@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NCKP1_HUMAN: (2018-07-13 )
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
Atome Classification :
(20 SA)
---.........10..---......20...-----.....30...-.....40........50....--....60........70-........80----........90........100.......110.......120.......130.......140....----...150.......160.----.....---.170.......180.......190.......200.-......210.......220---------........230.......240--------........250....--------...260....--...270.........280.......--290.......300---....-...310..-....--.320.......330......--.340.......350.......360...---....370...--....380.......390-........400.......410---.......420....------...430-----...-.....440.......450.......460.......470-------....-----------...480---..-.-....490.......500.......----510.........520-----..--..-.....530......--.-----540..----.....550-----.....--------...560.......570-----.........580-----------.------........590.......600------....---.....610..--.....620.......630...----------...-.640.......----650.....-..660.......670..-----------.....680.......690.....-----..700.----------.--.....710.......720------....-....-----.730.......--740.......750....-...760...-....770.......780....-...790.--...-------...800......-.-----------810......----.-------------820----..--.-...---------...830---.......840-........850.------------------......860..---.....870.....-..---880........890......------.------900---------.-........910.......920....----...930.......-----940.......-950.......960.......970.......980.......990.......1000......1010......1020----......1030......1040---......1050......1060......1070.....----.1080.......--.1090......1100......1110......1120.....-----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSRSVLQ
P
S
Q
Q
K
L
---
A
E
K
L
T
ILNDR
G
-----
V
G
M
L
T
R
L
Y
N
I
-
K
K
ACGDPKAKP
S
Y
L
IDK
N
L
E
S
--
A
V
K
F
I
V
R
KFPAVETRN-
N
N
Q
Q
L
A
Q
L
Q
K
----
E
K
S
E
I
L
K
N
L
A
L
Y
Y
F
T
F
V
D
V
M
E
F
K
D
H
V
C
E
L
L
N
T
I
D
V
C
Q
V
F
F
D
I
T
V
N
F
D
L
T
K
N
Y
L
D
L
I
I
T
Y
T
T
L
M
I
L
----
L
S
R
I
E
E
R
K
A
I
I
G
L
Y
N
Y
A
----
H
E
MTH---GASDREYP
R
L
G
Q
M
I
VD
Y
E
N
P
L
K
K
M
M
E
E
FVPHSK
S
L
-
S
D
A
L
I
S
L
Q
M
VYPRRNL
S
A
----------
D
Q
WR
N
A
Q
L
L
S
L
ISA
P
S
T
MLN---------PAQSDTMP
C
E
YL
S
L
D
--------
A
M
E
K
W
I
I
F
G
F
--
I
L
C
H
--
G
ILNTD
A
T
A
L
N
L
W
K
L
A
LQS--
S
S
C
L
S
L
F
R
D
E
V
F
H
---
I
H
KA-A
E
D
L
F
V
N
I
-RGY
N
--
K
R
I
N
D
I
R
E
C
K
E
A
A
V
S
H
A
G
S
M
--
H
R
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
V
LSDQPGLL
G
---
P
K
A
L
F
V
F
M
A
L
--
S
FA
R
D
E
I
I
W
L
L
R
HADN--MPKK
S
A
D
D
F
I
D
K
H
I
A
E
L
I
F
Y
M
---
E
E
L
R
A
H
V
R
K
Y
G
P
V
M
------
Q
R
Y
Y
V
------
Q
Y
L-SG
F
D
A
V
V
L
N
E
L
V
Q
NLSVCPE
D
E
S
I
I
M
S
S
F
V
N
T
M
T
S
L
S
V
-------
K
QVE-----------DG
E
V
F
D
---FR-G-
M
R
L
D
W
F
R
L
Q
A
Y
TSV
S
K
A
SLG
L
A
D
H
----
R
--
E
L
G
K
M
M
N
T
I
I
-------
F
H
--
T
K
-
M
V
D
S
L
V
E
M
L
VETSD--
L
-----
S
I
F
C
F
----
Y
S
R
A
F
E
K
------
M
F
Q
Q
C
--------
L
ELPSQSR
Y
S
I
A
F
P
-------
L
L
C
T
H
F
M
S
C
T
-------------
H
------
E
LC
P
E
E
R
HHIGD
R
S
L
S
L
C
N
--------
M
F
L
D
---
E
M
A
K
Q
A
R
N
L
I
--
T
D
I
C
T
E
QCTLSD
Q
L
L
P
K
H
C
A
K
----------
T
I
S
-
Q
A
V
N
K
K
S
K
KQT----GKKGEPER-EKP
G
V
E
S
M
RKN
R
L
V
VT
N
-----------
L
D
K
L
H
T
A
L
S
E
L
C
F
S
INYVPN
M
V
V
-----
W
EHTFT----------
P
--
R
E
Y
L
T
SH
L
E
I
R
F
T
K
S
I
--------
V
G
M
T
-
M
Y
N
Q
-----
A
T
Q
E
IA
K
P
S
E
L
--
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
-
V
Q
I
D
I
T
R
V
F
-
N
N
V
L
L
Q
Q
T
Q
H
LDSHGE
P
T
I
T
S
-
L
Y
T
N
W
Y
L
--
E
T
L
-------
L
R
QVSNG
H
I
A
Y
F
-
P
-----------
A
M
K
A
F
VNLP----T-------------E------N
E
--
L
-
T
F
N
---------
A
E
E
Y
S
D
---
I
S
E
M
R
S
L
S
E
--
L
L
G
P
Y
G
M
K
F
L
S
E
------------------
S
L
M
W
H
I
S
S
Q
V
A
---
E
L
K
K
L
V
V
E
N
V
D
V
L
-
T
Q
---
M
-
R
TSFDK
P
D
Q
M
A
A
L
F
K
R
L
S
------
S
------
V
-----------
D
-
S
V
L
K
R
M
T
I
I
G
V
I
L
S
F
R
S
L
A
Q
E
A
L
R
D
----
V
L
S
Y
H
I
P
F
L
V
S
S
I
-----
E
D
F
K
D
HIPRE-TD
M
K
V
A
M
N
V
Y
ELSSAAGLPCEIDP
A
L
V
V
A
LSSQKSENIS
P
E
E
E
Y
K
I
A
C
L
L
M
V
F
V
A
VS
L
P
T
L
A
S
N
V
M
S
Q
YSPAIE----GHC
N
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
---
F
T
IHKG
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
IGQETDKTTT----RN--R
E
S
V
Y
L
L
L
--
D
M
I
VQESPF
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
Q
SVTSSA-----------
14
Fugue
89.80
99%
-154
- C7 -
-
3P8C
1
NCKP1_HUMAN
B:
[7-1121]
---------
Q
P
S
Q
Q
K
L
---
A
E
K
L
T
I
L
N
D
R
G
-----
V
G
M
L
T
R
L
Y
N
I
-
K
K
A
C
G
D
P
K
A
K
P
S
Y
L
I
D
K
N
L
E
S
--
A
V
K
F
I
V
R
K
F
P
----
A
V
-
E
N
Q
Q
L
A
Q
L
Q
K
----
E
K
S
E
I
L
K
N
L
A
L
Y
Y
F
T
F
V
D
V
M
E
F
K
D
H
V
C
E
L
L
N
T
I
D
V
C
Q
V
F
F
D
I
T
V
N
F
D
L
T
K
N
Y
L
D
L
I
I
T
Y
T
T
L
M
I
L
----
L
S
R
I
E
E
R
K
A
I
I
G
L
Y
N
Y
A
----
H
E
M
T
H
---
G
A
S
D
R
E
Y
P
R
L
G
Q
M
I
V
D
Y
E
N
P
L
K
K
M
M
E
E
F
V
P
H
S
K
S
L
-
S
D
A
L
I
S
L
Q
M
V
Y
P
R
R
N
L
S
A
----------
D
Q
W
R
N
A
Q
L
L
S
L
I
S
A
P
S
T
M
L
N
---------
P
A
Q
S
D
T
M
P
C
E
Y
L
S
L
D
--------
A
M
E
K
W
I
I
F
G
F
--
I
L
C
H
--
G
I
L
N
T
D
A
T
A
L
N
L
W
K
L
A
L
Q
S
--
S
S
C
L
S
L
F
R
D
E
V
F
H
---
I
H
K
A
-
A
E
D
L
F
V
N
I
-
R
G
Y
N
--
K
R
I
N
D
I
R
E
C
K
E
A
A
V
S
H
A
G
S
M
--
H
R
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
V
L
S
D
Q
P
G
L
L
G
---
P
K
A
L
F
V
F
M
A
L
--
S
F
A
R
D
E
I
I
W
L
L
R
H
A
D
N
--
M
P
K
K
S
A
D
D
F
I
D
K
H
I
A
E
L
I
F
Y
M
---
E
E
L
R
A
H
V
R
K
Y
G
P
V
M
------
Q
R
Y
Y
V
------
Q
Y
L
-
S
G
F
D
A
V
V
L
N
E
L
V
Q
N
L
S
V
C
P
E
D
E
S
I
I
M
S
S
F
V
N
T
M
T
S
L
S
V
-------
K
Q
V
E
-----------
D
G
E
V
F
D
---
F
R
-
G
-
M
R
L
D
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
G
L
A
D
H
----
R
--
E
L
G
K
M
M
N
T
I
I
-------
F
H
--
T
K
-
M
V
D
S
L
V
E
M
L
V
E
T
S
D
--
L
-----
S
I
F
C
F
----
Y
S
R
A
F
E
K
------
M
F
Q
Q
C
--------
L
E
L
P
S
Q
S
R
Y
S
I
A
F
P
-------
L
L
C
T
H
F
M
S
C
T
-------------
H
------
E
L
C
P
E
E
R
H
H
I
G
D
R
S
L
S
L
C
N
--------
M
F
L
D
---
E
M
A
K
Q
A
R
N
L
I
--
T
D
I
C
T
E
Q
C
T
L
S
D
Q
L
L
P
K
H
C
A
K
----------
T
I
S
-
Q
A
------------------
V
N
K
-
E
K
P
G
V
E
S
M
R
K
N
R
L
V
V
T
N
-----------
L
D
K
L
H
T
A
L
S
E
L
C
F
S
I
N
Y
V
P
N
M
V
V
-----
W
E
H
T
F
T
----------
P
--
R
E
Y
L
T
S
H
L
E
I
R
F
T
K
S
I
--------
V
G
M
T
-
M
Y
N
Q
-----
A
T
Q
E
I
A
K
P
S
E
L
--
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
-
V
Q
I
D
I
T
R
V
F
-
N
N
V
L
L
Q
Q
T
Q
H
L
D
S
H
G
E
P
T
I
T
S
-
L
Y
T
N
W
Y
L
--
E
T
L
-------
L
R
Q
V
S
N
G
H
I
A
Y
F
-
P
-----------
A
M
K
A
F
V
N
L
P
----
T
-------------
E
------
N
E
--
L
-
T
F
N
---------
A
E
E
Y
S
D
---
I
S
E
M
R
S
L
S
E
--
L
L
G
P
Y
G
M
K
F
L
S
E
------------------
S
L
M
W
H
I
S
S
Q
V
A
---
E
L
K
K
L
V
V
E
N
V
D
V
L
-
T
Q
---
M
-
R
T
S
F
D
K
P
D
Q
M
A
A
L
F
K
R
L
S
------
S
------
V
-----------
D
-
S
V
L
K
R
M
T
I
I
G
V
I
L
S
F
R
S
L
A
Q
E
A
L
R
D
----
V
L
S
Y
H
I
P
F
L
V
S
S
I
-----
E
D
F
K
D
H
D
M
K
V
------
A
M
N
V
Y
E
L
S
S
A
A
G
L
P
C
E
I
D
P
A
L
V
V
A
L
S
S
------
S
P
E
E
E
Y
K
I
A
C
L
L
M
V
F
V
A
V
S
L
P
T
L
A
S
N
V
M
S
Q
Y
S
P
A
I
E
----
G
H
C
N
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
---
F
T
I
H
K
G
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
I
G
Q
E
T
D
K
T
T
T
----
R
N
--
R
E
S
V
Y
L
L
L
--
D
M
I
V
Q
E
S
P
F
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
------------------
2
PsiBlast_PDB
89.71
100%
-155
- C7 -
-
4N78
10
NCKP1_HUMAN
B:
[7-1121]
---------
Q
P
S
Q
Q
K
L
---
A
E
K
L
T
I
L
N
D
R
G
-----
V
G
M
L
T
R
L
Y
N
I
-
K
K
A
C
G
D
P
K
A
K
P
S
Y
L
I
D
K
N
L
E
S
--
A
V
K
F
I
V
R
K
F
P
A
V
---------
L
A
Q
L
Q
K
----
E
K
S
E
I
L
K
N
L
A
L
Y
Y
F
T
F
V
D
V
M
E
F
K
D
H
V
C
E
L
L
N
T
I
D
V
C
Q
V
F
F
D
I
T
V
N
F
D
L
T
K
N
Y
L
D
L
I
I
T
Y
T
T
L
M
I
L
----
L
S
R
I
E
E
R
K
A
I
I
G
L
Y
N
Y
A
----
H
E
M
T
H
---
G
A
S
D
R
E
Y
P
R
L
G
Q
M
I
V
D
Y
E
N
P
L
K
K
M
M
E
E
F
V
P
H
S
K
S
L
-
S
D
A
L
I
S
L
Q
M
V
Y
P
R
R
N
L
S
A
----------
D
Q
W
R
N
A
Q
L
L
S
L
I
S
A
P
S
T
M
L
N
---------
P
A
Q
S
D
T
M
P
C
E
Y
L
S
L
D
--------
A
M
E
K
W
I
I
F
G
F
--
I
L
C
H
--
G
I
L
N
T
D
A
T
A
L
N
L
W
K
L
A
L
Q
S
--
S
S
C
L
S
L
F
R
D
E
V
F
H
---
I
H
K
A
-
A
E
D
L
F
V
N
I
-
R
G
Y
N
--
K
R
I
N
D
I
R
E
C
K
E
A
A
V
S
H
A
G
S
M
--
H
R
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
V
L
S
D
Q
P
G
L
L
G
---
P
K
A
L
F
V
F
M
A
L
--
S
F
A
R
D
E
I
I
W
L
L
R
H
A
D
N
--
M
P
K
K
S
A
D
D
F
I
D
K
H
I
A
E
L
I
F
Y
M
---
E
E
L
R
A
H
V
R
K
Y
G
P
V
M
------
Q
R
Y
Y
V
------
Q
Y
L
-
S
G
F
D
A
V
V
L
N
E
L
V
Q
N
L
S
V
C
P
E
D
E
S
I
I
M
S
S
F
V
N
T
M
T
S
L
S
V
-------
K
Q
V
E
-----------
D
G
E
V
F
D
---
F
R
-
G
-
M
R
L
D
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
G
L
A
D
H
----
R
--
E
L
G
K
M
M
N
T
I
I
-------
F
H
--
T
K
-
M
V
D
S
L
V
E
M
L
V
E
T
S
D
--
L
-----
S
I
F
C
F
----
Y
S
R
A
F
E
K
------
M
F
Q
Q
C
--------
L
E
L
P
S
Q
S
R
Y
S
I
A
F
P
-------
L
L
C
T
H
F
M
S
C
T
-------------
H
------
E
L
C
P
E
E
R
H
H
I
G
D
R
S
L
S
L
C
N
--------
M
F
L
D
---
E
M
A
K
Q
A
R
N
L
I
--
T
D
I
C
T
E
Q
C
T
L
S
D
Q
L
L
P
K
H
C
A
K
----------
T
I
S
-
Q
A
V
N
K
-------------------
E
K
P
G
V
E
S
M
R
K
N
R
L
V
V
T
N
-----------
L
D
K
L
H
T
A
L
S
E
L
C
F
S
I
N
Y
V
P
N
M
V
V
-----
W
E
H
T
F
T
----------
P
--
R
E
Y
L
T
S
H
L
E
I
R
F
T
K
S
I
--------
V
G
M
T
-
M
Y
N
Q
-----
A
T
Q
E
I
A
K
P
S
E
L
--
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
-
V
Q
I
D
I
T
R
V
F
-
N
N
V
L
L
Q
Q
T
Q
H
L
D
S
H
G
E
P
T
I
T
S
-
L
Y
T
N
W
Y
L
--
E
T
L
-------
L
R
Q
V
S
N
G
H
I
A
Y
F
-
P
-----------
A
M
K
A
F
V
N
L
P
----
T
-------------
E
------
N
E
--
L
-
T
F
N
---------
A
E
E
Y
S
D
---
I
S
E
M
R
S
L
S
E
--
L
L
G
P
Y
G
M
K
F
L
S
E
------------------
S
L
M
W
H
I
S
S
Q
V
A
---
E
L
K
K
L
V
V
E
N
V
D
V
L
-
T
Q
---
M
-
R
T
S
F
D
K
P
D
Q
M
A
A
L
F
K
R
L
S
------
S
------
V
-----------
D
-
S
V
L
K
R
M
T
I
I
G
V
I
L
S
F
R
S
L
A
Q
E
A
L
R
D
----
V
L
S
Y
H
I
P
F
L
V
S
S
I
-----
E
D
F
K
D
H
I
P
---
T
D
M
K
V
A
M
N
V
Y
E
L
S
S
A
A
G
L
P
C
E
I
D
P
A
L
V
V
A
L
S
S
------
S
P
E
E
E
Y
K
I
A
C
L
L
M
V
F
V
A
V
S
L
P
T
L
A
S
N
V
M
S
Q
Y
S
P
A
I
E
----
G
H
C
N
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
---
F
T
I
H
K
G
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
I
G
Q
E
T
D
K
T
T
T
----
R
N
--
R
E
S
V
Y
L
L
L
--
D
M
I
V
Q
E
S
P
F
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
------------------
4
HHSearch
89.69
100%
-154
- C7 -
-
3P8C
1
NCKP1_HUMAN
B:
[7-1121]
---------
Q
P
S
Q
Q
K
L
---
A
E
K
L
T
I
L
N
D
R
G
-----
V
G
M
L
T
R
L
Y
N
I
-
K
K
A
C
G
D
P
K
A
K
P
S
Y
L
I
D
K
N
L
E
S
--
A
V
K
F
I
V
R
K
F
P
A
V
E
-----
N
Q
Q
L
A
Q
L
Q
K
----
E
K
S
E
I
L
K
N
L
A
L
Y
Y
F
T
F
V
D
V
M
E
F
K
D
H
V
C
E
L
L
N
T
I
D
V
C
Q
V
F
F
D
I
T
V
N
F
D
L
T
K
N
Y
L
D
L
I
I
T
Y
T
T
L
M
I
L
----
L
S
R
I
E
E
R
K
A
I
I
G
L
Y
N
Y
A
----
H
E
M
T
H
---
G
A
S
D
R
E
Y
P
R
L
G
Q
M
I
V
D
Y
E
N
P
L
K
K
M
M
E
E
F
V
P
H
S
K
S
L
-
S
D
A
L
I
S
L
Q
M
V
Y
P
R
R
N
L
S
A
----------
D
Q
W
R
N
A
Q
L
L
S
L
I
S
A
P
S
T
M
L
N
---------
P
A
Q
S
D
T
M
P
C
E
Y
L
S
L
D
--------
A
M
E
K
W
I
I
F
G
F
--
I
L
C
H
--
G
I
L
N
T
D
A
T
A
L
N
L
W
K
L
A
L
Q
S
--
S
S
C
L
S
L
F
R
D
E
V
F
H
---
I
H
K
A
-
A
E
D
L
F
V
N
I
-
R
G
Y
N
--
K
R
I
N
D
I
R
E
C
K
E
A
A
V
S
H
A
G
S
M
--
H
R
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
V
L
S
D
Q
P
G
L
L
G
---
P
K
A
L
F
V
F
M
A
L
--
S
F
A
R
D
E
I
I
W
L
L
R
H
A
D
N
--
M
P
K
K
S
A
D
D
F
I
D
K
H
I
A
E
L
I
F
Y
M
---
E
E
L
R
A
H
V
R
K
Y
G
P
V
M
------
Q
R
Y
Y
V
------
Q
Y
L
-
S
G
F
D
A
V
V
L
N
E
L
V
Q
N
L
S
V
C
P
E
D
E
S
I
I
M
S
S
F
V
N
T
M
T
S
L
S
V
-------
K
Q
V
E
-----------
D
G
E
V
F
D
---
F
R
-
G
-
M
R
L
D
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
G
L
A
D
H
----
R
--
E
L
G
K
M
M
N
T
I
I
-------
F
H
--
T
K
-
M
V
D
S
L
V
E
M
L
V
E
T
S
D
--
L
-----
S
I
F
C
F
----
Y
S
R
A
F
E
K
------
M
F
Q
Q
C
--------
L
E
L
P
S
Q
S
R
Y
S
I
A
F
P
-------
L
L
C
T
H
F
M
S
C
T
-------------
H
------
E
L
C
P
E
E
R
H
H
I
G
D
R
S
L
S
L
C
N
--------
M
F
L
D
---
E
M
A
K
Q
A
R
N
L
I
--
T
D
I
C
T
E
Q
C
T
L
S
D
Q
L
L
P
K
H
C
A
K
----------
T
I
S
-
Q
A
V
N
K
-------------------
E
K
P
G
V
E
S
M
R
K
N
R
L
V
V
T
N
-----------
L
D
K
L
H
T
A
L
S
E
L
C
F
S
I
N
Y
V
P
N
M
V
V
-----
W
E
H
T
F
T
----------
P
--
R
E
Y
L
T
S
H
L
E
I
R
F
T
K
S
I
--------
V
G
M
T
-
M
Y
N
Q
-----
A
T
Q
E
I
A
K
P
S
E
L
--
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
-
V
Q
I
D
I
T
R
V
F
-
N
N
V
L
L
Q
Q
T
Q
H
L
D
S
H
G
E
P
T
I
T
S
-
L
Y
T
N
W
Y
L
--
E
T
L
-------
L
R
Q
V
S
N
G
H
I
A
Y
F
-
P
-----------
A
M
K
A
F
V
N
L
P
----
T
-------------
E
------
N
E
--
L
-
T
F
N
---------
A
E
E
Y
S
D
---
I
S
E
M
R
S
L
S
E
--
L
L
G
P
Y
G
M
K
F
L
S
E
------------------
S
L
M
W
H
I
S
S
Q
V
A
---
E
L
K
K
L
V
V
E
N
V
D
V
L
-
T
Q
---
M
-
R
T
S
F
D
K
P
D
Q
M
A
A
L
F
K
R
L
S
------
S
------
V
-----------
D
-
S
V
L
K
R
M
T
I
I
G
V
I
L
S
F
R
S
L
A
Q
E
A
L
R
D
----
V
L
S
Y
H
I
P
F
L
V
S
S
I
-----
E
D
F
K
D
H
------
D
M
K
V
A
M
N
V
Y
E
L
S
S
A
A
G
L
P
C
E
I
D
P
A
L
V
V
A
L
S
S
------
S
P
E
E
E
Y
K
I
A
C
L
L
M
V
F
V
A
V
S
L
P
T
L
A
S
N
V
M
S
Q
Y
S
P
A
I
E
----
G
H
C
N
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
---
F
T
I
H
K
G
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
I
G
Q
E
T
D
K
T
T
T
----
R
N
--
R
E
S
V
Y
L
L
L
--
D
M
I
V
Q
E
S
P
F
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
------------------
1
PsiBlast_PDB
89.69
100%
-154
- C7 -
-
3P8C
1
NCKP1_HUMAN
B:
[7-1121]
---------
Q
P
S
Q
Q
K
L
---
A
E
K
L
T
I
L
N
D
R
G
-----
V
G
M
L
T
R
L
Y
N
I
-
K
K
A
C
G
D
P
K
A
K
P
S
Y
L
I
D
K
N
L
E
S
--
A
V
K
F
I
V
R
K
F
P
A
V
E
-----
N
Q
Q
L
A
Q
L
Q
K
----
E
K
S
E
I
L
K
N
L
A
L
Y
Y
F
T
F
V
D
V
M
E
F
K
D
H
V
C
E
L
L
N
T
I
D
V
C
Q
V
F
F
D
I
T
V
N
F
D
L
T
K
N
Y
L
D
L
I
I
T
Y
T
T
L
M
I
L
----
L
S
R
I
E
E
R
K
A
I
I
G
L
Y
N
Y
A
----
H
E
M
T
H
---
G
A
S
D
R
E
Y
P
R
L
G
Q
M
I
V
D
Y
E
N
P
L
K
K
M
M
E
E
F
V
P
H
S
K
S
L
-
S
D
A
L
I
S
L
Q
M
V
Y
P
R
R
N
L
S
A
----------
D
Q
W
R
N
A
Q
L
L
S
L
I
S
A
P
S
T
M
L
N
---------
P
A
Q
S
D
T
M
P
C
E
Y
L
S
L
D
--------
A
M
E
K
W
I
I
F
G
F
--
I
L
C
H
--
G
I
L
N
T
D
A
T
A
L
N
L
W
K
L
A
L
Q
S
--
S
S
C
L
S
L
F
R
D
E
V
F
H
---
I
H
K
A
-
A
E
D
L
F
V
N
I
-
R
G
Y
N
--
K
R
I
N
D
I
R
E
C
K
E
A
A
V
S
H
A
G
S
M
--
H
R
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
V
L
S
D
Q
P
G
L
L
G
---
P
K
A
L
F
V
F
M
A
L
--
S
F
A
R
D
E
I
I
W
L
L
R
H
A
D
N
--
M
P
K
K
S
A
D
D
F
I
D
K
H
I
A
E
L
I
F
Y
M
---
E
E
L
R
A
H
V
R
K
Y
G
P
V
M
------
Q
R
Y
Y
V
------
Q
Y
L
-
S
G
F
D
A
V
V
L
N
E
L
V
Q
N
L
S
V
C
P
E
D
E
S
I
I
M
S
S
F
V
N
T
M
T
S
L
S
V
-------
K
Q
V
E
-----------
D
G
E
V
F
D
---
F
R
-
G
-
M
R
L
D
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
G
L
A
D
H
----
R
--
E
L
G
K
M
M
N
T
I
I
-------
F
H
--
T
K
-
M
V
D
S
L
V
E
M
L
V
E
T
S
D
--
L
-----
S
I
F
C
F
----
Y
S
R
A
F
E
K
------
M
F
Q
Q
C
--------
L
E
L
P
S
Q
S
R
Y
S
I
A
F
P
-------
L
L
C
T
H
F
M
S
C
T
-------------
H
------
E
L
C
P
E
E
R
H
H
I
G
D
R
S
L
S
L
C
N
--------
M
F
L
D
---
E
M
A
K
Q
A
R
N
L
I
--
T
D
I
C
T
E
Q
C
T
L
S
D
Q
L
L
P
K
H
C
A
K
----------
T
I
S
-
Q
A
V
N
K
-------------------
E
K
P
G
V
E
S
M
R
K
N
R
L
V
V
T
N
-----------
L
D
K
L
H
T
A
L
S
E
L
C
F
S
I
N
Y
V
P
N
M
V
V
-----
W
E
H
T
F
T
----------
P
--
R
E
Y
L
T
S
H
L
E
I
R
F
T
K
S
I
--------
V
G
M
T
-
M
Y
N
Q
-----
A
T
Q
E
I
A
K
P
S
E
L
--
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
-
V
Q
I
D
I
T
R
V
F
-
N
N
V
L
L
Q
Q
T
Q
H
L
D
S
H
G
E
P
T
I
T
S
-
L
Y
T
N
W
Y
L
--
E
T
L
-------
L
R
Q
V
S
N
G
H
I
A
Y
F
-
P
-----------
A
M
K
A
F
V
N
L
P
----
T
-------------
E
------
N
E
--
L
-
T
F
N
---------
A
E
E
Y
S
D
---
I
S
E
M
R
S
L
S
E
--
L
L
G
P
Y
G
M
K
F
L
S
E
------------------
S
L
M
W
H
I
S
S
Q
V
A
---
E
L
K
K
L
V
V
E
N
V
D
V
L
-
T
Q
---
M
-
R
T
S
F
D
K
P
D
Q
M
A
A
L
F
K
R
L
S
------
S
------
V
-----------
D
-
S
V
L
K
R
M
T
I
I
G
V
I
L
S
F
R
S
L
A
Q
E
A
L
R
D
----
V
L
S
Y
H
I
P
F
L
V
S
S
I
-----
E
D
F
K
D
H
------
D
M
K
V
A
M
N
V
Y
E
L
S
S
A
A
G
L
P
C
E
I
D
P
A
L
V
V
A
L
S
S
------
S
P
E
E
E
Y
K
I
A
C
L
L
M
V
F
V
A
V
S
L
P
T
L
A
S
N
V
M
S
Q
Y
S
P
A
I
E
----
G
H
C
N
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
---
F
T
I
H
K
G
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
I
G
Q
E
T
D
K
T
T
T
----
R
N
--
R
E
S
V
Y
L
L
L
--
D
M
I
V
Q
E
S
P
F
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
------------------
17
Fugue
39.53
19%
-130
* C7 *
-
2P5T
-
PEZA_STRPN
A:
[67-158]
-------
L
N
P
V
E
D
Y
E
L
---
T
L
K
I
E
I
V
K
E
R
G
-----
A
N
L
L
S
R
L
Y
R
Y
-
Q
D
S
Q
G
I
S
I
D
D
E
S
N
P
W
I
L
M
S
D
D
--
L
S
D
L
I
H
T
N
I
Y
L
V
E
T
----
F
D
E
I
E
R
Y
S
G
----
Y
L
D
G
I
E
R
M
L
E
I
S
E
K
R
M
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
38.46
17%
-9
* C6 *
-
5IFE
-
SF3B1_HUMAN
C:
[463-1304]
----
N
L
P
F
L
K
P
D
D
I
Q
Y
---
F
D
K
L
L
V
D
V
D
E
S
E
E
Q
K
E
R
K
I
M
K
L
L
L
K
I
-
K
N
G
T
P
P
M
R
K
A
A
L
R
Q
I
T
D
K
A
R
E
FG
A
G
P
L
F
N
Q
I
L
P
L
L
M
S
P
T
L
E
D
Q
E
R
H
L
L
V
K
----
V
I
D
R
I
L
Y
K
L
D
------------------------------------
D
L
V
R
P
Y
V
H
K
I
L
V
V
I
E
P
L
L
I
DED
Y
Y
A
R
V
E
G
R
E
I
I
S
N
L
A
K
A
A
----
G
----------------
L
A
T
M
I
S
T
M
R
P
D
I
D
N
M
-
D
E
Y
V
R
N
T
T
A
R
-
A
F
A
V
V
A
S
A
L
----------------------
G
I
P
S
L
L
P
F
L
K
A
V
C
K
S
K
K
---------
S
W
Q
A
R
H
T
G
I
K
I
V
Q
Q
I
--------
A
I
L
M
--------------------------------
G
--
C
A
I
L
P
H
L
R
S
L
V
E
I
---
I
E
H
G
-
L
V
D
------------
E
Q
Q
K
V
R
T
I
S
A
L
A
I
A
A
L
A
E
A
A
--
T
P
Y
G
I
E
S
F
D
S
V
L
K
P
L
W
K
G
I
R
Q
H
R
G
-------
K
G
L
A
A
F
L
K
A
--
I
G
Y
L
I
P
L
-----------
M
D
A
E
Y
A
N
Y
Y
T
R
E
V
M
L
I
L
I
R
E
F
---
Q
S
P
D
E
E
M
K
K
I
--
V
L
------
K
--
V
V
------
K
Q
C
-
C
G
T
D
G
V
E
A
N
Y
I
K
T
E
----------
I
L
P
P
F
F
K
H
--------------------------------
F
W
---
Q
H
-
R
-
M
A
L
D
---
R
R
N
Y
R
Q
L
V
D
T
T
V
E
L
A
N
K
----
V
--
G
A
A
E
I
I
S
R
I
V
-------
D
D
--
L
K
D
E
A
E
Q
Y
R
K
M
V
M
E
T
I
E
--
K
-----
I
M
G
N
L
GAAD
I
D
H
K
L
E
E
------
Q
L
I
D
G
--------
I
L
Y
A
F
Q
E
Q
T
T
-
E
D
S
-------
V
M
L
N
G
F
G
T
V
V
-------------
N
------
A
L
G
K
R
V
K
P
Y
L
P
Q
I
C
G
T
V
L
W
--------
R
L
N
N
KSA
K
V
R
Q
Q
A
A
D
L
I
--
S
R
T
A
V
V
M
K
T
C
Q
E
E
K
L
M
G
H
L
G
V
----------
V
L
Y
-
E
Y
L
G
-------------------------------------------------
E
E
Y
P
E
V
L
G
S
I
L
G
A
L
K
A
I
V
N
-
V
I
-----
G
M
H
K
M
T
----------
P
P
I
K
D
L
L
P
R
L
T
P
I
L
K
N
R
H
E
--------
K
V
Q
E
-
N
C
I
D
-----
L
V
G
R
I
A
D
R
G
A
E
--
Y
V
S
A
R
E
W
M
R
I
C
F
E
L
L
E
L
-
L
K
A
H
K
K
A
I
R
-
R
A
T
V
N
T
F
G
Y
I
A
K
A
I
G
P
H
D
V
L
A
-
T
L
Q
N
R
V
C
--
T
T
V
-------
A
I
A
I
V
A
E
T
C
S
P
F
-
T
-----------
V
L
P
A
L
M
N
--------------------
E
------
Y
R
--
V
-
P
E
L
---------
N
V
Q
N
G
V
---
L
K
S
L
S
F
L
F
E
--
Y
I
G
E
M
G
K
D
Y
------------------------------
I
Y
---
A
V
T
P
L
L
E
D
A
L
---------
M
-
D
R
D
L
V
H
R
Q
T
A
S
A
V
V
Q
H
M
S
------
L
------
G
-----------
V
---------------
Y
G
F
G
C
E
D
S
L
N
H
----
L
L
N
Y
V
W
P
N
V
F
E
T
-------------
S
P
H
-
V
I
Q
A
V
M
G
A
L
E
G
L
R
V
A
I
G
-----------------------------
P
C
R
M
L
Q
Y
C
L
Q
G
L
F
-------------------------
H
P
A
R
K
V
R
D
V
Y
W
K
I
Y
---
N
S
I
Y
I
G
S
Q
D
A
L
I
A
H
Y
P
R
I
Y
N
D
---------
D
K
N
T
Y
----
I
R
--
Y
E
L
D
Y
I
L
------------------------------------------------------
21
Fugue
37.08
16%
-4
- C6 -
-
5IM3
4
?
A:
[32-912]
-----
L
R
V
I
K
R
N
G
T
V
V
P
YT
D
D
K
I
T
V
A
I
T
K
A
-----
F
L
A
V
E
-----------
G
G
T
A
A
A
S
S
R
I
H
D
T
V
R
R
--
L
T
E
Q
V
T
A
T
F
K
R
R
M
P
S
G
-
G
T
I
H
I
E
E
I
Q
D
----
Q
V
E
L
A
L
M
R
A
G
-------------------------------------------
E
Q
K
V
A
R
D
Y
V
I
Y
R
----
E
A
R
A
A
E
R
K
N
A
G
A
A
S
D
V
A
----
Q
P
------
H
P
S
I
R
I
T
R
A
D
G
S
L
S
P
L
D
M
G
R
L
N
T
I
I
S
E
A
C
E
G
L
A
E
V
-
D
G
A
L
I
E
R
E
T
L
K
---
N
L
Y
D
----------
G
V
A
E
K
D
V
N
T
A
L
V
M
T
A
R
T
L
V
E
---------
R
E
P
N
Y
S
Y
V
T
A
R
L
L
M
D
--------
T
L
R
A
E
A
L
G
F
L
------------
G
V
A
E
S
A
T
H
H
E
M
A
E
L
Y
--
A
K
A
L
P
A
Y
---------
I
E
K
G
-
A
E
F
E
L
V
D
-----------
A
K
L
K
E
F
D
L
E
K
L
G
K
A
I
D
H
--
E
R
D
Q
Q
-
F
T
Y
L
G
L
Q
T
L
Y
D
R
Y
F
I
H
K
D
G
I
R
FEL
P
Q
I
F
F
M
R
V
A
M
--
G
L
A
I
E
E
----------------------
K
D
R
E
A
R
A
I
E
F
Y
---
N
L
L
S
S
F
---------------
D
Y
M
S
------
S
T
P
-
T
L
F
N
A
---
G
T
L
R
P
Q
L
S
------
S
C
Y
L
T
T
V
P
D
D
L
S
G
I
Y
G
-------
A
I
H
D
-----------
N
A
M
L
S
K
---
F
A
G
G
-
L
G
N
D
W
T
P
V
R
A
L
G
S
Y
I
K
G
T
N
G
K
S
Q
G
-------------------------------
V
V
P
F
L
K
V
V
N
D
T
A
V
A
--
V
-----
N
A
V
C
A
----
Y
L
E
T
W
H
L
------
D
I
E
E
F
--------
L
E
L
R
K
N
T
G
D
----
D
-------
R
R
R
T
H
D
M
N
T
A
-------------
N
------
W
I
P
---------------
D
--------
L
F
M
K
---
R
V
F
D
D
G
S
W
T
L
F
S
P
S
D
V
P
D
L
H
D
L
Y
G
K
A
F
E
E
R
Y
E
Y
----------
Y
E
A
-
L
A
S
Y
G
K
L
K
L
H
K
----
V
V
Q
A
K
D
L
W
-
R
K
M
L
S
M
L
F
E
T
G
H
P
W
L
T
F
-----------
K
D
P
C
N
L
R
S
P
Q
Q
H
V
G
V
V
H
S
S
N
L
C
T
------
E
I
T
L
N
-----------------
T
N
K
D
E
I
A
V
C
-
N
L
--------
G
S
I
N
-
L
V
N
H
-----
I
V
D
G
K
L
D
T
A
K
L
--
E
K
T
V
K
---
T
A
V
R
M
L
D
N
V
-
I
D
I
N
Y
Y
S
V
---------
P
Q
A
Q
N
S
N
F
K
H
R
P
V
G
-
L
G
I
M
G
F
Q
--
D
A
L
-------
Y
L
Q
----
H
I
P
Y
G
S
D
-----------
A
A
I
A
F
A
D
Q
S
----
M
-------------
E
------
A
I
--
S
-
Y
Y
A
---------
I
Q
A
S
C
D
---
L
A
D
E
R
--------
G
A
Y
--
Q
T
F
Q
G
------------------
S
L
-
W
----------
S
Q
G
I
L
P
I
D
S
E
K
K
L
-
I
E
---
E
-
R
G
A
------------
K
Y
I
------
E
------
V
-----------
D
---------
L
S
E
T
L
D
W
A
P
L
R
E
R
V
Q
K
G
----
I
R
N
S
N
I
M
A
I
A
P
T
A
-----
T
I
A
N
I
T
G
V
S
Q
-
S
I
E
P
T
Y
Q
N
L
Y
V
K
S
N
L
S
G
E
F
T
V
I
N
P
Y
L
V
R
D
L
K
A
R
---------------------------------
G
L
W
D
P
V
M
V
----
N
D
L
K
Y
Y
D
G
S
V
Q
Q
I
E
R
I
P
Q
D
L
---
K
D
L
Y
A
T
A
F
E
V
E
T
R
W
I
V
E
A
A
S
R
R
Q
K
W
I
D
Q
-------------------
A
Q
S
L
--
N
L
Y
I
A
G
A
---
S
G
K
K
L
D
V
T
Y
R
M
A
W
F
R
-
G
L
K
T
T
Y
Y
L
R
A
L
A
A
T
-----------
22
Fugue
35.93
14%
-12
- C4 -
-
1UF2
-
P3_RDVA
A:
[50-1016]
Q
S
V
V
S
R
T
P
I
P
L
S
K
I
G
L
---
Q
D
-----------------
V
K
K
L
F
D
I
-
N
V
I
K
C
G
S
S
L
R
I
V
D
------
E
P
--
Q
V
T
F
I
V
S
Y
-----
A
K
D
-
I
Y
D
K
F
M
C
I
E
H
DSAY
E
P
S
L
T
M
H
R
V
R
V
I
Y
S
M
L
N
D
------
Y
C
A
K
M
I
S
E
V
P
Y
E
S
S
F
V
G
----------------
E
L
P
V
K
S
V
T
----
L
N
K
L
G
D
R
N
M
D
A
L
A
E
H
L
L
----
F
E
H
D
V
---
V
N
A
Q
R
E
N
R
I
F
Y
Q
R
K
S
A
P
A
V
P
V
I
-
F
G
D
D
L
E
P
A
V
R
E
R
-
A
N
L
Y
H
R
Y
S
V
P
Y
H
Q
I
E
L
A
L
----------
H
A
L
A
N
-
D
L
L
S
I
Q
Y
C
H
P
T
V
V
Y
---------
N
Y
L
S
S
R
A
P
-
N
F
L
R
L
D
--------
D
Q
V
S
L
K
L
T
S
A
--
G
I
-
G
--
T
L
M
P
R
P
V
V
Q
L
L
D
Y
D
L
V
Y
M
S
--
P
L
A
L
N
N
L
A
S
R
L
L
R
K
I
S
L
H
L
V
-
M
Q
M
V
T
A
V
Q
-
Q
D
L
G
--
E
V
V
S
V
S
S
N
V
T
N
P
A
S
A
C
L
V
R
M
--
N
V
Q
G
V
Q
T
L
A
V
F
I
A
Q
S
M
L
N
P
N
I
S
Y
G
M
I
S
---
G
L
T
L
D
C
F
S
N
F
--
I
Y
G
A
C
L
M
L
F
Q
A
L
I
P
P
S
--
A
L
T
A
R
Q
R
L
D
I
N
N
R
F
A
Y
F
L
I
K
C
HAT
Q
A
T
T
A
R
L
V
A
N
Q
V
I
Y
------
P
V
D
A
I
------
D
Q
W
-
Q
S
N
G
R
D
V
L
V
A
I
Y
N
N
L
L
P
G
E
L
V
L
T
N
L
I
Q
T
Y
F
R
G
N
T
A
Q
Q
A
-------
A
E
I
L
IPADQTSYG
A
N
E
T
R
A
L
S
APY
L
F
-
G
-
A
P
I
N
M
L
A
P
D
A
R
L
S
T
Y
K
R
D
L
A
L
P
D
R
----
S
PI
L
I
T
T
V
E
G
Q
N
S
-------
I
S
--
I
E
-
N
L
R
H
K
T
G
L
I
R
A
---------------
M
----
Y
L
N
G
F
V
T
------
Q
------------------------------------------------------------------
P
P
A
W
I
R
N
A
N
S
N
T
A
L
L
S
--------
R
F
L
D
---
A
T
P
N
-
L
L
G
I
Y
--
E
A
I
L
---------------
A
N
----------
T
Y
A
-
N
A
V
N
-----------------------------------
V
Y
-----------
C
D
S
V
Y
R
A
---------
D
I
P
I
E
W
K
-----
L
H
Q
S
V
D
----------
P
--
Q
D
L
L
F
G
V
F
G
I
V
P
Q
Y
Q
I
--------------
L
N
E
-----
A
V
P
D
F
F
A
G
G
E
D
--
I
L
I
L
Q
L
I
R
A
V
Y
D
T
L
S
N
K
-
L
G
R
N
P
A
D
I
F
------
H
L
E
E
V
F
K
V
I
E
E
I
V
S
V
L
-
V
Q
Q
K
I
D
V
--
R
K
Y
-------
F
T
E
S
M
R
S
G
S
F
S
K
-
P
-----------
R
W
D
N
F
L
R
R
P
----
V
-------------
A
------
Q
R
--
L
P
N
L
Y
---------
S
V
I
M
T
Q
---
A
D
H
V
Y
N
Y
M
T
--
Q
L
T
H
I
-
I
P
I
T
D
C
------------------
F
Y
I
V
K
N
S
G
F
V
D
RGS
T
G
P
V
I
A
S
S
S
V
Y
E
N
V
L
K
---
V
-
V
H
T
I
A
D
F
D
A
A
N
A
L
R
L
Q
R
R
------
R
------
V
-----------
D
-
N
T
S
Y
T
D
S
L
S
D
M
F
N
G
L
R
S
I
S
S
S
E
F
V
R
----
S
V
N
G
R
S
V
F
T
E
G
R
I
-----
D
A
I
K
V
N
M
R
A
K
-
F
D
L
Q
F
I
T
E
E
G
G
Y
S
K
P
P
N
V
K
K
L
M
F
S
D
F
L
S
F
L
D
S
H
K
S
D
Y
R
P
P
--------
L
L
T
V
P
I
T
I
G
L
N
N
L
-----------------
G
E
T
N
S
-------------------
N
T
L
R
M
R
S
E
A
I
D
E
Y
F
S
S
Y
V
G
A
Q
I
L
V
P
I
N
V
V
D
T
R
V
Y
----
T
E
--
F
S
E
L
R
N
F
F
T
G
D
V
V
I
R
D
D
P
F
D
V
W
D
G
V
K
A
----
T
Y
I
P
I
G
V
H
G
V
R
L
D
P
N
G
D
Q
------------
15
Fugue
33.40
8%
-30
- C7 -
-
3P8C
4
CYFP1_HUMAN
A:
[5-1250]
----------
V
T
L
E
D
A
---
L
S
N
V
D
L
L
E
E
L
P
-----
L
A
R
Y
I
E
Q
A
T
V
-
H
S
S
M
N
E
M
L
E
E
G
Q
E
Y
A
V
M
L
Y
----
T
W
R
S
C
S
R
A
I
P
Q
V
K
C
N
E
-
Q
P
N
R
V
E
I
Y
E
K
----
T
V
E
V
L
E
P
E
V
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
R
F
C
G
E
V
R
R
L
-
C
H
A
E
R
R
K
D
F
V
S
E
A
Y
L
I
T
L
G
K
F
I
N
M
F
A
V
L
D
E
L
----
K
N
M
K
C
S
V
K
N
D
H
S
A
Y
K
R
A
----
A
Q
F
L
R
KMA
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
A
N
H
N
K
I
T
Q
S
L
Q
Q
Q
L
E
V
I
S
G
Y
-
E
E
L
L
A
D
I
V
N
L
C
V
D
Y
Y
E
N
R
----------
M
Y
L
T
P
S
E
K
H
M
L
L
K
V
M
G
F
G
L
Y
---------
L
M
D
G
S
V
S
-----
N
I
Y
--------
K
L
D
A
K
K
R
I
N
L
--
S
K
I
D
--
K
Y
F
K
Q
L
Q
V
V
P
L
F
G
D
M
Q
I
E
L
--
A
R
Y
I
K
T
S
A
-
H
Y
E
E
---
N
K
S
R
-
W
T
C
T
S
S
I
C
-
E
Q
M
I
--
Q
I
R
E
D
H
M
R
F
I
S
E
L
A
R
Y
S
A
Q
K
--
T
D
A
E
Y
R
K
L
F
D
L
A
L
Q
G
L
Q
L
L
S
Q
W
S
A
H
V
M
---
E
V
Y
S
W
K
L
V
H
P
TD
K
Y
S
N
K
D
C
P
D
S
A
E
E
Y
E
R
--
A
T
R
Y
N
Y
T
S
E
E
K
F
A
L
V
E
V
I
A
M
I
---
K
G
L
Q
V
L
M
G
R
M
E
S
V
F
------
N
H
A
I
R
------
H
T
V
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
A
I
K
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
T
V
C
-------
D
W
E
T
-----------
G
H
E
P
F
N
---
D
P
-
A
-
L
R
G
E
K
D
P
F
D
I
K
V
P
R
R
A
V
G
P
S
S
T
Q
L
----
Y
--
M
V
R
T
M
L
E
S
L
I
AKTLRSS
L
E
--
G
P
-
T
I
L
D
I
E
K
F
H
R
E
S
F
F
--
Y
-----
T
H
L
I
N
----
F
S
E
T
L
Q
Q
C
C
DLSQ
L
W
F
R
E
--------
F
F
L
E
L
T
M
G
R
R
I
Q
F
P
-------
I
E
M
S
M
P
W
I
L
T
-------------
D
------
H
I
L
E
T
K
E
A
S
M
M
E
Y
V
L
Y
S
L
D
--------
L
Y
N
D
---
S
A
H
Y
A
L
T
R
F
N
--
K
Q
F
L
Y
D
E
I
E
A
E
V
N
L
C
F
D
Q
F
V
Y
----------
K
L
A
-
D
Q
I
F
A
Y
Y
K
V
M
A
----
G
S
L
L
L
D
K
R
-
L
R
S
E
C
K
N
Q
G
A
T
I
H
L
P
P
S
-----------
N
-
R
Y
E
T
L
L
K
Q
--------
R
H
V
Q
L
-----
L
G
R
S
I
D
----------
L
--
N
R
L
I
T
Q
R
V
S
A
A
M
Y
K
S
L
--------
E
L
A
I
-
G
R
F
E
S
E
DLT
S
I
V
E
L
D
G
L
L
E
I
--
N
R
M
T
H
K
L
L
S
R
Y
L
T
L
D
G
F
-
D
A
M
F
R
E
A
---
N
H
N
V
S
A
P
Y
G
R
I
T
L
H
V
F
W
E
L
N
Y
D
F
L
P
N
Y
C
Y
--
N
G
S
-------
T
N
R
F
V
R
T
V
L
P
F
S
-
Q
E
F
Q
R
DKQPNAQ
P
Q
Y
L
H
G
S
K
A
----
L
-------------
N
------
L
A
--
Y
-
S
S
I
---------
Y
G
S
Y
R
N
FVG
P
P
H
F
Q
V
I
C
R
--
L
L
G
Y
Q
G
I
A
V
V
M
E
------------------
E
L
L
K
V
V
K
S
L
L
Q
G
--
T
I
L
Q
Y
V
K
T
L
M
E
V
M
-
P
K
---
I
-
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
------
H
------
Q
L
K
DIVEYAELK
T
-
V
C
F
Q
N
L
R
E
V
G
N
A
I
L
F
C
L
L
I
E
Q
S
L
S
L
----
E
E
V
C
D
L
L
H
A
A
P
F
Q
NIL
P
R
V
H
V
K
E
G
E
R
L
D
-
A
K
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
P
L
I
E
R
L
G
T
P
Q
Q
I
A
I
A
R
E
G
D
L
L
T
K
E
R
L
C
C
G
L
S
M
F
E
V
I
L
T
R
I
R
-
S
F
L
D
D
P
I
W
R
G
P
L
P
S
N
G
VMHV
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
V
Y
C
I
P
---
V
G
T
H
E
F
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
G
Q
Q
R
R
F
A
V
LD
F
C
Y
H
--
L
L
K
V
Q
K
H
D
--
G
K
D
E
I
I
K
N
V
P
L
K
K
M
V
E
R
I
R
K
F
Q
I
L
N
D
E
I
I
T
I
L
D
K
Y
L
K
E
H
V
R
C
F
Q
P
P
IHQSL
6
HHSearch
33.17
15%
-23
- C7 -
-
4N78
1
CYFP1_HUMAN
A:
[751-1038]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
R
H
V
Q
L
-----
L
G
R
S
I
D
----------
L
--
N
R
L
I
T
Q
R
V
S
A
A
M
Y
K
S
L
--------
E
L
A
I
G
R
F
-------
E
S
E
D
L
T
S
I
V
E
L
--
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
-
L
T
L
D
G
F
D
A
M
F
R
E
A
N
H
N
V
S
A
P
---
Y
G
---
R
I
T
-
L
H
V
F
W
E
L
N
Y
D
F
L
-------
P
------
N
Y
C
Y
N
-
G
-----------
S
T
N
R
F
V
R
T
V
----
L
PF
S
Q
E
F
Q
R
D
K
Q
P
N
A
Q
PQYLH
G
S
--
K
-
A
L
N
L
A
Y
S
S
I
Y
GS
Y
R
N
F
V
G
---
P
P
H
F
Q
V
I
C
R
--
L
L
G
Y
Q
G
I
A
V
V
M
E
------------------
E
L
L
K
V
V
K
S
L
L
Q
G
--
T
I
L
Q
Y
V
K
T
L
M
E
V
M
-
P
K
I
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
DIVEYA
E
------
L
-----------
K
T
V
C
F
Q
N
L
R
E
V
G
N
A
I
L
F
C
L
L
I
E
Q
S
L
S
L
E
E
V
C
D
L
L
H
A
A
P
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
32.26
11%
-39
- C7 -
-
4PS2
-
?
A:
[16-52]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Q
V
A
R
Q
I
P
---
R
L
K
A
M
L
A
M
-
R
S
L
L
-
R
D
---
L
-
K
A
N
L
L
D
N
V
T
F
R
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
31.78
15%
-20
- C7 -
-
3P8C
2
CYFP1_HUMAN
A:
[751-1038]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
R
H
V
Q
L
-----
L
G
R
S
I
D
----------
L
--
N
R
L
I
T
Q
R
V
S
A
A
M
Y
K
S
L
--------
E
L
A
I
G
R
F
-------
E
S
E
D
L
T
S
I
V
E
L
--
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
-
L
T
L
D
G
F
D
A
M
F
R
E
A
N
H
N
V
S
A
P
---
Y
G
---
R
I
T
-
L
H
V
F
W
E
L
N
Y
D
F
L
-------
P
------
N
Y
C
Y
N
-
G
-----------
S
T
N
R
F
V
R
T
V
----
L
PFSQ
E
F
Q
R
DKQPN
A
QPQYLH
G
S
--
K
-
A
L
N
L
A
Y
S
S
I
Y
GS
Y
R
N
F
V
G
---
P
P
H
F
Q
V
I
C
R
--
L
L
G
Y
Q
G
I
A
V
V
M
E
------------------
E
L
L
K
V
V
K
S
L
L
Q
G
--
T
I
L
Q
Y
V
K
T
L
M
E
V
M
-
P
K
ICR
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
DIVEYA
E
------
L
-----------
K
T
V
C
F
Q
N
L
R
E
V
G
N
A
I
L
F
C
L
L
I
E
Q
S
L
S
L
E
E
V
C
D
L
L
H
A
A
P
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
31.28
24%
-113
- C7 -
-
3CK6
-
?
A:
[50-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
H
V
P
R
A
-
T
---
V
D
H
L
L
A
D
E
S
R
P
S
F
H
P
L
D
D
D
N
F
M
L
I
L
R
G
I
N
M
N
E
N
A
S
P
E
D
M
L
S
I
R
I
L
Y
F
Q
G
A
L
I
S
T
R
K
I
P
S
R
A
I
M
E
I
R
Q
A
L
A
----
E
H
-
K
G
P
K
S
L
A
S
L
L
N
Q
I
I
E
G
L
N
G
K
I
D
L
Y
L
D
T
I
E
E
T
L
N
E
F
D
V
N
D
E
S
T
Y
N
H
I
A
A
Q
K
A
L
I
S
I
----
K
R
F
I
R
P
Q
Q
Y
A
I
R
--
D
L
I
E
S
E
S
E
L
V
T
----------------------------------------
16
Fugue
31.18
14%
27
- C3 -
-
4CMP
-
CAS9_STRP1
A:
[8-1367]
--K
Y
S
I
G
L
D
I
G
T
--------------
N
S
V
G
-----
W
A
V
I
T
D
E
Y
K
V
P
S
K
K
F
K
V
L
G
N
T
D
R
H
S
I
K
K
N
L
I
G
--
A
L
L
F
-----
D
S
G
E
T
A
E
-
A
T
R
L
K
R
T
A
R
R
----
R
Y
T
R
R
K
N
R
I
C
Y
L
Q
E
I
F
S
N
E
M
A
K
V
D
D
--
S
F
F
H
R
L
E
R
H
P
I
F
G
N
I
V
D
E
V
A
Y
H
E
K
Y
P
T
I
Y
H
L
R
K
K
L
V
D
S
----
T
D
K
A
D
L
R
L
I
Y
L
A
L
A
H
M
I
K
F
RG
H
F
L
I
E
---
G
D
L
N
P
D
N
S
D
V
D
K
L
F
I
Q
L
V
Q
T
Y
N
Q
L
F
E
E
N
P
I
N
A
S
G
V
D
A
K
A
I
L
S
A
R
L
S
K
S
R
R
L
E
N
L
I
A
Q
L
PGEKKN
G
L
F
G
N
L
I
A
L
S
L
G
L
T
P
N
F
K
S
N
FDLA
E
D
A
K
L
Q
L
S
K
D
T
Y
D
D
D
L
D
N
L
L
--------
A
Q
I
G
D
Q
Y
A
D
L
--
F
L
A
A
--
K
N
L
S
D
A
I
L
L
S
D
I
L
R
K
A
P
L
S
--
A
S
M
I
K
R
Y
D
E
H
H
Q
D
---
L
T
L
L
-
K
A
L
V
R
Q
Q
L
P
E
K
Y
K
--
E
I
F
F
D
Q
S
K
N
G
Y
A
G
Y
I
D
G
G
A
S
--
Q
E
E
F
Y
K
F
I
K
P
I
L
E
K
M
D
----------
G
---
T
E
E
L
L
V
K
L
N
------
R
E
D
L
L
R
K
Q
R
T
F
D
N
G
S
I
P
H
Q
I
H
L
G
E
L
H
A
I
L
R
R
Q
E
D
F
Y
---
P
F
L
K
D
N
R
E
K
I
E
K
I
L
T
FRPN
E
K
V
L
P
K
------
H
S
L
-
L
Y
E
Y
F
T
V
Y
N
E
L
T
K
V
L
S
--
G
E
Q
K
K
A
I
V
D
L
L
F
K
T
N
R
K
V
T
V
-------
K
Q
L
K
-----------
E
----
D
---
F
N
-
A
-
S
L
G
T
Y
H
D
L
L
K
I
I
K
----
D
K
D
F
L
D
N
----
E
--
E
N
E
D
I
L
E
D
I
V
-------
L
T
--
L
T
-
L
F
E
D
-
R
E
M
I
E
E
R
L
K
--
T
-----
Y
A
H
L
F
----
D
D
K
V
M
K
Q
------
L
K
R
R
R
Y
T
G
W
G
RLS
R
K
L
I
N
G
I
R
D
K
T
I
L
D
-------
F
L
K
R
N
F
M
Q
L
I
-------------
H
DDSLT
F
K
E
D
I
Q
K
A
Q
V
S
D
S
L
H
E
H
I
A
N
--------
L
A
G
S
---
P
A
I
K
K
G
I
L
Q
T
--
V
K
V
V
D
E
L
V
K
V
M
G
R
H
K
P
E
N
I
V
I
----------
E
M
A
K
N
S
R
E
R
M
K
R
I
E
E
----
G
I
K
E
L
H
P
V
-
E
N
T
Q
L
Q
N
E
K
L
Y
L
Y
Y
L
Q
N
GRDMYVDQ
E
L
D
I
N
R
L
S
D
Y
D
V
D
H
I
V
P
Q
S
F
L
K
D
D
S
I
-----
D
N
K
V
L
T
RKNRGKSDNV
P
--
S
E
E
V
V
K
K
M
K
N
Y
W
R
Q
L
L
--------
N
A
K
L
-
I
T
Q
R
-----
K
F
D
N
L
T
K
L
S
E
L
D
K
A
G
F
I
K
R
Q
L
V
E
T
R
Q
I
T
K
H
-
V
A
Q
I
L
D
S
R
M
-
N
T
K
Y
D
E
N
D
K
L
I
R
E
V
K
V
I
T
L
K
S
-
K
L
V
S
D
F
R
--
K
D
F
QFYKVRE
I
N
N
Y
H
H
A
H
D
A
Y
L
-
N
-----------
A
V
V
G
T
A
L
I
K
K
YPK
L
-------------
E
------
S
E
--
F
-
V
Y
G
---------
D
Y
K
V
Y
D
---
V
R
K
M
I
A
K
S
E
QY
F
F
Y
S
N
I
M
N
F
F
K
T
------------------
E
I
T
--
L
A
N
G
E
I
---
R
K
R
P
L
I
E
T
N
G
E
----
T
---
G
-
E
I
V
W
D
K
G
R
D
F
A
T
V
R
K
V
L
S
------
M
------
P
-----------
Q
-
V
N
I
V
K
K
T
E
V
Q
T
P
T
V
A
Y
S
V
L
V
V
S
V
K
E
----
L
L
G
I
T
I
M
E
R
S
S
F
E
-----
K
N
P
I
D
F
L
E
A
K
G
K
D
L
I
I
K
L
P
K
Y
-------
S
L
F
E
L
E
N
G
R
K
R
M
L
A
S
A
G
E
L
Q
K
G
N
E
L
A
L
P
S
K
Y
V
N
F
L
Y
L
A
S
H
Y
V
E
Q
H
K
H
Y
L
D
E
I
I
E
Q
I
S
----
E
F
S
K
R
V
I
L
A
D
A
N
L
D
K
V
L
S
A
Y
---
N
K
H
R
D
K
P
I
R
E
Q
A
E
N
I
I
H
L
F
T
L
T
N
L
----------------
G
--
A
P
A
A
F
K
Y
F
--
D
T
T
I
D
R
K
R
Y
T
S
T
K
E
V
L
D
A
---
T
L
I
H
Q
S
I
T
G
L
Y
E
T
R
I
D
L
S
------------
9
HHSearch
30.21
23%
-25
- C7 -
-
2MN2
-
?
A:
[4-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
---------
P
K
-
R
H
D
---
V
A
Q
L
K
F
L
C
E
--
S
L
Y
D
E
G
I
A
T
L
G
D
SHHGWVNDPTS
A
V
N
L
Q
L
N
D
L
I
E
H
I
A
S
F
V
M
---
S
F
K
I
K
Y
P
D
D
G
D
L
S
-
E
L
---
V
-
E
E
Y
L
D
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
27.41
24%
-128
- C7 -
-
1KON
-
YEBC_ECOLI
A:
[85-125]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
Y
E
--
G
Y
G
P
G
G
T
A
I
M
I
E
------------------
C
L
S
D
N
R
N
R
T
V
A
---
E
V
R
H
A
F
S
K
C
G
G
N
L
-
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
26.86
18%
10
- C2 -
-
5DNK
1
Y789_RICPR
A:
[45-554]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
P
Y
A
I
T
N
-
P
Y
H
L
S
T
L
A
T
L
F
---
G
I
N
A
----------
P
E
V
E
N
S
K
I
L
E
L
G
C
A
A
G
G
N
L
I
---------
P
H
A
V
L
Y
P
N
A
H
F
V
G
V
D
LS
K
V
Q
I
D
E
A
N
K
N
V
R
A
L
G
L
KN
I
E
F
H
HC
S
I
T
D
I
D
D
S
F
G
K
F
D
Y
I
I
C
H
G
VI
S
W
V
P
K
I
V
R
D
K
I
F
K
---
V
C
N
R
N
L
S
T
N
G
I
A
Y
-
I
S
Y
N
T
L
P
G
W
N
M
V
R
T
I
R
D
M
M
L
Y
H
S
S
S
F
TN
I
R
D
R
I
A
Q
S
R
L
L
L
E
F
V
K
D
S
L
E
H
S
K
T
------
P
Y
A
E
V
L
K
T
E
A
--
G
L
L
A
K
Q
T
D
H
Y
L
R
H
-
D
H
--
L
E
E
E
N
A
Q
-----------
F
Y
F
---
H
E
F
M
N
E
A
R
K
H
N
---------
L
Q
Y
L
A
DCNIST
M
Y
L
-
G
N
M
P
P
K
V
V
E
Q
L
K
A
V
N
D
I
V
R
T
E
Q
Y
M
D
F
I
T
N
R
R
F
R
T
T
L
L
C
H
ND
L
K
I
N
R
N
I
N
-----------
N
D
D
I
K
K
---
F
N
-
I
-
I
----
F
N
V
I
P
E
K
P
L
K
E
V
D
L
N
N
A
T
E
N
L
Q
F
F
--
L
N
G
N
K
E
S
N
L
S
-------
T
T
--
S
P
-
Y
M
K
A
I
L
Y
T
F
S
E
N
L
N
N
P
L
-----
S
F
K
Q
V
----
T
S
E
A
N
T
K
------
L
N
N
T
K
--------
L
N
E
I
K
N
E
L
L
N
N
A
M
K
-------
L
V
L
Q
G
Y
I
S
I
T
-------------
N
------
Q
---
K
H
R
S
K
P
V
L
D
K
P
K
T
T
Q
--------
M
V
I
Y
---
Q
A
K
Y
T
P
S
M
W
V
--
T
N
L
K
H
E
P
I
G
V
N
--
F
F
E
K
F
A
L
R
----------
Y
M
D
-
G
R
N
D
K
K
A
I
I
E
A
I
L
G
H
V
E
K
G
E
L
T
L
-
S
R
E
G
Q
K
I
E
N
K
E
E
-
I
R
K
E
-----------
L
E
S
L
F
T
P
M
I
E
K
F
C
S
N
A
L
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
24.49
16%
23
- C1 -
-
4BHW
1
EP300_HUMAN
A:
[14-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
F
K
P
E
E
L
R
Q
A
L
M
P
T
L
E
A
L
Y
R
-------
Q
--------------
D
P
E
S
L
P
---
F
R
-
Q
P
V
D
P
Q
L
L
G
I
P
D
Y
F
D
I
V
K
S
P
M
---
D
L
----
S
--
T
I
K
R
K
L
D
T
G
Q
-------
Y
Q
E
P
W
Q
-
Y
V
D
D
I
W
L
M
F
N
N
A
W
L
--
Y
NRKTS
R
V
Y
K
Y
----
C
S
K
L
S
E
V
------
F
E
Q
E
I
--------
D
P
V
M
Q
S
L
G
Y
C
C
G
R
K
L
E
F
S
PQT
L
C
C
Y
G
K
Q
L
C
T
I
P
R
D
A
T
Y
Y
S
Y
QNR
Y
------
H
F
C
E
K
C
F
N
E
I
Q
G
E
S
V
S
L
G
D
DPSQPQ
T
T
I
N
K
E
---
Q
F
S
K
R
K
N
D
T
L
--
D
P
E
L
F
V
E
C
T
E
C
G
R
K
M
H
Q
I
C
V
L
HHEIIWPAGF
V
C
D
-
G
C
L
K
K
S
A
R
T
R
K
----
E
N
K
F
S
A
K
R
L
P
S
T
R
L
G
T
F
L
E
N
R
V
N
D
F
L
-----------
R
R
Q
N
H
P
E
S
G
E
V
T
V
R
V
V
H
A
S
D
K
T
V
E
V
K
P
G
M
K
A
R
F
V
----------
D
--
S
G
E
M
A
E
S
F
P
Y
R
-
T
K
A
L
F
A
F
E
E
I
DG
V
D
L
C
-
F
F
G
M
-----
H
V
Q
E
Y
G
S
D
C
P
P
--
P
N
Q
R
R
V
Y
I
S
Y
L
D
S
V
H
F
F
R
P
K
C
L
R
T
A
V
Y
-
H
E
I
L
I
G
Y
L
E
Y
V
K
K
L
G
--------
Y
T
---------------------
T
G
H
I
W
A
C
-
P
-------------------
P
----
S
-------------
E
------
G
D
DY
I
-
F
H
C
---------
H
P
P
D
Q
K
---
I
P
K
P
K
R
L
Q
E
--
W
F
K
K
M
L
D
K
A
V
S
E
------------------
R
I
V
H
D
Y
K
D
I
F
K
---
Q
A
T
E
D
R
L
T
S
A
K
E
L
-
P
Y
---
F
-
E
G
D
F
-
W
P
N
V
L
E
E
S
I
K
E
S
G
------
G
SGSQK
L
Y
-----------
A
-
T
M
E
K
H
K
E
V
F
F
V
I
R
L
I
A
G
P
A
A
N
S
L
P
P
----
I
V
D
P
D
P
L
I
P
C
D
L
M
-----
D
G
------
R
D
-
A
F
L
T
L
A
R
D
K
H
L
E
F
S
S
L
R
R
A
Q
W
S
T
M
C
M
L
V
E
L
H
T
Q
S
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
24.11
12%
-99
- C7 -
-
1LFP
-
Y1575_AQUAE
A:
[85-125]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
E
--
G
Y
A
P
G
G
V
A
V
M
V
L
------------------
A
T
T
D
N
R
N
R
T
T
S
---
E
V
R
H
V
F
T
K
H
G
G
N
L
-
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
18.86
17%
-127
- C7 -
-
1GVN
-
EATX_STRPY
A:
[7-30]
---------------
K
---
T
F
E
I
E
I
I
N
E
L
S
-----
A
S
V
Y
N
R
V
L
N
Y
-
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------