Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDDLDKPIAYGRTAEIFAWG---ENQVLKLFHAWV-GFDAVEYEYRIARTMQSCGLPVPQVGEIIEYKGRYGITCQRIKGI-SMTESLARAPWKILRYARRMAELHARVHAVTHP--TDIP--PLNPKMARKILQA-Q--SLP--ARLREKALTRLEKLPEGHDLCHGDFHPDNILLTP-QGEVILDWMDAGTGNPLADLARTSIILKGSIESGQIRHPLLKRLAHLFHRAYLAQYFSLRPGGE-SEYALWLPIIAAARLSENISELEGWLVAQAERGLS 4R78 Chain:A ((43-277)) -----EQL-GGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDI---EAGIKVNEYIESAITLDSTS--IK----TKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEF--T-------------SQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVY---------------

General information: TITO was launched using: RESULT: Template: 4R78.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 907 4028 4.44 18.39 target 2D structure prediction score : 0.65 Monomeric hydrophicity matching model chain A : 0.62 3D Compatibility (PKB) : 4.44 2D Compatibility (Sec. Struct. Predict.) : 0.65 1D Compatibility (Hydrophobicity) : 0.62 QMean score : 0.384

(partial model without unconserved sides chains): PDB file : Tito_4R78.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4r78-query.scw PDB file : Tito_Scwrl_4R78.pdb: