Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEVEDVRLGAELERLTEGATWCPVWHLQRPLSPTTATAAPPLPSSTYLKMAPA---GTLAADVAVMQLLKSCDVPAPHVLHYAQGGEGQADFLLISALAGVHGATAEALSRPEALVRSFAGGLQSLHGQHSTALLRSAEDLGAKF-DRRVAVRVARVERRLRVGEVPGHAERLEAILAHVAKPPPNVESDLVFTHGDYCLPNVIFQILNNQAGETEAELRVVGFVDLGSAGVADRYVDLASAVWSLRFN----GLEKHVPAFLQCYTARSELSGHKITINQDKLDWYINMFTLT 4H05 Chain:A ((9-267)) ------------RGRYPGCEWVVVEDGASGAGVYRLRG---GGRELFVKVAALGAGVGLLGEAERLVWLAEVGIPVPRVVEGGG--DERVAWLVTEAVPGRPASARWPREQRLDVAVALAGLARSLHA-LDWERCPFDR--SLAVTVPQAARAVAEGSVDLEDLDEERKGWSGERLLAELERTRP-ADEDLAVCHGDLCPDNVLLD--PR-------TCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPECSAAFLREYGR---GWDG--AVSEEKLAFYRLLDEFF

General information: TITO was launched using: RESULT: Template: 4H05.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1183 -29869 -25.25 -119.00 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain A : 0.69 3D Compatibility (PKB) : -25.25 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.69 QMean score : 0.295

(partial model without unconserved sides chains): PDB file : Tito_4H05.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4h05-query.scw PDB file : Tito_Scwrl_4H05.pdb: