Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSSPQGIEVPDALVASYTRNGGEEERAWIARLPALVAELLDRWKLERDGGIRSGEASLVVPVRRTDGTRAALKLQMPREETTAALIGLRAWNGDG-IV---------RLLDHDPESSAMLLERLDGSRTLASVEDDDVAM-TTLAGLMARLHSVPAPEGLR-----------------------------GLGDLARDMLASVPDALAALPNPEDRRRLHGWASAVTELVGEPGDRMLHWDLHYDNVLAAEREPWLVIDPEPLIGD-PGFDLWP-ALDTGWERIHSTGNAPRVVRRR-FDLLTEALGLDRRRAAG-W-------TLARLLQNTLWDIEDGRTDIDPSQTIVAEALPRH----- 2Q83 Chain:A ((11-346)) -----------------------LSAEDAKKLTELAENVLQGWDVQAE-KIDVIQ-ALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGILPNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGVPIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLLQSTYVPWTEQLKKSPN--LCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP----LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSALPKEELESAFEYERIKANALRQLI

General information: TITO was launched using: RESULT: Template: 2Q83.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1074 -3745 -3.49 -13.57 target 2D structure prediction score : 0.53 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -3.49 2D Compatibility (Sec. Struct. Predict.) : 0.53 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.396

(partial model without unconserved sides chains): PDB file : Tito_2Q83.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2q83-query.scw PDB file : Tito_Scwrl_2Q83.pdb: