEPDEESL---TLDDFQTLGRITASLHEHSQRWTRP-AGFG----RFSWDWEHCLGD-TPRWG-RWQDAEGVGASETALLTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANLLVDSSTPQRTITVIDFDD-CGFGWYFYDFGTAVSFIEHDPRLGEWQESWVAGYR-SRRELPAADEAMLPSFVFLRRLLLLAWMGS--------------------------------

General information: TITO was launched using: RESULT: Template: 6EF6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1168 -9967 -8.53 -38.19 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -8.53 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.300

(partial model without unconserved sides chains): PDB file : Tito_6EF6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6ef6-query.scw PDB file : Tito_Scwrl_6EF6.pdb: