@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_36_2420: (2018-07-13 )
MRMPSVFTAPSTYMADLEVGAATAYHAHSEAATAGESDTCKPAATTASTRPPLAPHAADADAHNAVELSISSTAVAPAYQLRGELGRGQYGCVYLVEECVRHHLLAVKATYDPIQVAAVRERQRRQERQQQKPSKGSGGCAREAAFSPYAQHEEGHAVVPFPPLLPHFSNEVMCLRECHSPFIVRLEGADKGENGEDLLLMEYVDCGDLRREIRRRCAAGTPFTETEAVFVFLQLCMAVDHLHQLNILHHDLKPENVMLSSTGIIKLGDFGFAKKYREPVSQRVASTGCGTPYYLSPEALRGDRYSLKSEMWALGVILYELLALTGPFAAATRAELRAKVHNSDYAKLPATYSNELRSVCYQLLTLDPDQRPSTRDLFQDNEYLREKLNALRRISECSVNMSTEEKGSMFHSISAALRRKPPSAKGPATASFNLGWGGSCKISSHGHGSARPEAAPKPRVERPAEMTPVARTRSVC
Atome Classification :
(36 SA)
--------------------------------------------------.........10........20........30........40........50........60-.........70........80........90........100.......110.......120.....--..130.......140....----..----.150.......160.......170......-.180.......190......-.200.......210.......220.......230.......240....-...250.......260-.---.----.-.....270.......280.---------------......290.......300-----...-.....310.......320.-......330--.........340..--.---.---.---.--.350.---.......360.......370-.....----....380.......390.......400.......410.......420.......430.......440.......450.......460.......470....--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------MRMPSVFTAPS
T
Y
M
A
D
L
EVG
A
A
T
A
YHAHSEAATAGESDTCKPAATTASTRPPLAPHAADA--DAH
N
A
V
E
L
S
ISSTAVA
P
A
Y
Q
L
R
GELGRGQ
Y
G
C
V
Y
L
V
E
E
C
V
R
H
H
L
L
A
V
KATYD
P
I
Q
V
A
A
V
R
E
R
Q
R
R
Q
E
--
R
Q
QQKPSKGSGGCAREAAF----SP----YAQHEEG
H
A
VVPFPPLLPHFSN
E
V
M
C
L
R
EC-HS
P
F
I
V
R
L
EGADKGENG
E
D
L
-
L
L
M
E
YV
D
C
G
D
L
R
R
E
I
R
R
RCAAGTPFT
E
T
E
A
V
F
V
F
L
Q
L
C
M
A
V
D
H
L
H
Q
L
N
-
I
L
HHDLKPE
N
V
M
LSS--T---
G
----
I
-
I
K
LGD
F
G
F
A
K
K
Y
R
E
P
V
S
Q
R
---------------
V
A
STGCGT
P
Y
YL
S
P
E
ALR------GD
R
-
Y
S
L
K
S
E
M
W
A
L
G
V
I
L
Y
E
L
L
A
-LTGP
F
A
A
----
A
T
R
A
E
L
R
A
KVHNSD--Y---A---K---L--
P
A
T
-
Y
---
S
N
E
L
R
S
V
C
Y
Q
L
LTLDPDQ---RP
S
T
R
----
D
L
FQD
N
E
Y
L
R
E
K
L
N
A
L
R
R
I
S
E
CSVNMST
E
E
K
G
S
M
F
H
S
I
S
A
A
L
RRKPPSAKGP
A
T
A
S
F
NLGWGGS
C
K
I
SSHGHGSARPEAAPKPRVERPAEMTPVARTRSVC--
31
HHSearch
73.98
31%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-270]
-------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
----
S
A
---------------------------------------------------
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
-
E
E
G
F
H
Y
-
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
-
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
--
K
SKG
A
----
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
--
Q
---------------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
----
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
DFP
S
---
P
---
E
--
W
D
T
-
V
---
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
---
R
I
T
A
S
----
E
A
L
K
H
-
P
W
I
C
Q
--------------------------------------------------------------------------------------------
42
Fugue
69.27
22%
-33
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
--
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
---------------------------------------------------------
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
-
E
M
V
-
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
---
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
-
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
--
K
KA-
S
----
S
-
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
---------------
V
T
---
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
----
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
--
W
---
E
---
F
---
D
--
E
D
A
-
F
SSV
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
---
R
L
T
V
H
----
D
A
L
E
-
H
P
W
L
K
G
D
H
S
----------
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
-----
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------
1
PsiBlast_PDB
67.80
36%
-147
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[73-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
-
E
N
G
S
L
Y
-
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
--
D
---
G
----
T
-
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
---------------
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
-
L
K
H
A
F
E
A
----
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
---
P
---
P
---
V
--
S
L
H
-
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
---
R
P
S
V
N
----
S
I
L
E
---------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.59
36%
-143
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[73-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
-
E
N
G
S
L
Y
-
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
--
D
---
G
----
T
-
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
---------------
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
-
L
K
H
A
F
E
A
----
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
---
P
---
P
---
V
--
S
L
H
-
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
---
R
P
S
V
N
----
S
I
L
E
---------------------------------------------------------------------------------------------------
24
HHSearch
67.53
26%
-90
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-293]
------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
----
S
S
P
------------------------------------------------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
-
S
D
G
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
---------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
----
T
K
E
R
L
-
F
E
G
I
I
K
G
K
--
Y
---
K
M
N
P
R
---
Q
--
W
S
H
-
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
----
E
A
L
N
H
-
P
W
L
K
E
R
-------------------------------------------------------------------------------------------
35
HHSearch
67.35
30%
-50
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-277]
------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---
R
-
R
-----------------------------------------------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
-
N
K
T
D
V
I
-
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
-
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
---------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
----
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
--
Y
EFE
D
---
E
---
Y
--
F
S
N
-
T
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
T
I
Q
----
D
S
L
Q
H
-
P
W
I
K
P
--------------------------------------------------------------------------------------------
23
HHSearch
67.15
26%
-89
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[22-293]
------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
----
S
S
P
------------------------------------------------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
-
S
D
G
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
---------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
----
T
K
E
R
L
-
F
E
G
I
I
K
G
K
--
Y
---
K
MNP
R
---
Q
--
W
S
H
-
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
----
E
A
L
N
H
-
P
W
L
K
E
R
-------------------------------------------------------------------------------------------
49
Fugue
66.64
22%
-50
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
----------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
--
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
--
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
--------------------------------------------------------------
L
E
V
F
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
P
W
V
N
-
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
-
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
---
G
----
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
-------------------------
G
T
E
T
H
M
A
P
E
V
V
L
------
G
R
S
-
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
----
F
F
R
G
P
L
C
L
K
I
A
S
E
P
--
P
---
P
---
V
---
R
EI
P
P
S
-
C
---
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
---
R
V
S
A
A
----
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
----------------------
P
W
R
G
E
Y
K
E
P
R
H
P
---------------------------------------------------
51
Fugue
64.47
21%
15
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
YL
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
KATG
K
L
----
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
-
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
--
D
---
G
----
N
-
V
R
I
S
D
L
G
L
A
V
E
L
K
A
--
G
Q
T
---------------
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
------
G
E
E
-
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
-
A
R
G
P
F
R
A
RG
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
------
V
---
T
---
Y
--
P
D
K
-
F
---
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
---
R
L
G
F
R
----
D
---
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
--
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
-----------
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
RP
28
HHSearch
62.56
24%
-78
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
-------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
-------
Q
--------------------------------------------------
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
-
V
G
D
E
L
W
-
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
---
G
----
R
-
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
---------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
N
----
E
P
P
L
K
A
M
K
M
I
R
D
N
L
--
P
---
P
RL-
K
---
N
--
L
H
K
-
V
---
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
---
R
A
T
A
A
----
E
L
L
K
H
-
P
F
L
A
K
A
-------------------------------------------------------------------------------------------
40
HHSearch
62.32
23%
-89
- C1 -
-
3BKB
7
A:
[113-368]
-------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
----
P
----------------------------------------------------
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
Y
-
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
-
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
--
K
---
N
----
V
-
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
---------------
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
------
Y
G
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
----
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
--
R
---
L
---
P
---
C
--
P
E
L
-
C
---
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
---
R
P
S
F
S
----
T
I
Y
Q
E
--------------------------------------------------------------------------------------------------
41
HHSearch
61.19
23%
-90
- C1 -
-
3CBL
3
A:
[113-368]
-------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
-----
P
---------------------------------------------------
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
Y
-
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
-
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
--
K
---
N
----
V
-
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
---------------
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
------
Y
G
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
----
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
--
R
---
L
---
P
---
C
--
P
E
L
-
C
---
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
---
R
P
S
F
S
----
T
I
Y
Q
E
--------------------------------------------------------------------------------------------------
37
HHSearch
61.10
26%
-112
- C1 -
-
5K00
1
MELK_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-----
G
---------------------------------------------------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
-
T
A
N
K
I
F
-
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
-
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
--
Y
---
H
----
K
-
L
K
L
I
D
F
G
L
C
A
K
P
-----------------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
D
----
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
--
Y
-------
D
---
V
--
P
K
W
-
L
---
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
---
R
I
S
M
K
----
N
L
L
N
H
-
P
W
I
M
Q
D
-------------------------------------------------------------------------------------------
26
HHSearch
60.95
27%
-41
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
-------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
-
L
S
P
E
------------------------------------------------
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
-
S
S
S
F
M
F
-
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
---------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
----
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
--
Y
---
Q
---
F
SSP
E
--
W
D
D
-
R
---
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
----
Q
A
L
Q
H
-
P
F
F
E
---------------------------------------------------------------------------------------------
43
Fugue
60.83
22%
-41
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
----------------------------------------------------------
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
-
E
L
V
-
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
---
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
---------------
L
L
F
---
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
----
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
--
Y
---
T
---
F
---
D
--
E
E
A
-
F
KEI
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
T
A
S
----
E
A
L
Q
-
H
P
W
L
K
Q
K
I
E
R
V
S
---------
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
----------------------
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
---
48
Fugue
60.58
20%
18
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
---
P
E
V
P
R
Q
L
V
T
--
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
--------
K
N
T
F
--
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
----
R
A
TG
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
-
T
K
D
A
L
C
-
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
--
H
---
G
----
H
-
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
------------------
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
------
N
E
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
-
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
------
E
---
E
---
Y
--
S
E
R
-
F
---
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
---
R
L
G
C
R
GGS
A
R
E
V
K
E
H
P
L
F
K
K
L
------------------------
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---
27
HHSearch
60.23
27%
-45
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
-------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
R
L
S
P
E
------------------------------------------------
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
-
S
S
S
F
M
F
-
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
---------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
----
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
--
Y
---
Q
---
F
SSP
E
--
W
D
D
-
R
---
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
----
Q
A
L
Q
H
-
P
F
F
E
---------------------------------------------------------------------------------------------
34
HHSearch
59.12
26%
-56
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[101-452]
-------------------------------------------------------------------------------------------------------------------------------
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
----
K
--------------------------------------------------
K
---------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
-
D
A
Q
Y
L
Y
-
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
----
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
-
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
--
R
---
G
----
H
-
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
YNRQQ
I
Q
T
W
R
KSRRL
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
Q
G
-
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
-
G
W
P
P
F
C
S
----
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
--
Q
T--
L
---
Q
F
P
-
D
--
D
I
H
-
I
---
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
G
A
D
----
E
I
K
S
H
-
P
F
F
R
G
V
-------------------------------------------------------------------------------------------
36
HHSearch
58.71
25%
-78
- C1 -
-
4G3F
1
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
--------------------------------------------------------------
F
R
V
E
E
L
V
A
C
A
G
L
-
S
S
P
R
I
V
P
L
Y
G
A
V
R
-
E
G
P
W
V
N
-
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
-
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
---
G
S---
R
-
A
A
L
C
D
F
G
H
A
L
C
L
------------------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
------
G
K
P
-
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
----
Y
F
R
G
P
L
C
L
K
I
A
S
E
P
PP
I
---
R
---
E
---
I
--
P
P
S
-
C
---
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
---
R
A
S
A
M
----
E
L
R
R
K
--------------------------------------------------------------------------------------------------
22
HHSearch
58.57
25%
-69
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-284]
-------------------------------------------------------------------------------------------------------------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
-------
D
---------------------------------------------------
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
-
S
M
E
E
L
V
-
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
---
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---
D
---------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
----
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
--
Y
TFD
E
---
E
---
A
--
F
K
E
-
I
---
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
T
A
S
----
E
A
L
Q
H
-
P
W
L
K
Q
K
I
E
R
----------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.15
34%
-122
- C1 -
-
2WQN
1
NEK7_HUMAN
A:
[82-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
Y
Y
-
A
S
F
I
E
D
N
E
L
N
-
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
--
T
---
G
----
V
-
V
K
L
G
D
L
-----------------------------------
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
Q
S
P
F
Y
-----
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
--
Y
---
P
---
P
---
L
--
P
S
D
H
Y
---
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
---
R
P
D
V
------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.41
35%
-62
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
L
A
R
I
L
--------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.70
35%
-29
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
-------------------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.67
35%
-59
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
-----------------
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.57
35%
-59
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.33
35%
-57
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
L
------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
51.74
35%
-55
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
L
------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
51.25
35%
-55
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
-----------------------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
51.01
35%
-57
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.97
35%
-52
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
----------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
50.89
35%
-56
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
--------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.57
35%
-58
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.36
35%
-60
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
---------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.05
35%
-54
- C1 -
-
2XNN
5
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
G
-------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.04
35%
-56
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
-----------------------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.15
35%
-25
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[54-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
----
N
-
V
K
L
G
D
F
-----------------------------------
T
P
Y
Y
M
S
P
E
Q
M
N
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
M
P
P
F
T
A
----
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
---
R
---
R
---
I
--
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
S
V
E
----
E
I
L
E
N
--------------------------------------------------------------------------------------------------